Patents Assigned to Lupin Limited
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Publication number: 20240123169Abstract: A breath actuated metered dose inhaler including a housing, a canister and a trigger mechanism. The trigger mechanism is activated by the inhalation of air which comprises of a diaphragm. The central rigid disk of the diaphragm is provided with the interlocking means to firmly secure and bound the peripheral flexible polymer ring with the central rigid disc. The mechanical interlock between a central rigid disk and a peripheral flexible polymer ring on the diaphragm prevent peripheral flexible polymer ring from being peeled off from the central rigid disc while the vacuum is being retained prior to inhalation.Type: ApplicationFiled: October 17, 2023Publication date: April 18, 2024Applicant: Lupin LimitedInventors: Imran Shaikh, Mukul Dalvi, Keith Grider
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Patent number: 11952380Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.Type: GrantFiled: May 6, 2022Date of Patent: April 9, 2024Assignee: LUPIN LIMITEDInventors: Prathap Sreedharan Nair, Ganesh Bhausaheb Gudade, Sachin Sethi, Dipak Raychand Lagad, Chetan Sanjay Pawar, Mahadeo Bhaskar Tryambake, Chaitanya Prabhakar Kulkarni, Anil Kashiram Hajare, Balasaheb Arjun Gore, Sanjeev Anant Kulkarni, Milind Dattatraya Sindkhedkar, Venkata P. Palle, Rajender Kumar Kamboj
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Publication number: 20230140054Abstract: This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.Type: ApplicationFiled: January 17, 2021Publication date: May 4, 2023Applicant: Lupin LimitedInventors: Rajender Kumar KAMBOJ, Kamlesh Jyotindra PADIYA, Kamalakannan PRABAKARAN, Kumar Ram NAIK, Bhavani Shankar RAJESH, Ganpati Powar RAJENDRA, Subhash Ingawale SACHIN, Dattatray Karche AMIT, Shankar Dange SANTOSHKUMAR, Barve SITARAM RAMBHAU
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Publication number: 20230066014Abstract: The invention relates to substituted nucleoside analogues of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.Type: ApplicationFiled: December 2, 2020Publication date: March 2, 2023Applicant: Lupin LimitedInventors: Prathap Sreedharan NAIR, Ganesh Bhausaheb GUDADE, Shankar Bhaskar BHAGWAT, Amol Maruti YADAV, Chaitanya Prabhakar KULKARNI, Milind Dattatraya SINDKHEDKAR, Venkata P. PALLE, Rajender Kumar KAMBOJ
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Patent number: 11459330Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.Type: GrantFiled: December 13, 2018Date of Patent: October 4, 2022Assignee: LUPIN LIMITEDInventors: Prathap Sreedharan Nair, Ganesh Bhausaheb Gudade, Sachin Sethi, Dipak Raychand Lagad, Chetan Sanjay Pawar, Mahadeo Bhaskar Tryambake, Chaitanya Prabhakar Kulkarni, Anil Kashiram Hajare, Balasaheb Arjun Gore, Sanjeev Anant Kulkarni, Milind Dattatraya Sindkhedkar, Venkata P. Palle, Rajender Kumar Kamboj
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Publication number: 20220306732Abstract: The present invention provides a method of treating ocular disorders by administering a suitable amount of VEGF inhibitors in a patient in need thereof, wherein the suitable amount of VEGF inhibitor is determined with respect to the body weight of the patient. Further, present invention also provides a method of treating ocular disorders by administering a personalized dose of a suitable amount of VEGF inhibitors intravitreally, wherein the dose is decided based on the body weight of the said patient at any given point in time.Type: ApplicationFiled: September 10, 2020Publication date: September 29, 2022Applicant: Lupin LimitedInventors: Dhananjay Sadashiv BAKHLE, Chirag Anilkumar SHAH, Preetam Nivrutti CHAVAN
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Publication number: 20220267339Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.Type: ApplicationFiled: May 6, 2022Publication date: August 25, 2022Applicant: LUPIN LIMITEDInventors: Prathap Sreedharan Nair, Ganesh Bhausaheb Gudade, Sachin Sethi, Dipak Raychand Lagad, Chetan Sanjay Pawar, Mahadeo Bhaskar Tryambake, Chaitanya Prabhakar Kulkarni, Anil Kashiram Hajare, Balasaheb Arjun Gore, Sanjeev Anant Kulkarni, Milind Dattatraya Sindkhedkar, Venkata P. Palle, Rajender Kumar Kamboj
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Patent number: 11365418Abstract: The present invention relates to the dual, independent cistron expression system in a single vector for the production of protein of interest proteins and peptides expressed as insoluble inclusion bodies formed in the bacteria E. coli. The present invention also provides the process for the expression of protein of interest using said bicistronic vector.Type: GrantFiled: April 24, 2019Date of Patent: June 21, 2022Assignee: Lupin LimitedInventors: Shardul Salunkhe, Brajesh Varshney, Sudheerbabu Soorapaneni
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Publication number: 20220144852Abstract: Disclosed are the macrocyclic compounds having the general Formula (I) and their tautomeric forms, stereoisomers, pharmaceutically acceptable salts, and their combination with suitable medicament, corresponding processes for the synthesis and pharmaceutical compositions and uses of compounds disclosed herein.Type: ApplicationFiled: March 21, 2020Publication date: May 12, 2022Applicant: LUPIN LIMITEDInventors: Navnath Popat KARCHE, Moloy BANERJEE, Pradeep Rangrao PATIL, Vinod Popatrao VYAVAHARE, Deepak Sahebrao WALKE, Vaibhav Madhukar KALHAPURE, Vidya RAMDAS, Venkata P. PALLE, Rajender Kumar KAMBOJ
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Patent number: 11278502Abstract: The present invention provides a modified release formulation of lacosamide. The modified release formulation of the present invention comprising lacosamide and modified release polymer provides modified release of lacosamide with minimal Cmax to Cmin peak to trough variation over a period of at least 12 hrs.Type: GrantFiled: September 28, 2018Date of Patent: March 22, 2022Assignee: LUPIN LIMITEDInventors: Shirishkumar Kulkarni, Satish Kumar Dalal, Harshal Jahagirdar, Kishore Kumar Konda
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Patent number: 11248005Abstract: Provided herein is a process for the intermediates used for preparation of HIV Integrase Inhibitor such as Bictegravir, Dolutegravir, Cabotegravir or their pharmaceutically acceptable salts.Type: GrantFiled: July 7, 2020Date of Patent: February 15, 2022Assignee: Lupin LimitedInventors: Harishchandra Sambhaji Jadhav, Dhananjai Shrivastava, Umesh Parasharam Aher, Sharad Chandrabhan Deokar, Deepak Babasaheb Nale, Suryakant Tukaram Honrao, Girij Pal Singh
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Publication number: 20210338586Abstract: A stable lyophilized dosage form of protein is provided that comprises a lyophilate and a reconstitution liquid such that upon reconstitution the formulation will be qualitatively and quantitatively same as that of an already established or developed ready-to-use liquid dosage form of the same protein.Type: ApplicationFiled: June 26, 2019Publication date: November 4, 2021Applicant: LUPIN LIMITEDInventors: Prasanna DEVARANENI, Vaibhav DEOKAR, Rustom MODY
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Publication number: 20210163486Abstract: The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.Type: ApplicationFiled: December 13, 2018Publication date: June 3, 2021Applicant: LUPIN LIMITEDInventors: Prathap Sreedharan Nair, Ganesh Bhausaheb Gudade, Sachin Sethi, Dipak Raychand Lagad, Chetan Sanjay Pawar, Mahadeo Bhaskar Tryambake, Chaitanya Prabhakar Kulkarni, Anil Kashiram Hajare, Balasaheb Arjun Gore, Sanjeev Anant Kulkarni, Milind Dattatraya Sindkhedkar, Venkata P. Palle, Rajender Kumar Kamboj
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Patent number: 10953021Abstract: Provided herein are compositions and methods for treating or preventing a skin disease or skin condition on the skin of a subject by administering a topical flunisolide composition comprising a therapeutically effective amount of flunisolide and a solubilizing agent that solubilizes the flunisolide.Type: GrantFiled: March 14, 2014Date of Patent: March 23, 2021Assignee: Lupin LimitedInventors: Douglas Anthony Bakan, Steven B. Newhard, Nilendu Sen, Amol Subhash Mandhare, Tushar Deoram Jadhav, Mukesh Kumar
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Publication number: 20200375959Abstract: A solid dispersion of rifaximin comprising rifaximin and pharmaceutically acceptable carrier. A pharmaceutical composition comprising the solid dispersion of rifaximin.Type: ApplicationFiled: May 6, 2020Publication date: December 3, 2020Applicant: Lupin LimitedInventors: Shirishkumar KULKARNI, Satish Kumar DALAL, Harshal Anil JAHAGIRDAR
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Patent number: 10786464Abstract: The present invention provides a modified release formulation of lacosamide. The modified release formulation of the present invention comprising lacosamide and modified release polymer provides modified release of lacosamide with minimal Cmax to Cmin peak to trough variation over a period of at least 12 hrs.Type: GrantFiled: November 3, 2010Date of Patent: September 29, 2020Assignee: LUPIN LIMITEDInventors: Shirishkumar Kulkarni, Satish Kumar Dalal, Harshal Jahagirdar, Kishore Kumar Konda
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Patent number: 10781250Abstract: A refolding process of Ranibizumab is disclosed wherein the solubilized solution of heavy chain and/or light chain of Ranibizumab treated with refolding buffer under suitable conditions including pH, temperature and incubation period and the pH and temperature shift is performed at suitable interval to obtain high quality and quantity of refolded protein.Type: GrantFiled: August 17, 2016Date of Patent: September 22, 2020Assignee: Lupin LimitedInventors: Sandeep Somani, Ashish Pandey, Ashok Mishra, Rustom Sorab Mody
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Patent number: 10752586Abstract: The present invention provides process for preparation of molindone (I) comprising: a) reacting compound with cyclohexane-1,3-dione to form 2-(2-oxopentan-3-yl)cyclohexane-1,3-dione wherein X is Cl, Br or I, b) cyclizing 2-(2-oxopentan-3-yl)cyclohexane-1,3-dione to 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole, c) reacting 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole with morpholine and formaldehyde to give molindone (I), and d) optionally converting molindone (I) to its salt. The present invention further provides process for preparation of compound comprising: a) reacting compound with ethyl halide and another halide source to form compound wherein R is alkyl and X is Cl, Br or I; b) converting compound to compound.Type: GrantFiled: February 14, 2020Date of Patent: August 25, 2020Assignee: LUPIN LIMITEDInventors: Amit Madanrao Agarkar, Tejas Vilas Puranik, Rajesh Bharat Gapat, Umesh Babanrao Rananaware, Radhakrishna Bhikaji Shivdavkar, Girij Pal Singh
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Patent number: 10752618Abstract: The present invention provides improved, commercially viable and consistently reproducible processes for the preparation of pure and stable crystalline Raltegravir potassium Form 3 and pharmaceutical composition thereof.Type: GrantFiled: September 13, 2017Date of Patent: August 25, 2020Assignee: LUPIN LIMITEDInventors: Purna Chandra Ray, Samir Shanteshwar Shabade, Surinder Kumar Arora, D. Rajput Lalitkumar, B. Shivdavkar Radhakrishna, G. Varade Shantanu, D. Ausekar Govind, Girij Pal Singh, Shreyas Pandurang Deshmukh, Gaurav Amrut Patil
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Publication number: 20200262788Abstract: The present invention provides process for preparation of molindone (I) comprising: a) reacting compound with cyclohexane-1,3-dione to form 2-(2-oxopentan-3-yl)cyclohexane-1,3-dione wherein X is Cl, Br or I, b) cyclizing 2-(2-oxopentan-3-yl)cyclohexane-1,3-dione to 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole, c) reacting 2-methyl-3-ethyl-4-oxo-4,5,6,7-tetrahydroindole with morpholine and formaldehyde to give molindone (I), and d) optionally converting molindone (I) to its salt. The present invention further provides process for preparation of compound comprising: a) reacting compound with ethyl halide and another halide source to form compound wherein R is alkyl and X is Cl, Br or I; b)converting compound to compound.Type: ApplicationFiled: February 14, 2020Publication date: August 20, 2020Applicant: LUPIN LIMITEDInventors: Amit Madanrao AGARKAR, Tejas Vilas PURANIK, Rajesh Bharat GAPAT, Umesh Babanrao RANANAWARE, Radhakrishna Bhikaji SHIVDAVKAR, Girij Pal SINGH