Patents Assigned to Lupin Limited
  • Modified SAK gene for the production of recombinant proteins
    Patent number: 9670262
    Abstract: The present invention relates to modified SAK gene having amino acid SEQ ID 2. The present invention further relates to process for cloning and expressing modified SAK gene fusion protein which imparts improved stability to the heterologous protein of interest. Further the invention relates to process of purification of recombinant heterologous proteins from bacterial inclusion bodies using modified SAK.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: June 6, 2017
    Assignee: LUPIN LIMITED
    Inventors: Shardul Salunkhe, Bhaskarjyoti Prasad, Praveen Muneshwar, Anjali Apte Deshpande, Sriram Padmanabhan
  • PROCESS FOR THE PURIFICATION OF TNFR:FC FUSION PROTEIN
    Publication number: 20170152298
    Abstract: The present invention relates to the purification of TNFR:Fc fusion protein. More specifically related to process of purification of TNFR:Fc fusion protein wherein the HCP is reduced. The present invention is directed to the use of mixed-mode chromatography and/or affinity chromatography to produce TNFR:Fc fusion protein which is substantially free of at least one of the protein degrading enzyme present in HCP.
    Type: Application
    Filed: June 13, 2015
    Publication date: June 1, 2017
    Applicant: LUPIN LIMITED
    Inventors: Abir BANERJEE, Chandranath GANAPATHY, Sorab Rustom MODY, Ashok MISHRA
  • QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS
    Publication number: 20170137421
    Abstract: Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R4, and n are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PI3K enzyme of a subject.
    Type: Application
    Filed: July 1, 2015
    Publication date: May 18, 2017
    Applicant: Lupin Limited
    Inventors: Manojkumar Ramprasad Shukla, Nirmal Kumar Jana, Sachin Jaysing Mahangare, Prashant Popatrao Vidhate, Dipak Raychand Lagad, Anand Jagannath Tarage, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
  • HETEROCYCLYL COMPOUNDS
    Publication number: 20170112840
    Abstract: The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them.
    Type: Application
    Filed: January 6, 2017
    Publication date: April 27, 2017
    Applicant: LUPIN LIMITED
    Inventors: Bhavesh DAVE, Rakesh Kumar BANERJEE, Samiron PHUKAN, Abhijit Datta KHOJE, Rajkumar HANGARGE, Jitendra Sambhaji JADHAV, Venkata P. PALLE, Rajender Kumar KAMBOJ
  • HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
    Publication number: 20170101408
    Abstract: The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment.
    Type: Application
    Filed: December 22, 2016
    Publication date: April 13, 2017
    Applicant: LUPIN LIMITED
    Inventors: Bhavesh DAVE, Rakesh Kumar BANERJEE, Samiron PHUKAN, Abhijit Datta KHOJE, Rajkumar HANGARGE, Jitendra Sambhaji JADHAV, Venkata P. PALLE, Rajender Kumar KAMBOJ
  • Pyrrole derivatives as alpha 7 nAChR modulators
    Patent number: 9617211
    Abstract: Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and m are as described herein, as a modulator of nicotinic acetylcholine receptors particularly ?7 subtype, its tautomeric forms, its stereoisomers, its pharmaceutically acceptable salts, its pharmaceutical composition, and its combinations with suitable medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: April 11, 2017
    Assignee: Lupin Limited
    Inventors: Neelima Sinha, Navnath Popat Karche, Anil Kashiram Hajare, Baban Rupaji Thube, Dnyaneshwar Changdeo Bhanage, Venkata P. Palle, Rajender Kumar Kamboj
  • Pyrrole derivatives as alpha 7 NACHR modulators
    Patent number: 9617210
    Abstract: Disclosed are compounds of the Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and m are as described herein, as modulators of the nicotinic acetylcholine receptors, particularly the ?7 subtype, their tautomeric forms, stereoisomers, and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and combinations thereof with suitable other medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and/or treatment of disorders such as Alzheimer's disease, mild cognitive impairment, and senile dementia.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: April 11, 2017
    Assignee: Lupin Limited
    Inventors: Neelima Sinha, Navnath Popat Karche, Shridhar Keshav Adurkar, Venkata P. Palle, Rajender Kumar Kamboj
  • Heterocyclyl compounds
    Patent number: 9573944
    Abstract: The present invention is related to heteroaryl compounds as MEK inhibitors. The invention includes heteroaryl compounds of formula I, their tautomers and pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: February 21, 2017
    Assignee: Lupin Limited
    Inventors: Bhavesh Dave, Rakesh Kumar Banerjee, Samiron Phukan, Abhijit Datta Khoje, Rajkumar Hangarge, Jitendra Sambhaji Jadhav, Venkata P. Palle, Rajender Kumar Kamboj
  • Heterocyclyl compounds as MEK inhibitors
    Patent number: 9555035
    Abstract: The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: January 31, 2017
    Assignee: Lupin Limited
    Inventors: Bhavesh Dave, Rakesh Kumar Banerjee, Samiron Phukan, Abhijit Datta Khoje, Rajkumar Hangarge, Jitendra Sambhaji Jadhav, Venkata P. Palle, Rajender Kumar Kamboj
  • Pyrrole derivatives as alpha 7 nAChR modulators
    Patent number: 9504680
    Abstract: Disclosed are compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and m are as described herein, as modulators of the nicotinic acetylcholine receptors, particularly the ?7 subtype, their tautomeric forms, stereoisomers, and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, and combinations thereof with suitable other medicaments. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and/or treatment of disorders such as Alzheimer's disease, mild cognitive impairment, and senile dementia.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: November 29, 2016
    Assignee: Lupin Limited
    Inventors: Neelima Sinha, Navnath Popat Karche, Shridhar Keshav Adurkar, Dnyaneshwar Changdeo Bhanage, Venkata P. Palle, Rajender Kumar Kamboj
  • HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
    Publication number: 20160331753
    Abstract: The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment.
    Type: Application
    Filed: July 25, 2016
    Publication date: November 17, 2016
    Applicant: LUPIN LIMITED
    Inventors: Bhavesh DAVE, Rakesh Kumar BANERJEE, Samiron PHUKAN, Abhijit Datta KHOJE, Rajkumar HANGARGE, Jitendra Sambhaji JADHAV, Venkata P. PALLE, Rajender Kumar KAMBOJ
  • 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yl)benzenesulfonamide as alpha 7 nAChR modulator
    Patent number: 9447037
    Abstract: Disclosed are an alpha 7 nAChR receptor modulator compound, 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yljbenzenesulfonamide, its tautomeric form, its pharmaceutically acceptable salts, pharmaceutical compositions comprising the compound or a salt thereof, and a method of treating various diseases, disorders or conditions, for example, Alzheimer's disease, mild cognitive impairment, senile dementia, vascular dementia, dementia of Parkinson's disease, and attention deficit disorder.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: September 20, 2016
    Assignee: Lupin Limited
    Inventors: Neelima Sinha, Navnath Popat Karche, Ajay Ramchandra Tilekar, Venkata P. Palle, Rajender Kumar Kamboj
  • Heterocyclyl compounds as MEK inhibitors
    Patent number: 9428499
    Abstract: The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: August 30, 2016
    Assignee: LUPIN LIMITED
    Inventors: Bhavesh Dave, Rakesh Kumar Banerjee, Samiron Phukan, Abhijit Datta Khoje, Rajkumar Hangarge, Jitendra Sambhaji Jadhav, Venkata P. Palle, Rajender Kumar Kamboj
  • Oral controlled release pharmaceutical compositions of bepotastine
    Patent number: 9421165
    Abstract: The present invention relates to oral controlled release pharmaceutical compositions comprising Bepotastine. The oral controlled release pharmaceutical composition comprises Bepotastine or pharmaceutically acceptable salts thereof and at least one release controlling agent. The present invention also provides the use of oral controlled release pharmaceutical compositions of Bepotastine for the treatment of allergic rhinitis and for the treatment of pruritus caused by urticaria.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: August 23, 2016
    Assignee: LUPIN LIMITED
    Inventors: Ashish Ashokrao Deshmukh, Pravin Meghrajji Bhutada, Sajeev Chandran, Shirishkumar Kulkarni
  • Substituted pyrazole compounds as CRAC modulators
    Patent number: 9409898
    Abstract: The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: August 9, 2016
    Assignee: LUPIN LIMITED
    Inventors: Nageswara Rao Irlapati, Gokul Keruji Deshmukh, Nilesh Raghunath Khedkar, Kiran Chandrashekhar Kulkarni, Zubair Abdul Wajid Shaikh, Neelima Sinha, Venkata P. Palle, Rajender Kumar Kamboj
  • Substituted pyridine compounds as CRAC modulators
    Patent number: 9399638
    Abstract: The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: July 26, 2016
    Assignee: LUPIN LIMITED
    Inventors: Nageswara Rao Irlapati, Zubair Abdul Wajid Shaikh, Vijay Pandurang Karche, Gokul Keruji Deshmukh, Neelima Sinha, Venkata P. Palle, Rajender Kumar Kamboj
  • Heteroaryl derivatives as alpha7 nAChR modulators
    Patent number: 9393247
    Abstract: Disclosed is a compound of formula I: wherein Z, m and R1-R6 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the ?7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: July 19, 2016
    Assignee: Lupin Limited
    Inventors: Neelima Sinha, Gourhari Jana, Sachchidanand Sachchidanand, Sanjay Pralhad Kurhade, Navnath Popat Karche, Anil Kashiram Hajare, Ajay Ramchandra Tilekar, Venkata P. Palle, Rajender Kumar Kamboj
  • Thiazole derivatives as alpha 7 nAChR modulators
    Patent number: 9388196
    Abstract: Disclosed is a compound of formula (I) wherein Y, Ring D, m and R1-R4 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the ?7 subtype, in a subject in need thereof, as well as pharmaceutically acceptable salts, polymorphs, solvates, and isomers thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: July 12, 2016
    Assignee: Lupin Limited
    Inventors: Neelima Sinha, Navnath Popat Karche, Anil Kashiram Hajare, Shridhar Keshav Adurkar, Bikramjit Singh Lairikyengbam, Firoj Aftab Raje, Ajay Ramchandra Tilekar, Baban Rupaji Thube, Venkata P. Palle, Rajender Kumar Kamboj
  • Inhaler base plate with mouthpiece
    Patent number: D789518
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: June 13, 2017
    Assignee: LUPIN LIMITED
    Inventors: Vishwajit Bhide, Raghuram Amperayani Pattabhi, Rohini Pimple, Bishu Choubey
  • Inhaler base plate
    Patent number: D790684
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: June 27, 2017
    Assignee: LUPIN LIMITED
    Inventors: Vishwajit Bhide, Raghuram Amperayani Pattabhi, Rohini Pimple, Bishu Choubey