Patents Assigned to Ma'at
  • Use of Perfusion Seed Cultures to Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality
    Publication number: 20160289633
    Abstract: Methods of improving the efficiency of production of a protein product of interest in mammalian cell culture are presented. In particular, the methods result in an increase in the quantity of a protein product produced, or decreases protein product production time in a manufacturing-scale bioreactor cell culture. The disclosed methods comprise: (a) culturing the N-1 bioreactor culture to high viable cell densities; and (b) seeding the production bioreactor culture at high viable cell seeding densities.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 6, 2016
    Applicant: Biogen MA Inc.
    Inventors: William C. YANG, Jiuyi LU, Yao-Ming HUANG, Hang YUAN, Rashmi KSHIRSAGAR, Thomas RYLL
  • PROCOAGULANT FUSION COMPOUND
    Publication number: 20160289273
    Abstract: The present invention provides a fusion compound comprising a procoagulant compound and an immunoglobulin constant region or a portion thereof and methods of making and using the fusion compound. The fusion compounds of the present disclosure are useful for the treatment of coagulation disorders, such as hemophilia. In some aspects, the invention includes a method of reducing or preventing aggregates which comprise a procoagulant compound comprising fusing the procoagulant compound to an immunoglobulin constant region or a portion thereof wherein the procoagulant compound comprises an amino acid sequence. In another embodiment, the fusion compound forms less aggregates compared to a compound consisting of the procoagulant compound.
    Type: Application
    Filed: November 7, 2014
    Publication date: October 6, 2016
    Applicant: Biogen MA Inc.
    Inventor: Karina THORN
  • Method for delivering interferon-?
    Patent number: 9452106
    Abstract: The method described herein reduces the amount of aggregating metal released into solutions of Interferon-.beta.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: September 27, 2016
    Assignee: Biogen MA Inc
    Inventors: Eric Anthony Faulkner, Mary Diana DiBiase
  • THROMBIN CLEAVABLE LINKER WITH XTEN AND ITS USES THEREOF
    Publication number: 20160251408
    Abstract: The present invention provides a chimeric molecule comprising a VWF protein fused to a heterologous moiety via a VWF linker. The invention provides an efficient VWF linker that can be cleaved in the presence of thrombin. The chimeric molecule can further comprise a polypeptide chain comprising a FVIII protein and a second heterologous moiety, wherein the chain comprising the VWF protein and the chain comprising the FVIII protein are associated with each other. The invention also includes nucleotides, vectors, host cells, methods of using the chimeric proteins.
    Type: Application
    Filed: June 27, 2014
    Publication date: September 1, 2016
    Applicant: Biogen MA Inc.
    Inventors: Ekta Seth CHHABRA, John KULMAN, Tongyao LIU
  • POLYMER CONJUGATES OF INTERFERON BETA-1a AND USES
    Publication number: 20160250340
    Abstract: An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications.
    Type: Application
    Filed: April 18, 2016
    Publication date: September 1, 2016
    Applicant: BIOGEN MA INC.
    Inventors: Blake PEPINSKY, Laura RUNKEL, Margot BRICKELMAIER, Adrian WHITTY, Paula HOCHMAN
  • Silicon-containing fumaric acid esters
    Patent number: 9421273
    Abstract: The present invention is directed to silicon-containing fumaric acid esters of the Formulae I-IV. The silicon-containing fumaric acid esters of Formulae I-IV are useful in transplantation medicine and for the treatment of autoimmune diseases and autoimmune-related diseases. (I), (II), (III) & (IV).
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 23, 2016
    Assignee: Biogen MA Inc.
    Inventor: Jianhua Chao
  • Process for preparing high purity and crystalline dimethyl fumarate
    Patent number: 9422226
    Abstract: The present invention describes a process for the preparation of dimethyl fumarate. The process involves the esterification of fumaric acid and methanol in the presence of sulfuric acid as an acid catalyst. The high purity dimethyl fumarate contains no more than trace amounts of dimethyl sulfate. The present invention also provides a process for the preparation of highly pure dimethyl fumarate with a particle size from 20 to 250???.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: August 23, 2016
    Assignee: Biogen MA Inc.
    Inventors: John Guzowski, William Kiesman, Erwin Irdham
  • Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters
    Publication number: 20160237399
    Abstract: The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 18, 2016
    Applicant: Biogen MA Inc.
    Inventors: William YANG, Yao-Ming Huang, Kyle McElearney, Lia Tescione, James Lambropoulos, An Zhang, Valerie Tsang, Thomas Ryll
  • THROMBIN CLEAVABLE LINKER
    Publication number: 20160229903
    Abstract: The present invention provides a chimeric molecule comprising a VWF protein fused to a heterologous moiety via a VWF linker. The invention provides an efficient VWF linker that can be cleaved in the presence of thrombin. The chimeric molecule can further comprise a polypeptide chain comprising a FVIII protein and a second heterologous moiety, wherein the chain comprising the VWF protein and the chain comprising the FVIII protein are associated with each other. The invention also includes nucleotides, vectors, host cells, methods of using the VWF fragment, or the chimeric proteins.
    Type: Application
    Filed: June 27, 2014
    Publication date: August 11, 2016
    Applicant: Biogen MA Inc.
    Inventors: Ekta Seth CHHABRA, John KULMAN, Tongyao LIU
  • TRANSGENIC ANIMALS FOR IN VIVO IMAGING
    Publication number: 20160228577
    Abstract: Compositions, methods and transgenic animals for in vivo detection of ectopically expressed sodium iodide symporter (NIS) are provided.
    Type: Application
    Filed: October 15, 2014
    Publication date: August 11, 2016
    Applicant: Biogen MA Inc.
    Inventors: Ajay Verma, John William Hoppin, Roger Askew
  • TREATMENT OF MELANOMA WITH INTERFERON-BETA AND RAS-RAF-MEK-ERK INHIBITOR COMBINATION THERAPY
    Publication number: 20160228513
    Abstract: This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.
    Type: Application
    Filed: October 15, 2015
    Publication date: August 11, 2016
    Applicant: BIOGEN MA INC.
    Inventors: Darren P. BAKER, Ingrid B.J.K. JOSEPH, Xinzhong WANG
  • Linker peptides and polypeptides comprising same
    Patent number: 9409950
    Abstract: The invention is based, at least in part, on the finding that linker peptides which lack the amino acid sequence GSG reduce or eliminate the addition of posttranslational modifications to the polypeptides which comprise them. More specifically, the novel linker peptides disclosed herein reduce the ability of enzymes to link carbohydrate adducts to polypeptides comprising these linker peptides, e.g., reduce the ability of xylosyltransferase to link xylose to polypeptides. These novel linker peptides, molecules comprising same, and methods of their use are described.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: August 9, 2016
    Assignee: Biogen MA Inc.
    Inventors: Brian Robert Miller, Scott Glaser, Justin Caravella, Susan Foley, Xiaoping Hronowski, Tigran Aivazian
  • Lighting control console having a slide control
    Patent number: 9402291
    Abstract: The invention relates to a lighting control console for controlling a lighting system. At least one slide control is provided in the control panel of the lighting control console, which slide control allows users to enter input values by linearly adjusting a control knob, wherein a contact holder is provided at the slide control. A linkage lever links the control knob and the contact holder. In the housing of the lighting control console, at least one light source is provided, wherein at least one light exit is provided at the control knob, and wherein a light conducting element is provided between the light source and the light exit, in which element the light of the light source can be transmitted to the light exit at the control knob.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: July 26, 2016
    Assignee: MA LIGHTING TECHNOLOGY GMBH
    Inventor: Michael Adenau
  • Pyrimidinyl tyrosine kinase inhibitors
    Patent number: 9394277
    Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: July 19, 2016
    Assignees: Biogen MA Inc., Sunesis Pharmaceuticals, Inc.
    Inventors: Brian T. Hopkins, Patrick Conlon, Timothy R. Chan, Tracy J. Jenkins, Xiongwei Cai, Michael Humora, Xianglin Shi, Ross A. Miller, Andrew Thompson
  • FACTOR VIII-XTEN FUSIONS AND USES THEREOF
    Publication number: 20160199454
    Abstract: The present invention provides chimeric proteins comprising a Factor VIII (FVIII) polypeptide and XTEN polypeptides. The FVIII polypeptide can have a reduced affinity for von Willebrand Factor (VWF). XTEN polypeptides of appropriate sizes are inserted into the FVIII polypeptide at particular locations in order to extend the half-life of the FVIII polypeptide. The invention also includes nucleotides, vectors, host cells, and methods of using the chimeric proteins, e.g., to treat bleeding diseases and disorders.
    Type: Application
    Filed: August 14, 2014
    Publication date: July 14, 2016
    Applicants: Biogen MA Inc., Amunix Operating Inc.
    Inventors: Tongyao LIU, Pei-Yun CHANG, John KULMAN, Volker SCHELLENBERGER, Haiyan JIANG, Robert T. PETERS, Ekta Seth CHHABRA
  • Methods of treating a patient having an autoimmune disorder by administering a soluble BCMA
    Patent number: 9387237
    Abstract: Therapeutic regimens for administration of BAFF antagonists for treatment of immunologic and related disorders are described. Regimens involve a short-term BAFF antagonist administration course followed by an extended no-treatment period prior the round of administration.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: July 12, 2016
    Assignee: BIOGEN MA INC.
    Inventors: Susan Kalled, Sambasiva Rao
  • ANTIBODIES AGAINST MONOCYTE CHEMOTACTIC PROTEINS
    Publication number: 20160185846
    Abstract: The invention provides antibodies that bind to a plurality of ?-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. The invention also provides cells producing the antibodies, and methods of making and using the same.
    Type: Application
    Filed: June 22, 2015
    Publication date: June 30, 2016
    Applicant: BIOGEN MA INC.
    Inventors: Antonin R. DE FOUGEROLLES, Victor E. KOTELIANSKI, Carl REID, Ellen GARBER
  • PURIFICATION OF CHIMERIC FVIII MOLECULES
    Publication number: 20160185817
    Abstract: The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity chromatography, and subjecting the chimeric protein to an AEX chromatography; wherein the chimeric protein comprises a factor VIII protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor VIII activity.
    Type: Application
    Filed: August 8, 2014
    Publication date: June 30, 2016
    Applicant: Biogen MA Inc.
    Inventors: Lily ZHU, Anxhela KOLE, John KULMAN, Marisol ACOSTA
  • Anti-VLA-4 related assays
    Patent number: 9377458
    Abstract: Methods and apparatus for assaying the level of analytes in a sample, related to VLA-4, are disclosed. A method of decreasing the level of an anti-integrin antibody in a subject is described including a) contacting a biological sample from a subject with a detectable capture agent associated with a substrate, wherein the capture agent can bind an anti-integrin antibody in the sample; b) detecting binding of the capture agent with the level of the anti-integrin antibody; and c) treating the subject with plasma exchange until the level of the anti-integrin antibody in the sample reaches a predetermined level.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: June 28, 2016
    Assignee: BIOGEN MA INC.
    Inventors: Tatiana Plavina, Paula S. Hochman, Michaela Lerner
  • Use of nuclear magnetic resonance and near infrared to analyze biological samples
    Patent number: 9360421
    Abstract: In one aspect, the disclosure provides methods for using NMR and NIR to evaluate biological samples. In some embodiments, the methods include a step of performing a Nuclear Magnetic Resonance (NMR) analysis on a sample to obtain an NMR spectrum, a step of performing a Near Infrared Spectroscopy (NIR) analysis on the sample to obtain an NIR spectrum, and/or a step of performing a data fusion analysis to evaluate the NIR spectrum.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: June 7, 2016
    Assignee: Biogen MA Inc.
    Inventors: Maureen Lanan, Amr Ali