Patents Assigned to Ma'at
  • USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM
    Publication number: 20160025633
    Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: Biogen MA Inc.
    Inventors: Justin Moretto, Brandon Berry, Alex Doane
  • Compositions and methods for the treatment of progressive multifocal leukoencephalopathy (PML)
    Patent number: 9233107
    Abstract: The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are useful to prevent or treat DNA virus associated conditions (e.g., PML) in subjects that are immunocompromised. Compositions are provided that inhibit intracellular replication of DNA viruses.
    Type: Grant
    Filed: September 13, 2008
    Date of Patent: January 12, 2016
    Assignee: Biogen MA Inc.
    Inventors: Leonid Gorelik, Margot Brickelmaier, Alexey Lugovskoy
  • HIGH RESOLUTION MELTING ANALYSIS ASSAY FOR THE DETECTION OF VIRAL DNA
    Publication number: 20160002743
    Abstract: In one aspect, the disclosure provides methods, kits and compositions for determining the presence of a JC virus mutant in a sample.
    Type: Application
    Filed: March 15, 2014
    Publication date: January 7, 2016
    Applicant: Biogen MA Inc.
    Inventors: Soma Ray, Ian David Faulkner
  • FACTOR IX POLYPEPTIDE FORMULATIONS
    Publication number: 20160000888
    Abstract: The present invention provides formulations comprising a Factor IX-FcRn Binding Partner (FIXFBP) polypeptide, and methods of administering FIXFBP.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 7, 2016
    Applicant: Biogen MA Inc.
    Inventor: Mark BRADER
  • MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES
    Publication number: 20160002265
    Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein i.a. Ring A is phenylene or 5- to 6-membered heteroarylene; Ring B is phenylene, 5- to 6-membered heterocycloalkylene or 5- to 6-membered heteroarylen; R4 is absent, heteroarylene, arylene, C1-3 alkylene, or R4 and R3 taken together with the nitrogen to which they are bound form a 3- to 7-membered heterocycloalkyl ring; R5 is absent, C(0)NR51, NR52 or 0; R6 is C2-10 alkylene or alkenylene, wherein one or two of the carbon atoms in the alkylene chain is optionally replaced by an 0, S, SO, SO2 or NR61, and wherein two of the carbon atoms in the alkylene chain are optionally connected by a two or three carbon atom alkylene chain to form a 5- to 7-membered ring; R7 is absent, NR71 or O. The compounds are IRAK4 inhibitors useful for the treatment of inflammatory diseases.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 7, 2016
    Applicant: BIOGEN MA INC.
    Inventors: Tracy Jenkins, Jeffery Vessels
  • Nogo receptor antagonists and methods of increasing neurite outgrowth
    Patent number: 9228015
    Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: January 5, 2016
    Assignee: Biogen Idec MA Inc.
    Inventors: Daniel H. S. Lee, Dingyi Wen, R. Blake Pepinsky, Jane K. Relton, Xinzhong Wang, Alexey Lugovskoy, Werner Meier, Ellen A. Garber, Laura Silvian, Paul H. Weinreb
  • Optimized Factor VIII Gene
    Publication number: 20150361158
    Abstract: The present invention provides codon optimized Factor VIII sequences, vectors and host cells comprising codon optimized Factor VIII sequences, polypeptides encoded by codon optimized Factor VIII sequences, and methods of producing such polypeptides.
    Type: Application
    Filed: February 14, 2014
    Publication date: December 17, 2015
    Applicant: Biogen MA Inc.
    Inventors: Siyuan TAN, Robert T. PETERS
  • ASSAY FOR DETECTION OF JC VIRUS DNA
    Publication number: 20150361417
    Abstract: In one aspect, the disclosure provides methods for isolating nucleic acid from a Cerebrospinal Fluid (CSF) sample. In one aspect, the disclosure provides methods for determining the amount of JC virus DNA in a sample.
    Type: Application
    Filed: January 30, 2014
    Publication date: December 17, 2015
    Applicant: Biogen MA Inc.
    Inventor: Soma Ray
  • Nutrient monitoring and feedback control for increased bioproduct production
    Patent number: 9212379
    Abstract: The present invention pertains to methods of increasing the efficiency of producing a bioproduct. In some embodiments, the method increases the quantity of a bioproduct produced, or decreases bioproduct production time, in a bioreactor cell culture producing the bioproduct, the method comprising, (a) intermittently or continuously analyzing the concentration of one or more nutrients in the bioreactor cell culture; and (b) adding to the bioreactor cell culture additional nutrient media when the concentration of the one or more nutrients is lower than a target value.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: December 15, 2015
    Assignee: Biogen Idec MA Inc.
    Inventors: Valerie Liu Tsang, Angela Xiaoying Wang, Helena Yusuf-Makagiansar
  • CHIMERIC CLOTTING FACTORS
    Publication number: 20150353911
    Abstract: The invention provides chimeric clotting factors comprising an activatable clotting factor and an enhancer moiety. The activatable clotting factor allows the chimeric clotting factor to be activated at the site of coagulation. The enhancer moiety can additionally improve procoagulation activities of the chimeric clotting factors. The chimeric clotting factors can further be improved by fusion to a half-life extender, which improves a pharmacokinetics property of the chimeric clotting factor. The invention also includes methods of making and methods of using these chimeric clotting factors.
    Type: Application
    Filed: June 7, 2013
    Publication date: December 10, 2015
    Applicant: Biogen Idec MA Inc.
    Inventors: Joe Salas, Elena Kistanova, Vu Phong Hong, Adam R. Mezo, Robert T. Peters
  • Use of DR6 Antagonists to Improve Motor Neuron Disease
    Publication number: 20150329638
    Abstract: The present invention relates to Death Receptor-6 (DR6) antagonists and methods of their use in improving motor neuron disease. Novel affinity enhanced anti-DR6 antibodies are also provided. The invention also pertains to methods of identifying additional anti-DR6 antagonists.
    Type: Application
    Filed: December 27, 2013
    Publication date: November 19, 2015
    Applicant: Biogen MA Inc.
    Inventor: Sha MI
  • Bicyclic aryl sphingosine 1-phosphate analogs
    Patent number: 9186367
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: November 17, 2015
    Assignee: BOIGEN MA INC.
    Inventors: Jermaine Thomas, Xiaogao Liu, Edward Yin-Shiang Lin, Guo Zhu Zheng, Ma Bin, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Arthur G. Taveras
  • Heterobicyclic sphingosine 1-phosphate analogs
    Patent number: 9181191
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: November 10, 2015
    Assignee: BIOGEN MA INC.
    Inventors: Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Xiaogao Liu, Bin Ma, Daniel M. Scott, Zhan Shi, Jermaine Thomas, Arthur G. Taveras, Guo Zhu Zheng
  • METHODS AND COMPOSITIONS FOR INACTIVATING ENVELOPED VIRUSES
    Publication number: 20150306223
    Abstract: Aspects of the invention provide therapeutic recombinant protein preparations and methods of preparing therapeutic recombinant protein, which methods include contacting recombinant protein preparations with zwitterionic detergent at or above critical micelle concentration of the detergent.
    Type: Application
    Filed: August 6, 2013
    Publication date: October 29, 2015
    Applicant: Biogen Idec MA Inc.
    Inventors: Lynn Edward Conley, Yinying Tao
  • Channelled nonwoven with reduced surface expansion of liquid for the production of sanitary towels and relative process of manufacture
    Patent number: 9169586
    Abstract: A sanitary towel for physiological liquids includes as topsheet layer a layer of nonwoven cotton (10) having density which varies transversely and provided with a first plurality of longitudinal lines (1) along which the textile has a higher density of fibers with respect to the rest of the textile, each of the longitudinal lines (1) of the first plurality of lines being alternated with a respective longitudinal line (2) of a second plurality of longitudinal lines (2) along which the textile has a lower density of fibers with respect to the longitudinal lines (1).
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: October 27, 2015
    Assignee: FA-MA JERSEY S.P.A.
    Inventor: Marco Maranghi
  • ANTIBODIES TO VLA-1
    Publication number: 20150299323
    Abstract: Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
    Type: Application
    Filed: January 15, 2015
    Publication date: October 22, 2015
    Applicant: BIOGEN MA INC.
    Inventors: Michael Karpusas, Paul D. Lyne, Ellen A. Garber Stark, Jose William Saldanha
  • ARC SUPPRESSOR FOR FUSIBLE ELEMENTS
    Publication number: 20150294828
    Abstract: An arc suppressor fixable to a fusible element to suppress electrical arcs and prevent the spread of electric arc “burn-back.” The arc suppressor includes first and second inner members comprised of pre-cured silicone rubber, and first and second outer members comprised of an arc suppressing material (e.g., melamine). The inner and outer members form a sandwich around a portion of the fusible element, wherein the first inner member is located adjacent to a first surface of the fusible element and the second inner member is located adjacent to an opposing second surface of the fusible element. The first outer member is located adjacent to the first inner member and the second outer member is located adjacent to the second inner member. Mechanical fasteners tightly engage together the first and second inner members, the fusible element, and the first and second outer members.
    Type: Application
    Filed: April 14, 2014
    Publication date: October 15, 2015
    Applicant: Mersen USA Newburyport-MA, LLC
    Inventor: Robert M. Burge
  • FACTOR VIII COMPLEX WITH XTEN AND VON WILLEBRAND FACTOR PROTEIN, AND USES THEREOF
    Publication number: 20150266943
    Abstract: The present invention includes a chimeric protein comprising a VWF protein with D? domain and D3 domain of VWF, one or more XTEN sequence, and a FVIII protein, wherein the VWF fragment, the XTEN sequence, or the FVIII protein are linked to or associated with each other. The chimeric protein can further comprise one or more Ig constant region or a portion thereof (e.g., an Fc region). A polypeptide chain of a VWF fragment is associated with a FVIII polypeptide chain linked to an XTEN sequence. The VWF fragment polypeptide chain can prevent or inhibit binding of endogenous VWF to FVIII protein linked to the XTEN sequence. By preventing or inhibiting binding of endogenous VWF to FVIII protein, VWF fragment can extend half-life of chimeric protein comprising FVIII protein. The invention includes nucleotides, vectors, host cells, use of VWF fragment, or chimeric proteins.
    Type: Application
    Filed: July 10, 2013
    Publication date: September 24, 2015
    Applicants: AMUNIX OPERATING INC., BIOGEN MA INC.
    Inventors: Ekta Seth Chhabra, Tongyao Liu, Pei-yun Chang, Robert T. Peters, John Kulman
  • Methods of Using FVIII Polypeptide
    Publication number: 20150266944
    Abstract: The present invention provides methods of reducing or decreasing the annualized bleeding rate of a human subject having hemophilia by administering a long acting Factor VIII polypeptide. The long-acting FVIII polypeptide can be used for individual prophylaxis, weekly prophylaxis, episodic (on-demand) treatment, or perioperative management of hemophilia. The present invention relates generally to the field of therapeutics for hemostatic disorders.
    Type: Application
    Filed: October 30, 2013
    Publication date: September 24, 2015
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Haiyan Jiang, Srividya Neelakantan, Ivan Nestorov, Shuanglian Li
  • Package
    Patent number: D741703
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: October 27, 2015
    Assignee: Biogen MA Inc.
    Inventors: Christine P. Janson, Ethan B. Jacoby