Abstract: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.

Abstract: The present invention is in the fields of cell biology, immunology and oncology. The invention provides humanized antibodies that recognize ?v?6 integrins, which antibodies comprise a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also provides methods for preparation of such antibodies, pharmaceutical compositions comprising them, and methods of treating, diagnosing and/or preventing various diseases and disorders by administering the humanized anti-?v?6 antibodies of the invention. The invention also relates to the identification of differential expression of the integrin ?v?6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin ?v?6.

Abstract: A lighting system includes at least one lighting control console for controlling lighting devices, at least two redundant data networks, at least one conversion module, and at least one lighting device actuated by the DMX control data of the conversion module. The conversion module includes at least two redundant conversion devices. At least one switch-over device is interconnected between the two conversion devices on the one side and at least one lighting device actuated by the conversion devices on the other side. The two conversion devices on the one side and the switch-over device on the other side are connected to one another via at least one monitoring data line over which monitoring signals are transmitted. The switch-over device can be switched depending on the monitoring signals.

Abstract: A medium voltage controllable fuse that provides fast activation in response to both low current and high current faults, and at load currents in response to an external condition detected by an external sensing device. The controllable fuse includes a high-current fault interrupting section, a low-current fault interrupting section, and a trigger element responsive to a fuse controller.

Abstract: The present disclosure provides compositions and methods relating to the evaluation of BAFF in a biological sample from a subject.

Abstract: An electric fuse, having a first fusible element and a disconnect section electrically connected in series to the first fusible element. The disconnect section is comprised of a first stationary contact, a second stationary contact and a movable contact movable from a first position electrically connecting the first and second stationary contacts to form a conductive path through the disconnect section to a second position electrically separating the first and second stationary contacts from each other and terminating the conductive path through the disconnect section. A retaining element holds the movable contact in the first position, the retaining element operable to release the movable contact from the first position when activated by an electrical (actuation) signal from an external source.

Abstract: An insulating garment includes an inner fabric having a knitted laminar structure adapted to absorb perspiration of a user. The inner fabric utilizes polymer fibers and a mixture of polyamide and polyester multifilaments present in an amount of between 30-50% and have a thickness between 0.3-3 dtex. An outer fabric has a knitted laminar structure and an inner surface including a moisture repellent finish adapted to repel perspiration of a user. The outer fabric utilizes polyester-brushed cotton threads in an amount of between 40-60% of the fabric. The end portions of the inner and outer fabrics are stitched together to form an air chamber there between. In use, perspiration from a user is absorbed by the inner fabric into the air chamber, where it can evaporate.

Abstract: Aspects of the invention are directed to arginine-free polypeptide-containing compositions and methods for treating disorders associated with inflammation or the autoimmune response. In particular, the polypeptide is etanercept.

Abstract: In one aspect, the disclosure provides methods for isolating nucleic acid from a Cerebrospinal Fluid (CSF) sample. In one aspect, the disclosure provides methods for determining the amount of JC virus DNA in a sample.

Abstract: A novel receptor in the TNF family is provided: BAFF-R. Chimeric molecules and antibodies to BAFF-R and methods of use thereof are also provided.

Abstract: A relocking mechanism that blocks the path of a bolt within a lock assembly is presented. The relocking mechanism comprises a breakaway member that is repositioned when the lock assembly is attacked by some mechanical means, such as impact applied via a hammer and punch to the lock housing through a spindle hole in a door. The breakaway member prior to attack holds a preloaded relocking plunger clear from bolt movement. When the breakaway member is repositioned upon attack, the plunger is free to move under a biasing force into position so as to block the bolt thus keeping the lock in a secure locked state regardless of the state of the locks default blocking mechanism.

Abstract: A fault current limiter (FCL) for limiting a fault current in a power line during a fault condition. The FCL includes a magnetic coupling circuit for monitoring current in the power line through magnetic coupling; a sensing circuit for sensing the current in the power line and providing a signal indicative of the sensed current; a control circuit receiving the signal indicative of the sensed current in the power line and determining whether the sensed current indicates that the fault condition exists; and high and low impedance paths that are connected in parallel. The high impedance path includes a discharging impedance circuit for limiting the fault current. The low impedance path includes a reactor circuit and a switching unit having an ON state for conducting current through the low impedance path and an OFF state for conducting current through the high impedance path.

Abstract: Therapeutic regimens for administration of BAFF antagonists for treatment of immunologic and related disorders are described. Regimens involve a short-term BAFF antagonist administration course followed by an extended no-treatment period prior the round of administration.

Abstract: The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered O-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.

Abstract: A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which maintain fixed volumes and which may be used on patients of variable weight.

Abstract: The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects in, or at risk of chronic renal failure, or at risk of a need for renal replacement therapy. The methods involve the administration of certain integrin antagonists.

Abstract: A voltage suppression device for suppressing voltage surges in an electrical circuit having a voltage sensitive assembly comprised of a plurality of tubular sections within a tubular casing.

Abstract: The invention relates to methods for producing mammalian cells having enhanced characteristics such as faster growth rates and the ability to grow to higher cell densities. The invention also relates to methods for producing cells having the ability to grow in media lacking components such as insulin and insulin substitutes. The invention also relates to isolated mammalian cells having improved growth characteristics and/or the ability to grow in media lacking components such as insulin and insulin substitutes.

Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.