Patents Assigned to Ma'at
  • NOGO receptor binding protein
    Patent number: 8932821
    Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 13, 2015
    Assignee: Biogen Idec MA Inc.
    Inventors: Sha Mi, John McCoy, R. Blake Pepinsky, Daniel H. S. Lee
  • Adjustable rotation base
    Patent number: 8910646
    Abstract: An outdoor umbrella includes an awning frame, a supporting shaft and an adjustable rotation base including a base housing and a transportation arrangement. The base housing is arranged to couple with the supporting shaft to support the awning frame in an upright manner, and includes a plurality of transferring wheels. The transportation arrangement is provided at the base housing to operate the base housing between an idle mode and a transportation mode, wherein in the idle mode, the transferring wheels are suspenedly lifted up to position above the bottom edge of the base housing such the base housing is sat on the ground surface in a stationary manner, wherein in the transportation mode, the base housing is lifted up by air pressure for allowing the transferring wheels to move out of the receiving cavity at a position below the bottom edge of the base housing.
    Type: Grant
    Filed: July 21, 2012
    Date of Patent: December 16, 2014
    Assignee: Ma, Oliver Joen-An
    Inventor: Wanda Ying Li
  • CHOLESTEROL-BASED MEDIA SUPPLEMENTS FOR CELL CULTURE
    Publication number: 20140363845
    Abstract: The disclosure provides compositions and methods for high density cell culture and banking of cholesterol auxotrophic cells.
    Type: Application
    Filed: May 15, 2014
    Publication date: December 11, 2014
    Applicant: Biogen Idec MA Inc.
    Inventors: Marty Sinacore, Yiwen Tao, Thomas Ryll, Helena Yusuf-Makagiansar
  • METHODS OF TREATING PROGRESSIVE FORMS OF MULTIPLE SCLEROSIS
    Publication number: 20140356351
    Abstract: The present disclosure relates to methods of treating individuals suffering from progressive forms of multiple sclerosis.
    Type: Application
    Filed: August 8, 2012
    Publication date: December 4, 2014
    Applicants: biogen idec ma inc.
    Inventors: Steven Jay Greenberg, Jacob Stephen Broomall Elkins
  • USE OF NUCLEAR MAGNETIC RESONANCE AND NEAR INFRARED TO ANALYZE BIOLOGICAL SAMPLES
    Publication number: 20140353503
    Abstract: In one aspect, the disclosure provides methods for using NMR and NIR to evaluate biological samples. In some embodiments, the methods include a step of performing a Nuclear Magnetic Resonance (NMR) analysis on a sample to obtain an NMR spectrum, a step of performing a Near Infrared Spectroscopy (NIR) analysis on the sample to obtain an NIR spectrum, and/or a step of performing a data fusion analysis to evaluate the NIR spectrum.
    Type: Application
    Filed: August 31, 2012
    Publication date: December 4, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Maureen Lanan, Amr Ali
  • Immunoglobulin formulation and method of preparation thereof
    Patent number: 8900577
    Abstract: A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which maintain fixed volumes and which may be used on patients of variable weight.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: December 2, 2014
    Assignee: Biogen Idec Ma Inc.
    Inventors: David J. Burke, Shaun E. Buckley, Sherwood Russ Lehrman, Barbara Horsey O'Connor, James Callaway, Christopher P. Phillips
  • TREATMENT USING NEUBLASTIN POLYPEPTIDES
    Publication number: 20140349930
    Abstract: The invention relates to treatments of neuropathic pain, including tactile allodynia, and to treatments for reducing loss of pain sensitivity associated with neuropathy. The present treatments involve the use of neublastin (NBN) polypeptides.
    Type: Application
    Filed: November 12, 2013
    Publication date: November 27, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventor: Dinah W. Y. Sah
  • Use of DR6 and p75 antagonists to promote survival of cells of the nervous system
    Patent number: 8894999
    Abstract: The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating apoptosis in cells of the nervous system. In addition, it has been discovered that p75 is a ligand for DR6. As a result, this invention relates to methods for inhibiting the interaction of DR6 and p75 using DR6 and/or p75 antagonists. In addition, the methods described herein include methods of promoting survival of cells of the nervous system using DR6 antagonists, optionally in combination with p75 antagonists, and methods of treating neurodegenerative conditions by the administration of a DR6 antagonists, optionally in combination with a p75 antagonist.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: November 25, 2014
    Assignee: Biogen Idec MA Inc.
    Inventors: Sha Mi, Kenneth J. Rhodes, R. Blake Pepinsky
  • HETERODIMERIC FC REGIONS, BINDING MOLECULES COMPRISING SAME, AND METHODS RELATING THERETO
    Publication number: 20140341906
    Abstract: The present invention features inter alia polypeptides comprising heterodimeric Fc regions. In addition, the instant invention provides methods for treating or preventing a disease or disorder in subject by administering the polypeptides of the invention to said subject.
    Type: Application
    Filed: July 13, 2012
    Publication date: November 20, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Frederick R. Taylor, Justin A. Caravella, Alexey A. Lugovskoy, Amna Saeed-Kothe, Ellen A. Garber
  • Stabilized polypeptide compositions
    Patent number: 8892364
    Abstract: The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: November 18, 2014
    Assignee: Biogen Idec MA Inc.
    Inventors: Scott Glaser, Stephen Demarest, Brian Robert Miller, William B. Snyder, Xiufeng Wu, Norman Wang, Lisa J. Croner, Alexey Alexandrovich Lugovskoy
  • Neuroprotection in Demyelinating Diseases
    Publication number: 20140323570
    Abstract: Methods of treating neurological disorders characterized by extensive demyelination and/or axonal loss are provided. Examples of such disorders include secondary progressive multiple sclerosis and Devic's disease. The disclosed methods include administering to a subject having such a disorder a therapeutically effective amount of, for example, dimethyl fumarate or monomethyl fumarate.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 30, 2014
    Applicant: Biogen Idec MA Inc.
    Inventor: Ralf GOLD
  • METHOD OF ASSESSING RISK OF PML
    Publication number: 20140322164
    Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).
    Type: Application
    Filed: May 31, 2012
    Publication date: October 30, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Gary L. Bloomgren, Carmen Bozic, Sophia Lee, Meena Subramanyam, Tatiana Plavina
  • REFOLDING TRANSFORMING GROWTH FACTOR BETA FAMILY PROTEINS
    Publication number: 20140322752
    Abstract: Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product.
    Type: Application
    Filed: March 26, 2014
    Publication date: October 30, 2014
    Applicant: Biogen Idec MA Inc.
    Inventors: Anthony Rossomando, R. Blake Pepinsky, BangJian Gong
  • Methods and products for evaluating an immune response to a therapeutic protein
    Patent number: 8871449
    Abstract: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab). A second aspect of the invention concerns the chronological details of sample collection for determining the titre of antibodies against the therapeutic protein, e.g. the collection of at least two samples at two different time points. A third aspect of the invention relates to the selection of the critical threshold level, which corresponds to the antibody titre of untreated patients increased by the double of the standard deviation of this control antibody titre.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: October 28, 2014
    Assignee: Biogen Idec MA Inc.
    Inventors: Meena Subramanyam, Lakshmi Amaravadi, Eric Wakshull, Frances Lynn, Michael Panzara, Robin McDaid Barbour, Julie Elizabeth Taylor
  • Method of treating lung fibrosis using ST2 polypeptide
    Patent number: 8865645
    Abstract: Methods and compositions for treating fibrosis are disclosed.
    Type: Grant
    Filed: May 23, 2007
    Date of Patent: October 21, 2014
    Assignee: Biogen Idec MA Inc.
    Inventors: Aldo Amatucci, Tatiana Novobrantseva, Alexander Ibraghimov, Alan Gill
  • BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS
    Publication number: 20140309190
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 16, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Jermaine Thomas, Xiaogao Liu, Edward Yin-Shiang Lin, Guo Zhu Zheng, Ma Bin, Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Arthur G. Taveras
  • Factor VIII Polypeptide Formulations
    Publication number: 20140308280
    Abstract: The present invention provides a formulation of a Factor VIII polypeptide, e.g., FVIII-Fc, and methods of using the same. The FVIII polypeptide can be a recombinant FVIII protein, a short-acting FVIII protein, or a long-acting FVIII protein. The pharmaceutical formulation comprising a FVIII polypeptide can be used for individual prophylaxis, weekly prophylaxis, episodic (on-demand) treatment, or perioperative management of hemophilia.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 16, 2014
    Applicant: Biogen Idec MA Inc.
    Inventors: Kevin MALONEY, Daniel Gage, Ahmad Abdul-Fattah
  • Pro-Coagulant Compounds and Methods of Use Thereof
    Publication number: 20140303084
    Abstract: Provided are pro-coagulant compounds (e.g., pro-coagulant peptides or peptide derivatives) and methods of using and making those compounds. Further provided are conjugates between a pro-coagulant compound of the present disclosure (e.g., pro-coagulant peptide or peptide derivative) and a polypeptide selected from FIX, FVIIa, FVIII, and platelet targeting moieties (e.g., PDG-13), wherein the compound is linked to the polypeptide optionally via a linker. The compounds and conjugates are useful for the treatment of coagulation disorders, such as hemophilia A and hemophilia B. Further provided are methods of using and making the conjugates.
    Type: Application
    Filed: June 9, 2012
    Publication date: October 9, 2014
    Applicant: Biogen IDEC MA Inc.
    Inventors: Karina Thorn, Garabet G. Toby, Adam R. Mezo
  • Method For Operating A Lighting System Integrating A Video Camera
    Publication number: 20140301710
    Abstract: A method for operating a lighting system includes the steps of a) illuminating a stage with light from at least one light source; b) recording a portion of the stage with the video camera and generating digital video signals; c) transmitting the digital video signals to a video conversion device; d) converting the video signals into digital image data signals; e) transmitting the digital image data signals to the digital memory of the lighting control console; f) starting a display task in the digital processor of the lighting control console, in order to process the image data signals for displaying the same at the display of the lighting control console; and g) graphically representing a portion of the stage by displaying the image data signals which have been processed in the digital processor at the display of the lighting control console.
    Type: Application
    Filed: April 4, 2013
    Publication date: October 9, 2014
    Applicant: MA Lighting Technology GmbH
    Inventors: Michael Adenau, Hartmut Cordes
  • Adjustable rotation base
    Patent number: 8851093
    Abstract: An outdoor umbrella includes an awning frame, a supporting shaft and an adjustable rotation base including a base housing and a transportation arrangement. The base housing is arranged to couple with the supporting shaft to support the awning frame in an upright manner, and includes a plurality of transferring wheels. The transportation arrangement is provided at the base housing to operate the base housing between an idle mode and a transportation mode, wherein in the idle mode, the transferring wheels are suspenedly lifted up to position above the bottom edge of the base housing such the base housing is sat on the ground surface in a stationary manner, wherein in the transportation mode, the base housing is lifted up by air pressure for allowing the transferring wheels to move out of the receiving cavity at a position below the bottom edge of the base housing.
    Type: Grant
    Filed: July 21, 2012
    Date of Patent: October 7, 2014
    Assignee: Oliver Joen-An Ma
    Inventor: Wanda Ying Li