Abstract: The invention relates to a system (01) comprising a lighting control console (02) for controlling a lighting system, and an external simulation computer (03), wherein digital adjusting commands that can be transmitted to the lighting devices of the lighting system via data links are generated in the lighting control console (02), and wherein the lighting control console (02) includes at least one housing, in which the hardware components are disposed for protection from external influences, and wherein the lighting control console (02) includes multiple operating elements (06, 07, 08), particularly keys (06), slide controllers (07), and/or rotary controllers (08), which elements are arranged on the top of the housing and can be used for entering operating commands, and wherein the lighting control console (02) includes at least one display device (09, 10, 11, 12), and wherein the external simulation computer (03) is connected to the lighting control console (02) via a data link, and wherein the simulation com

Abstract: Receptor coupling agents, including multivalent constructs comprising anti-TNF receptor binding moieties, for treating cancer and inhibiting tumor volume in a subject are disclosed.

Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.

Abstract: The present invention relates to a method of producing a recombinant protein comprising using a selection method other than antibiotics. In particular, it relates to a stable host/vector system based on the pyrC gene complementation designed to produce high level of heterologous recombinant protein in Escherichia coli. The expression system of the present invention allows rapid selection of plasmid containing cells during the cloning phases and lead to high protein expression during fermentation. This system has a strong selective efficiency, especially during the induction phase, leading to the selection of an almost homogeneous and stable plasmid bearing cell population. Moreover the productivity of the culture is to a large extent better than the one based on antibiotic resistance. This elevated vector stability combined with its high productivity fulfils the requirements for heterologous protein production in Escherichia coli to an industrial level.

Abstract: This document describes, among other things, systems and methods for visual representation and review of media files. A method comprises: 1) accessing a media file that includes at least an audio track; accessing a media review file, wherein the media review file is associated with the media file and further wherein the media review file includes annotation data, the annotation data including two or more users' annotation comments; 2) presenting the media file and the media review file using a graphical user interface, wherein the graphical user interface includes a vertical time bar, wherein the vertical time bar includes an indicator to indicate a position in the audio track included in the media file and further wherein annotation data displayed in the user interface vertically scrolls in synchronization with the indicator on the vertical time bar; and 3) saving any modifications to annotation data in the media review file.

Abstract: An electrical dimmer circuit comprising the electrical dimmer circuit for dimming the electrical power of a plurality of lighting means having at least one digital input channel, at which digital low-voltage input signals for specifying the light power of the various lighting means can be received, and having at least two output channels, on which output signals for dimming the electrical power of the respectively assigned lighting means can be output by pulse width modulation of a high alternating voltage.

Abstract: The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.

Abstract: The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications.

Abstract: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.

Abstract: The present invention disclosed recombinant anti-VLA-4 antibody molecules, including humanized recombinant anti-VLA-4 antibody molecules. These antibodies are useful in the treatment of specific and non-specific inflammation, including asthma and inflammatory bowel disease. In addition, the humanized recombinant anti-VLA-4 antibodies disclosed can be useful in methods of diagnosing and localizing sites of inflammation.

Abstract: The present invention provides compounds having the formula: wherein A-B together represent one of the following structures: n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.

Abstract: The invention relates to a lighting control console (01, 26, 27) for controlling a lighting system, wherein digital control commands are generated in the lighting control console (01, 26, 27) and can be transmitted via data links to the lighting devices of the lighting system, and wherein the lighting control console (01, 26, 27) includes at least one housing (02, 21), in which the hardware components are arranged with protection against external influences, and wherein the lighting control console (01, 26, 27) includes a plurality of operating elements (04, 05, 06, 07, 08, 09, 24), particularly keys, slide controls and/or rotary controls, which are arranged on the upper side of the housing (02, 21) and may be used for entering operating commands, and wherein the lighting control console (01, 26, 27) includes at least one display device (03) on which a user interface can be displayed, wherein the lighting control console (01, 26, 27) is composed of at least two console modules (10, 11, 20, 23, 25), wherein th

Abstract: A pharmaceutical preparation comprising as an active ingredient micron-sized sulphur particles [?(300 microns]. The pharmaceutical preparation further comprises an excipient, i.e. a sodium lignin sulphate or other suitable agents. The preparation is used for the prevention and treatment of pathogenic disorders in humans and animals, in a nutritional and/or supplemental regime, as well as, to improve feed and reproductive performance. A variety of conditions were treated including: pneumonia, arthritis, ulcers, diabetes mellitus, GI cancer, lupus, herpes, psoriasis and early menopause.

Abstract: The present invention relates to novel BR3 binding antibodies having altered Fc effector function and/or having a mature core carbohydrate structure in the Fc region which lacks fiicose. The present invention also relates to the use of those BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.

Abstract: Compositions and methods comprising “lymphotoxin-? receptor blocking agents” which block lymphotoxin-? receptor signaling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.

Abstract: The disclosure provides an expression cassette and a vector comprising the cassette for expression of a polynucleotide. The expression cassette includes a promoter/enhancer, an intervening region, and a polyadenylation signal domain. Expression systems and methods of using the expression cassette and vector are also provided.

Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Abstract: Compositions and methods for treating Th2- and ThI-mediated disease are provided.

Abstract: The invention relates to a method for operating a lighting system comprising at least one central control unit and a plurality of lighting devices, whereby provision is made in the lighting devices for a positioning sensor system, by means of which the locations of the lighting devices can be determined and wherein location data for describing the respective location can be transmitted to the central control device from each lighting device comprising a data interface and wherein a stage set database, which describes a stage set model and in which the locations of the various lighting devices in a stage set can be stored, is stored in the central control device, comprising the following method steps: a) determining the respectively current locations of the lighting devices by means of the positioning sensor system in the lighting devices; b) transferring the respectively current location data from the lighting devices to the central control device; c) storing the location data in the stage set database.

Abstract: This document describes, among other things, systems and methods for visual representation and review of media files. A method comprises: 1) accessing a media file that includes at least an audio track; accessing a media review file, wherein the media review file is associated with the media file and further wherein the media review file includes annotation data, the annotation data including two or more users' annotation comments; 2) presenting the media file and the media review file using a graphical user interface, wherein the graphical user interface includes a vertical time bar, wherein the vertical time bar includes an indicator to indicate a position in the audio track included in the media file and further wherein annotation data displayed in the user interface vertically scrolls in synchronization with the indicator on the vertical time bar; and 3) saving any modifications to annotation data in the media review file.