Patents Assigned to Magyar Tudomanyos Akademia
-
Patent number: 10744127Abstract: The present invention is related to 8-hydroxy-quinoline derivatives having multidrug-resistance reversing activity with improved selectivity and increased cytotoxicity towards multidrug-resistant cancer cells, preparation thereof and use of the same in the treatment of cancer, especially multidrug-resistant variants thereof.Type: GrantFiled: April 5, 2017Date of Patent: August 18, 2020Assignee: Magyar Tudományos Akadémia Természettudományi KutatóközpontInventors: Gergely Szakács, Tibor Soós, Roberta Ferenczi-Palkó, András Füredi, Szilárd Tóth, Dóra Türk, Veronika Pape, Ferenc Fülöp, István Szatmári, György Dormán
-
Publication number: 20190151306Abstract: The present invention is related to 8-hydroxy-quinoline derivatives having multidrug-resistance reversing activity with improved selectivity and increased cytotoxicity towards multidrug-resistant cancer cells, preparation thereof and use of the same in the treatment of cancer, especially multidrug-resistant variants thereof.Type: ApplicationFiled: April 5, 2017Publication date: May 23, 2019Applicant: Magyar Tudományos Akadémia Természettudományi KutatóközpontInventors: Gergely SZAKÁCS, Tibor SOÓS, Roberta FERENCZI-PALKÓ, András FÜREDI, Szilárd TÓTH, Dóra TÜRK, Veronika PAPE, Ferenc FÜLÖP, István SZATMÁRI, György DORMÁN
-
Patent number: 9548584Abstract: The present invention relates to a method and an arrangement to generate a coherent electromagnetic radiation containing at most a few optical cycles in the extreme ultraviolet/vacuum ultraviolet domain. The inventive method comprises the steps of providing an electron package (15) of relativistic velocity; modulating said electron package (15) with high intensity laser light (17) in an undulator (20) having an undulator period smaller than the undulator period (?u) satisfying the resonance condition, producing thereby an electron package formed of electron microbunches; and passing the electron package (15) of electron microbunches leaving said undulator (20) through a static magnetic field, and generating thereby a coherent electromagnetic radiation, wherein said static magnetic field is generated in conformity with the coherent electromagnetic radiation to be achieved.Type: GrantFiled: March 5, 2014Date of Patent: January 17, 2017Assignees: University of Pécs, Magyar Tudományos Akadémia Támogatott KutatócsoportokInventors: Gábor Almási, János Hebling, Mátyás Mechler, György Tóth, Zoltán Tibai
-
Patent number: 8451446Abstract: The invention relates to a differential polarizing laser-scanning microscope (DP LSM) for determining differential polarization quantities of a material, comprising a laser light source (L) for scanning the sample and illuminating it with a coherent and monochromatic light, a microscope unit (ME) with a sample holder for providing a preselected optical magnification and imaging and a polarization state setting unit (PAA) positioned in the illuminating beam path (between the light source and the sample holder). The microscope is further provided with detectors (D1, D2) in the observing beam path, at least one filter holder in front of the detectors and a signal-processing unit (VE) for processing the electrical signals of the detectors. In the DP-LSM microscope an optical element (DP) is located in the common beam path comprising the illuminating and the observing beams, for separating the orthogonal polarization components.Type: GrantFiled: September 26, 2008Date of Patent: May 28, 2013Assignee: Magyar Tudomanyos Akademia Szegedi Biologiai KoezpontInventors: Gyözö Garab, Istvá Pomozi
-
Publication number: 20100245822Abstract: The invention relates to a differential polarizing laser-scanning microscope (DP LSM) for determining differential polarization quantities of a material, comprising a laser light source (L) for scanning the sample and illuminating it with a coherent and monochromatic light, a microscope unit (ME) with a sample holder for providing a preselected optical magnification and imaging and a polarization state setting unit (PAA) positioned in the illuminating beam path (between the light source and the sample holder). The microscope is further provided with detectors (D1, D2) in the observing beam path, at least one filter holder in front of the detectors and a signal-processing unit (VE) for processing the electrical signals of the detectors. In the DP-LSM microscope an optical element (DP) is located in the common beam path comprising the illuminating and the observing beams, for separating the orthogonal polarization components.Type: ApplicationFiled: September 26, 2008Publication date: September 30, 2010Applicant: MAGYAR TUDOMANYOS AKADEMIA Szegedi Biologial KozpontInventors: Gyözö Garab, István Pomozi
-
Patent number: 5068424Abstract: The invention relates to a process for preparing arylsulphonyl isocyanates of the general formula (I) ##STR1## and addition derivatives thereof--where in the formula the meaning of the substituents are as follows:Ar represents optionally substituted aryl, naphthyl- or thienyl group, andHX is a chemical bond or XZR.sub.1 stands for a group where Z is oxygen or sulphur,R.sub.1 is saturated or unsaturated alkyl, benzyl, cyclohexyl or substituted phenyl group orX is an NR.sub.2 R.sub.3 groupwherein R.sub.2 R.sub.3 is hydrogen, alkyl, unsubstituted alkyl, aryl, substituted aryl, aroyl or acyl group, and the essence of the process is that an N-halogen sulphonamidate is carbonylated in the presence of a carbonylating catalyst, in the presence or absence of alcohol, (thio) alcohol or amine reactants and the carbonylated compound obtained is reacted subsequently with the reactants.Type: GrantFiled: June 14, 1989Date of Patent: November 26, 1991Assignees: Nitrokemia Ipartelepek, Magyar Tudomanyos Akademia Kozponti Kemiai Kutato IntezeteInventors: Gabor Besenyei, Sandor Nemeth, Laszlo Simandi, Maria Belak, Jozsef Dukai, Lajos Nagy, Elemer Tomordi, Csaba Soptei, Erzsebet E. Dioszegine
-
Patent number: 5005146Abstract: The invention relates to a signal processing method and apparatus for nuclear spectrometers, whereby the peaking time is set, which is optimal from the point of view of the signal-to-noise ratio, where in case of an input signal of staircase shape modulated with noise, the so called base-line filtering interval preceeding the actual signal and the signal filtering interval following the actual signal are chosen so that their widths are equal to the width of the optimal peaking time (T.sub.p), the momentary value measured in the base-line filtering interval (A.sub.i) is subtracted from the momentary value measured in the signal filtering interval (J.sub.i), where said momentary values (A.sub.i and J.sub.i) are measured in the time scale symmetrically with regard to the rising edge of the signal, and the differences (J.sub.i -A.sub.i) are summed with weighting factors (W.sub.i).Type: GrantFiled: December 20, 1988Date of Patent: April 2, 1991Assignee: Magyar Tudomanyos Akademia Atommag Kutato IntezeteInventors: Tamas Lakatos, Jozsef Molnar, Endre Madarasz
-
Patent number: 4995939Abstract: In a process for determining the layer thickness of semiconductor layer structures, a sample of a multilayer semi-conductor (4) is placed in contact with an electrolyte (2) then subjected to anodic etching during which the depth of etching is determined by integration of the current. During etching, the sample (4) is also excited by an electric signal and the real component of the admittance and hence the conductance of the probe at the frequency of excitation is determined, the extreme values of this component are analyzed, and the values of the depth of etching corresponding to these extremes, which characterize the junctions between the layers of the sample (4) tested, are determined.Type: GrantFiled: February 8, 1989Date of Patent: February 26, 1991Assignee: Magyar Tudomanyos Akademia Muszaki Fizikai Kutato IntezeteInventors: Gyorgy Ferenczi, Katalin Erdelyi, Maria Somogyi, Janos Boda, Gyorgy Fule, Gabor Aszodi
-
Patent number: 4973237Abstract: An apparatus for the production of grains using the rolling layer technique. The apparatus has a container formed from multiple concentric sections, a truncated cone shaped lower section, a cylindrical shaped middle section, and, at least one cylindrical shaped upper section, and is supported for rotation about the longitudinal axis of the container. The lower section tapers outward from a lower end face plate to an upper end which communicates with the lower end of the middle section to form a transfer port between the lower and middle sections, while the upper end of the middle section communicates with the holed lower face of the upper section to form a transport port between the upper and the middle sections. An annular ridge-like structure exists on the interior surface of the lower face of the upper section, circumferentially surrounding the transfer port. The cross-sectional diameters and the heights of the sections vary relative to each other.Type: GrantFiled: June 7, 1989Date of Patent: November 27, 1990Assignee: Magyar Tudomanyos Akademia Muszaki Kemiai Kutato IntezetInventors: Rudolf Hajou, Erno Horvath, Zoltan Ormos, Karoly Pataki, Andras Szalay
-
Patent number: 4954628Abstract: The invention relates to a process for preparing sulphonyl-ureas of the general formula (I) ##STR1## wherein Ar.sub.1 represents a phenyl, naphthyl or thienyl group, the derivatives thereof substituted by C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, (halo)alkoxycarbonyl, (halo)alkyloxy, nitro, cyano groups as well as by halogen atoms,Ar.sub.2 represents a phenyl, pyridyl, pirimidinyl or triazinyl group and the derivatives thereof substituted by C.sub.1-4 (halo)alkyl, C.sub.1-4 (halo)alkyloxy, amino, O-acyl, O-arylsulphonyl, O-(substituted carbamoyl) groups as well as by halogen atoms.Type: GrantFiled: March 2, 1989Date of Patent: September 4, 1990Assignees: Nitrokaelepek, Magyar Tudomanyos Akademia Kozponti Kemiai Kutato IntezeteInventors: Gabor Besenyei, Sandor Nemeth, Laszlo Simandi, Maria Belak, Maria Szabo, Jozsef Dukai, Lajos Nagy, Elemer Tomordi, Csaba Soptei, Erzsebet E. Dioszegine
-
Patent number: 4939410Abstract: Electrode arrangement with liquid-metal electrode of controllable surface, comprising a liquid-metal reservoir, a capillary connected thereto through a controllable valve and contact means being in electric contact with the liquid-metal in the capillary. According to the invention at least one section of the capillary is formed within a metal body not reacting chemically with the liquid-metal, said metal body constituting the contact means. Preferably, the metal body is formed so that an elastic closing element of the valve fits to a surface of the metal body surrounding an opening of the capillary section formed therein.Type: GrantFiled: September 27, 1988Date of Patent: July 3, 1990Assignee: Magyar Tudomanyos Akademia Kutatas- es Szervezetelemzo IntezeteInventors: Geza Nagy, Jozsef Tarcali, Erno Pungor, Klara Toth, Veronika, nee Mohacsi Karpati, Zsofia Feher, Gyorgy Horvai, Peter Sarkany, Istvan Bokor
-
Patent number: 4850173Abstract: The invention relates to a process for inhibiting spread of fire in buildings on fire and for protection against the effect of fire wherein heat insulating layer is applied onto the surface of movable and fixed building structures, involving the use of heat insulating materials in the joints of movable and fixed building structures wherein as heat insulating material heat-absorbent hydrophylic silica and/or aluminosilicate based adsorbent, preferably synthetic A-, X- or P-zeolite is used.Type: GrantFiled: November 13, 1987Date of Patent: July 25, 1989Assignee: Magyar Tudomanyos Akademia Kozponti Kemiai Kutato Intezete and Epitestudomanyi IntezetInventors: Herman Beyer, Gabriella Borbely, Sandor Dombi, Alajos Kalman, Gyula Meszaros, Peter Miasnikov, Pal Rozsa
-
Patent number: 4839588Abstract: A method for the examination of electrically active impurities of semiconductor materials or semiconductor structures is disclosed. The method comprises the steps of providing a junction in a sample taken from the semiconductor to be tested, inserting the sample in a microwave field, providing a space charge layer in the junction by applying a reverse bias thereto, filling the electrically active defects of the space charge layer, and examining the thermal emission process proceeding to reach a thermal equilibrium state that occurs following the filling step by measuring the change of the microwave field that takes place due to changes in microwave absorption in the sample during the thermal emission process. The microwave field should be present at least during the examination of the transient microwave absorption.Type: GrantFiled: November 25, 1987Date of Patent: June 13, 1989Assignee: Magyar Tudomanyos Akademia Muszaki Fizikai Kutato IntezetInventors: Wolfgang Jantsch, Gyorgy Ferenczi
-
Patent number: 4739081Abstract: The invention relates to new crown ether derivatives of the general Formula I ##STR1## and a process for the preparation thereof wherein Z.sup.1 is a group of the general Formula ##STR2## R.sub.a and R.sub.b may be the same or different and R.sub.a represents an alkyl group having 1-4 carbon atoms and R.sub.b is an alkyl group having 1-20 carbon atoms.The new crown ethers are useful in the preparation of ion-selective electrodes having a long lifetime.Type: GrantFiled: November 1, 1984Date of Patent: April 19, 1988Assignee: Magyar Tudomanyos AkademiaInventors: Laszlo Toke, Bela gai, Istvan Bitter, Erno Pungor, Klara Szepesvary nee Toth, Erno Lindner, Maria Forro nee Horvath, Jeno Havas
-
Patent number: 4634982Abstract: The invention relates to a capacitive measuring element intended for continuous measurements of conductance in streaming solutions. The essence of the measuring element is that in the measuring space the surfaces limiting it are covered by an electrically insulating material. A method for obtaining the dimensions of the measuring element has also been proposed. According to the measuring element of the invention the measurements of concentration from very low values with high accuracy and low noise level are possible. The life duration and the reliability of the measuring element are high, and it shows a high resistivity against corrosive media to be measured.Type: GrantFiled: September 13, 1983Date of Patent: January 6, 1987Assignee: Magyar Tudomanyos Akademia Kozponti HivatalsInventors: Erno Pungor, Klara Toth, Ferenc Pal, Bela Eros, Jozsef Nagy, Laszlo Bihatsi
-
Patent number: 4571541Abstract: A method for determining charged energy states of a sample of a semiconductor or insulator material by using deep level transient spectroscopy.Type: GrantFiled: November 4, 1982Date of Patent: February 18, 1986Assignee: Magyar Tudomanyos Akademia Muszaki Fizikai Kutato IntezeteInventors: Gyorgy Ferenczi, Janos Boda, Ferenc Toth, Peter Horvath, Laszlo Benkovics, Laszlo Dozsa
-
Patent number: 4534782Abstract: The invention relates to a new method for increasing the biological value of manures, dung-waters, organic wastes and/or soils rich in lysine. According to the invention manure, dung-water, an organic waste and/or soil rich in lysine, either of natural composition or supplemented with lysine, a lysine source and/or one or more agricultural chemical(s), is treated with at least 0.01 mole of formaldehyde or an equivalent amount of a formaldehyde source, calculated for one mole of free or bound lysine present.The treatment according to the invention results in a significant increase of plant growth and crop yield.Type: GrantFiled: October 6, 1981Date of Patent: August 13, 1985Assignees: Magyar Tudomanyos Akademia Kozponti Hivatala, Lenin Mezogazdasagi TermeloszovetkezetInventors: Istvan Rusznak, Lajos Trezl, Dezso Foldesi, Bela Szabo, Imre Bodi, Szilveszter Csaszar, Mihaly Szopko, Mihaly Gombar, Gabriella Kovacs, Erno Tyihak
-
Patent number: 4531007Abstract: New crown ether derivatives of formula (I) ##STR1## wherein R stands for hydrogen or C.sub.1-4 alkyln stands for 1,2,X stands for oxygen, sulphur or a NH-groupY represents hydrogen or nitroZ represents a chemical bond, --CH.sub.2 --, --(CH.sub.2).sub.2-4 --, --CH.sub.2 OCH.sub.2 --, --CH.sub.2 SCH.sub.2 --, ##STR2## or a group of the formula ##STR3## suitable for forming cation complexes, process for the preparation thereof and alkali or alkali earth metal ion-selective membrane electrodes containing said compounds are described.Type: GrantFiled: March 7, 1983Date of Patent: July 23, 1985Assignee: Magyar Tudomanyos AkademiaInventors: Laszlo Toke, Bela gai, Istvan Bitter, Erno Pungor, Klara Szepesvary nee Toth, Erno Lindner, Maria Horvath, Jeno Havas
-
Patent number: 4492494Abstract: The invention relates to a process for stabilizing an aqueous gel-forming system comprising one or more water-soluble acrylic monomer as gellifying agent, methylenebis-acrylamide co-monomer and/or one or more mono- or bivalent aldehyde as cross-linking agent, a redox catalyst system containing an alkali metal and/or ammonium persulfate as oxidizing component along with one or more amine compound as reducing component, furthermore optionally one or more water-soluble polymer for adjusting the viscosity of the solution and/or modifying the gel structure. According to the invention said gel-forming system is stabilized by saturating it with molecular oxygen.The invention relates further to a process for improving the strength and impermeability of particulate materials and/or solid articles.Type: GrantFiled: August 5, 1981Date of Patent: January 8, 1985Assignees: Magyar Tudomanyos Akademia Termeszettudomanyi Kutato Laboratorium, Foldmero es Talajvizsgalo VallalatInventors: Tamas Szekely, Ferenc Csanda, Gabor Nagy, Gyozo Czerny
-
Patent number: 4437060Abstract: A Deep Level Transient Spectroscopy (DLTS) method in which a high frequency measuring signal is applied continuously on a semiconductor junction, and exciting pulses are generated which are coupled through fast semiconductor switching elements to the junction to alternatively bias the junction in reverse and forward (or slightly reverse) directions. The high frequency measuring signal passed through the junction is evaluated by means of a lock-in amplifier phase-locked with a constant phase angle, independent of the repetition rate of the exciting pulses.The evaluation circuits of the apparatus including the lock-in amplifier are controlled by switching elements driven by control signals generated from the exciting pulses.Type: GrantFiled: June 3, 1981Date of Patent: March 13, 1984Assignee: Magyar Tudomanyos Akademia Muszaki Fizikai Kutato IntezeteInventors: Gyorgy Ferenczi, Peter Horvath, Ferenc Toth, Jozsef Kiss, Janos Boda