Abstract: The present invention discloses composition(s) for increasing the levels of tyrosine hydroxylase in the mammalian brain of human subjects and thus increasing the levels of brain catecholamines, in treating neurological related disorders. The composition(s) comprise(s) a biological extract obtained from the oil palm fruit bunch or aqueous stream of the processing or milling of oil palm fruit bunches. In an embodiment, the extract is obtained from the oil palm fruit bunch or aqueous stream of the processing or milling of oil palm fruit bunches. The extract is water-soluble. In another embodiment, the extract further comprises one or more organic compounds. The one or more organic compounds are selected from the group consisting of but not limited to sugars, phenolic compounds, flavonols, stilbenoids, dihydroflavonols, anthocyanins, shikimic acid, soluble fibres and peptides.
Type:
Application
Filed:
November 23, 2020
Publication date:
November 2, 2023
Applicant:
MALAYSIAN PALM OIL BOARD
Inventors:
Vera V. KOLEDOVA, Robert P. WEINBERG, Anthony SINSKEY, Chokyun RHA, Kenneth C. HAYES, Ravigadevi SAMBANTHAMURTHI, Kirsten C. SCHNEIDER, Anastasia A. ARTAMONOVA, Soon Sen LEOW
Abstract: Methods, compositions, kits, and computer program code are provided for predicting somaclonal abnormality (e.g., a Mantled phenotype) in a plant and or sorting plants based on the predicted presence or absence of somaclonal abnormality.
Type:
Grant
Filed:
April 25, 2018
Date of Patent:
April 25, 2023
Assignee:
Malaysian Palm Oil Board
Inventors:
Meilina Ong Abdullah, Ooi Siew Eng, Leslie Low Eng Ti, Rajinder Singh, Rajanaidu Nookiah, Ravigadevi Sambanthamurthi, Nan Jiang, Steven W. Smith, Nathan D. Lakey, Rob Martienssen, Jared Ordway, Michael Hogan
Abstract: Methods, compositions, and kits for predicting and controlling fruit color in palm.
Type:
Grant
Filed:
May 1, 2020
Date of Patent:
January 24, 2023
Assignee:
Malaysian Palm Oil Board
Inventors:
Rajinder Singh, Leslie Ooi Cheng Li, Leslie Low Eng Ti, Rahimah Abdul Rahman, Meilina Ong Abdullah, Jayanthi Nagappan, Rozana Rosli, Mohd Amin Ab Halim, Rajanaidu Nookiah, Chan Kuang Lim, Norazah Azizi, Ravigadevi Sambanthamurthi, Rob Martienssen, Steven W. Smith, Nathan D. Lakey, Andrew Van Brunt, Jared Ordway, Michael Hogan, Chunyan Wang
Abstract: Present invention discloses an oil palm composition for use in prevention or treatment of Alzheimer's disease. The composition is useful in impeding formation of neurotoxic peptide. Present invention can be used in preparation of a medicament in a therapeutic effective amount for prevention or treatment of Alzheimer's disease and diseases related thereto.
Type:
Application
Filed:
August 13, 2022
Publication date:
December 8, 2022
Applicant:
MALAYSIAN PALM OIL BOARD
Inventors:
Robert P. WEINBERG, Chokyun RHA, Anthony J. SINSKEY, Yew Ai TAN, Ravigadevi SAMBANTHAMURTHI
Abstract: Present invention discloses an oil palm composition for use in prevention or treatment of Alzheimer's disease. The composition is useful in impeding formation of neurotoxic peptide. Present invention can be used in preparation of a medicament in a therapeutic effective amount for prevention or treatment of Alzheimer's disease and diseases related thereto.
Type:
Grant
Filed:
July 10, 2019
Date of Patent:
December 6, 2022
Assignee:
MALAYSIAN PALM OIL BOARD
Inventors:
Robert P. Weinberg, Chokyun Rha, Anthony J. Sinskey, Yew Ai Tan, Ravigadevi Sambanthamurthi
Abstract: The present invention relates to processes and composition meant for delaying ageing process in a subject comprising of palm fruit juice whole or its fractions, alone or in combination with other components in the form of a composition. Palm Fruit Juice alone or in combination with other additives can be administered preferably orally in pharmaceutically acceptable dosage forms.
Type:
Grant
Filed:
March 8, 2019
Date of Patent:
September 20, 2022
Assignee:
MALAYSIAN PALM OIL BOARD
Inventors:
Soon Sen Leow, Ravigadevi Sambanthamurthi, Kenneth C. Hayes
Abstract: Nucleic acid sequences for predicting and controlling shell phenotype in palm.
Type:
Grant
Filed:
March 24, 2020
Date of Patent:
June 28, 2022
Assignee:
Malaysian Palm Oil Board
Inventors:
Rajinder Singh, Leslie Low Eng Ti, Leslie Ooi Cheng Li, Meilina Ong Abdullah, Rajanaidu Nookiah, Ravigadevi Sambanthamurthi, Steven W. Smith, Nathan D. Lakey, Rob Martienssen, Jared Ordway, Michael Hogan
Abstract: The present invention relates to a composition for the treatment of colon disorder comprising oil palm polyphenolics (OPP) and fibres extracted from the vegetation liquor generated during the milling and extraction of oil from the oil palm fruit administered to a patient in an effective concentration of 50 mg gallic acid equivalents (GAE). The present invention further relates to a method of treatment and prevention of colon disorders and maintenance of gut health.
Type:
Application
Filed:
August 16, 2019
Publication date:
February 17, 2022
Applicant:
MALAYSIAN PALM OIL BOARD (MPOB)
Inventors:
Syed Fairus SYED ABU BAKAR, Ravigadevi SAMBANTHAMURTHI, Yew Ai TAN, Mahinda ABEYWARDENA
Abstract: Compositions comprising oil palm phenolics and shikimic acid or derivatives thereof and their use in enhancing anti-oxidative and anti-inflammatory properties.
Type:
Grant
Filed:
March 17, 2017
Date of Patent:
June 15, 2021
Assignee:
MALAYSIAN PALM OIL BOARD
Inventors:
Ravigadevi Sambanthamurthi, Tan Yew AI, T. G. Sambandan, Cho Kyun Rha, Anthony J. Sinskey
Abstract: A composition comprising extracts containing oil palm phenolics in an amount effective for use in a method of reducing cholesterol biosynthesis and thus preventing obesity. The composition up regulates fatty acid beta oxidation and down regulates cholesterol biosynthesis in livers. The composition is useful for prevention of obesity associated diseases. The composition delays the onset of obesity and attenuates the inflammatory response of atherogenic diet, whereby the composition aids to suppress the inflammatory response thereby ameliorating artherosclerosis. The composition delays weight gain or obesity thereby preventing the effects of dyslipidemia.
Type:
Grant
Filed:
February 17, 2018
Date of Patent:
May 11, 2021
Assignee:
MALAYSIAN PALM OIL BOARD
Inventors:
Soon Sen Leow, Ravigadevi Sambanthamurthi, Yew Ai Tan, Kalyana Sundram P. Manickam, Mohd Basri wahid
Abstract: Nucleic acid and polypeptide sequences for predicting and controlling shell phenotype in palm.
Type:
Grant
Filed:
June 14, 2016
Date of Patent:
February 2, 2021
Assignee:
Malaysian Palm Oil Board
Inventors:
Rajinder Singh, Leslie Low Eng Ti, Leslie Ooi Cheng Li, Meilina Ong Abdullah, Rajanaidu Nookiah, Ravigadevi Sambanthamurthi, Andrew Van Brunt, Muhammad A. Budiman, Steven W. Smith, Nathan D. Lakey, Rob Martienssen, Jared Ordway
Abstract: The present invention relates to processes and composition meant for delaying ageing process in a subject comprising of palm fruit juice whole or its fractions, alone or in combination with other components in the form of a composition. Palm Fruit Juice alone or in combination with other additives can be administered preferably orally in pharmaceutically acceptable dosage forms.
Type:
Application
Filed:
March 8, 2019
Publication date:
December 24, 2020
Applicant:
MALAYSIAN PALM OIL BOARD
Inventors:
Soon Sen LEOW, Ravigadevi SAMBANTHAMURTHI, Kenneth C. HAYES
Abstract: Methods, compositions and kits for the prevention and treatment of mitochondrial dysfunction, mitochondrial DNA damage and genomic DNA damage are provided. The methods use the administration of palm fruit juice and/or compositions containing phenolic compounds present in palm fruit juice. The methods, compositions, and kits can be used to reduce DNA damage in subjects being treated with nucleoside reverse transcriptase inhibitors, such as patients having HIV or AIDS.
Type:
Grant
Filed:
February 6, 2014
Date of Patent:
October 27, 2020
Assignees:
MALAYSIAN PALM OIL BOARD, BRANDEIS UNIVERSITY
Inventors:
Adam E. Osborne, Lawrence J. Wangh, Kenneth C. Hayes, Ravigadevi Sambanthamurthi
Abstract: A composition for preventing, treating, reversing, protecting against ameliorating the injuring effect of an ionizing radiation upon living cells, tissues, organs, and organisms, comprising oil palm phenolics (OOP) or vegetation liquor extract obtained from aqueous stream of a palm oil milling effluent is provided.
Type:
Application
Filed:
April 20, 2020
Publication date:
August 6, 2020
Applicant:
MALAYSIAN PALM OIL BOARD
Inventors:
Ravigadevi SAMBANTHAMURTHI, Yew Ai TAN, Vera Vladimirovna KOLEDOVA, Robert Paul WEINBERG, Cho Kyun RHA, Anthony J. SINSKEY
Abstract: A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives.
Type:
Application
Filed:
February 28, 2020
Publication date:
June 25, 2020
Applicant:
MALAYSIAN PALM OIL BOARD
Inventors:
T.G. SAMBANDAN, ChoKyun RHA, Anthony J. SINSKEY, Ravigadevi SAMBANTHAMURTHI, Yew Ai TAN, Kalyana Sundram P. MANICKAM, Mohd Basri WAHID
Abstract: Nucleic acid sequences for predicting and controlling shell phenotype in palm.
Type:
Grant
Filed:
September 13, 2016
Date of Patent:
April 28, 2020
Assignee:
The Malaysian Palm Oil Board
Inventors:
Rajinder Singh, Leslie Low Eng Ti, Leslie Ooi Cheng Li, Meilina Ong Abdullah, Rajanaidu Nookiah, Ravigadevi Sambanthamurthi, Steven W. Smith, Nathan D. Lakey, Rob Martienssen, Jared Ordway, Michael Hogan
Abstract: A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives.
Type:
Grant
Filed:
April 3, 2018
Date of Patent:
March 31, 2020
Assignee:
MALAYSIAN PALM OIL BOARD
Inventors:
T.G. Sambandan, ChoKyun Rha, Anthony J. Sinskey, Ravigadevi Sambanthamurthi, Yew Ai Tan, Kalyana Sundram P. Manickam, Mohd Basri Wahid
Abstract: Present invention discloses an oil palm composition for use in prevention or treatment of Alzheimer's disease. The composition is useful in impeding formation of neurotoxic peptide. Present invention can be used in preparation of a medicament in a therapeutic effective amount for prevention or treatment of Alzheimer's disease and diseases related thereto.
Type:
Application
Filed:
July 10, 2019
Publication date:
March 19, 2020
Applicant:
Malaysian Palm Oil Board
Inventors:
Robert P. WEINBERG, Chokyun RHA, Anthony J. SINSKEY, Yew Ai TAN, Ravigadevi SAMBANTHAMURTHI
Abstract: Present invention relates to a composition to inhibit cancer cell proliferation, wherein said composition comprises oil palm extracts. The composition is useful for prevention of pancreatic cancer by inhibiting clonogenicity, inducing apoptosis, regulating gene expression, inducing anti-invasive effect, and induces cell cycle arrest in S phase. Present invention also discloses a composition that inhibits NF-?B activity and reduces cell invasion, cell migration and metastasis. Present invention further discloses the use of therapeutically effective amount of a composition in inhibiting the growth of pancreatic cancer.
Type:
Grant
Filed:
January 6, 2017
Date of Patent:
July 9, 2019
Assignee:
Malaysian Palm Oil Board
Inventors:
Smiti V. Gupta, Pramod Khosla, Xiangming Ji, Ravigadevi Sambanthamurthi, Yew Ai Tan
Abstract: The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm-based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).
Type:
Grant
Filed:
April 3, 2018
Date of Patent:
June 4, 2019
Assignee:
MALAYSIAN PALM OIL BOARD
Inventors:
Sambandan Tg, Chokyun Rha, Ravigadevi Sambanthamurthi, Anthony J. Sinskey, Yew Ai Tan, Kalyana Sundram P. Manickam, Mohd Basri Wahid