Patents Assigned to Mallinckrodt
  • Apparatus and method for humidity conditioning sample gas of a patient breathing circuit affiliated with a ventilator and/or nitric oxide delivery system
    Patent number: 10485945
    Abstract: A therapeutic gas is administered to a patient. A sample gas is drawn from the therapeutic gas supply, and passed through a water-permeable tubular membrane. Concurrently, a section of the water permeable tubular membrane is maintained as a ventilated water permeable tubular membrane, by exposing outer surfaces of the ventilated water permeable tubular membrane to an ambient air flow. The ambient air flow may in some examples be moved over the tubular membrane via forced air such as for example via a fan associated with a housing surrounding the tubular membrane.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: November 26, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: John P. Stanton, John V. Berndt
  • Compensating for disruptions in breathing gas flow measurement
    Patent number: 10478584
    Abstract: The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, using techniques to compensate for disruptions in breathing gas flow measurement, such as when breathing gas flow measurement is unavailable or unreliable. Such techniques include using historical breathing gas flow rate data, such as moving average flow rates, moving median flow rates and/or flow waveforms. At least some of these techniques can be used to ensure that interruption in therapeutic gas delivery is minimized or eliminated.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: November 19, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Jaron M. Acker, Craig R. Tolmie
  • Biodegradable extravascular stent
    Patent number: 10456505
    Abstract: The present invention relates to extravascular supports. In particular, to extravascular supports which are used in vein grafting. More in particular, it relates to extravascular supports which are biodegradable.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: October 29, 2019
    Assignee: Mallinckrodt Pharma IP Trading D.A.C.
    Inventor: Jacob Laurens Koopman
  • Centrifuge system and method with component tracking
    Patent number: 10434239
    Abstract: Devices, methods, and systems are provided for priming, separating, and collecting blood components. At least one disposable component may be utilized, and a determination may be made as to whether such a disposable component is authentic, is new/unused or used, or both.
    Type: Grant
    Filed: September 11, 2016
    Date of Patent: October 8, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Dennis Briggs, Simon Do, Mark Vandlik, Kevin Murphy
  • Apparatus and method for monitoring nitric oxide delivery
    Patent number: 10426913
    Abstract: Described is an apparatus for monitoring nitric oxide delivery, wherein such apparatus comprises a display that provides a visual and/or numeric indication of the calculated dose of nitric oxide. Also described is a method of monitoring nitric oxide delivery, wherein the breathing gas flow rate and therapeutic gas flow rate are measured and used to determine the calculated dose of nitric oxide, which is then displayed. In some embodiments, an alert is provided when the calculated dose rises above or falls below a predetermined level or range.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: October 1, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Craig R. Tolmie, Robert Schnitman, Joseph J. Medicis, Jim Potenziano, Jaron Acker, Jeffrey Schmidt
  • Use and monitoring of inhaled nitric oxide with left ventricular assist devices
    Patent number: 10398820
    Abstract: Described are systems and methods for administration of nitric oxide (NO) with use of left ventricular assists devices (LVADs), as well as systems and methods for monitoring the NO delivery devices and/or the LVAD.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: September 3, 2019
    Assignee: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
    Inventors: Jim Potenziano, Douglas Alan Greene, Craig Flanagan
  • Methods of using inhaled nitric oxide gas for treatment of acute respiratory distress syndrome in children
    Patent number: 10391120
    Abstract: The present invention provides a treatment of acute respiratory distress syndrome (ARDS) in children using dosing of nitric oxide at low concentrations, such as less than 10 ppm.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: August 27, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Jim Potenziano, Ronald Bronicki, James Baldassarre
  • Systems and methods for manufacturing and safety of an NO-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient
    Patent number: 10384031
    Abstract: The principles and embodiments of the present invention relate to methods and systems for safely providing NO to a recipient for inhalation therapy. There are many potential safety issues that may arise from using a reactor cartridge that converts NO2 to NO, including exhaustion of consumable reactants of the cartridge reactor. Accordingly, various embodiments of the present invention provide systems and methods of determining the remaining useful life of a NO2-to-NO reactor cartridge and/or a breakthrough of NO2, and providing an indication of the remaining useful life and/or breakthrough.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: August 20, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Jaron M. Acker, Thomas Kohlmann
  • Reduced dose intravenous acetaminophen
    Patent number: 10383834
    Abstract: Described herein are compositions and methods for intravenous administration of acetaminophen at a single dose level of less than about 1000 mg for the treatment or prevention of pain (e.g., postoperative pain) and/or fever.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: August 20, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Mike Allan Royal, James Bradley Breitmeyer
  • Liposomal cisplatin compositions for cancer therapy
    Patent number: 10383823
    Abstract: The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-65 mol % of a phosphatidylcholine lipid, 30-45 mol % of cholesterol, and 2-8 mol % of a PEG-lipid; and cisplatin. Cisplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the cisplatin weight is from about 65:1 to about 95:1. Methods for the preparation of liposomal cisplatin and the treatment of cancer are also disclosed.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: August 20, 2019
    Assignee: MALLINCKRODT LLC
    Inventor: William McGhee
  • Methods of Administering Inhaled Nitric Oxide Gas
    Publication number: 20190231814
    Abstract: The invention relates methods of reducing the risk or preventing the occurrence of an adverse event (AE) or a serious adverse event (SAE) associated with a medical treatment comprising inhalation of nitric oxide.
    Type: Application
    Filed: April 8, 2019
    Publication date: August 1, 2019
    Applicant: MALLINCKRODT HOSPITAL PRODUCTS IP LIMITED
    Inventor: James S. Baldassarre
  • (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
    Patent number: 10363251
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat a variety of disorders.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: July 30, 2019
    Assignee: Mallinckrodt LLC
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • Therapeutic gas delivery device with pulsed and continuous flow control
    Patent number: 10342948
    Abstract: Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: July 9, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Jaron Acker, Thomas Kohlmann, Craig R. Tolmie
  • Method of treating patients with hepatorenal syndrome type 1
    Patent number: 10335452
    Abstract: The principles and embodiments of the present disclosure relate to methods for using terlipressin to treat a patient having impaired renal function associated with liver disease. A patient identified as suffering from HRS-1 is tested to determine if the patient meets at least two out of three criteria, wherein the three criteria include a WBC<4 or >12 cells/?L; HR>90 bpm; and any one of HCO3<21 mmol/L or PaCO2<32 mmHg or >20 breaths per minute. If the patient meets at least two of the criteria, he or she is administered terlipressin in an amount effective to produce a reduction in serum creatinine of at least 1.0 mg/dL.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: July 2, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Khurram Jamil, Stephen Chris Pappas, Jim Potenziano
  • Therapeutic gas delivery device with pulsed and continuous flow control
    Patent number: 10328231
    Abstract: Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: June 25, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Jaron M. Acker, Thomas Kohlmann, Craig R. Tolmie
  • ACTH prophylactic treatment of renal disorders
    Patent number: 10286041
    Abstract: Provided herein are methods for prophylactic treatment of renal disorders comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual suspected of having, predisposed to, or at risk of developing a renal disorder.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: May 14, 2019
    Assignees: Mallinckrodt ARD IP Limited, Rhode Island Hospital
    Inventors: Steve Cartt, Rujun Gong
  • Gas delivery device and system
    Patent number: 10272225
    Abstract: A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: April 30, 2019
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Duncan Bathe, John Klaus, David Christensen
  • Process of generating germanium
    Patent number: 10262766
    Abstract: The present disclosure generally relates to a new process for generating germanium-68 from an irradiated target body. The process includes irradiation of the target body followed by various extraction techniques to generate the germanium-68.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: April 16, 2019
    Assignee: MALLINCKRODT NUCLEAR MEDICINE LLC
    Inventors: William C. Uhland, David Wayne Pipes, Melissa Dianne Perrigo
  • ACTH for treatment of acute respiratory distress syndrome
    Patent number: 10232018
    Abstract: Provided herein are methods of treatment of acute respiratory distress syndrome comprising administration of adrenocorticotropic hormone (ACTH). or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual in need thereof.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 19, 2019
    Assignee: Mallinckrodt ARD IP Limited
    Inventors: James Knight, Steve Cartt, David Young, Patrice Becker
  • Systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement
    Patent number: 10232138
    Abstract: The present invention generally relates to systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement. At least some of these enhanced BCG flow measurements can be used to address some surprising phenomena that may, at times, occur when wild stream blending therapeutic gas into breathing gas that a patient receives from a breathing circuit affiliated with a ventilator. Utilizing at least some of these enhanced BCG flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives from a ventilator can at least be more accurate and/or over delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: March 19, 2019
    Assignee: Mallinckrodt Hospital Product IP Limited
    Inventors: Jaron M. Acker, Craig R. Tolmie