Patents Assigned to MannKind Corporation
  • Expression vectors encoding epitopes of target-associated antigens and methods for their design
    Patent number: 8252916
    Abstract: The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing a substrate polypeptide sequence including the epitope, wherein the substrate polypeptide permits processing by a proteasome; contacting the substrate polypeptide with a composition including the proteasome, under conditions that support processing of the substrate polypeptide by the proteasome; and assaying for liberation of the epitope. The invention further relates to vectors including a housekeeping epitope expression cassette. The invention relates to epitope cluster regions and to vectors including epitope cluster regions. The invention also relates to a method of activating a T cell comprising contacting a substrate polypeptide with an APC and contacting the APC with a T cell.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: August 28, 2012
    Assignee: MannKind Corporation
    Inventors: John J. L. Simard, David C. Diamond, Zhiyong Qiu, Xiang-Dong Lei
  • Unit Dose Capsules and Dry Powder Inhaler
    Publication number: 20120192865
    Abstract: Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 2, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Solomon S. Steiner, Robert Feldstein, Per B. Fog, Trent Poole
  • Powder dispensing and sensing apparatus and methods
    Patent number: 8230887
    Abstract: Powder dispensing and sensing apparatus and methods are provided. The powder dispensing and sensing apparatus includes a tray support structure to receive a cartridge tray holding cartridges, a powder dispenser assembly including powder dispenser modules to dispense powder into respective cartridges of a batch of cartridges in the cartridge tray, a powder transport system to deliver powder to the powder dispenser modules, a sensor module including sensor cells to sense respective fill states, such as the weights, of each of the cartridges in the batch of cartridges, and a control system to control the powder dispenser modules in response to the respective sensed fill states of each of the cartridges of the batch of cartridges.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: July 31, 2012
    Assignee: MannKind Corporation
    Inventors: Trent A. Poole, David F. Bonneau, Per B. Fog
  • Diketopiperazine microparticles with defined isomer contents
    Patent number: 8227409
    Abstract: Disclosed herein are fumaryl diketopiperazine (FDKP) compositions and microparticles having a specific trans isomer content of about 45% to about 65%. The FDKP microparticles can comprise a drug such as an endocrine hormone, including, peptide, including, insulin, glucagon, parathyroid hormones and the like and can be used to make a powder formulation for pulmonary delivery of the drug.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: July 24, 2012
    Assignee: MannKind Corporation
    Inventors: Kelly S. Kraft, Karla Somerville
  • Powder transport systems and methods
    Patent number: 8220505
    Abstract: Powder dispensing and sensing apparatus and methods are provided. The powder dispensing and sensing apparatus includes a tray support structure to receive a cartridge tray holding cartridges, a powder dispenser assembly including powder dispenser modules to dispense powder into respective cartridges of a batch of cartridges in the cartridge tray, a powder transport system to deliver powder to the powder dispenser modules, a sensor module including sensor cells to sense respective fill states, such as the weights, of each of the cartridges in the batch of cartridges, and a control system to control the powder dispenser modules in response to the respective sensed fill states of each of the cartridges of the batch of cartridges.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: July 17, 2012
    Assignee: MannKind Corporation
    Inventors: Trent A. Poole, David F. Bonneau, Per B. Fog
  • Catalysis of Diketopiperazine Synthesis
    Publication number: 20120178935
    Abstract: Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ?-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.
    Type: Application
    Filed: March 16, 2012
    Publication date: July 12, 2012
    Applicant: MannKind Corporation
    Inventors: John J. Stevenson, Destardi Moye-Sherman
  • Unit Dose Capsules and Dry Powder Inhaler
    Publication number: 20120174923
    Abstract: Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece.
    Type: Application
    Filed: March 15, 2012
    Publication date: July 12, 2012
    Applicant: Mannkind Corporation
    Inventors: Solomon S. Steiner, Robert Feldstein, Per B. Fog, Trent Poole
  • Unit dose cartridge and dry powder inhaler
    Patent number: 8215300
    Abstract: A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: July 10, 2012
    Assignee: MannKind Corporation
    Inventors: Solomon S. Steiner, Trent A. Poole, Per B. Fog, Roderike Pohl, Michael Crick, Robert Feldstein
  • Diketopiperazine Microparticles with Defined Specific Surface Areas
    Publication number: 20120164186
    Abstract: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
    Type: Application
    Filed: June 11, 2010
    Publication date: June 28, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Marshall L. Grant, Grayson W. Stowell, Paul Menkin
  • Catalysis of diketopiperazine synthesis
    Patent number: 8202992
    Abstract: Provided is a method for the synthesis of N-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine including the step of heating a solution of ?-amino protected lysine in the presence of a catalyst selected from the group consisting of sulfuric acid, phosphoric acid, and phosphorus pentoxide.
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: June 19, 2012
    Assignee: MannKind Corporation
    Inventors: John J. Stevenson, Destardi Moye-Sherman
  • SSX-2 peptide analogs
    Patent number: 8202841
    Abstract: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: June 19, 2012
    Assignee: MannKind Corporation
    Inventors: Liping Liu, Zhidong Xie, David C. Diamond
  • MULTIVALENT ENTRAIN-AND-AMPLIFY IMMUNOTHERAPEUTICS FOR CARCINOMA
    Publication number: 20120148613
    Abstract: The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
    Type: Application
    Filed: December 23, 2011
    Publication date: June 14, 2012
    Applicant: MannKind Corporation
    Inventors: Adrian Ion Bot, Chih-Sheng Chiang, David C. Diamond, Jian Gong, Kent Andrew Smith, Liping Liu, Xiping Liu, Zhiyong Qiu
  • Use of Ultrarapid Acting Insulin
    Publication number: 20120122775
    Abstract: Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
    Type: Application
    Filed: January 25, 2012
    Publication date: May 17, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Anders Hasager Boss, Richard Petrucci, Campbell Howard, Alfred Mann
  • Use of Ultrarapid Acting Insulin
    Publication number: 20120115777
    Abstract: Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
    Type: Application
    Filed: January 17, 2012
    Publication date: May 10, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Peter Richardson, Robert A. Baughman, Elizabeth Potocka, Anders Hasager Boss, Richard Petrucci
  • Inhalation apparatus
    Patent number: 8166970
    Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: May 1, 2012
    Assignee: MannKind Corporation
    Inventors: Trent Poole, Solomon S. Steiner
  • Method for Treating Hyperglycemia with GLP-1
    Publication number: 20120094905
    Abstract: A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
    Type: Application
    Filed: January 8, 2010
    Publication date: April 19, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Donald Costello, Peter Richardson, Robert A. Baughman, Mark T. Marino
  • Unit dose capsules and dry powder inhaler
    Patent number: 8156936
    Abstract: Described are dry powder inhalers comprising an intake section, a mixing section and a mouthpiece. The mixing section can accommodate a capsule having a top keying portion and containing a dry powder medicament. The top keying portion of the capsules may fit within complementary keying structures in inhaler mixing sections.
    Type: Grant
    Filed: November 2, 2007
    Date of Patent: April 17, 2012
    Assignee: MannKind Corporation
    Inventors: Solomon S. Steiner, Per B. Fog, Trent Poole, Robert Feldstein
  • Unit dose capsules and dry powder inhaler
    Patent number: 8146588
    Abstract: Described are dry powder inhalers composing an intake section, a mixing section and a mouthpiece. The mixing section can accommodate a capsule having a top keying portion and containing a dry powder medicament. The top keying portion of the capsules may fit within complementary keying structures in inhaler mixing sections.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: April 3, 2012
    Assignee: MannKind Corporation
    Inventors: Solomon S. Steiner, Robert Feldstein, Per B. Fog, Trent A. Poole
  • Method and Composition for Treating Migraines
    Publication number: 20120071510
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Application
    Filed: November 9, 2011
    Publication date: March 22, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Andrea Leone-Bay, Grayson W. Stowell, Joseph J. Guarneri, Dawn M. Carlson, Marshall Grant, Chad C. Smutney
  • Cartridge for a dry powder inhaler
    Patent number: D664640
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: July 31, 2012
    Assignee: MannKind Corporation
    Inventors: Chad C. Smutney, John M. Polidoro, Benoit Adamo, P. Spencer Kinsey