Patents Assigned to MannKind Corporation
  • Unit dose capsules and dry powder inhaler
    Patent number: 8146588
    Abstract: Described are dry powder inhalers composing an intake section, a mixing section and a mouthpiece. The mixing section can accommodate a capsule having a top keying portion and containing a dry powder medicament. The top keying portion of the capsules may fit within complementary keying structures in inhaler mixing sections.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: April 3, 2012
    Assignee: MannKind Corporation
    Inventors: Solomon S. Steiner, Robert Feldstein, Per B. Fog, Trent A. Poole
  • Method and Composition for Treating Migraines
    Publication number: 20120071510
    Abstract: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
    Type: Application
    Filed: November 9, 2011
    Publication date: March 22, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Andrea Leone-Bay, Grayson W. Stowell, Joseph J. Guarneri, Dawn M. Carlson, Marshall Grant, Chad C. Smutney
  • Carbon-substituted diketopiperazine delivery systems
    Patent number: 8133514
    Abstract: Compositions useful in the delivery of active agents are provided. These delivery compositions include (a) an active agent; and (b) a carrier of at least one mono-C-substituted or di-C-substituted diketopiperazine. Methods for preparing these compositions and administering these compositions are also provided.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: March 13, 2012
    Assignee: MannKind Corporation
    Inventor: Samuel J. Milstein
  • IRE-1? substrates
    Patent number: 8124343
    Abstract: IRE-1? substrates useful for identifying agonists and antagonists of IRE-1? RNase activity.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: February 28, 2012
    Assignee: MannKind Corporation
    Inventors: John Bruce Patterson, Kori Shallyn Volkmann, Duane Brumm, Caryn Stiles
  • Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin
    Patent number: 8119593
    Abstract: Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin, and administration of a first dose of insulin glargine within 6 hours of waking for a day.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: February 21, 2012
    Assignee: MannKind Corporation
    Inventors: Peter Richardson, Robert A. Baughman, Elizabeth Potocka, Anders Hasager Boss, Richard Petrucci
  • Method for Treating Hyperglycemia with GLP-1
    Publication number: 20120040899
    Abstract: A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
    Type: Application
    Filed: September 16, 2011
    Publication date: February 16, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Donald Costello, Peter Richardson, Robert A. Baughman, Mark T. Marino
  • EPITOPE SYNCHRONIZATION IN ANTIGEN PRESENTING CELLS
    Publication number: 20120010384
    Abstract: Disclosed herein are vaccines and methods for inducing an immune response against cancer cells and cells infected with intracellular parasites. Vaccines having housekeeping epitopes are disclosed. The housekeeping epitope is formed by housekeeping proteasomes in peripheral cells, but not by professional antigen presenting cells. A vaccine containing a housekeeping epitope that is derived from an antigen associated with a peripheral target cell can thus direct an immune response against the target cell. Methods of treatment are also disclosed, which involve administering a vaccine having a housekeeping epitope.
    Type: Application
    Filed: December 20, 2010
    Publication date: January 12, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: John J.L. SIMARD, David C. Diamond
  • Method for Improving the Pharmaceutic Properties of Microparticles Comprising Diketopiperazine and an Active Agent
    Publication number: 20120010133
    Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
    Type: Application
    Filed: September 22, 2011
    Publication date: January 12, 2012
    Applicant: MANNKIND CORPORATION
    Inventors: Bryan R. Wilson, Marshall Grant
  • Multivalent entrain-and-amplify immunotherapeutics for carcinoma
    Patent number: 8084592
    Abstract: The present invention provides a method of treating a cell proliferative disease such as cancer by providing to a subject in need thereof an immunogenic composition comprising plasmid and peptide(s) or analogues thereof. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: December 27, 2011
    Assignee: MannKind Corporation
    Inventors: Adrian Ion Bot, Chih-Sheng Chiang, David C. Diamond, Jian Gong, Kent Andrew Smith, Liping Liu, Xiping Liu, Zhiyong Qiu
  • EPITOPE ANALOGS
    Publication number: 20110301327
    Abstract: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.
    Type: Application
    Filed: February 28, 2011
    Publication date: December 8, 2011
    Applicant: MANNKIND CORPORATION
    Inventors: Liping Liu, Adrian Bot, David C. Diamond
  • IRE-1alpha SUBSTRATES
    Publication number: 20110287952
    Abstract: IRE-1? substrates useful for identifying agonists and antagonists of IRE-1? RNase activity.
    Type: Application
    Filed: July 19, 2011
    Publication date: November 24, 2011
    Applicant: MANNKIND CORPORATION
    Inventors: John Bruce Patterson, Kori Shallyn Volkmann, Duane Brumm, Caryn Stiles
  • INTRACELLULAR KINASE INHIBITORS
    Publication number: 20110281850
    Abstract: Intracellular kinase inhibitors and their therapeutic uses for patients with T cell malignancies, B cell malignancies, autoimmune disorders, and transplanted organs.
    Type: Application
    Filed: July 7, 2011
    Publication date: November 17, 2011
    Applicant: MANNKIND CORPORATION
    Inventors: Gary A. Flynn, Sandra Aeyoung Lee, Mary Faris, David William Brandt, Subrata Chakravarty
  • CANCER IMMUNOTHERAPY AND METHOD OF TREATMENT
    Publication number: 20110274723
    Abstract: The instant disclosure relates to methods for treating a cancer patient with an active immunotherapeutic, wherein the methods include assessing a patient's pre-existing immunoreactivity to at least one target antigen, choosing an immunotherapeutic regimen based on the level of pre-existing immunoreactivity, and administering an active immunotherapeutic according to the regimen.
    Type: Application
    Filed: October 22, 2010
    Publication date: November 10, 2011
    Applicant: MANNKIND CORPORATION
    Inventors: Adrian Ion Bot, Zhiyong Qiu, David C. Diamond, Mihail Obrocea
  • METHODS AND COMPOSITIONS TO ELICIT MULTIVALENT IMMUNE RESPONSES AGAINST DOMINANT AND SUBDOMINANT EPITOPES, EXPRESSED ON CANCER CELLS AND TUMOR STROMA
    Publication number: 20110269949
    Abstract: The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
    Type: Application
    Filed: July 8, 2011
    Publication date: November 3, 2011
    Applicant: MANNKIND CORPORATION
    Inventors: Zhiyong Qiu, Adrian Ion Bot
  • Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
    Patent number: 8039431
    Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
    Type: Grant
    Filed: February 22, 2007
    Date of Patent: October 18, 2011
    Assignee: MannKind Corporation
    Inventors: Bryan R. Wilson, Marshall Grant
  • Powder feed system
    Patent number: 8025188
    Abstract: A fine powder is reliably dispensed from a hopper into containers on a moving conveyor belt with the assistance of a powder feed system. The hopper serves as a powder inlet that dispenses by gravity into a feed chamber that is form fitted to the sweep of a relatively slow rotating feed wheel with two spaced sets of pins. A relatively fast rotating agitator is located below the feed wheel which has a series of agitating blades that rotate between the span of the feed wheel pins, the blades in at least one embodiment resemble a J-shape. The agitator is located directly above a rotary trap chamber wheel, which has recesses that take doses of powder and dispense them into awaiting containers moving on a conveyor belt below.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: September 27, 2011
    Assignee: MannKind Corporation
    Inventor: Michael A. White
  • Powder dispenser modules and powder dispensing methods
    Patent number: 8025082
    Abstract: Powder dispensing and sensing apparatus and methods are provided. The powder dispensing and sensing apparatus includes a tray support structure to receive a cartridge tray holding cartridges, a powder dispenser assembly including powder dispenser modules to dispense powder into respective cartridges of a batch of cartridges in the cartridge tray, a powder transport system to deliver powder to the powder dispenser modules, a sensor module including sensor cells to sense respective fill states, such as the weights, of each of the cartridges in the batch of cartridges, and a control system to control the powder dispenser modules in response to the respective sensed fill states of each of the cartridges of the batch of cartridges.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: September 27, 2011
    Assignee: MannKind Corporation
    Inventors: Trent A. Poole, David F. Bonneau, Per B. Fog
  • MULTICISTRONIC VECTORS AND METHODS FOR THEIR DESIGN
    Publication number: 20110230548
    Abstract: Embodiments of the present invention relate to multicistronic vectors and methods for their design. Methods and compositions of the invention include a vector including at least two cistrons, wherein a first cistron includes a first promoter and a first nucleic acid sequence encoding one or more therapeutic agents, and wherein a second cistron comprises a second promoter and a second nucleic acid sequence encoding one or more RNA molecules that interfere with the expression of a biological response modifier or the therapeutic agent, wherein the expression of the first sequence is under control of the first promoter and expression of the second sequence is under control of the second promoter.
    Type: Application
    Filed: February 22, 2011
    Publication date: September 22, 2011
    Applicant: MANNKIND CORPORATION
    Inventors: Adrian Ion Bot, David C. Diamond, Zhiyong Qiu
  • IRE-1? substrates
    Patent number: 8017331
    Abstract: IRE-1? substrates useful for identifying agonists and antagonists of IRE-1? RNase activity.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: September 13, 2011
    Assignee: MannKind Corporation
    Inventors: John Bruce Patterson, Kori Shallyn Volkmann, Duane Brumm, Caryn Stiles
  • POWDER DISPENSING AND SENSING APPARATUS AND METHODS
    Publication number: 20110197990
    Abstract: Powder dispensing and sensing apparatus and methods are provided. The powder dispensing and sensing apparatus includes a tray support structure to receive a cartridge tray holding cartridges, a powder dispenser assembly including powder dispenser modules to dispense powder into respective cartridges of a batch of cartridges in the cartridge tray, a powder transport system to deliver powder to the powder dispenser modules, a sensor module including sensor cells to sense respective fill states, such as the weights, of each of the cartridges in the batch of cartridges, and a control system to control the powder dispenser modules in response to the respective sensed fill states of each of the cartridges of the batch of cartridges.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 18, 2011
    Applicant: MannKind Corporation
    Inventors: Trent A. Poole, David F. Bonneau, Per B. Fog