Patents Assigned to Marina Biotech, Inc.
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Patent number: 8314227Abstract: The present invention is directed to RNA oligonucleotides or complexes of RNA oligonucleotides, denoted herein together as RNA complexes, containing at least one, but optionally more that one, hydroxymethyl substituted nucleotide monomer(s). By a hydroxymethyl substituted nucleotide monomer is understood a nucleotide monomer containing a hydroxymethyl group (that may be unsubstituted, O-substituted for example with a conjugating group, or converted into an optionally substituted or conjugated aminomethyl group). This hydroxymethyl group is not partaking in formation of an internucleotide linkage and is not the hydroxymethyl group (containing the 5?-hydroxy group) of a natural RNA monomer. The RNA complexes of the invention may be useful for therapeutic applications, diagnostic applications or research applications.Type: GrantFiled: May 21, 2008Date of Patent: November 20, 2012Assignee: Marina Biotech, Inc.Inventor: Jesper Wengel
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Publication number: 20120277289Abstract: Activity-generating delivery molecules comprising the structure R3—(C?O)-Xaa-NH—R4 wherein Xaa is any D- or L-amino acid residue with a non-hydrogen, substituted or unsubstituted side chain, R3—(C?O)— and —NH—R4 are independently a long chain group, each long chain group containing one or more carbon-carbon double bonds, and salts, compositions and methods of use thereof. The activity-generating delivery compounds and compositions are useful for generating activity of an active agent in a cell, tissue, or subject.Type: ApplicationFiled: November 4, 2010Publication date: November 1, 2012Applicant: MARINA BIOTECH, INC.Inventors: Renata Fam, Roger C. Adami, Kathy L. Fosnaugh, Pierrot Harvie, Rachel E. Johns, Shaguna Seth, Michael E. Houston, JR., Michael V. Templin
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Patent number: 8299236Abstract: Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells. The transported nucleic acids are active in target cells as small inhibitory nucleic acids (siNAs) that modulate expression of target genes, mediated at least in part by RNA interference (RNAi). The siNA/polypeptide compositions and methods of the invention provide effective tools to modulate gene expression and alter phenotype in mammalian cells, including by altering phenotype in a manner that eliminates disease symptoms or alters disease potential in targeted cells or subject individuals to which the siNA/polypeptide compositions are administered.Type: GrantFiled: September 8, 2008Date of Patent: October 30, 2012Assignee: Marina Biotech, Inc.Inventors: Lishan Chen, Kunyuan Cui, Yuching Chen, Sasha J. Mayer, Michael E. Houston, Jr.
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Publication number: 20120237589Abstract: The invention concerns lipid assemblies, liposomes having an outer surface comprising a mixture of anionic and cationic moieties; wherein at least a portion of the cationic moieties are imino moieties that are essentially charged under physiological conditions, and their use for serum resistant transfection of cells.Type: ApplicationFiled: July 2, 2010Publication date: September 20, 2012Applicant: MARINA BIOTECH, INC.Inventors: Steffen Panzner, Evgenios Siepi
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Patent number: 8236770Abstract: The invention relates to amphoteric liposomal formulations which are provided with great serum stability and are suitable for the intracellular delivery of oligonucleotides.Type: GrantFiled: March 29, 2005Date of Patent: August 7, 2012Assignee: Marina Biotech, Inc.Inventors: Gerold Endert, Yvonne Kerwitz, Monika Fellermeier
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Patent number: 8192753Abstract: The invention suggests a pH-sensitive cationic lipid with a pKa value between 3.5 and 8, according to the general formula cation-spacer-Y-spacer-X-lipid, wherein Y and X represent linking groups. Furthermore, liposomes are described, which liposomes include said optionally cationic lipids.Type: GrantFiled: February 19, 2003Date of Patent: June 5, 2012Assignee: Marina Biotech, Inc.Inventors: Frank Essler, Steffen Panzner, Gerold Endert
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Patent number: 8193246Abstract: Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety-pH sensitive hydrophilic moiety??(II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I): Lipid moiety-[Hydrophobic moiety-pH sensitive hydrophilic moiety]??(I).Type: GrantFiled: December 19, 2007Date of Patent: June 5, 2012Assignee: Marina Biotech, Inc.Inventors: Steffen Panzner, Evgenios Siepi, Silke Lutz, Christian Reinsch, Claudia Müller
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Publication number: 20120094903Abstract: What is described is a pharmaceutical formulation for intranasal delivery of insulin to a patient, comprising an aqueous mixture of human insulin, a solubilizing agent, a surface active agent, and a thickening agent, wherein said formulation provides a ultra-rapid acting profile to regular human insulin.Type: ApplicationFiled: December 7, 2011Publication date: April 19, 2012Applicant: MARINA BIOTECH INC.Inventors: Henry R. Costantino, Annemarie Stoudt Cohen, Anthony P. Sileno
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Publication number: 20110313020Abstract: This disclosure provides double-stranded RNA complexes having one or more hydroxymethyl substituted nucleomonomer(s) in the passenger strand (or sense strand) of an RNA complex. RNA complexes of the disclosure may be useful for therapeutic applications, diagnostic applications or research applications. RNA complexes include short interfering RNA complexes (siRNA) capable of modulating gene expression comprising an antisense strand and a continuous or a discontinuous passenger strand (“sense strand”). Further, one or more hydroxymethyl substituted nucleomonomer(s) of this disclosure may be positioned at the 3?-end, at the 5?-end, at both the 3?-end and 5?end.Type: ApplicationFiled: December 3, 2009Publication date: December 22, 2011Applicant: MARINA BIOTECH, INC.Inventors: Michael V. Templin, Narendra K. Vaish, Barry A. Polisky, Michael E. Houston, Jr.
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Patent number: 8063178Abstract: Trp cage binding domains polypeptides are disclosed. The Trp cage binding domains have the generic formulae of SEQ ID NO: 2, 7, 10 or 11. They can be efficiently produced and screened using phage display technology.Type: GrantFiled: December 12, 2007Date of Patent: November 22, 2011Assignee: Marina Biotech, Inc.Inventors: Steven C. Quay, Douglas L. Badders, Richard E. Herman, Michael E. Houston, Jr., Paul Hickok Johnson
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Publication number: 20110236972Abstract: The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing BIRC5 gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a BIRC5 mRNA. Also provided are methods of decreasing expression of a BIRC5 gene in a cell or in a subject to treat a BIRC5-related disease.Type: ApplicationFiled: August 5, 2009Publication date: September 29, 2011Applicant: MARINA BIOTECH, INC.Inventors: Steven C. Quay, James McSwiggen, Narendra K. Vaish, Kathy L. Fosnaugh, Shaguna Seth
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Publication number: 20110177160Abstract: This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.Type: ApplicationFiled: March 30, 2011Publication date: July 21, 2011Applicant: Marina Biotech, Inc.Inventors: Steven C. Quay, Michael Houston, JR., Pierrot Harvie, Roger C. Adami, Renata Fam, Mary Gallagher Prieve, Kathy Lynn Fosnaugh, Shaguna Seth
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Publication number: 20110136233Abstract: The present disclosure provides RNA molecules, for example, meroduplex ribonucleic acid molecules (mdRNA), capable of decreasing or silencing gene expression of PLK1 gene. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to a PLK1 mRNA. Also provided are methods of decreasing expression of a PLK1 gene in a cell or in a subject to treat a PLK family member-related disease.Type: ApplicationFiled: August 5, 2009Publication date: June 9, 2011Applicant: MARINA BIOTECH, INC.Inventors: Steven C. Quay, Narendra K. Vaish, Kathy L. Fosnaugh, Shaguna Seth
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Publication number: 20110130327Abstract: Multi-arm amine compounds and compositions for enhancing intracellular, in vitro, and in vivo delivery of drug, active, and therapeutic substances including ribonucleic acids. This disclosure provides novel compounds and compositions for making and using delivery materials and carriers which increase the efficiency of delivery of biologically active and pharmacologically active molecules. Embodiments of this disclosure may further provide delivery of various therapeutic agents including nucleic acid therapeutics such as regulatory RNA, interfering RNA, and agents for RNAi, as well as other protein and peptide therapeutics. In some aspects, this disclosure provides multi-arm amine compounds and compositions which can enhance permeation of a drug substance.Type: ApplicationFiled: November 26, 2010Publication date: June 2, 2011Applicant: MARINA BIOTECH, INC.Inventors: MICHAEL E. HOUSTON, JR., ROGER C. ADAMI, STEVEN C. QUAY, PHUONG NGUYEN, HARRY C. WANG, DIANE E. FRANK
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Patent number: 7939505Abstract: This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.Type: GrantFiled: May 2, 2008Date of Patent: May 10, 2011Assignee: Marina Biotech, Inc.Inventors: Steven C. Quay, Michael Houston, Jr., Pierrot Harvie, Roger C. Adami, Renata Fam, Mary Gallagher Prieve, Kathy Lynn Fosnaugh, Shaguna Seth
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Publication number: 20110077284Abstract: A dry powder formulation for delivery to a mammal by inhalation, the formulation comprising particles comprising a lipid, a carrier, and one or more double-stranded siRNA molecules or dicer-active precursors targeted to influenza virus A method for treating or preventing influenza in a mammal comprising administering a therapeutically-effective amount of a dry powder formulation.Type: ApplicationFiled: October 13, 2010Publication date: March 31, 2011Applicant: MARINA BIOTECH, INC.Inventors: Luis Brito, Donghao Chen, Qing Ge, Douglas A. Treco