Patents Assigned to Marshfield Clinic
  • Patent number: 5075217
    Abstract: The present invention is directed to a product and process for characterizing the human genome utilizing polymorphic DNA fragments containing (dC-dA).sub.n .multidot.(dG-dT).sub.n. The process comprises identifying polymorphic DNA fragments containing the above tandem repeat sequence followed by characterizing admixtures of genomic material by amplification of fragments containing the tandem repeat sequence using substantially unique and non-polymorphic primer sequences and appropriate separation of the so amplified fragments.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: December 24, 1991
    Assignee: Marshfield Clinic
    Inventor: James L. Weber
  • Patent number: 5005585
    Abstract: A biopsy needle assembly comprising an outer tubular cannula having an angular distal end. The inner surface of the cannula adjacent the distal end is cylindrical and an end of the inner cylindrical surface opposite the distal end of the cannula is undercut to provide a sharp annular interior edge. A solid stylus is disposed within the cannula and has an angular distal end. The stylus is in sliding contact with the inner cylindrical surface of the cannula. When the needle assembly is inserted into engagement with the tissue to be removed a specimen is collected internally of the cannula and the sharp undercut interior edge secures the specimen within the cannula. After removal of the cannula from the tissue, a rod-like probe is inserted in the distal end of the cannula to push the specimen through the entire length of the cannula to remove the specimen intact.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: April 9, 1991
    Assignee: Marshfield Clinic
    Inventor: Joseph J. Mazza