Abstract: A non-contact system for the sensing of pH includes a hyperspectral imaging device configured to capture a hyperspectral image of a fluid, a flow cell configured to enable the capturing of a hyperspectral image of a fluid, a process, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the system to generate a hyperspectral image of the fluid in the flow cell, generate several spectral signals based on the hyperspectral image, provide the spectral signal as an input to a machine learning network, and predict by the machine learning network a pH of a fluid.

Abstract: The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. The disclosed cannula can be implemented as a single lumen cannula or a double lumen cannula, which can be used with ventricular assist devices for heart support or pump-oxygenators for ECMO and respiratory support. Through a self-sealing mechanism fixed on the ventricular wall or atrial wall, a cannula body is attached to the self-sealing fixture and blood is drawn into the lumen via an external pump and returned to the circulation system through a separate cannula. In the case of the double lumen cannula embodiment, the blood will be drawn into the drainage lumen of the double lumen cannula and returned through an infusion lumen at the desired location.

Abstract: The present invention provides a universal, yet adaptable, anti-tag chimeric antigen receptor (AT-CAR) system which provides T cells with the ability and specificity to recognize and kill target cells, such as tumor cells, that have been marked by tagged antibodies. As an example, ?FITC-CAR-expressing T cells have been developed that specifically recognize various human cancer cells when those cells are bound by cancer-reactive FITC-labeled antibodies. The activation of ?FITC-CAR-expressing T cells is shown to induce efficient target lysis, T cell proliferation, and cytokine/chemokine production. The system can be used to treating subjects having cancer.

Abstract: Disclosed is a system and method for the placement of elongate medical members within a patient's body using coaptive ultrasound that combines magnetic guidance with ultrasound visualization of the medical member in the patient's body. A coaptive ultrasound probe adaptor magnetically attracts an elongate medical member within the patient with sufficient force so as to allow the operator to manually guide the member to its intended location. The adaptor mates with an ultrasound probe to provide the medical operator ultrasound feedback of the position of the member, thus allowing internal placement without the need for more specialized medical equipment.

Abstract: Embodiments are disclosed for generating continuous curve textures based on an input exemplar. A method of generating continuous curve textures may include receiving an input exemplar which represents a repetitive pattern as a plurality of vector curves, generating an input graph representation of the input exemplar which represents a geometry and a topology of the input exemplar, synthesizing an output graph based on the input graph representation, and reconstructing output vector curves from the output graph.

Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.

Abstract: The present invention relates to rhomboidal phase bismuth oxide that maintains electric conductivity of at least about 1×10?2 S/cm at temperature of about 500° C. for at least about 100 hours. In particular, the bismuth oxides of the invention have stable conductivity at a temperature range from about 500° C. to about 550° C.

Abstract: A method of using the transverse relaxation time (T2) of solvent NMR signal to detect filling errors of an alum-containing product in real-time and in-line during manufacturing, for example during a fill-finish unit operation. This method can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe.

Abstract: A method for training an algorithm for predicting a knee adduction moment (KAM) includes, while each subject walks over forceplates, capturing kinematic data, generating first ground reaction force (GRF) data, generating second GRF data, and generating reference KAM data based on the kinematic data and the first GRF data. While repeatedly training the algorithm by incrementing i by one, the method performs generating a model, which predicts reference KAM data, validating the predicted reference KAM data based on reference KAM data of the subjects other than the i-th subject, adjusting internal parameters by minimizing an error between the predicted KAM data and reference KAM data of the subjects other than the i-th subject, and producing an accuracy score for the model based on an error between the predicted reference KAM data and the reference KAM data of the i-th subject.

Abstract: Systems and methods for generation and use of vendor management platform architectures are disclosed. A compliance component may be utilized to receive user input data indicating supply contracts between a client and a vendor. The user input data may be utilized to determine insurable obligations associated with the supply contract and provide indications as to whether or not the vendor is compliant with the insurable obligation required by the supply contract. An exposure assessment component may be utilized to determine an exposure score associated with a client account and/or a vendor account based on various compliance factors, spending amounts, and/or properties associated with at least one of goods and/or services that a vendor will supply to a client.

Abstract: The invention provides compositions comprising multipotent progenitor cells isolated from tonsillar tissue and differentiated cells derived therefrom and methods for using the cells for the treatment of diseases or disorders.

Abstract: A delignified wood material is formed by removing substantially all of the lignin from natural wood. The resulting delignified wood retains cellulose-based lumina of the natural wood, with nanofibers of the cellulose microfibrils being substantially aligned along a common direction. The unique microstructure and composition of the delignified wood can provide advantageous thermal insulation and mechanical properties, among other advantages described herein. The thermal and mechanical properties of the delignified wood material can be tailored by pressing or densifying the delignified wood, with increased densification yielding improved strength and thermal conductivity. The chemical composition of the delignified wood also offers unique optical properties that enable passive cooling under solar illumination.

Abstract: Systems and methods for digital property protection are disclosed. For example, indication may be received that an entity has applied for an insurance policy to insure against theft of digital property. The digital property may be registered and a valuation of the digital property may be generated. Due diligence processes may be performed, including assessment of physical and/or network security mechanisms to prevent theft of the digital property. A recommendation to issue the insurance policy may be generated and sent in examples where the due diligence processes return favorable results. Terms generation and/or identification may be performed, and claims processing based at least in part on loss matrixes may also be performed.

Abstract: The present disclosure relates to photo-immunoconjugate formulations comprising a nanoparticle carrier comprising first and second therapeutic agents coupled to the nanoparticle carrier, and a photosensitizer molecule coupled to the first therapeutic agent or the nanoparticle carrier, and methods of treating cancer via administration of the photo-immunoconjugate formulations.

Abstract: The invention is directed to HIV-1 neutralizing antibodies and methods for their uses.

Abstract: A method of using the relaxation rate (R1 and/or R2) of solvent NMR signal to noninvasively assess whether viral capsids in a capsid preparation are full or empty, and the percentage of full capsids if the vial contains a mixture of full and empty capsids. The method can simply, rapidly, and non-invasively prove the safety and potency of the capsid preparation and thus whether the capsid preparation can be approved for clinical use, without requiring any sample preparation or reagent addition.

Abstract: The present invention is directed to solid-state composite cathodes that comprise Na2S or Li2S, Na3PS4, or Li3PS4, and mesoporous carbon. The present invention is also directed to methods of making the solid-state composite cathodes and methods of using the solid-state composite cathodes in batteries and other electrochemical technologies.

Abstract: Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The delivery devices can be configured to be actuated to form a distal anchor made of a pre-formed knot. The delivery devices deliver the pre-formed knot in an elongate configuration. Actuation of the delivery device causes the pre-formed knot to transition from the elongate configuration to the deployed configuration by approximating opposite ends of a suture coupled to a coiled configuration to form one or more loops. After formation of the knot, the delivery device can be withdrawn.

Abstract: A quantum EIT-based optical switch includes a first waveguide, linear or nonlinear, a separate nonlinear waveguide evanescently coupled to the first waveguide, and a pump coupled to the nonlinear waveguide. A quantum STIRAP-based optical transduction device, which includes an auxiliary, intermediate spectral state for the quantum signal that aids efficient transduction of the quantum signal from the input spectral state to the output spectral state in a single device.

Abstract: Systems and methods of quantum sensing include obtaining information regarding a target signal in electronic spin states of quantum defects in an ensemble of quantum defects, mapping the information regarding the target signal from the electronic spin states of the quantum defects to corresponding nuclear spin states associated with the quantum defects, applying a light pulse to the ensemble of quantum defects to reset the electronic spin states of the quantum defects, and repeating a readout stage a plurality of times within a readout duration. The readout stage includes mapping the information regarding the target signal back from the nuclear spin states to the corresponding electronic spin states and applying a data acquisition readout pulse to optically measure the electronic spin states of the quantum defects.