Abstract: The present invention relates to compositions which may comprise a non-naturally occurring or engineered artificial transcription factor, wherein the transcription factor may comprise a sequence specific DNA binding domain, a sliding domain, and one or more linkers, wherein the DNA binding domain and the sliding domain are operably connected by the one or more linkers, and uses thereof. Methods involving the use of a non-naturally occurring or engineered artificial transcription factors and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.

Abstract: A particle can be discretely ejected from a orifice.

Abstract: Methods and reagents are disclosed for improved detection of inorganic oxidizers, such as but not limited to chlorates, perchlorates, permanganates, dichromates, and osmium tetraoxides. In one aspect of the invention, latent acid-generating reagents are employed that are chemically stable at room temperature but undergo an acidic transformation when exposed to an elevated temperature or radiation. The latent reagent can be activated by heat or radiation (e.g., UV radiation). The resulting acidic reagent can then transfer a proton to the anion (i.e., chlorate, perchlorate, etc.) of the target analyte, forming an acid (i.e., chloric acid, perchloric acid) that is more easily vaporized and, hence, more easily detected. In another aspect of the invention, heat-sensitive inorganic salts and/or photosensitive onium salts are disclosed as reagents to carry out this method.

Abstract: The present disclosure provides devices and uses thereof. A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.

Abstract: Disclosed are methods for the manufacture of n-type and p-type filled skutterudite thermoelectric legs of an electrical contact. A first material of CoSi2 and a dopant are ball-milled to form a first powder which is thermo-mechanically processed with a second powder of n-type skutterudite to form a n-type skutterudite layer disposed between a first layer and a third layer of the doped-CoSi2. In addition, a plurality of components such as iron, and nickel, and at least one of cobalt or chromium are ball-milled form a first powder that is thermo-mechanically processed with a p-type skutterudite layer to form a p-type skutterudite layer “second layer” disposed between a first and a third layer of the first powder. The specific contact resistance between the first layer and the skutterudite layer for both the n-type and the p-type skutterudites subsequent to hot-pressing is less than about 10.0 ??·cm2.

Abstract: A system for associating a string of natural language with items in a relational database includes a first subsystem having a pre-trained first artificial neural network configured to apply a semantic tag selected from a predefined set of semantic labels to a segment of a plurality of tokens representing the string of natural language. A second subsystem includes a second artificial neural network configured to convert the plurality of labeled tokens into a first multi-dimensional vector representing the string of natural language. A third subsystem is configured to rank the first multi-dimensional vector against a second multi-dimensional vector representing a plurality of items in the relational database.

Abstract: Platinum-containing compounds are generally described. Inventive compositions and uses thereof are also described.

Abstract: Methods of sensing carbon dioxide, sensors, and related articles and systems are generally described.

Abstract: The present disclosure provides methods for inhibiting intra and inter-cellular signaling pathways by modification of post-translation modification sites on select target RNA molecules. In certain example embodiments, the present disclosure provides methods for inhibiting intracellular phosphorylation of serine, threonine and tyrosine residues by editing the genetic codon of these amino acids by means of site-directed RNA editing or RNA molecules. Embodiments disclosed herein further provide methods of inhibiting pathological activation of cell signaling meditated by post-translational modifications, such as phosphorylation, which are involved in many diseases, including cancer, immunodeficiency, infectious diseases, inflammatory disorders and neurodegenerative disorders.

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

Abstract: Foam mitigation using a variety of articles, systems, and methods is generally described. According to certain embodiments, surfaces with certain wetting properties can be used to reduce or eliminate the formation of foam from bubble-containing liquids. In some embodiments, a surface with certain wetting properties is configured and/or arranged within bubble-containing liquids such that the surface provides a gaseous fluidic pathway through which gas from the bubbles within the liquid may be channeled to a gaseous environment outside the liquid.

Abstract: Compositions and methods for adsorption of a species (e.g., ammonia, water, a halogen) comprising metal organic frameworks (MOFs) are generally provided. In some embodiments, a MOF comprises a plurality of metal ions, each coordinated with at least one ligand comprising at least two unsaturated N-heterocyclic aromatic groups arranged about an organic core.

Abstract: Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9)-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 and a substitution of residues ADKKLRKRSGKLATE in position 365-379 in the ScCas9 open reading frame (Sc++). Also included are CRISPR-associated DNA endonucleases with a PAM specificity of 5?-NG-3? or 5?-NNG-3? and a method of altering expression of a gene product by utilizing the engineered ScCas9 variants.

Abstract: A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.

Abstract: A mechanical interface connecting a biological body segment, such as a limb, portion of a limb or other body segment, to a wearable device such as a prosthetic, orthotic or exoskeletal device, is fabricated by quantitatively mapping a characterized representation of the body segment to form a digital representation of the mechanical interface shape and mechanical interface impedance. The mechanical interface includes a continuous socket defining a contoured inside surface and a contoured outside surface, and includes a material having an intrinsic impedance that varies through the material, so that the intrinsic impedance varies along the contoured inside surface.

Abstract: A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.

Abstract: An ultrasonic imaging system is described in which a column-row-parallel architecture is provided at the circuit level of an ultrasonic transceiver. The ultrasonic imaging system can include a N×M array of transducer elements and a plurality of transceiver circuits where each transceiver circuit is connected to a corresponding one transducer element of the N×M array of transducer elements. A shared pulser gate driver and a shared VGA is provided for each row and column. Selection logic includes row select, column select, and per-element bit select. Through the column-row-parallel architecture, a variety of aperture configurations can be achieved.

Abstract: A method of making a nanocrystal includes slowly infusing a M-containing compound and a X donor into a mixture including a nanocrystal core, thereby forming an overcoating including M and X on the core.

Abstract: In-band full-duplex (IBFD) wireless systems offer the ability to revolutionize frequency spectrum utilization for future networks. For IBFD systems to work, the self-interference (SI) generated by each wireless node should be sufficiently mitigated, which becomes more challenging as the bandwidth increases. RF cancellation enables this interference reduction but has been limited so far to narrowband operation or restricted to distinctive environments. Fortunately, a photonic-enabled RF canceller can provide broadband interference cancellation using photonic components in a wideband vector modulator architecture with tunable time-delay taps. An example of this canceller with 20 canceller taps provides 25 and 20 dB of cancellation over 500-MHz and 1-GHz instantaneous bandwidths, respectively, and is tunable between 0.5 and 5.5 GHz. This photonic-enabled RF canceller provides the wideband operation and high tap counts for successfully deploying future wireless systems with IBFD technology.

Abstract: Surveillance systems and methods taught herein provide automated detection and classification of objects of interest in a submerged or underwater environment such as a body of water. The sonar systems and methods taught herein can detect and classify a variety of objects in echograms without feedback or instructions from a human operator. The sonar systems and methods taught herein include a data model that is partially trained using non-echogram image data and can associate geolocation information with detected objects of interest.