Patents Assigned to Massachusetts Institute Technology
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Publication number: 20240344991Abstract: The present invention relates to the use of Raman spectroscopy for the real time detection and quantitation of innate immunity response in plants. More specifically, the present invention provides Raman spectroscopy as a tool for rapid, non-invasive, and early detection and quantitation of plant innate immune response.Type: ApplicationFiled: August 19, 2022Publication date: October 17, 2024Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Pil Joong CHUNG, Sayuj KOYYAPPURATH, Nam-Hai CHUA, Rajani SAROJAM, Gajendra Pratap SINGH, Rajeev J. RAM
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Publication number: 20240346350Abstract: A system and method provide two-qubit gates and quantum computing circuits built therefrom. Pairs of qubits are inductively or capacitively coupled using a coupler that is driven using an off-resonant microwave drive. By controlling the drive, the ZZ interaction between the qubits can be precisely controlled. In particular, the interaction may be selectively reduced or suppressed, thereby isolating the qubits from each other, or the interaction may be increased to provide fast, controlled-Z, two-qubit gates with high fidelity. Moreover, qubits and couplers may be arranged according to their resonant frequencies into unit cells and replicated to arbitrary size, thereby forming a quantum computer.Type: ApplicationFiled: October 21, 2022Publication date: October 17, 2024Applicants: Massachusetts Institute of Technology, SOCPRA SCIENCES ET GENIE S.E.C., A/S TransferTech SherbrookeInventors: Augustin DI PAOLO, William D. OLIVER, Catherine LEROUX, Alexandre BLAIS
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Publication number: 20240342361Abstract: Articles such as dual-barrel injectors are generally described. Associated systems and methods are also described. In some embodiments, the articles are useful for injecting viscous fluids, such as concentrated drug formulations. In certain embodiments, the article comprises a first conduit (e.g., for transporting a viscous fluid) and a second conduit (e.g., for transporting a lubricating fluid). In some embodiments, the fluid from the second conduit (e.g., a lubricating fluid) lubricates the flow of the fluid from the first conduit (e.g., a viscous drug) by surrounding the fluid from the first conduit, and the lower viscosity of the fluid from the second conduit allows the fluid from the first conduit to flow more easily through the system.Type: ApplicationFiled: April 11, 2022Publication date: October 17, 2024Applicant: Massachusetts Institute of TechnologyInventors: Kripa K. Varanasi, Vishnu Jayaprakash
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Publication number: 20240342099Abstract: An ingestible device may include one or more deployable limbs configured to orient the ingestible device in a desired orientation. The one or more limbs may be attached to body of the device and wrap around the device in an initial configuration (e.g., prior to deployment of the one or more limbs). The one or more limbs may be configured to deploy when exposed to a predetermined condition. Once the predetermined condition is met, the one or more limbs may extend outwards away from the body such that the one or more deployed limbs serve to orient the ingestible device.Type: ApplicationFiled: August 4, 2022Publication date: October 17, 2024Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Novo Nordisk A/SInventors: Carlo Giovanni Traverso, Declan Gwynne, Jacob Wainer, Graham Arrick, Jesper Windum, Kuldeep Sanger, Adam Bohr, Brian Mouridsen, Nikolaj Eusebius Jakobsen, Morten Revsgaard Frederiksen, Jens Lolle Laursen, Ludwig Erik Aguilar
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Patent number: 12115171Abstract: Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a Plk inhibitor and methods of use thereof for treating cancer are disclosed. Administration of the combination of the active agents can be effective to reduce cancer cell proliferation or viability in a subject with cancer to the same degree, or a greater degree than administering to the subject the same amount of either active agent alone. The active agents can be administered together or separately. Methods of selecting and treating subjects with cancers, particular prostate cancers including castration resistant prostate cancer, breast cancers, particularly androgen receptor positive breast cancers, and pancreatic cancers are also provided.Type: GrantFiled: June 9, 2022Date of Patent: October 15, 2024Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Michael B. Yaffe, Jesse C. Patterson
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Patent number: 12116623Abstract: Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.Type: GrantFiled: June 24, 2022Date of Patent: October 15, 2024Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Alexander Green, Dana Braff, Melissa Takahashi, Keith Pardee, James J. Collins, Guillaume Lambert, Thomas Ferrante
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Patent number: 12116619Abstract: The present invention relates to in vivo methods for modeling tumor formation and/or tumor evolution comprising the use of eukaryotic cells in which one or more genetic target locus has been altered by the CRISPR/Cas system, and which cells are transplanted in non-human eukaryote as a model system for tumor formation and tumor evolution. In particular in vivo genetic screening methods for identifying genes involved in tumorigenesis and metastasis are disclosed. The invention further relates to kits and components for practicing the methods, as well as materials obtainable by the methods, in particular tumor and metastasis samples and cells or cell lines derived therefrom. The invention also relates to diagnostic and therapeutic methods derived from the information obtained in the modeling methods.Type: GrantFiled: June 30, 2017Date of Patent: October 15, 2024Assignees: The Broad Institute, Inc., Massachusetts Institute of TechnologyInventors: Sidi Chen, Randall Jeffrey Platt, Neville Espi Sanjana, Phillip A. Sharp, Feng Zhang
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Publication number: 20240336502Abstract: Various aspects described herein relate to electrochemical devices, e.g., for separation of one or more target organic or inorganic molecules (e.g., charged or neutral molecules) from solution, and methods of using the same. In particular embodiments, the electrochemical devices and methods described herein involve at least one redox-functionalized electrode, wherein the electrode comprises an immobilized redox-species that is selective toward a target molecule (e.g., charged molecule such as ion or netural molecule). The selectivity is based on a Faradaic/redox-activated chemical interaction (e.g., directional hydrogen binding) between the oxidized state of the redox species and a moiety of the target molecule (e.g., charged molecule such as ion or netural molecule).Type: ApplicationFiled: February 13, 2024Publication date: October 10, 2024Applicant: Massachusetts Institute of TechnologyInventors: Xiao Su, Demetra S. Achilleos, Trevor Alan Hatton
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Publication number: 20240338583Abstract: Fermions are the building blocks of matter. Here, we disclose a robust quantum register composed of hundreds of fermionic atom pairs trapped in an optical lattice. With each fermion pair forming a spin-singlet, the qubit is realized as a set of near-degenerate, symmetry-protected two-particle wavefunctions describing common and relative motion. Degeneracy is lifted by the atomic recoil energy, which depends on mass and lattice wavelength, thereby rendering two-fermion motional qubits insensitive to noise of the confining potential. The quantum coherence can last longer than ten seconds. Universal control is provided by modulating interactions between the atoms. Via state-dependent, coherent conversion of free atom pairs into tightly bound molecules, we tune the speed of motional entanglement over three orders of magnitude, yielding 104 Ramsey oscillations within the coherence time.Type: ApplicationFiled: June 24, 2021Publication date: October 10, 2024Applicant: Massachusetts Institute of TechnologyInventors: Martin Zwierlein, Thomas Richard Hartke, Ningyuan Jia, Botond Oreg
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Publication number: 20240337541Abstract: A high temperature superconductor (HTS) cable includes at least one HTS tape stack extending along a length of the HTS cable; and at least one optical fiber extending along the HTS cable. The at least one optical fiber has a plurality of gratings spaced apart from one another along the length of the HTS cable to detect a quench of the at least one HTS tape stack.Type: ApplicationFiled: August 5, 2022Publication date: October 10, 2024Applicant: Massachusetts Institute of TechnologyInventors: Erica SALAZAR, Zachary HARTWIG
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Publication number: 20240337191Abstract: A construction system for mechanical metamaterials based on discrete assembly of a finite set of modular, mass-produced parts. A modular construction scheme enables a range of mechanical metamaterial properties to be achieved, including rigid, compliant, auxetic and chiral, all of which are assembled with a consistent process across part types, thereby expanding the functionality and accessibility of this approach. The incremental nature of discrete assembly enables mechanical metamaterials to be produced efficiently and at low cost, beyond the scale of the 3D printer. Additionally, a lattice structure constructed of two or more rigid, compliant, auxetic and chiral part types enable the creation of heterogenous macroscopic metamaterial structures.Type: ApplicationFiled: June 18, 2024Publication date: October 10, 2024Applicant: Massachusetts Institute of TechnologyInventor: Benjamin Jenett
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Patent number: 12113061Abstract: A semiconductor device having relatively linear and constant parasitic capacitance of an operation range includes a first component having a negatively charged carrier channel and a second component comprising a positively charged carrier channel. The first component has source terminal and a drain terminal. The second component has bias terminal. Both components share a gate terminal that is electrostatically coupled to the negatively charged carrier channel of the first component and the positively charged carrier channel of the second component to produce a capacitance profile that stays relatively linear and constant as a voltage at the gate terminal changes.Type: GrantFiled: April 8, 2021Date of Patent: October 8, 2024Assignee: Massachusetts Institute of TechnologyInventors: Tomas Palacios, Nadim Chowdhury, Qingyun Xie
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Patent number: 12110573Abstract: In accordance with one embodiment, a method comprises dissolving a sulfide of a first metal in a solvent comprising molten aluminum; aluminothermically reduce at least a portion of the sulfide through reactive vacuum distillation to form gaseous aluminum sulfide distillate and elemental first metal that remains in the molten aluminum; and at least one of (e.g., one, two, or all three of) (a) reacting the aluminum sulfide distillate with at least one material in the molten aluminum; (b) reacting the aluminum sulfide distillate with at least one material outside of the molten aluminum; or (c) condensing the gaseous aluminum sulfide distillate.Type: GrantFiled: October 27, 2023Date of Patent: October 8, 2024Assignee: Massachusetts Institute of TechnologyInventors: Antoine Allanore, Caspar R. Stinn
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Patent number: 12110131Abstract: A method for autonomously assembling a plurality of tiles is performed in a microgravity environment. Each tile includes a shell having a first geometrical shape and an arrangement of first magnets and a controller that are supported by the shell. The controller controls operation of the arrangement of first magnets to self-assemble the shell with another tile. The first magnets are controlled to mate with a complementary arrangement of second magnets on the other tile when the complementary arrangement of second magnets floats to within a range of magnetic attractive force of the arrangement of first magnets, with or without the aid of propulsion. The controllers in the tiles detect the status of the magnetic bonds to determine whether each pair of tiles is properly bonded or has a magnetic bond error. When an error is detected, the tiles are controlled to disassemble and reassemble to correct the error.Type: GrantFiled: February 2, 2022Date of Patent: October 8, 2024Assignee: Massachusetts Institute of TechnologyInventors: Ariel Ekblaw, Joseph A. Paradiso
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Patent number: 12111289Abstract: Systems and methods are provided for imaging of soft and hard tissues with ultrasound. Such systems and methods can provide for non-contact and quantitative ultrasound images of bone and soft tissue. A method for imaging a biological body segment of soft and hard tissues includes setting geometry and material properties according to a model of the biological body segment to thereby generate a simulated time series data set. The method further includes collecting reflective and transmissive time series data of the biological body segment to thereby form an experimental time series data set and minimizing a difference between the simulated time series data set and the experimental time series data set, thereby imaging the biological body segment. Regularizing travel-time and/or using full waveform tomographic techniques with level set methods enable recovery of cortical bone geometry.Type: GrantFiled: June 26, 2019Date of Patent: October 8, 2024Assignee: Massachusetts Institute of TechnologyInventors: Jonathan Randall Fincke, Brian W. Anthony
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Patent number: 12110490Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.Type: GrantFiled: December 16, 2016Date of Patent: October 8, 2024Assignees: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Feng Zhang, Bernd Zetsche, Fei Ran, James E. Dahlman
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Patent number: 12109301Abstract: Provided are formulations and methods for treating one or more genitourinary conditions. The formulations may include a therapeutic agent that includes a calcium channel blocker, a rho kinase inhibitor, or a combination thereof. The methods may include locally administering a therapeutic agent into a ureter. Systems for delivering a therapeutic agent also are provided.Type: GrantFiled: November 15, 2022Date of Patent: October 8, 2024Assignees: Massachusetts Institute of Technology, The General Hospital CorporationInventors: Xiang Li, Michael J. Cima, Brian H. Eisner
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Patent number: 12109311Abstract: System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.Type: GrantFiled: June 25, 2021Date of Patent: October 8, 2024Assignee: Massachusetts Institute of TechnologyInventors: Alexander H. Slocum, Bernhardt Levy Trout
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Publication number: 20240333254Abstract: Resonators comprising a single-crystalline semiconductor, and related systems and methods, are generally described.Type: ApplicationFiled: July 19, 2022Publication date: October 3, 2024Applicant: Massachusetts Institute of TechnologyInventors: Sang-Gook Kim, Jeehwan Kim
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Publication number: 20240328001Abstract: Described herein is a carbon-efficient bicarbonate electrolyzer and assembly. In some embodiments, an electrolyzer assembly comprises: a cathode disposed in a cathode chamber having ports for receiving a bicarbonate (HCO3?) solution; an anode disposed in an anode chamber having ports for receiving an anolyte; a cation exchange membrane disposed between the cathode chamber and the anode chamber; and a buffer layer disposed between the cathode chamber and the cation exchange membrane. In some embodiments, the electrolyzer assembly is configured to convert the bicarbonate (HCO3?) solution to a formate (OOCH?) solution by movement of cations from the anode to the cathode via the cation exchange membrane.Type: ApplicationFiled: April 1, 2024Publication date: October 3, 2024Applicant: Massachusetts Institute of TechnologyInventors: Ju Li, Zhen Zhang, Zhichu Ren
