Abstract: A structural electronics wireless sensor node is provided that includes layers of electronic components fabricated from patterned nanostructures embedded in an electrically conductive matrix. In some aspects, the structural electronics wireless sensor node includes a plurality of nanostructure layers that each form individual electronic components of the structural electronics wireless sensor node. In certain embodiments, the structural electronics wireless sensor node includes electronic components such as a resistor, a inductor, a capacitor, and/or an antenna.
Type:
Grant
Filed:
June 12, 2020
Date of Patent:
May 7, 2024
Assignees:
Analog Devices, Inc., Massachusetts Institute of Technology
Inventors:
Brian L. Wardle, Yosef Stein, Estelle Cohen, Michael Murray
Abstract: The present disclosure, at least in part, provides RNA cleavage based engineered bi-stable toggle switch utilizing the Programmable Endonucleolytic Scission-Induced Stability Tuning (PERSIST) platform. Also provided herein, are vectors encoding the engineered bi-stable toggle switch, and uses thereof.
Type:
Application
Filed:
May 1, 2023
Publication date:
May 2, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Ron Weiss, Breanna E. DiAndreth, Noreen Wauford
Abstract: Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 and a substitution of residues ADKKLRKRSGKLATE [SEQ ID No. 4] in position 365-379 in the ScCas9 open reading frame (Sc++). Also included are CRISPR-associated DNA endonucleases with a PAM specificity of 5?-NG-3? or 5?-NNG-3? and a method of altering expression of a gene product by utilizing the engineered ScCas9 variants.
Type:
Application
Filed:
July 11, 2023
Publication date:
May 2, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Pranam Chatterjee, Noah Michael Jakimo, Joseph M. Jacobson
Abstract: Methods, apparatuses, and systems related to electrochemical capture of Lewis acid gases from fluid mixtures are generally described. Certain embodiments are related to electrochemical methods involving selectively removing a first Lewis acid gas from a fluid mixture containing multiple types of Lewis acid gases (e.g., a first Lewis acid gas and a second Lewis acid gas). Certain embodiments are related to electrochemical systems comprising certain types of electroactive species having certain redox states in which the species is capable of binding a first Lewis acid gas but for which binding with a second Lewis acid gas is thermodynamically and/or kinetically unfavorable. The methods, apparatuses, and systems described herein may be useful in carbon capture and pollution mitigation applications.
Type:
Application
Filed:
November 9, 2023
Publication date:
May 2, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Sahag Voskian, Trevor Alan Hatton, Cameron G. Halliday
Abstract: The present description provides methods, assays and reagents useful for sequencing proteins. Sequencing proteins in a broad sense involves observing the plausible identity and order of amino acids, which is useful for sequencing single polypeptide molecules or multiple molecules of a single polypeptide. In one aspect, the methods are useful for sequencing multiple polypeptides. The methods and reagents described herein can be useful for high resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.
Type:
Grant
Filed:
October 12, 2022
Date of Patent:
April 30, 2024
Assignee:
Massachusetts Institute of Technology
Inventors:
Daniel Masao Estandian, Alexi Georges Choueiri, Edward Stuart Boyden, Asmamaw Wassie
Abstract: Systems and methods are disclosed herein for quantitatively identifying a patient's sedation level and predicting adverse events, based on one or more capnograms or outputs from a pharmacokinetic, pharmacodynamic, or ventilatory model. A sensor measures a carbon dioxide concentration of air exhaled by a patient into a breath receiver. A processor processes the sensor data to generate a capnogram including one or more respiratory cycles, computes the outputs of pharmacokinetic, pharmacodynamic, or ventilatory models, and extracts one or more of the resulting features from the capnogram and pharmacokinetic, pharmacodynamic, or ventilatory model outputs. A multi-parameter metric is computed based on the one or more extracted features and estimates the current or predicted sedation level of the patient.
Type:
Grant
Filed:
June 26, 2019
Date of Patent:
April 30, 2024
Assignees:
Massachusetts Institute of Technology, Children's Medical Center Corporation
Inventors:
George Cheeran Verghese, Margaret Gan Guo, Rebecca Mieloszyk, Thomas Heldt, Baruch Shlomo Krauss
Abstract: The present disclosure provides compositions and methods for improved pre-targeted radioimmunotherapeutics (PRIT) to treat various hematological disorders, such as B cell hyperproliferative disorders and solid tumors. The disclosed compositions include bispecific antibody compositions having a first domain that specifically bind to an antigen such as CD38, BCMA, Muc1, GPRC5D, or Slam7, and a second domain that specifically binds to a radioactive ligand. Methods include administering the disclosed bispecific antibody reagent and separately administering the radioactive ligand. In some embodiments, a clearing agent is also administered. In some embodiments, the therapeutic methods comprise administering a combination of two or more bispecific antibody reagents. In some embodiments, an enhancing agent, such as ATRA, gamma secretase inhibitor, or dextramethasone, is also administered to enhance expression of the target antigen on the target cells.
Type:
Grant
Filed:
November 8, 2018
Date of Patent:
April 30, 2024
Assignees:
Fred Hutchinson Cancer Center, Massachusetts Institute of Technology
Inventors:
Damian J. Green, Yukang Lin, Oliver W. Press, Alice Tzeng, Karl Dane Wittrup
Abstract: Disclosed is a laser system including a first laser and a second laser. The first laser includes a laser cavity, and a gas phase molecular gain medium disposed in the laser cavity, the gain medium having an absorption band. The second laser is a solid state laser configured to be continuously tunable, with respect to an emission wavelength of the second laser, over the absorption band of the gain medium, and the second laser is tuned to pump rotational vibrational transitions in the gain medium to achieve a rotational population inversion.
Type:
Grant
Filed:
November 12, 2020
Date of Patent:
April 30, 2024
Assignees:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, Massachusetts Institute of Technology, The United States of America as Represented by the Secretary of the Army
Inventors:
Paul Chevalier, Arman Amirzhan, Marco Piccardo, Fan Wang, Steven Glen Johnson, Henry O. Everitt, Federico Capasso
Abstract: A ruggedized adjustable mounting system is described for adjustably coupling and selectively locking a component supported in a fixture of the mount in a desired orientation. In some embodiments, the mounting system includes one or more kinematic couplings that support a fixture on a base and one or more adjustable couplings that are configured to adjust a separation distance between two opposing portions of the fixture and the base to selectively pivot the fixture about one or more axes of rotation.
Type:
Grant
Filed:
November 19, 2020
Date of Patent:
April 30, 2024
Assignee:
Massachusetts Institute of Technology
Inventors:
Andrew Guzman, Joseph Flaherty, Steven R. Gillmer, Kevin Edward Sullivan, Steven Augst
Abstract: Quantum sensors provide excellent performance combining high sensitivity with spatial resolution. Unfortunately, they can only detect signal fields at frequencies in a few accessible ranges, typically low frequencies up to the experimentally achievable control field amplitudes and a narrow window around their resonance frequencies. Fortunately, arbitrary-frequency signals can be detected by using the sensor qubit as a quantum frequency mixer, enabling a variety of sensing applications. The technique leverages nonlinear effects in periodically driven (Floquet) quantum systems to achieve quantum frequency mixing of the signal and an applied AC bias field. The frequency-mixed field can be detected using Rabi and CPMG sensing techniques with the bias field. Frequency mixing can distinguish vectorial components of an oscillating signal field, thus enabling arbitrary-frequency vector magnetometry.
Type:
Application
Filed:
March 31, 2023
Publication date:
April 25, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Guoqing WANG, Yixiang LUI, Jennifer SCHLOSS, Scott ALSID, Danielle A. BRAJE, Paola CAPPELLARO
Abstract: Reaction schemes involving acids and bases; reactors comprising spatially varying chemical composition gradients (e.g., spatially varying pH gradients), and associated systems and methods, are generally described.
Type:
Application
Filed:
December 22, 2023
Publication date:
April 25, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Yet-Ming Chiang, Leah Ellis, Andres Badel
Abstract: Electrochemical removal of chemical products in seawater, or other aqueous environments, resulting from increased atmospheric carbon dioxide levels is described.
Type:
Application
Filed:
February 17, 2022
Publication date:
April 25, 2024
Applicant:
Massachusetts Institute of Technology
Inventors:
Trevor Alan Hatton, Kripa K. Varanasi, John Lake, Seoni Kim
Abstract: Systems and methods involving nanomaterial-based electrodes, such as supercapacitor and battery electrodes that can be flexible, are described.
Type:
Application
Filed:
October 24, 2023
Publication date:
April 25, 2024
Applicants:
Massachusetts Institute of Technology, Analog Devices, Inc.
Inventors:
Karen K. Gleason, Brian L. Wardle, Estelle Cohen, Yue Zhou, Xiaoxue Wang, Yosef Stein
Abstract: The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.
Type:
Grant
Filed:
September 16, 2022
Date of Patent:
April 23, 2024
Assignees:
Massachusetts Institute of Technology, Universität Zürich
Inventors:
Angela Nicole Koehler, Shelby Doyle, Becky Leifer, Madeleine Henley, Beat W. Schaefer, Marco Wachtel
Abstract: Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
Type:
Grant
Filed:
December 22, 2021
Date of Patent:
April 23, 2024
Assignees:
Janssen Vaccines & Prevention B.V., Massachusetts Institute of Technology
Inventors:
Ronald Vogels, Marijn Van Der Neut Kolfschoten, Darrell J. Irvine, Ron Weiss, Ely Blanton Porter, Mariane Bandeira Melo, Tasuku Kitada
Abstract: This disclosure provides a method for imaging lymph nodes and lymphatic vessels without a contrast agent. The method includes providing, using an optical source, an infrared illumination to a region of a subject having at least one lymphatic component, detecting a reflected portion of the infrared illumination directly reflected from the region using a sensor positioned thereabout, and generating at least one image indicative of the at least one lymphatic component in the subject using the reflected portion of the infrared illumination.