Abstract: A computer system selects features of a dataset for predictive modeling. A first set of features that are relevant to outcome are selected from a dataset comprising a plurality of cases and controls. A subset of cases and controls having similar values for the first set of features is identified. The subset is analyzed to select a set of additional features relevant to outcome. A first and second predictive model are evaluated to determine that the second predictive model more accurately predicts outcome, wherein the first predictive model is based on the first set of features and the second predictive model is based on the first set of features and the additional features. The second predictive model is utilized to predict outcomes. Embodiments of the present invention further include a method and program product for selecting features of a dataset for predictive modeling in substantially the same manner described above.

Abstract: Electrical propulsion systems and related methods are generally described. In some embodiments, an electrical propulsion system may include an electrically-actuated valve to selectively permit flow of propellant from a reservoir tank to a thruster. The valve may physically isolate the propellant from the thruster when inactivated, exhibiting a non-wetting surface which may inhibit propellant from passing through the valve towards the thrusters. In some embodiments, a valve may be activated through application of a voltage potential to the valve relative to the propellant, which may change the wettability of the valve, permitting propellant to wet and subsequently pass through the valve. The voltage potential may be adjusted to vary the wettability of the valve, resulting in the valve effectively regulating propellant flow rate. The valve may include a conductive layer, a dielectric or insulating layer, and a non-wetting layer to enhance the non-wetting behavior of the valve.

Abstract: An example methodology implementing the disclosed techniques includes receiving a plurality of measured semiconductor properties of one or more partially completed semiconductor devices, determining a measure of short circuit current density (JSC) of each of the one or more partially completed semiconductor devices, the JSC, measure based on a measure of semiconductor diffusion length (LD) and a measure of thickness, and determining a current voltage relationship of each of the one or more partially completed semiconductor devices.

Abstract: A drug delivery device for administration to a subject may include a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device may also include a trigger operatively associated with the potential energy source. The trigger may be configured to actuate at a predetermined location within the subject to deploy a jet of the active pharmaceutical ingredient into a tissue of an adjacent portion of the gastrointestinal tract. In some instances, the jet may be deployed into tissue of the stomach and/or small intestine of the subject. Further, in some embodiments, the operating parameters of the jet may be selected such that the jet penetrates the tissue of the gastrointestinal tract to form a depot of the active pharmaceutical ingredient disposed within the tissue.

Abstract: An ultra-wide bandwidth acoustic transducer may include multiple layers, including an inner piezoelectric layer, a polymer coupling layer and an outer piezoelectric layer. The polymer layer may be located between, and may be bonded to, the inner and outer piezoelectric layers. The transducer may have multiple eigenfrequencies of vibration. These eigenfrequencies may include primary resonant frequencies of the inner and outer piezoelectric layers respectively and may also include resonant frequencies that arise due to coupling between the layers. An acoustic backscatter system may employ such a transducer in backscatter nodes as well as in a transmitter. The multiple eigenfrequencies may enable the system to perform spread-spectrum communication at a high throughput. These multiple eigenfrequencies may also enable each backscatter node to shift frequency of an uplink signal, which in turn may enable the system to mitigate self-interference and to decode concurrent signals from multiple backscatter nodes.

Abstract: A closed-loop system for blood pressure control that accounts for various mechanisms of the cardiovascular system. In some example cases, a pharmacokinetic-pharmacodynamic model of the cardiovascular system's response to cardiovascular system actuators, such as vasoactive drugs, is generated. Two example actuators are employed in the example framework: phenylephrine, to raise blood pressure, and nicardipine, to lower blood pressure. The pharmacodynamic components employs a two-element Windkessel model. A model predictive control framework is built based on the pharmacokinetic-pharmacodynamic model.

Abstract: A two-layer hybrid solid wedged etalon was fabricated and combined with a traditional imager to make a compact computational spectrometer. The hybrid wedge was made of Nb2O5 and Infrasil 302 and was designed to operate from 0.4-2.4 ?m. Initial demonstrations used a CMOS imager and operated from 0.4-0.9 ?m with spectral resolutions <30 cm?1 from single snapshots. The computational spectrometer operates similarly to a spatial Fourier Transform infrared (FTIR) spectrometer with spectral reconstruction using a non-negative least squares fitting algorithm based on analytically computed wavelength response vectors determined from extracted physical thicknesses across the entire two-dimensional wedge. This computational technique resulted in performance and spectral resolutions exceeding those that could be achieved from Fourier techniques. With an additional imaging lenses and translational scanning, the system can be converted into a hyperspectral imager.

Abstract: Disclosed are copolymer micelles for simultaneous delivery of Cas9 mRNA and guide RNA for Cas9 CRISPR gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.

Abstract: A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.

Abstract: A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices.

Abstract: The present invention relates to methods of detecting region(s) of interest in a gene comprising a polyA tail. The region(s) of interest can include gene(s), region(s), mutation(s), deletion(s), insertion(s), indel(s), and/or translocation(s). The region(s) can be greater than or less than 1 kilobases from the polyA tail. Methods can include forming a library of single cell transcripts comprising the region(s) in close proximity to a cell barcode and a unique molecular identifier (UMI). Methods for distinguishing cells by genotype can include amplifying the transcripts using PCR methods and detecting the cell barcode and UMI using single cell sequencing methods. Transcripts can be enriched using tagged region-specific PCR primers. Cell barcodes can be brought into close proximity to the region(s) by circularizing the transcripts. Sequencing of the transcripts can include using primer binding sites added during PCR amplification and library indexes for multiplexed sequencing.

Abstract: A sensor for carbon dioxide can include an amidine functional group.

Abstract: Fluidic multiwell bioreactors are provided as a microphysiological platform for in vitro investigation of multi-organ crosstalks for an extended period of time of at least weeks and months. The disclosed platform is featured with one or more improvements over existing bioreactors, including on-board pumping for pneumatically driven fluid flow, a redesigned spillway for self-leveling from source to sink, a non-contact built-in fluid level sensing device, precise control on fluid flow profile and partitioning, and facile reconfigurations such as daisy chaining and multilayer stacking. The platform supports the culture of multiple organs in a microphysiological, interacted systems, suitable for a wide range of biomedical applications including systemic toxicity studies and physiology-based pharmacokinetic and pharmacodynamic predictions. A process to fabricate the disclosed bioreactors is also provided.

Abstract: Articles and methods related to passivation materials on alkaline earth metals are generally described.

Abstract: The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorders.

Abstract: Provided herein are lipidoid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipidoid compounds, compositions, or formulations for treating and/or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein.

Abstract: Peptide-E3 ubiquitin ligase fusions representing minimal protein to proteasome linkers are specifically targeted to degrade endogenous FOXP3 proteins in regulatory T cells. An engineered peptide for functional inactivation of a target regulatory T cell includes a fusion protein comprising a targeting domain and a ubiquitin ligase recruiting domain, wherein the targeting domain is engineered to bind FOXP3 of the target regulatory T cell for mediated degradation by the ubiquitin-proteosome pathway. The targeting domain may comprise a peptide having amino acid [SEQ ID No. 3], [SEQ ID No. 4], [SEQ ID No. 5], [SEQ ID No. 6], or [SEQ ID No. 7]. The ubiquitin ligase recruiting domain recruits an E3 ubiquitin ligase, which may be CHIP?TPR [SEQ ID No. 2]. An engineered minimal, specific, nucleotide-encodable, FOXP3 protein to proteasome linker comprises a peptide-E3 ubiquitin ligase fusion in which the peptide binds to FOXP3.

Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.

Abstract: Electroaerodynamic devices and their methods of operation are disclosed. In one embodiment, ions are formed by dielectric barrier discharge using a time varying voltage differential applied between a first electrode and a second electrode. The ions are then accelerated in a downstream direction using a second voltage differential applied between a third electrode and the first and/or second electrodes, where the third electrode is located down stream from the first and second electrodes. The ions may then collide with naturally charged molecules and/or atoms within a fluid to accelerate the fluid in the downstream to create an ionic wind and an associated thrust.

Abstract: An electromyography (EMG) sensor for a wearable device, such as a prosthetic device attachable to a residual limb, includes a flexible substrate comprising an elongated portion and an electrode portion. At least two electrodes are disposed at a surface of the electrode portion of the flexible substrate, and leads from the at least two electrodes extend through the elongated portion of the flexible substrate.