Abstract: An analog computing system with coupled non-linear oscillators can solve complex combinatorial optimization problems using the weighted Ising model. The system is composed of a fully-connected LC oscillator network with low-cost electronic components and compatible with traditional integrated circuit technologies. Each LC oscillator, or node, in the network can be coupled to each other node in the array with a multiply and accumulate crossbar array or optical interconnects. When implemented with four nodes, the system performs with single-run ground state accuracies of 98% on randomized MAX-CUT problem sets with binary weights and 84% with five-bit weight resolutions. The four-node system can obtain solutions within five oscillator cycles with a time-to-solution that scales directly with oscillator frequency. A scaling analysis suggests that larger coupled oscillator networks may be used to solve computationally intensive problems faster and more efficiently than conventional algorithms.

Abstract: The present disclosure is directed to rheometric fixtures for making rheological measurements of yield stress fluids. In some embodiments, the fixture can be an improvement of a typical vane by having the ability to create a more homogeneous shear profile in a test material, e.g., a yield stress fluid. These vane fixtures having fractal-like cross-sectional structures enable robust rheological measurements of the properties of yield stress fluids due to several outer contact edges that lead to increased kinematic homogeneity at the point of yielding and beyond. The branching structure of the fractal-like fixtures can alter the shape of a wetted perimeter of the fixture while minimizing an area thereof to allow the fixture to be inserted into fluids with less disturbance. In some embodiments, a cup with a ribbed inner surface can be used to hold the sample fluid and disassembles for ease of cleaning following completion of the measurement.

Abstract: A component for a lithium battery including a first layer including a lithium garnet having a porosity of 0 percent to less than 25 percent, based on a total volume of the first layer; and a second layer on the first layer and having a porosity of 25 percent to 80 percent, based on a total volume of the second layer, wherein the second layer is on the first layer and the second layer has a composition that is different from a composition of the first layer.

Abstract: Corona Phase Molecular Recognition (CoPhMoRe) utilizing a template heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte can be used for macromolecular analytes, including proteins.

Abstract: Qubit circuits having components formed deep in a substrate are described. The qubit circuits can be manufactured using existing integrated-circuit technologies. By forming components such as superconducting current loops, inductive, and/or capacitive components deep in the substrate, the footprint of the qubit circuit integrated within the substrate can be reduced. Additionally, coupling efficiency to and from the qubit can be improved and losses in the qubit circuit may be reduced.

Abstract: Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9)-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 and a substitution of residues ADKKLRKRSGKLATE [SEQ ID No. 4] in position 365-379 in the ScCas9 open reading frame (Sc++). Also included are CRISPR-associated DNA endonucleases with a PAM specificity of 5?-NG-3? or 5?-NNG-3? and a method of altering expression of a gene product by utilizing the engineered ScCas9 variants.

Abstract: Swept-source Raman spectroscopy uses a tunable laser and a fixed-wavelength detector instead of a spectrometer or interferometer to perform Raman spectroscopy with the throughput advantage of Fourier transform Raman spectroscopy without bulky optics or moving mirrors. Although the tunable laser can be larger and more costly than a fixed wavelength diode laser used in other Raman systems, it is possible to split and switch the laser light to multiple ports simultaneously and/or sequentially. Each site can be monitored by its own fixed-wavelength detector. This architecture can be scaled by cascading fiber switches and/or couplers between the tunable laser and measurement sites. By multiplexing measurements at different sites, it is possible to monitor many sites at once. Moreover, each site can be meters to kilometers from the tunable laser. This makes it possible to perform swept-source Raman spectroscopy at many points across a continuous flow manufacturing environment with a single laser.

Abstract: Disclosed herein are methods for inhibiting or activating the transcription of a gene of interest, or inhibiting or activating the transcription of specific mRNA isoforms of a gene by using antisense oligonucleotides and/or small molecules. Also described herein are methods for activating transcription from a promoter and increasing overall gene expression by creating of a new splice site in a gene of a cell.

Abstract: A method for the design, manufacture, and assembly of modular lattice structures composed of cuboctahedron unit cells.

Abstract: The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

Abstract: In some embodiments, a body anchor for supporting an assistive device can include: a cuff to exert a compression force on a body part of a user; and one or more tensile elements having first ends and second ends. The first ends of the tensile elements can be configured to be attached to the assistive device. The second ends of the tensile elements can be arranged about the cuff to cause the compression force to vary in proportion to a load exerted by the assistive device.

Abstract: A holographic display is comprised of space-multiplexed elemental modulators, each of which consists of a surface acoustic wave transducer atop an anisotropic waveguide. Each “line” of the overall display consists of a single anisotropic waveguide across the display's length with multiple surface acoustic wave transducers spaced along the waveguide length, although for larger displays, the waveguide may be divided into segments, each provided with separate illumination. Light that is undiffracted by a specific transducer is available for diffraction by subsequent transducers. Per transducer, guided-mode light is mode-converted to leaky-mode light, which propagates into the substrate away from the viewer before encountering a volume reflection grating and being reflected and steered towards the viewer. The display is transparent and all reflection volume gratings operate in the Bragg regime, thereby creating no dispersion of ambient light.

Abstract: Joining methods and corresponding structures are disclosed. In some instances, a method for joining two or more components may include generating a shockwave in a first component to form a jet of a material of the first component directed towards a second component. The jet may penetrate the second component to connect the first component with the second component. Articles of pre-joined and joined components are also described.

Abstract: A closed-loop feedback system and method of active noise cancellation to maintain a desired operating frequency of a qubit during a quantum computation, even when that frequency is relatively sensitive to flux noise. A series of Ramsey experiments is performed on the qubit to estimate an offset between its actual and desired operating frequencies, and the error is accumulated. After the probing is complete, the accumulated error is supplied to an arbitrary waveform generator that produces a magnetic flux that is coupled to the qubit, thereby tuning the qubit and actively controlling its operating frequency. Having corrected the operating frequency of the qubit and extended its coherence time, the quantum state of the qubit is allowed to evolve according to the computation.

Abstract: According to some embodiments, a method includes: receiving an endpoint impedance matrix representing a desired stiffness or damping at the robot endpoint; reflecting the endpoint impedance matrix to an equivalent joint-space matrix associated with one or more of the robot joints, the equivalent joint-space matrix having a nullspace corresponding to near-zero-valued eigenvalues; generating a nullspace-filled impedance matrix from the equivalent joint-space matrix based in part on replacing the near-zero-valued eigenvalues with selected finite positive real values; generating a robot control law using the nullspace-filled impedance matrix; and using the robot control law to control the robot.

Abstract: A sensor, such as a photoplethysmography sensor, for non-invasively monitoring a characteristic of an organism, such as a vital body sign. The sensor has multiple light sources disposed on a substrate and an array of optical probing channels for conveying light from the light sources to a probed region. Each detector pixel of an array of detector pixels receives light from a respective optical detection channel after interaction with a subregion of the probed region and spatial filtering, and generates a corresponding pixel signal.

Abstract: The present disclosure, in various embodiments, discloses hydrothermal methods, hydrothermally modified materials and dried hydrothermally modified materials. Certain dried hydrothermally modified materials can readily releases ionic species such as alkali metal ions (K+, Na+), silicate salts, and alkaline earth metal ions (Mg2+, Ca2+). Some dried hydrothermally modified materials can readily release aluminum ions and/or silicon, such as in the form of soluble silicates. Such processes and materials are useful, for example in economically preparing potassium releasing fertilizers.

Abstract: Magnetic transmissions and related methods are described. In one embodiment, an apparatus includes a magnetic screw comprising an elongate body, a nut selectively magnetically coupled to the magnetic screw, and a potential energy storage system and/or a resistive force component. The nut is configured to be displaced relative to the elongate body in a first direction in response to manipulation of a magnetic field between the magnetic screw and the nut when the nut is magnetically coupled to the magnetic screw. In embodiments including a potential energy storage system, the potential energy storage system may store potential energy when the nut is displaced in the first direction. In embodiments including a resistive force component, the resistive force component may resist motion of the nut in the first direction by applying a resistive force to the nut at least partially in an opposing second direction.

Abstract: Techniques are disclosed for a chemical sensor architecture based on a fabric-based spectrometer. An example apparatus implementing the techniques includes a portable spectrometer device including a first fabric layer and a second fabric layer coupled to the first fabric layer to form a pouch. The second fabric layer includes a fiber fabric spectrometer substrate comprising a fiber material including one or more electronic devices, wherein the pouch is configured to receive a colorimetric substrate and the fiber fabric spectrometer substrate is configured to measure reflectance of a colorimetric substrate disposed in the pouch.

Abstract: A monolithic, three-dimensional (3D) integrated circuit (IC) device includes a sensing layer, a memory layer, and a processing layer. The sensing layer includes a plurality of carbon nanotube field-effect transistors (CNFETs) that are functionalized with at least 50 functional materials to generate data in response to exposure to a gas. The memory layer stores the data generated by the plurality of CNFETs, and the processing layer identifies one or more components of the gas based on the data generated by the plurality of CNFETs.