Abstract: The present invention utilizes a plurality of spectroscopic systems and methods to measure characteristics of tissue useful in the diagnosis of disease. In a preferred embodiment, a combination of fluorescence, reflectance and light scattered spectra can be measured and processed to provide biochemical, architectural and morphological state of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.

Abstract: A high density integrated optical chip. The optical chip features an optical function connected to a low minimum bending radius dielectric waveguide, and a large mode field size dielectric waveguide to interface with an external optical device, such as an optical fiber. The large mode field size dielectric waveguide is optically connected to the low minimum bending radius dielectric waveguide on the optical chip.

Abstract: An instrument for enabling a precise determination of the force-displacement characteristics of a compliant structure, including both in-plane and out-of-plane structure deflection, is provided by the invention. The instrument includes a fixture that is oriented for constraining an end of the compliant structure with respect to mechanical ground as the force-displacement characteristic is determined. A mechanical probe of the instrument is disposed relative to the fixture to enable pushing of the probe against a free end of the compliant structure. A mechanical stage is provided, including a support for the probe, and being free with respect to mechanical ground to advance the probe relative to the fixture. This enables pushing of the probe against the free end of the compliant structure.

Abstract: Methods and apparatus are provided for monitoring resistance spot welding process conditions in real time by using welding data in an energy balance model in integral form to estimate the mean weld temperature and to predict process conditions such as occurrence of splash, and weld diameter. Using predicted welding process conditions, welding parameters are modified in real time to prevent splash and produce sound welds.

Abstract: Apparatus and techniques for detecting malfunctions, anomalies and attacks upon optical devices of a transparent all-optical network, including amplified links and optical nodes, of the network. A portion of an input signal of the optical device and a portion of an output signal from the optical device are coupled to an optical processing unit and a an optical to electrical signal converter. The electrical output signal of the converter is coupled to an electronic processing unit which generates a difference signal which is a function of the input and output signal portions for comparison to a predetermined set of parameters. The result of the comparison is an alarm signal indicative of the occurrence of a malfunction. Also described is an optical comparator capable of generating the difference signal which is indicative of perturbations in the optical device.

Abstract: The invention is methods and products related to FGF dimerization. In particular compositions of FGF dimers are provided.

Abstract: The system described herein determines an input command profile for a dynamic system that can be modeled as a linear system, the input command profile for transitioning an output of the dynamic system from one point to another point. The system identifies characteristics of the dynamic system, and then selects a command profile which defines an input to the dynamic system based on the identified characteristics. The command profile comprises one or more pulses which rise and fall at switch times, and the command profile is useable with substantially any dynamic system that can be modeled as a linear system. The system then imposes a plurality of constraints on the dynamic system, at least one of the constraints being defined in terms of the switch times, and determines the switch times for the input to the dynamic system based on the command profile and the plurality of constraints.

Abstract: Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 &mgr;m and 30 &mgr;m. The particles may be formed of biodegradable mat as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung.

Abstract: The compositions and methods disclosed herein provide heterobifunctional programmable genotoxic compounds that can be designed to kill selected cells present in a heterogenous cell population. The present compounds comprise a first agent that inflicts damage on cellular DNA, and a second agent that attracts a macromolecular cell component such as a protein, which in turn shields genomic lesions from repair. Unrepaired lesions therefore persist in the cellular genome and contribute to the death of selected cells. In contrast, lesions formed in nonselected cells, which lack the cell component, are unshielded and thus are repaired. As a result, compounds described herein are less toxic to nonselected cells. Compounds of this invention can be designed to cause the selective killing of transformed cells, viral-infected cells and the like.

Abstract: An electronic device comprising a population of quantum dots embedded in a host matrix and a primary light source which causes the dots to emit secondary light of a selected color, and a method of making such a device. The size distribution of the quantum dots is chosen to allow light of a particular color to be emitted therefrom. The light emitted from the device may be of either a pure (monochromatic) color, or a mixed (polychromatic) color, and may consist solely of light emitted from the dots themselves, or of a mixture of light emitted from the dots and light emitted from the primary source. The dots desirably are composed of an undoped semiconductor such as CdSe, and may optionally be overcoated to increase photoluminescence.

Abstract: An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber.

Abstract: A device having at least one dielectric inner core region in which electromagnetic radiation is confined, and at least two dielectric outer regions surrounding the inner core region, each with a distinct refractive index. The outer regions confine electromagnetic radiation within the inner core region. The refractive indices, the number of outer regions, and thickness of the outer regions result in a reflectivity for a planar geometry that is greater than 95% for angles of incidence ranging from 0° to at least 80° for all polarizations for a range of wavelengths of the electromagnetic radiation. In exemplary embodiments, the inner core region is made of a low dielectric material, and the outer regions include alternating layers of low and high dielectric materials. In one aspect of the invention, the device is a waveguide, and in another aspect the device is a microcavity.

Abstract: Provided is a force-controlled hydro-elastic actuator, including a hydraulic actuator, having a connection to hydraulic fluid and including a mechanical displacement member positioned to be mechanically displaced by fluid flow at the actuator. A valve is connected at the hydraulic actuator connection and has a port for input and output of fluid to and from the valve. At least one elastic element is provided in series with the mechanical displacement member of the hydraulic actuator and is positioned to deliver, to a load, force generated by the hydraulic actuator. A transducer is positioned to measure a physical parameter indicative of the force delivered by the elastic element and to generate a corresponding transducer signal. A force controller is connected between the transducer and the valve to control the valve, based on the transducer signal, for correspondingly actuating the hydraulic actuator and deflecting the elastic element.

Abstract: Stitchable electrical components have flexible, conductive leads and are encased, at least partially, in sealed packages. Conductive threads, yarns, or fiber bundles are patterned onto a flexible substrate (e.g., a textile panel). To form a circuit, the component leads are conductively stitched, spot welded, or otherwise joined to a textile panel so as to form connections between at least some of the stitched leads so as to form an electrical circuit. Alternatively, leads stitched into or otherwise joined to a textile pattern may be welded or otherwise permanently joined to flexible or non-flexible component leads to form a circuit. Multiple panels of circuitry so formed may then be physically and electrically joined at various locations by a combination of stitching, welding, and/or other joining means, preferably with interposed insulating layers, to form a multilayer flexible circuit.

Abstract: InxGa1−xAs structures with compositionally graded buffers grown with organometallic vapor phase epitaxy (OMPVE) on GaAs substrates. A semiconductor structure and a method of processing such a structure including providing a substrate of GaAs; and epitaxially growing a relaxed graded layer of InxGa1−xAs at a temperature ranging upwards from about 600° C.

Abstract: A programmable integrated circuit utilizes a large number of intermediate-grain processing elements which are multibit processing units arranged in a configurable mesh. The coarse-grain resources, such as memory and processing, are deployable in a way that takes advantage of the opportunities for optimization present in given problems. To accomplish this, the interconnect supports three different modes of operation: a static value in which a value set by the configuration data is provided to a functional unit, static source in which another functional unit serves as the value source, and a dynamic source mode in which the source is determined by the value from another functional unit.

Abstract: Instantaneous radio positioning method and system. Signals from a plurality of spatially distributed transmitters are received at a known reference position and at an unknown position to be determined. A composite of the radio signals, simultaneously including a component signed from each of the transmitters, is digitized and then processed to measure phases that is then digitized. Ambiguity is resolved by finding the location in parameter space of the maximum of an ambiguity function related to sets of phase-measurement data. Position is determined at a point in time without keeping track of phase history.

Abstract: A method and apparatus for identifying a weather condition from visible imagery. A sequential series of visible images depicting a field of view is received. A composite visible image representing a long-term average of the monitored field of view is maintained and updated with each subsequent image. Each received image and the composite visible image are edge-detection filtered. Persistent edges existing in both the received image and the composite visible image are extracted and used to predict a weather condition. In one embodiment, a statistical value determined from the extracted edge image is used to predict visibility using a predetermined scoring function.

Abstract: This invention provides an article, compositions, methods of making and uses of vapor-deposited metal compounds immobilized on porous substrates. The substrate is a porous substrate having an average pore size of at least about 8 Å and a surface area of at least about 10 m2/g. The methods describe the vapor-deposition of an inorganic compound onto the substrate where the deposition is accomplished with a relatively small amount of ligand loss. The substrate can be pre-treated to achieve a uniformly dispersed metal compound deposited on the substrate. The inorganic compound can decompose into a metal compound. The article can also function as a catalyst for carbon-heteroatom coupling reactions such as carbon-carbon coupling reactions, most notably, the Heck reaction.

Abstract: A supermicrocellular foamed material and a method for producing such material, the material to be foamed such as a polymerplastic material, having a supercritical fluid, such as carbon dioxide in its supercritical state, introduced into the material to form a foamed fluid/material system having a plurality of cells distributed substantially throughout the material. Cell densities lying in a range from about 109 to about 1015 per cubic centimeter of the material can be achieved with the average cell sizes being at least less than 2.0 microns and preferably in a range from about 0.1 micron to about 1.0 micron.