Patents Assigned to Max-Planck-Gesellschaft
  • Patent number: 10703735
    Abstract: The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: July 7, 2020
    Assignees: Lead Discovery Center GmbH, Max Planck Gesellschaft zur Förderung der Wissenschaften e. V.
    Inventors: Raffaella Di Lucrezia, Tim Bergbrede, Peter Nussbaumer, Uwe Koch, Bert Klebl, Axel Choidas, Anke Unger, Nils-Göran Larsson, Maria Falkenberg-Gustafsson, Claes M. Gustafsson
  • Patent number: 10688169
    Abstract: The present invention relates to synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 that are related to carbapenem-resistant Klebsiella pneumoniae capsular polysaccharide and conjugates thereof. Said conjugates and pharmaceutical composition containing said conjugates are useful for prevention and/or treatment of diseases associated with carbapenem-resistant Klebsiella pneumoniae. Furthermore, the synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 are useful as marker in immunological assays for detection of antibodies against carbapenem-resistant Klebsiella pneumoniae bacteria.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: June 23, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Peter H. Seeberger, Claney Lebev Pereira, Guozhi Xiao, Naeem Khan, Chakkumkal Anish
  • Publication number: 20200193225
    Abstract: The invention relates to a system for detecting objects in a digital image. The system comprises a neural network which is configured to generate candidate windows indicating object locations, and to generate for each candidate window a score representing the confidence of detection. Generating the scores comprises: generating a latent representation for each candidate window, updating the latent representation of each candidate window based on the latent representation of neighboring candidate windows, and generating the score for each candidate window based on its updated latent representation The invention further relates to a system for rescoring object detections in a digital image and to methods of detecting objects and rescoring objects.
    Type: Application
    Filed: April 28, 2017
    Publication date: June 18, 2020
    Applicants: Toyota Motor Europe, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Daniel OLMEDA REINO, Bernt SCHIELE, Jan Hendrik HOSANG, Rodrigo BENENSON
  • Patent number: 10684253
    Abstract: The present invention relates to methods for the identification of compounds in carbohydrate mixture compositions as well as the determination of carbohydrate mixture composition patterns, based on e.g. orthogonal cross determining migration time (indices) using capillary gel electrophoresis-laser induced fluorescence and identifying said carbohydrate components based on comparing said migration time (indices) with standard migration time (indices) from a database which data are preferably also orthogonal cross determined. In a further aspect, the present invention relates to a method for carbohydrate mixture composition pattern profiling, like glycosylation pattern profiling using capillary gel electrophoresis-laser induced fluorescence (CGE-LIF). In another aspect, the present invention refers to a system for an automated determination and/or identification of carbohydrates and/or carbohydrate mixture composition patterns (e.g.: glycosylation patterns).
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: June 16, 2020
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Erdmann Rapp, Jana Schwarzer, Udo Reichl, Christian Bohne
  • Patent number: 10677652
    Abstract: A method and apparatus is provided for implementing a parametric down-conversion (PDC)-based calibration comprising calibrating a measuring instrument; disposing a pinhole at a position of a light-emitting sample for which the measuring instrument needs to be calibrated; irradiating a nonlinear crystal with a light source; setting the nonlinear crystal by ensuring a phase-matching wavelength of the nonlinear crystal is set at one boundary of a desired bandwidth; acquiring one or more PDC spectrums by the measuring instrument; obtaining peak values and their corresponding wavelengths from each acquired spectrum; and obtaining a response function based on the peak values and corresponding wavelengths.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: June 9, 2020
    Assignees: University of Ottawa, Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V., Friedrich-Alexander-Universitaet Erlangen-Nuernberg
    Inventors: Samuel Lemieux, Mathieu Manceau, Robert W. Boyd, Gerd Leuchs, Maria V. Chekhova
  • Patent number: 10675718
    Abstract: A method for reversibly attaching a phase changing metal to an object, the method comprising the steps of: providing a substrate having at least one surface at which the phase changing metal is attached, heating the phase changing metal above a phase changing temperature at which the phase changing metal changes its phase from solid to liquid, bringing the phase changing metal, when the phase changing metal is in the liquid phase or before the phase changing metal is brought into the liquid phase, into contact with the object, permitting the phase changing metal to cool below the phase changing temperature, whereby the phase changing metal becomes solid and the object and the phase changing metal become attached to each other, reheating the phase changing metal above the phase changing temperature to liquefy the phase changing metal, and removing the substrate from the object, with the phase changing metal separating from the object and remaining with the substrate.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: June 9, 2020
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
    Inventors: Zhou Ye, Guo Zhan Lum, Metin Sitti
  • Patent number: 10679046
    Abstract: Disclosed is a method including receiving an input image including a human, predicting, based on a convolutional neural network that is trained using examples consisting of pairs of sensor data, a corresponding body shape of the human and utilizing the corresponding body shape predicted from the convolutional neural network as input to another convolutional neural network to predict additional body shape metrics.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: June 9, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Michael Black, Eric Rachlin, Nicolas Heron, Matthew Loper, Alexander Weiss, Xiaochen Hu, Theodora Hinkle, Martin Kristiansen
  • Publication number: 20200165279
    Abstract: The present invention relates to a compound represented by the formula (E) which is useful for treating or preventing melanoma.
    Type: Application
    Filed: May 11, 2018
    Publication date: May 28, 2020
    Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V., LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN, GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN
    Inventors: Dorothea BECKER, Thomas M. JOVIN, Christian GRIESINGER, Andrei LEONOV, Sergey RYAZANOV, Armin GIESE, Tiago F. OUTEIRO, Diana F. LAZARO, Michael P. SCHÖN, Margarete SCHÖN
  • Publication number: 20200166699
    Abstract: A hollow-core photonic crystal fiber (HC-PCF)(10) for guiding at least one mode of a light field(1) along a mode guiding section(11) of the HC-PCF(10), comprises an outer jacket(12), an inner cladding(13) and a hollow core(14), which extend along the HC-PCF(10), wherein the inner clad-ding(13) is arranged on an interior surface of the outer jacket(12) and comprises anti-resonant structures(15) surrounding the hollow core(14), and the hollow core(14) has a mode guiding core diameter(d) provided along the mode guiding section of the HC-PCF(10), and wherein at least one fiber end (16) of the HC-PCF(10) has a light field coupling section(17) in which the hollow core(14) is tapered over an axial coupling section length from a fiber end core diameter(D) at the at least one fiber end (16) to the mode guiding core diameter(d). Furthermore, methods of using the HC-PCF and manufacturing the HC-PCF are described.
    Type: Application
    Filed: May 7, 2018
    Publication date: May 28, 2020
    Applicant: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V
    Inventors: Sebastian BAUERSCHMIDT, Patrick Sebastian UEBEL, Philip St. J. RUSSELL
  • Patent number: 10663383
    Abstract: The present disclosure relates to an apparatus and methods for applying a force on a sample. In particular, the present disclosure relates to a stress cell (200) comprising a frame (205); an actuator arrangement (210) coupled to the frame; and a coupler (220) for coupling the actuator arrangement to the sample (230). The coupler (220) includes a first coupler portion connected to the actuator arrangement (210) and a second coupler portion connectable to the sample (230). The first coupler portion is flexibly coupled to the frame. The actuator arrangement (210) comprises a first element (214) having a first variable length and a second element (212) having a second variable length, and is adapted to vary a difference between the first length and the second length to provide the force.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: May 26, 2020
    Assignees: Razorbill Instruments Limited, Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
    Inventors: Jack Matthew Barraclough, Clifford William Hicks, Alexander Steppke, Mark Barber
  • Patent number: 10633656
    Abstract: Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3? ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 28, 2020
    Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Whitehead Institute for Biomedical Research, UNIVERSITY OF MASSACHUSETTS
    Inventors: Thomas Tuschl, Sayda Mahgoub Elbashir, Winfried Lendeckel
  • Patent number: 10634888
    Abstract: The invention relates to a light microscope for examining microscopic objects with high throughput. The microscope comprises a light source for illuminating a measuring zone, a sample vessel, in which the microscopic objects can be successively moved into the measuring zone, and a detection device for measuring detection light, which originates from a microscopic object located in the measuring zone. According to the invention, the microscope is characterized in that the imaging means comprise a detection lens having a stationary front optics and movable focusing optics, wherein the focusing optics is arranged behind the front optics and in front of an intermediate image plane, and can be adjusted for the height adjustment of a detection plane. The invention further relates to a corresponding microscopy method.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: April 28, 2020
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V., Carl Zeiss Microscopy GmbH
    Inventors: Helmut Lippert, Jörg Siebenmorgen, Jan Huisken, Florian Fahrbach
  • Patent number: 10629815
    Abstract: The invention relates to new conjugated semiconducting polymers containing thermally cleavable side groups. The thermally cleavable side groups are selected from among carbonate groups and carbamate groups. By thermally cleaving side groups, the solubility or the polymers can be reduced in a targeted manner. The polymers are used as semiconductors in organic electronic (OE) devices, especially in organic photovoltaic (OPV) devices, organic photodetectors (OPDs), organic light emitting diodes (OLEDs), and organic field effect transistors (OFETs).
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: April 21, 2020
    Assignees: INNOVATIONLAB GMBH, KARLSRUHER INSTITUT FUER TECHNOLOGIE, TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Marius Kuhn, Torben Adermann, Manuel Hamburger, Klaus Muellen, Janusz Schinke, Alexander Colsmann, Stefan Hoefle, Ulrich Lemmer
  • Publication number: 20200115419
    Abstract: The invention relates to newly characterized light-inducible inward proton pumps and their use in medicine, their utility as optogenetic tools, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells comprising said nucleic acid construct or expression vector, and their respective uses.
    Type: Application
    Filed: April 11, 2018
    Publication date: April 16, 2020
    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Ernst Bamberg, Valentin Gordeliy, Thomas Mager, Vitaly Shevchenko
  • Publication number: 20200096682
    Abstract: A mirror includes a carrier, a reflecting layer disposed above a main face of the carrier, and a transparent layer disposed above the reflective layer. The carrier includes a base body, and the base body includes one or more of a material comprising a density in a range from 0.1 to 1.0 g/cm3, a porous material, a foamed material, a material comprising a structure containing closed cells, a material comprising a honeycomb structure, or a structure containing carbon fibers.
    Type: Application
    Filed: December 21, 2017
    Publication date: March 26, 2020
    Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V., MEDIA LARIO S.R.L.
    Inventors: Masahiro TESHIMA, Razmik MIRZOYAN, Guiseppe VALSECCHI, Robert BANHAM
  • Publication number: 20200093084
    Abstract: The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus.
    Type: Application
    Filed: August 12, 2019
    Publication date: March 26, 2020
    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Guy Reeves, Floyd Reed
  • Patent number: 10596272
    Abstract: The present invention relates to well-defined synthetic saccharides of general formula (I) that are related to the repeating unit of Streptococcus pneumoniae serotype 5 capsular polysaccharide and conjugates thereof. The conjugates and pharmaceutical compositions containing said conjugates are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically against diseases associated with Streptococcus pneumoniae serotype 5. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 24, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Chakkumkal Anish, Marilda Lisboa, Christopher Martin, Claney Lebev Pereira, Peter H. Seeberger, Naeem Khan
  • Patent number: 10588962
    Abstract: The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.
    Type: Grant
    Filed: March 19, 2013
    Date of Patent: March 17, 2020
    Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., UNIVERSITÄTSSPITAL BASEL
    Inventors: Peter H. Seeberger, Pierre Stallforth, Gennaro De Libero, Marco Cavallari
  • Patent number: 10586641
    Abstract: A magnetic closure device has two complementary magnetic closure elements. Each of the two complementary magnetic closure elements includes an elongated magnet carrier having a single direction of main extension, and a plurality of permanent magnets supported by the magnet carrier in defined positions along the direction of main extension. Each of the permanent magnets is permanently magnetized either longitudinally or diametrically with regard to the direction of main extension. The permanent magnets following to each other in the direction of main extension are arranged in a closure alignment pattern having a magnetic non-repetition length extending over three or more of the permanent magnets. The magnet carrier is bendable in at least one direction orthogonal to the direction of main extension.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: March 10, 2020
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventor: Garrett Hayes Good
  • Patent number: 10579684
    Abstract: A computer-implemented method for determining a relevance of a node in a network. A digital representation of a local neighborhood structure of the node in the network is obtained in a computer-readable non-volatile memory. A numerical value characteristic of the node's relevance is determined, and output to a user. The numerical value is determined based on the neighborhood structure of the node.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: March 3, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventor: Glenn Lawyer