Abstract: The present invention relates to a method for the in vitro detection of a latent tuberculosis infection (LTBI) in a subject, wherein said method comprises determining at least one nucleotide sequence and/or at least one polypeptide of Mycobacterium tuberculosis (Mtb) in a blood cell population of said subject, and wherein the presence of said at least one nucleotide sequence and/or said at least one polypeptide is indicative for said latent tuberculosis infection. In particular, the blood cell population is enriched for hematopoietic stem cells. The invention also relates to a pharmaceutical composition for use in the treatment of the LTBI in the subject, wherein it is determined if the nucleotide sequence and/or the polypeptide of Mtb is/are present in the blood cell population. Further, the invention relates to kits for carrying out the methods of the invention. The invention also relates to the use of the kits.

Abstract: The invention relates to a method for modifying the storage reserve content in plants, where leghemoglobin- and/or hemoglobin-expressing transformed plants are employed, to corresponding plants, and to their use.

Abstract: A method and a device for image producing measurement of fluorescent light, according to which a sample containing fluorophores of different species is irradiated with excitation light of at least one excitation channel defined by its spectral properties. The fluorescent light emitted by the sample is received by at least one detection channel defined by its spectral detection characteristic, and is converted into a digital signal, which is stored for further processing The properties of a number of measuring channels, respectively defined as specific combinations consisting of an excitation channel and a detection channel, are automatically set before conducting the measurement according to the result of a mathematical optimization process, which takes into account the fluorescence characteristics of at least some of the fluorophores presumed by the user to be in the sampler.

Abstract: A 9-cyano-substituted perylene-3,4-dicarboxylic monoimide I where the variables are defined as follows: X is a chemical bond; optionally substituted C1-C30-alkylene, C5-C8-cycloalkylene, arylene, hetarylene, C1l-C20-alkylarylene, C1-C20-alkylhetarylene, aryl- or hetaryl-C1-C20-alkylene; Y is a functional group Y? or a polymerizable group P; or X—Y together is an R radical; Y? is amino, hydroxyl, —COOH, —SO3H, chlorine or bromine; P is a radical II A, B are each independently hydrogen, C1-C6-alkyl or phenyl, or are together a cyclopentene or cyclohexene ring which contains the double bond to which A and B are bonded; Q is a chemical bond; an —O—, —NR2—, —S—, —OCO—, —OCOO—, —OCONR3—, —NR3CO—, —NR3COO—, —NR3CONR4—, —CO—, —COO—, —CONR3—, —SO2—O—, —SO2NR3—, —O-SO2— or —NR3SO2— moiety; n is 0, 1, 2 or 3; R is hydrogen; optionally substituted C1-C30-alkyl, C5-C8-cycloalkyl, aryl or hetaryl.

Abstract: Rylene dyes of the general formula I where the variables are defined as follows: R is hydrogen; optionally substituted C1-C30-alkyl, C5-C8-cycloalkyl, aryl or hetaryl; R? is bromine; cyano; —NR32; optionally substituted aryloxy, arylthio, hetaryloxy or hetarylthio; optionally substituted C3-C18-alk-1-ynyl; X, Y are both hydrogen or together are a radical of the formula Ia n is 2, 3, 4 or additionally 1 when X and Y are a radical of the formula Ia; n? is from 1 to 4; m is from 0 to 6.

Abstract: A process for preparing aqueous primary dispersions comprising at least one hydrophobic polyurethane obtainable in miniemulsion by reacting (a) at least one polyisocyanate and (b) at least one compound containing at least one isocyanate-reactive group in the presence of a catalyst.

Abstract: The invention relates to a method for modifying the storage reserve content in plants, where leghemoglobin- and/or hemoglobin-expressing transformed plants are employed, to corresponding plants, and to their use.

Abstract: Hybrid dispersions comprising polyadducts and free-radical addition polymers, obtainable by first emulsifying the constituent monomers of said polyadducts and polymers in water and then conducting the polyaddition to prepare the polyadducts and the free-radical addition polymerization to prepare the polymers, the respective monomers being emulsified in water before 40% of the monomers of which the polyadducts are composed have reacted to form such polyadducts.

Abstract: A process for preparing a supported catalyst comprises the steps of (1) preparation of a copolymer having comonomer units which comprise leaving groups; (2) polymer-analogous reaction with a substituted or unsubstituted cyclopentadienyl compound, and (3) reaction of the copolymer of (2) with a mono-Cp-metallocene compound.

Abstract: In order to investigate the reactants involved in a reaction between a gas and a solid by means of X-ray absorption spectroscopy an apparatus is provided which comprises, within a measuring chamber (2), a sample holder (23) for holding a sample (24) of the solid, means for forming an atmosphere of the gas in the measuring chamber under selectable pressure, a window (20) for the entry of X-rays for the irradiation of the sample (24) and a collector arrangement (21, 22) arranged spaced from the sample holder (23), in order to collect in the measuring chamber (2) electrons released by X-ray absorption. The collector arrangement comprises two collector electrodes (21 and 22) which are arranged mutually spaced from one another in sequence lengthwise along the X-ray path between the window (20) and the sample holder (23).

Abstract: In a process for detecting target patterns in a texture with which a system state can be represented as a distribution of points in an n-dimensional space, anisotropic scaling factors a.sub.ji are determined which are characteristic of the relationship between the projection of the point density onto coordinate j and the distance to examined point P.sub.i. A target is detected if the distribution of scaling factors deviates from predetermined comparison distributions of systems without target patterns.

Abstract: The invention relates to an antidote for hirudin and synthetic thrombin inhibitors; the antidote contains a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents. The present invention also relates to the application of a compound that splits prothrombin into meizothrombin, a prothrombin intermediate, or a pharmacologically acceptable salt thereof or a mixture of these compounds, together with conventional vehicles and/or diluents as an antidote for hirudin and synthetic thrombin inhibitors or for the preparation of an antidote for hirudin and synthetic thrombin inhibitors.

Abstract: The present invention provides a process for determining the content of hirudin or of a synthetic thrombin inhibitor in the blood. A prothrombin intermediate, or a compound that splits prothrombin into meizothrombin, or a mixture thereof, is added to a blood sample and a measurement is taken of the time that elapses between the addition of the reagent to the sample and the beginning of coagulation. Comparison is then made, where necessary, with a standard calibration curve.

Abstract: A circuit arrangement is described for preventing a reaction of a coil on an external high-frequency field of predetermined frequency containing the coil due to a current induced by the field in the coil for a multiple-coil probe of a nuclear magnetic resonance apparatus wherein the coil is coupled via a high-frequency line of predetermined characteristic impedance to a switching element and a circuit unit cooperating with the coil. The electrical length of the high-frequency line between the coil and the switching element is so dimensioned that any undesired reaction of an inactive coil on the other coil(s) is eliminated.

Abstract: A linear adjusting device, especially for cryogenic temperatures and under vacuum conditions, having an adjusting body being adjustable on a carrier body along a linear adjusting path and supported by more than one bending springs placed between said carrier body and adjusting body and bent to have a U-like shape, the U-legs of each of the U-shaped bending springs extending longitudinally along the adjusting path, and at their free ends, one of the legs of each bending spring is fixed to said carrier body and the other leg to said adjusting body, said bending springs being arranged in at least two groups of bending springs consisting of at least two bending springs spaced apart by a given distance along said adjusting path, the bending springs of at least one of said groups of bending springs are arranged at oblique angles to the bending springs of another group of bending springs, when seen in a cross section perpendicular to said adjusting path (FIG. 1).

Abstract: A sealing assembly for oppositely disposed flanges having a sealing frame interposed therebetween, is proposed. The sealing frame has oppositely disposed grooves into each of which are affixed metal sealing elements and the oppositely disposed flanges have grooves into which are positioned O-rings that engage the metal sealing elements in said sealing frame. Further, an annular channel is disposed in each of the flanges whereby a vacuum may be established between the O-rings.

Abstract: The new enzyme, seminal plasma ribonuclease, has a content of 1 mole of cysteine per mole, a K.sub.M of 0.42 mM against poly-r-U, a K.sub.M of 0.51 mM against poly-r(A-U) transcript, and is inactive against native RNA. It is obtained either by placing dialyzed seminal plasma on an anion exchanger and then on a cation exchanger and purifying the fraction not adsorbed on the cation exchanger by affinity chromatography, after a gel chromatography step if desired, or by subjecting it directly to affinity chromatography, a support material being used for the affinity chromatography which bears native RNA or a non-hydrolyzable analog of the enzyme substrate.

Abstract: Crystalline lithium nitride of increased conductivity having a hydrogen content of 0.2 to about 8 mole percent, a sodium, potassium and calcium content each of less than 10.sup.-2 weight percent and a silicon and iron content each between 10.sup.-2 to 10.sup.-3 weight percent, the metallic lithium from which said crystalline lithium was prepared having been of at least 99.9 weight percent purity.

Abstract: For the radioimmunological determination of procollagen (type III) and procollagen peptide (type III) a certain amount of radioactively tagged procollagen (type III) or procollagen peptide (type III) and a highly specific anti-procollagen (type III) serum or anti-procollagen peptide (type III) serum are brought to reaction together with a sample of an unknown content of procollagen (type III) or procollagen peptide (type III), the formed antigen-antibody complex is separated, desirably by the addition of a second antibody against the highly specific antiserum, and the radioactivity of the complex or of the supernatant liquid is measured. Highly purified procollagen peptide (type III) suitable for this purpose is obtained by the degradation of tissue or body fluids with collagenase and purification by immune adsorption and chromatography.