Abstract: A particle testing apparatus, being configured for investigating particles in a fluid medium, includes a waveguide device having a hollow optical waveguide with an input end and an output end, an irradiation device including a laser source being arranged for optically trapping at least one particle at the input end of the optical waveguide and propelling the particle through the optical waveguide toward the output end thereof, and a measuring device being arranged for sensing the at least one particle in the optical waveguide, wherein the measuring device is arranged for measuring an optical transmission of the optical waveguide. Furthermore, a particle testing apparatus is described.

Abstract: A method for training a mathematical model which describes a light propagation in a reflection microscopy includes radiating a light distribution I0 into an excitation path of a microscope, modulating the light distribution I0 to form a light distribution IA in the excitation path via an optical modulator, reflecting the light distribution IA at a location of a sample in a detection path of the microscope, modulating the light distribution IA to form a light distribution ID in the detection path via a further optical modulator, recording a reflected light distribution ID, repeating the above steps n-fold to generate an n-fold 3-tuple (MA, MD; ID), transferring the n-fold 3-tuple (MA, MD; ID) to a computer to implement a mathematical model F for a light propagation in reflection microscopy, and ascertaining the mathematical model F which describes the light propagation in reflection microscopy based on the n-fold 3-tuple (MA, MD; ID).

Abstract: An apparatus for determining an arrhythmia of a living heart comprises a signal evaluation device receiving a signal representing a present electric activity of the heart, and determining a frequency spectrum of the signal. The apparatus further comprises a pulse generator generating a sequence of electric pulses to be applied to the heart at a pulse repetition frequency that depends on the frequency spectrum and decreases by at least 20% over the sequence.

Abstract: In order to map the surface of a macromolecule, at least one fluorescent probe is introduced into a medium in which the macromolecule is embedded or will be embedded. Then, a plurality of spatial positions of the at least one fluorescent probe with regard to the macromolecule are determined via localization of the at least one singularized fluorescent probe with a simple standard deviation of no more than 2 nm. For this purpose, fluorescence light photons emitted by the singularized fluorescent probe are recorded. In addition, a bounding surface bounding the determined spatial positions with regard to the macromolecule is determined; and a three-dimensional map of at least a part of the surface of the macromolecule is generated from the bounding surface.

Abstract: In one aspect the application relates to a computing system for providing data for modelling a human brain comprises a database including a plurality of datasets (or allow access to a plurality of datasets), each dataset including at least a dynamical model of the brain including at least one node and a neurodataset of a neuroimaging modality input. The at least one node include a representation of a local dynamic model and a parameter set of the local dynamic model.

Abstract: An avalanche photodiode array for detecting electromagnetic radiation comprises: a semiconductor substrate (100) having a first main surface (101) and a second main surface (102), which are opposite one another, a plurality of n-doped anode regions (1) formed at the first main surface (101) and separated from one another by pixel isolation regions (7), a p-doped cathode region (3) arranged at the second main surface (102) opposite the anode regions, a drift region (4) between the plurality of anode regions (1) and the cathode region (3), and a p-doped multiplication layer (2) arranged below the plurality of anode regions (1) and below the pixel isolation regions (7), and is characterized by an n-doped field reduction layer (9) arranged below the plurality of anode regions (1) and the pixel isolation regions (7) and above the multiplication layer (2).

Abstract: The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2 and that have been selected for potent cross-reaction and cross-neutralization between the original Wuhan strain and the Alpha, Beta, Gamma, Delta, and Mu variants of concern.

Abstract: A broadband light source device for creating broadband light pulses includes a hollow-core fiber and a pump laser source device. The hollow-core fiber is configured to create the broadband light pulses by an optical non-linear broadening of pump laser pulses. The hollow-core fiber includes a filling gas, an axial hollow light guiding fiber core configured to support core modes of a guided light field, and an inner fiber structure surrounding the fiber core and configured to support transverse wall modes of the guided light field. The pump laser source device is configured to create and provide the pump laser pulses at an input side of the hollow-core fiber. The transverse wall modes include a fundamental transverse wall mode and second and higher order transverse wall modes.

Abstract: Sulfonated 2(7)-aminoacridone and 1-aminopyrene dyes and their use as fluorescent tags, in particular for carbohydrate analysis The invention relates to fluorescent dyes with multiple negatively charged groups in their ionized form which are aminoacridone sulfonamides or 1-aminopyrenes having of one of the following general formulae A-D: Formula (A), Formula (B), Formula (C), Formula (D), wherein the ionizable groups X are typically selected from the following: SH, COOH, SO3H, OSO3H, OP(O)(OH)2, OP(O)(OH)Ra, P(O)(OH)2, P(O)(OH)Ra, where Ra?C1-C4alkyl or substituted C1-C4alkyl. The invention further relates to the use of these dyes as fluorescent tags, in particular for reducing sugars and glycans.

Abstract: A magnetic memory device includes a conductive line that extends in a first direction, and a magnetic track line that extends in the first direction on a top surface of the conductive line. The conductive line may include a first region having a first width in a second direction, and a second region having a second width in the second direction. The first direction and the second direction are parallel to the top surface of the conductive line and are perpendicular to each other. The second width may be greater than the first width. The magnetic track line includes first domains arranged in the first direction on the first region of the conductive line, and second domains arranged in the first direction on the second region of the conductive line. A size of each of the second domains may be less than a size of each of the first domains.

Abstract: The present disclosure relates to an electronic tag for behavioural monitoring of animals, the electronic tag comprising a microprocessor and at least one sensor. The electronic tag is configured to obtain, via the at least one sensor, movement data of an animal to which the electronic tag is attached and to determine, based on the obtained movement data, a behaviour of the animal. The disclosure further encompasses a corresponding method as well as an ear tag.

Abstract: The present invention refers to a process for converting a feed gas stream comprising carbon monoxide and hydrogen as major components (synthesis gas) into higher (C3+) alcohols making use of a catalyst combination of a Fischer-Tropsch catalyst and an olefin hydroformylation catalyst. In a second aspect, the invention relates to a Fischer-Tropsch catalyst suitable to be applied in said process.

Abstract: A method for preparing a laser marking system to create a colored laser mark on a specimen by providing a laser marking system and a specimen comprising a surface layer, where the laser marking system has a preset number of laser parameters, and performing an exploration of a first gamut specified by the laser marking system and the specimen. The method further generally comprises creating a design space with a preset number of design points; performing a marking of a sample on the specimen for each design point; measuring the sample using at least one detection device and determining a performance point for each design point; evaluating the performance space with regard to preset performance criteria using an evaluation device; generating an offspring design space with offspring design points; and creating a first gamut using a subset of performance points.

Abstract: Disclosed are photoactivable fluorescent dye compounds of formula I: wherein: n=0, 1, 2, 3; X is selected from O, CRR?, SiRR? and GeRR?, where R and R? represent independently alkyl, cycloalkyl, alkenyl, alkynyl or aryl; Y is H, SO3H or SO3M, with M being a positively charged counterion, in particular selected from NH4+ and cations of organic ammonium compounds; R1 is H, CO2H, C(O)NH-linker-CO2H, C(O)O-ligand, C(O)NH-ligand or C(O)NH-linker-ligand; R2 may represent H, unsubstituted or substituted alkyl (including cycloalkyl); R3 and R4 may represent independently H or F; R5 is H, Me, CO2H, C(O)NH-linker-CO2H, C(O)O-ligand, C(O)NH-ligand or C(O)NH-linker-ligand; wherein the ligand moiety at each occurrence represents a reactive group or tag, capable to form a covalent or non-covalent bond or molecular complex with a target chemical entity or substance. Methods of using the compounds in imaging of fixed and living cells are also disclosed.

Abstract: The present invention relates to improved methods for obtaining purified contrast agents that are suitable for magnetic resonance imaging. The contrast agents are prepared by a method such dynamic nuclear polarization (DNP), hydrogenative parahydrogen induced polarization (PHIP), or Signal Amplification By Reversible Exchange (SABRE). High degrees of purity are achieved by performing an evaporation step to separate a signal enhanced precursor or the contrast agent from a metal catalyst or a source of radicals.

Abstract: A method for optimizing parameters of a physical light propagation model. The method includes making available a physical model of a light propagation in an optical system, radiating an input-light distribution into an excitation path of the optical system using an illumination unit, passing the input light distribution through a scattering body, wherein the scattering body is placed in the excitation path of the optical system so that the input-light distribution is changed to a reflection-light distribution, recording the reflection-light distribution, transferring the recorded reflection-light distribution to the physical model, and calculating distortion parameters of the physical model based on the reflection-light distribution. The distortion parameters characterize the scattering body. The reflection-light distribution is at least partially reflected as fluorescence radiation by a fluorescence-capable body within the scattering body.

Abstract: An optical component comprising a planar metasurface arranged on a surface of a first substrate and a top layer arranged in a height direction Z above the metasurface, wherein the metasurface comprises a plurality of scattering structures, wherein a dielectric material is deposited on a subset of the plurality of scattering structures, wherein an active media is sandwiched between the metasurface and the top layer, wherein an incident electromagnetic radiation is transmitted or reflected by the optical component, wherein a phase profile modulation is induced on the incident electromagnetic radiation during the reflection or transmission.

Abstract: The invention relates to a system for displaying information, comprising: an emission device arranged to emit light so as to display information to a user, the emission device being adapted to emit the light in a pulsed manner so that the intensity of the light varies between a high value and a low value, a selective viewing device comprising a panel, the panel being adapted so that the user can view the light which is emitted by the emission device through that panel so as to visually perceive the information being displayed, the panel having a variable transparency which can be varied between a state of high transparency and a state of low transparency, the system being adapted to synchronize the emission device and the selective viewing device so that the states of the emission device emitting light at a high-intensity value and the states of the panel of the selective viewing device of high transparency overlap in time, the system further comprising a photoelectric conversion means arranged to convert amb

Abstract: A method of creating an optical atom trap comprises the steps of providing an incoherent light field with a light source apparatus, by creating a pulsed laser light beam of laser pulses with a repetition rate equal to or above 100 kHz and a relative spectral width of 10?4 to 10?2, coupling the pulsed laser light beam to an input end of a multimode waveguide device and guiding the pulsed laser light beam by total internal reflection to an output end of the multimode waveguide device, wherein the incoherent light field is provided at the output end, and creating the optical atom trap for trapping atoms in an atom trap chamber device by coupling the incoherent light field to the atom trap chamber device, wherein the optical atom trap has a trap frequency and the atoms have multiple resonance frequencies, and the laser pulses for providing the incoherent light field are created such that the repetition rate is above the trap frequency and the spectral width is below a spectral range between the resonance frequenc

Abstract: The present invention relates to a method for transferring a two-spin order of a molecule (e.g. parahydrogen) into a hyperpolarization of at least one heteronucleus, the method comprising the steps of: providing a molecule (e.g. parahydrogen pH2) comprising two protons and at least one heteronucleus (S3, S4), the protons having nuclear spins being coupled to a nuclear spin of the at least one heteronucleus; exposing the protons and the at least one heteronucleus to an e.g.