Patents Assigned to Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
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Publication number: 20240159733Abstract: A measurement device 100 comprises neuronal, in particular retinal, tissue 110 grown from stem cells, the neuronal tissue 110 having a three-dimensional shape neuronal cells that change an electric potential in cells of the neuronal tissue 110 in response to influences that act on the neuronal cells, and a read-out device 130 that is configured to measure neuronal responses of the neuronal tissue 110 via changes in the electric potential generated by the neuronal cells.Type: ApplicationFiled: December 22, 2023Publication date: May 16, 2024Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventors: Friedhelm SERWANE, Joachim SPATZ
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Patent number: 11980932Abstract: The invention relates to a method of producing elongate metal strands or fibres with a crucible, the method comprising the steps of; directing molten metal through a nozzle having a nozzle direction in a deposition direction at a regulated pressure difference between the inside and the outside of the crucible; depositing said molten metal from said nozzle on a rotating planar surface having an axis of rotation; entraining said molten metal in one plane via said rotating planar surface to form elongate metal strands, wherein said rotating surface is aligned at an alignment angle, to the deposition direction during the entraining of the molten metal; cooling said elongate metal strands to form solidified metal strands; and guiding said metal strands to collecting means to collect the solidified metal strands formed on the rotating planar surface.Type: GrantFiled: May 11, 2020Date of Patent: May 14, 2024Assignee: Max-Planck-Gesellschaft, Zur Förderung Der Wissenschaften E.V.Inventor: Joachim P. Spatz
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Publication number: 20240138401Abstract: The present invention relates to a storage device (1) for storing cryogenic samples (2), comprising at least one sample holder (3), the sample holder being configured to hold at least one cryogenic sample (2). According to the present invention, the storage device (1) further comprises an elongated sample transport unit (4) configured to releasably hold the at least one sample holder (3) and to be inserted into an internal space (50) of a cryogenic storage dewar (5) through an opening (51) of the cryogenic storage dewar to completely submerge the sample transport unit into a cryogenic liquid (6) residing in the internal space, wherein the sample transport unit is further configured to move said at least one sample holder along a predefined path from a storage position into a removal position, from which the at least one sample holder can be removed from the internal space of the cryogenic storage dewar.Type: ApplicationFiled: March 2, 2022Publication date: May 2, 2024Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V.Inventors: Stefan RAUNSER, Sebastian TACKE, Joachim BESLER
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Patent number: 11965946Abstract: A method of processing magnetic resonance data of a sample under investigation includes the steps of provision of the MR data being collected with an MRI scanner apparatus, and machine learning based data analysis of the MR data by supplying the MR data to an artificial neural network being trained with predetermined training data, wherein at least one image parameter of the sample and additionally at least one uncertainty quantification measure representing a prediction error of the at least one image parameter are provided by output elements of the neural network. Furthermore, a magnetic resonance imaging (MRI) scanner apparatus being adapted for employing the method of processing MR data is described.Type: GrantFiled: December 4, 2020Date of Patent: April 23, 2024Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.Inventors: Moritz Zaiss, Felix Glang, Sergey Prokudin, Klaus Scheffler
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Patent number: 11959121Abstract: The invention relates to the detection of the cofactor reduced nicotinamide adenine dinucleotide phosphate (NADPH). Provided is a sensor molecule for the resonance energy transfer (RET)-based detection of NADPH, the sensor comprising a segment A connected via a linker to a segment B, wherein each of segment A and segment B comprises a member of a RET pair comprising a donor moiety and an acceptor moiety, further characterized in that (i) segment A comprises a binding protein (BP) for NADPH, the BP being dihydrofolate reductase (DHFR; EC 1.5.1.3) or a functional homolog, fragment, derivative or variant thereof, showing the desired NADPH binding properties, and wherein the BP comprises a heterologous protein domain inserted at or replacing at least part of the region corresponding to positions (20) to (27) of E.Type: GrantFiled: May 29, 2018Date of Patent: April 16, 2024Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Qiuliyang Yu, Kai Peter Johnsson
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Patent number: 11958796Abstract: The present invention relates to a compound having the general formula (1) wherein in the general formula (1) the residues R1 to R8 and Ar are the same or different and are independently from each other selected from the group consisting of hydrogen, unsubstituted hydrocarbon groups, substituted hydrocarbon groups and inorganic groups, wherein at least one of the residues R1 to R8 and Ar is a hydrophilic group, such as for instance a group comprising one or more polyethylene groups.Type: GrantFiled: September 30, 2019Date of Patent: April 16, 2024Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Qiang Chen, Akimitsu Narita, Klaus Müllen, Sapun Parekh, Mischa Bonn, Xiaomin Liu
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Patent number: 11939583Abstract: The present invention relates to autotrophic microorganisms with altered photorespiration and improved CO2 fixation as well as a method of producing said autotrophic microorganisms. Particularly, the autotrophic microorganisms show an improved growth rate, productivity and energy conversion efficiency.Type: GrantFiled: April 15, 2019Date of Patent: March 26, 2024Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Lennart Schada Von Borzyskowski, Tobias Jürgen Erb, Jan Zarzycki
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Publication number: 20240065988Abstract: A method of treating a psychiatric disorder in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an N-methyl-D-aspartate (NMDA) receptor antagonist and a therapeutically effective amount of a KCNQ channel activator. Pharmaceutical compositions comprising an NMDA receptor antagonist and a KCNQ channel activator are also disclosed.Type: ApplicationFiled: October 5, 2023Publication date: February 29, 2024Applicants: Yeda Research and Development Co. Ltd., Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Alon CHEN, Juan Pablo LOPEZ
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Publication number: 20240053510Abstract: An optical component (1) comprising a planar metasurface (2) arranged on a surface of a first substrate (3) and a top layer (4) arranged in a height direction Z above the metasurface (2), wherein the metasurface (2) comprises an array (9) of scattering structures (5, 5a, 5b), wherein the array (9) is a repeating pattern of unit cells (7), wherein a unit cell (7) comprises at least two different scattering structures wherein the optical properties of the metasurface (2) are controllable by a control signal, wherein first scattering structures (5, 5a) are at least partially contacting a layer of a first substance (6a) having a first refractive index and second scattering structures (5, 5b) are at least partially contacting a layer of a second substance (6b), which differs from the first substance (6a) and which provides a variable refractive index depending on the control signal.Type: ApplicationFiled: November 26, 2021Publication date: February 15, 2024Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Jianxiong LI, Robin KAISSNER, Laura Na LIU
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Publication number: 20240044729Abstract: A tactile sensing system having a sensor component which comprises a plurality of layers stacked along a normal axis Z and a detection unit electrically connected to the sensor component, wherein the sensor component comprises a first layer, designed as a piezoresistive layer, a third layer, designed as a conductive layer which is electrically connected to the detection unit, and a second layer, designed as a spacing layer between the first layer and the third layer, wherein the first layer comprises a plurality of electrodes In electrically connected to the detection unit, wherein at least one contact force along the normal axis Z on the sensor component is detectable by the detection unit due to a change of a current distribution between the first layer and the third layer, wherein at least one lateral strain on the sensor component is detectable by the detection unit due to a change of the resistance distribution change in the piezoresistive first layer.Type: ApplicationFiled: December 15, 2021Publication date: February 8, 2024Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Hyosang LEE, Katherine J. KUCHENBECKER
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Publication number: 20240018267Abstract: The present invention relates to novel anti-IgG nanobodies, particularly nanobodies directed against rabbit or mouse IgG. Further, the invention relates to the use of said nanobodies and methods for producing them.Type: ApplicationFiled: October 11, 2018Publication date: January 18, 2024Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Dirk GÖRLICH, Tino PLEINER
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Publication number: 20240002444Abstract: The invention relates to newly characterized light-inducible inward proton pumps and their use in medicine, their utility as optogenetic tools, nucleic acid constructs encoding same, expression vectors carrying the nucleic acid construct, cells comprising said nucleic acid construct or expression vector, and their respective uses.Type: ApplicationFiled: August 29, 2023Publication date: January 4, 2024Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Ernst Bamberg, Valentin Gordeliy, Thomas Mager, Vitaly Shevchenko
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Patent number: 11834463Abstract: High affinity macrocyclic FKB51-Inhibitors (HAM-FKB51-Inhibitors), which enable the selective inhibition of FK506-binding proteins (FKBPs). The molecules are useful for the treatment of psychiatric disorders, metabolic disorders, pain diseases, and cancers.Type: GrantFiled: August 27, 2021Date of Patent: December 5, 2023Assignees: Technische Universität Darmstadt, Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.Inventors: Felix Hausch, Andreas Voll, Michael Bauder
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Patent number: 11813596Abstract: The present invention relates to novel poly(heptazine imides), a photocatalytic system comprising such poly(heptazine imides) and a sulfur source as well as the application thereof in photocatalytic reactions.Type: GrantFiled: October 27, 2017Date of Patent: November 14, 2023Assignee: MAX PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Markus Antonietti, Oleksandr Savatieiev, Bogdan Kurpil, Dariya Dontsova
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Patent number: 11803046Abstract: An apparatus and method for simultaneous imaging and execution of contact-free directed hydrodynamic flow in a specimen. The apparatus includes a laser adapted to dynamically heat the specimen, a microscope with an objective adapted to image at least a part of the specimen and to guide a light beam of the laser into and/or onto the specimen to heat at least one specified location of the specimen, means for manipulating the specified location, and a sample chamber for the specimen that is accessible for imaging radiation and the light beam to allow simultaneous imaging and manipulation of the sample via the objective.Type: GrantFiled: November 23, 2018Date of Patent: October 31, 2023Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften E.V.Inventors: Moritz Kreysing, Anatol Fritsch, Matthaeus Mittasch
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Patent number: 11799745Abstract: Method and system for capturing summaries of data flows in an electronic, packet-switched communication network, the method comprising: receiving, from a node of the communication network, packet flow data; obtaining a subset of the packet flow parameters (IP src, IP dst, port src, port dst, protocol), based on the packet flow data; obtaining a packet flow statistic, based on the packet flow data; updating a collection of stored packet flow summaries, based on a subset of the packet flow parameters and the packet flow statistic. The stored packet flow summaries are arranged as nodes in a tree data structure.Type: GrantFiled: June 5, 2018Date of Patent: October 24, 2023Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Anja Feldmann, Said Jawad Saidi, Georgios Smaragdakis, Damien Foucard
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Patent number: 11795486Abstract: The present invention relates to an enzyme-catalyzed process for producing GDP-fucose from low-cost substrates guanosine and L-fucose or guanosine and D-Mannose in a single reaction mixture. Said process can be operated (semi)continuously or in batch mode. Further, said process can be adapted to produce fucosylated molecules and biomolecules including glycans, such as human milk oligosaccharides, proteins, peptides, glycoproteins or glycopeptides.Type: GrantFiled: March 31, 2020Date of Patent: October 24, 2023Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventors: Reza Mahour, Thomas F. T. Rexer
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Patent number: 11787702Abstract: The present invention relates to a material of the formula SnTiO3 having a crystal structure comprised of layers, wherein the layers comprise Sn(II) ions, Ti(IV) ions and edge-sharing O6-octahedra, the edge-sharing O6-octahedra form a sub-layer, the Ti(IV) ions are located within ? of the edge-sharing O6-octahedra, thus forming edge-sharing TiO6-octahedra, the edge-sharing TiO6-octahedra form a honeycomb structure within the sub-layer, the honeycomb structure comprising hexagons with Ti(IV)-vacancies within the hexagons, the Sn(II) ions are located above and below the Ti(IV)-vacancies with respect to the sub-layer, the Ti(IV) ions are optionally substituted with M, M is one or more elements selected from Group 4 and Group 14 elements, and the crystal structure satisfies at least one of the following features (i) and (ii): (i) the Sn(II) ions have a tetrahedral coordination sphere involving three O ions of the layer and the electron lone pair of the Sn(II) ions which is situated at an apical position relativeType: GrantFiled: May 2, 2019Date of Patent: October 17, 2023Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventors: Leo Peter Otto Diehl, Bettina Valeska Lotsch, Florian Pielnhofer
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Patent number: 11782995Abstract: A computer-implemented method for determining a relevance or rating score of a particular user in an electronic social network includes obtaining a digital representation of a local connection structure of the particular user in the network in a computer-readable non-volatile memory; determining a numerical value characteristic of the particular user's relevance; and outputting the numerical value. The numerical value is determined based on the connection structure of the particular user, and on degrees of all sets of users in the social network reachable from the particular user using at most k connections, where k is a fixed preset positive integer number, and based on a degree determined for each enumerated set, and where the degree of a set is determined as a number of connections connecting users inside the set to users outside.Type: GrantFiled: February 13, 2020Date of Patent: October 10, 2023Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.Inventor: Glenn Lawyer
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Publication number: 20230310777Abstract: An apparatus comprises a centrifugal fan having an inlet and outlet, the fan receives ventilation air at the inlet and provides the ventilation air at an adjustable pressure at the outlet, a first respiration line with a first end connected to the inlet and a second end for receiving inhalation air, a second respiration line having a first end connected to the outlet and a second end for coupling a filter and a ventilation mask, the second respiration line having a sensor, to measure a flow parameter in the second respiration line, and a device for controlling the fan according to an output signal of the sensor, the fan and second respiration lines forming a continuous bidirectional flow path, the adjustable ventilation pressure at the outlet comprises an inhalation or an exhalation pressure less than or equal to the inhalation pressure, and the second respiration line has an air filter.Type: ApplicationFiled: July 19, 2021Publication date: October 5, 2023Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.Inventor: FRANK HELLEIS