Abstract: A multiple frequency comb source apparatus (100) for simultaneously creating a first laser pulse sequence representing a first frequency comb (1) and at least one further laser pulse sequence representing at least one further frequency comb (2), wherein at least two of the first and at least one further pulse sequences have different repetition frequencies, comprises a laser resonator device (10) comprising multiple resonator mirrors including first end mirrors EM1,OC1 providing a first laser resonator (11), a laser gain medium (21, 22) being arranged in the laser resonator device (10), and a pump device (30) being arranged for pumping the laser gain medium (21), wherein the laser resonator device (10) is configured for creating the first and at least one further laser pulse sequences by pumping and passively mode-locking the laser gain medium (21), the resonator mirrors of the laser resonator device (10) include further end mirrors EM2, OC2 providing at least one further laser resonator (12), the first laser

Abstract: The invention relates to a DEPFET comprising: a semiconductor substrate (100) of a first conduction type, which has a first main surface (101) and a second main surface (102), which are opposite one another; a source terminal region (1s) of a second conduction type on the first main surface (101); a drain terminal region (1d) of a second conduction type; a channel region (10), which is arranged between the source terminal region (1s) and the drain terminal region (1d); a gate electrode (11), which is separated from the channel region (10) by a gate insulator (6); a rear activation region (104) of a second conduction type, which is formed on the second main surface (102); and a substrate doping increase region (2) of a first conduction type, which is formed at least under the source terminal region (1s) and under the channel region (10), the substrate doping increase region (2) having a signal charge control region (20) of the first conduction type below the gate electrode (11), in which signal charge control

Abstract: The invention relates to a method for processing a measuring probe which is intended for detecting surface properties or for modifying surface structures in the sub-micrometer range. The method comprises at least the following steps. First, providing a precursor containing molecules polymerizable by light or electron beams and a measuring probe comprising at least one carrier with a tip having an upper end opposite the carrier and a light or electron source for emitting light or electron beams with a wavelength and intensity, which fulfil an energy input at least required for polymerization of the precursor and means for variable positioning of the light or electron source and a control file and an electronic data processing system, wherein the control file describes at least a part of the surface of the measuring probe and serves to control a change in position of the light or electron source.

Abstract: An optical resonator device (100) with crossed cavities, in particular being configured for optically trapping atoms, comprises a first linear optical resonator (10) extending between first resonator mirrors (11A, 11B) along a first resonator light path (12) and supporting a first resonator mode, a second linear optical resonator (20) extending between second resonator mirrors (21A, 21B) along a second resonator light path (22) and supporting a second resonator mode, wherein the first and second resonator light paths (12, 22) span a main resonator plane, and a carrier device carrying the first and second resonator mirrors (11A, 11B, 21A, 21B), wherein the first and second resonator mirrors (11, 21) are arranged such that the first and second resonator modes cross each other for providing an optical lattice trap (1) in the main resonator plane.

Abstract: A display engine for a laser-scanning head-mounted display uses one or more photonic integrated circuit chips to generate multiple intensity-modulated laser beams. These beams are scanned across the field of view with an off-chip scanning mirror, one or more actuators integrated with the chip, or a combination of an off-chip scanning mirror and integrated actuators. The actuators move output couplers (e.g., waveguide emitters with waveguide edge couplers at the ends) that emit light from the photonic chip, forming multiple independent optical beams. Movement of the actuator translates the beams such that each of the beams addresses a portion of the field of view of a displayed image. An optical combiner and relay optics expands these beams and directs them toward the eye of the person wearing the display.

Abstract: The present invention relates to System for analysing tissue, comprising: a dissociation means for at least partially dissociating a tissue sample so as to obtain individual cells, a microfluidic flow device through which a fluid comprising the dissociated cells can be made to flow, and an evaluation device arranged to evaluate the cells as they are being transported through the microfluidic flow device, the system preferably being arranged for a label free analysis of tissue.

Abstract: A first aspect of the invention relates to a non-covalently-HaloTag-binding compound characterized by the general formula D-L-T (I), wherein D is or comprises a functional moiety Z, particularly a fluorescent dye, or D is a linkable moiety (i.e. a moiety that can be coupled to other functional groups), L is a linear linker of 10-15 atoms in length, and T is a moiety selected from the group comprising methylamine, methylsulfonamide, acetamide, or their respective fluorinated analogues, azide, or hydroxyl. Another aspect of the invention relates to a HaloTag variant wherein position D106 of the HaloTag7 sequence is exchanged for a proteinogenic amino acid different from D. The variant has a different binding specificity for HaloTag substrates compared to the non-variant Halotag polypeptide. Yet another aspect of the invention relates to kits comprising polypeptides or nucleic acids and the non-covalently-HaloTag-binding compound according to the invention.

Abstract: A method for photonic sampling of a test-waveform is provided. The method includes providing a sampling light pulse and generating a local oscillator by frequency multiplication of the sampling light pulse. The method further includes generating a signal wave by frequency mixing of the sampling light pulse and the test-waveform in a nonlinear optical element, wherein the frequency multiplication of the sampling light pulse and the frequency mixing of the sampling light pulse and the test-waveform are selected such that the local oscillator and the signal wave are at least partly spectrally overlapping. Moreover, the method includes detecting an interference signal of the local oscillator and the signal wave for various time delays of the sampling light pulse with respect to the test-waveform. A device for sampling a test-waveform is also disclosed.

Abstract: The invention relates to a DEPFET comprising: a semiconductor substrate (100) of a first conduction type, which has a first main surface (101) and a second main surface (102), which are opposite one another; a source terminal region (1s) of a second conduction type on the first main surface (101); a drain terminal region (1d) of a second conduction type; a channel region (10), which is arranged between the source terminal region (1s) and the drain terminal region (1d); a gate electrode (11), which is separated from the channel region (10) by a gate insulator (6); a rear activation region (104) of a second conduction type, which is formed on the second main surface (102); and a substrate doping increase region (2) of a first conduction type, which is formed at least under the source terminal region (1s) and under the channel region (10), the substrate doping increase region (2) having a signal charge control region (20) of the first conduction type below the gate electrode (11), in which signal charge control

Abstract: The present invention relates to the recombinant production of a protein of interest in a prokaryotic host cell or eukaryotic host cell wherein the protein of interest is obtained in a correctly folded and stable form. The protein of interest may be a difficult-to-make polypeptide for use as a vaccine or a pharmaceutical. The protein of interest is co-expressed with or fused to a ‘fold promoter’, which may be a VHH antibody recognizing the said protein.

Abstract: The present invention relates to the provision of new means and methods for enzymatic peptide-peptide ligation. In particular, the present invention provides a novel family of transpeptidase enzymes, herein subsequently also referred to as Adriase (Archaeal Peptide Recombinase), transpeptidase or polypeptide recombinase. The members of the Adriase family, which are characterized by an N-terminal DUF2121 domain with an N-terminal serine or threonine residue were surprisingly found to recombine and ligate substrate peptides in a sequence specific manner via a short DUF2121 recognition motif. This way, compounds like proteins, synthetic compounds and/or whole cells may be linked specifically as long as they contain the motif or the parts thereof recognized by an Adriase enzyme. The ligation reaction described herein can be used to engineer novel molecules in a modular way, with broad applications in both research and pharmacology.

Abstract: A measurement device 100 comprises neuronal, in particular retinal, tissue 110 grown from stem cells, the neuronal tissue 110 having a three-dimensional shape neuronal cells that change an electric potential in cells of the neuronal tissue 110 in response to influences that act on the neuronal cells, and a read-out device 130 that is configured to measure neuronal responses of the neuronal tissue 110 via changes in the electric potential generated by the neuronal cells.

Abstract: The invention relates to a method of producing elongate metal strands or fibres with a crucible, the method comprising the steps of; directing molten metal through a nozzle having a nozzle direction in a deposition direction at a regulated pressure difference between the inside and the outside of the crucible; depositing said molten metal from said nozzle on a rotating planar surface having an axis of rotation; entraining said molten metal in one plane via said rotating planar surface to form elongate metal strands, wherein said rotating surface is aligned at an alignment angle, to the deposition direction during the entraining of the molten metal; cooling said elongate metal strands to form solidified metal strands; and guiding said metal strands to collecting means to collect the solidified metal strands formed on the rotating planar surface.

Abstract: The present invention relates to a storage device (1) for storing cryogenic samples (2), comprising at least one sample holder (3), the sample holder being configured to hold at least one cryogenic sample (2). According to the present invention, the storage device (1) further comprises an elongated sample transport unit (4) configured to releasably hold the at least one sample holder (3) and to be inserted into an internal space (50) of a cryogenic storage dewar (5) through an opening (51) of the cryogenic storage dewar to completely submerge the sample transport unit into a cryogenic liquid (6) residing in the internal space, wherein the sample transport unit is further configured to move said at least one sample holder along a predefined path from a storage position into a removal position, from which the at least one sample holder can be removed from the internal space of the cryogenic storage dewar.

Abstract: A method of processing magnetic resonance data of a sample under investigation includes the steps of provision of the MR data being collected with an MRI scanner apparatus, and machine learning based data analysis of the MR data by supplying the MR data to an artificial neural network being trained with predetermined training data, wherein at least one image parameter of the sample and additionally at least one uncertainty quantification measure representing a prediction error of the at least one image parameter are provided by output elements of the neural network. Furthermore, a magnetic resonance imaging (MRI) scanner apparatus being adapted for employing the method of processing MR data is described.

Abstract: The present invention relates to a compound having the general formula (1) wherein in the general formula (1) the residues R1 to R8 and Ar are the same or different and are independently from each other selected from the group consisting of hydrogen, unsubstituted hydrocarbon groups, substituted hydrocarbon groups and inorganic groups, wherein at least one of the residues R1 to R8 and Ar is a hydrophilic group, such as for instance a group comprising one or more polyethylene groups.

Abstract: The invention relates to the detection of the cofactor reduced nicotinamide adenine dinucleotide phosphate (NADPH). Provided is a sensor molecule for the resonance energy transfer (RET)-based detection of NADPH, the sensor comprising a segment A connected via a linker to a segment B, wherein each of segment A and segment B comprises a member of a RET pair comprising a donor moiety and an acceptor moiety, further characterized in that (i) segment A comprises a binding protein (BP) for NADPH, the BP being dihydrofolate reductase (DHFR; EC 1.5.1.3) or a functional homolog, fragment, derivative or variant thereof, showing the desired NADPH binding properties, and wherein the BP comprises a heterologous protein domain inserted at or replacing at least part of the region corresponding to positions (20) to (27) of E.

Abstract: The present invention relates to autotrophic microorganisms with altered photorespiration and improved CO2 fixation as well as a method of producing said autotrophic microorganisms. Particularly, the autotrophic microorganisms show an improved growth rate, productivity and energy conversion efficiency.

Abstract: A method of treating a psychiatric disorder in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an N-methyl-D-aspartate (NMDA) receptor antagonist and a therapeutically effective amount of a KCNQ channel activator. Pharmaceutical compositions comprising an NMDA receptor antagonist and a KCNQ channel activator are also disclosed.

Abstract: An optical component (1) comprising a planar metasurface (2) arranged on a surface of a first substrate (3) and a top layer (4) arranged in a height direction Z above the metasurface (2), wherein the metasurface (2) comprises an array (9) of scattering structures (5, 5a, 5b), wherein the array (9) is a repeating pattern of unit cells (7), wherein a unit cell (7) comprises at least two different scattering structures wherein the optical properties of the metasurface (2) are controllable by a control signal, wherein first scattering structures (5, 5a) are at least partially contacting a layer of a first substance (6a) having a first refractive index and second scattering structures (5, 5b) are at least partially contacting a layer of a second substance (6b), which differs from the first substance (6a) and which provides a variable refractive index depending on the control signal.