Patents Assigned to Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
  • Patent number: 10969573
    Abstract: A spatio-temporally light modulated imaging system for confocal imaging an object includes a light modulating micro-mirror device, an imaging optic, and a camera device, wherein a carrier wheel device is provided for carrying multiple pairs of first and second dichroic beam splitters and multiple pairs of first and second emission filters, wherein the carrier wheel device is adjustable in multiple operational positions relative to the first and second optical axes, and wherein a casing is provided. Furthermore, a carrier wheel device for carrying optical members and a method for confocal imaging an object are disclosed.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: April 6, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Thomas M. Jovin, Anthony De Vries, Tobias Freund
  • Patent number: 10962459
    Abstract: For measuring rheological properties of a liquid sample, the sample is attached to two sample attachment surfaces opposing each other in a pulling direction. The sample attachment surfaces and the liquid sample attached thereto are arranged in a field of view of a light microscope and imaged onto an electronic camera by means of an objective lens of the light microscope. One of the two sample attachment surfaces is pulled away from the other one in the pulling direction, while a plurality of images of the sample attachment surfaces and the sample attached thereto are registered with the camera. For different distances of the two sample attachment surfaces, both a diameter of the liquid sample in a middle between the two sample attachment surfaces and the respective distances of the two sample attachment surfaces are determined from the images registered with the electronic camera during the step of pulling.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 30, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Oliver Kress, Marcin Makowski, Tanya Ostapenko
  • Patent number: 10962479
    Abstract: For spatial high resolution determining a position of a singularized molecule, which is excitable with excitation light for emission of luminescence light, in n spatial dimensions in a sample, the excitation light is directed onto the sample with an intensity distribution, which has a zero point and intensity increasing regions adjoining the zero point on both sides in each of the n spatial dimensions. The zero point is arranged at not more than n×3 different positions. The luminescence light emitted by the singularized molecule is separately registering for each of the different positions of the zero point. The position of the singularized molecule in the n spatial dimensions in the sample is deduced from intensities of the luminescence light separately registered for the not more than n×3 different positions of the zero point.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: March 30, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Francisco Balzarotti, Yvan Eilers, Klaus Gwosch, Stefan W. Hell
  • Publication number: 20210088516
    Abstract: The invention relates to a method of determining an association of a first plant with an arbuscular mycorrhizal fungus (AMF), said method comprising comparing the amount of a blumenol in an aerial part of said first plant to the amount of said blumenol in an aerial part of a second plant, wherein said second plant belongs to the same species as said first plant, and wherein an increased amount is indicative of increased association in said first plant as compared to said second plant, and a decreased amount is indicative of decreased association.
    Type: Application
    Filed: February 26, 2019
    Publication date: March 25, 2021
    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Ian T. BALDWIN, Rayko HALITSCHKE, Ming WANG, Dapeng LI, Martin SCHÅFER, Erica MCGALE, Sven HEILING
  • Patent number: 10955348
    Abstract: For high spatial resolution imaging a structure marked with luminescence markers, light that has an effect on the emission of luminescence light by the luminescence markers is directed onto a sample with an intensity distribution having a central zero point. Scan areas of the sample are scanned with the zero point. Luminescence light emitted out of a local area including the zero point is registered and assigned to the respective location of the zero point in the sample. Several copies of an object of interest are arranged in the scan areas and subjected to varying surrounding conditions. The individual scan areas are scanned with the respective zero point at least two times at two different stages of reactions to the varying surrounding conditions. Dimensions of the scan areas are limited such that they are not larger than 75% of a distance of intensity maxima delimiting the zero point.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: March 23, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Stefan W. Hell, Fabian Goettfert, Volker Westphal
  • Patent number: 10941081
    Abstract: A cohesive granular material comprises granules made of a stiff substance and having a grain size in the range from 55 ?m to 2.0 mm; an elastomeric substance connecting the granules, a Young's modulus of the elastomeric substance being at maximum 0.5 times a Young's modulus of the stiff substance; and voids between the granules, the voids being interconnected and providing a fluid permeability to the cohesive granular material.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: March 9, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Arnaud Hemmerle, Lucas Goehring, Matthias Schroeter, Stephan Herminghaus
  • Patent number: 10935674
    Abstract: A neutrino detector device (100) for detecting neutrinos comprises at least one target detector (10) including a target crystal (11) for creating phonons in response to an interaction of neutrinos to be detected with the target crystal (11) and a target temperature sensor (12) for sensing a temperature change in response to an absorption of phonons created in the target crystal (11), an inner veto detector (20) comprising at least one inner veto component (21) with an inner veto temperature sensor (23), wherein the at least one inner veto component (21) is adapted for supporting the at least one target detector (10) and for an anticoincidence based discrimination of alpha and beta background interaction events by creating phonons in response to the background interaction events and sensing a temperature change in response to an absorption of the phonons with the inner veto temperature sensor (23), and an outer veto detector (30) for accommodating the inner veto detector (20), wherein the outer veto detector (
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: March 2, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Raimund Strauss, Johannes Rothe, Dieter Hauff
  • Patent number: 10908089
    Abstract: For spatial high resolution determining a position of a singularized molecule, which is excitable with excitation light for emission of luminescence light, in a sample, the excitation light is provided with an intensity distribution comprising an intensity increasing region with a known strictly monotonic course of an intensity of the luminescence light over a distance of the singularized molecule to a model point of the intensity distribution. The model point is arranged at different preliminary positions such that the intensity increasing region extends over a preliminary local area of the sample including the singularized molecule. From intensity values including intensities of the luminescence light separately registered for the preliminary positions of the model point, a further local area is determined which includes the singularized molecule and which is smaller than the preliminary local area. These steps are repeated using the last further local area as the next preliminary local area.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: February 2, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Francisco Balzarotti, Yvan Eilers, Klaus Gwosch, Stefan W. Hell
  • Patent number: 10898619
    Abstract: The present invention relates to an ocular device for regulating intraocular fluid pressure comprising or consisting of a tubular body wherein the inner surface of the tubular body or the inner and outer surface is/are coated with covalently immobilized hyaluronic acid (HA). In more specific embodiments, the tubular body comprises or consists of a biocompatible material selected from the group comprising a biocompatible metal such as titanium, ceramics, glass, polymers and composites thereof, and the immobilized hyaluronic acid molecules are linked with further HA molecules to form a HA hydrogel. The ocular device is a stent free from mechanical valves or other mechanical means for actively regulating the flow of intraocular fluid.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: January 26, 2021
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.
    Inventors: Joachim P. Spatz, Fania Geiger, Michael Thaller, Christian Lingenfelder, Heike Boehm
  • Patent number: 10900901
    Abstract: For spatial high resolution determining a position of a singularized molecule, which is excitable with excitation light for emission of luminescence light, in n spatial dimensions in a sample, a preliminary local area including the singularized molecule is determined The excitation light is directed onto the sample with an intensity distribution, which has a zero point and intensity increasing regions adjoining the zero point on both sides in each of the n spatial dimensions. At first, the zero point is arranged at preliminary positions on known sides of the preliminary local area. Then, present positions of the zero point are successively shifted into the preliminary local area in each of the n spatial dimensions depending on photons of the luminescence light which is quasi-simultaneously separately registered for the present positions of the zero point in that the zero point is repeatedly shifted between the present positions of the zero point.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: January 26, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Francisco Balzarotti, Yvan Eilers, Klaus Gwosch, Stefan W. Hell
  • Patent number: 10893805
    Abstract: For characterizing spatial-temporal dynamics of a medium (1) excitable for deformation, an elastic model of the medium is defined. The medium is imaged at consecutive points in time to obtain a series of images. Shifts of structures of the medium (1) between the images of the series are determined. A dynamic description of a temporal development of spatial deformations of a predefined elastic model of the medium (1) is adapted to match the shifts of the structures; and temporal developments of rate of deformation patterns in the medium (1) are identified from the dynamic description.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: January 19, 2021
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Stefan Luther, Jan Christoph
  • Publication number: 20210008207
    Abstract: The present invention relates to inhibitors of the interaction between H. pylori IIopQ and a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family as well as to immunogenic compositions based on H. pylori HopQ. The present invention further relates to the use of the inhibitors and immunogenic compositions for preventing or treating a disease or disorder caused by or associated with H. pylori.
    Type: Application
    Filed: July 20, 2017
    Publication date: January 14, 2021
    Applicants: TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Anahita JAVAHERI, Tobias KRUSE, Markus GERHARD, Bernhard B. SINGER, Daniel HORNBURG, Han REMAUT, Matthias MANN, Felix MEISSNER, Steffen BACKERT
  • Patent number: 10883137
    Abstract: The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase activity, by detecting product formation of the nucleotide polymerase to be tested based on determination of close proximity of two labeled nucleotide probes able to bind the product of the nucleotide polymerase. It is preferred that proximity dependent energy transfer, such as forster resonance energy transfer, between said labeled nucleotide probes is determined. The invention further provides kits comprising components for carrying out the inventive methods for detection of nucleotide polymerase activity.
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: January 5, 2021
    Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V., LEAD DISCOVERY CENTER GMBH
    Inventors: Tim Bergbrede, Nils-Göran Larsson, Claes Gustafsson, Maria Falkenberg-Gustafsson
  • Patent number: 10884397
    Abstract: A method for devising an optimum control policy of a controller for controlling a system includes optimizing at least one parameter that characterizes the control policy. A Gaussian process model is used to model expected dynamics of the system. The optimization optimizes a cost function which depends on the control policy and the Gaussian process model with respect to the at least one parameter. The optimization is carried out by evaluating at least one gradient of the cost function with respect to the at least one parameter. For an evaluation of the cost function a temporal evolution of a state of the system is computed using the control policy and the Gaussian process model. The cost function depends on an evaluation of an expectation value of a cost function under a probability density of an augmented state at time steps.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: January 5, 2021
    Assignees: Robert Bosch GmbH, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Andreas Doerr, Sebastian Trimpe, Duy Nguyen-Tuong
  • Publication number: 20200410944
    Abstract: The invention relates to a system for displaying information to a user, comprising: an emission device (12, 13) arranged to emit light so as to display information to a user (18), the emission device (12, 13) being adapted to emit the light in a pulsed manner so that the intensity of the light varies between a high value and a low value, a selective viewing device (16) comprising a panel, the panel being adapted so that the user can view the light (11?) which is emitted by the emission device through that panel so as to visually perceive the information being displayed, the panel having a variable transparency which can be varied between a state of high transparency and a state of low transparency, the system being adapted to synchronize the emission device (12, 13) and the selective viewing device (16) so that the states of the emission device emitting light at a high-intensity value and the states of the panel of the selective viewing device of high transparency overlap in time, the emission device being ad
    Type: Application
    Filed: March 9, 2018
    Publication date: December 31, 2020
    Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Ivan C. Baines, Moritz Kreysing
  • Patent number: 10879477
    Abstract: The present invention relates to a cyclic amine surface modifier. In addition the present invention also relates to organic electronic devices comprising such cyclic amine surface modifier.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: December 29, 2020
    Assignees: MERCK PATENT GMBH, INNOVATIONLAB GMBH, TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Malte Jesper, Manuel Hamburger, Janusz Schinke, Milan Alt, Klaus Muellen
  • Patent number: 10877179
    Abstract: A method for forecasting an environmental event/a type of environmental event includes acquiring at least one test data set of at least one behavioural and/or physiological parameter of a population of animals; generating a test profile based on said at least one test data set, representing behaviour and/or physiological status of the population of animals; calculating a ratio between the test profile and a first reference profile; and setting an alert, if said ratio reaches a predefined threshold value.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: December 29, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Martin Wikelski, Uschi Müller, Wolfgang Arne Heidrich, Franz Xaver Kümmeth
  • Patent number: 10870006
    Abstract: An apparatus for applying at least one electric pulse to a living myocardial tissue comprises an input configured to receive an electric signal representing a present electric activity of the myocardial tissue; a signal processor configured to process the electric signal to calculate a present permutation value of the electric signal in the state space and to only output a control signal when the calculated present entropy value of the electric signal is lower than a predetermined entropy threshold value; a pulse generator configured to generate the at least one electric pulse in response to the control signal; and an output configured to output the at least one electric pulse to the myocardial tissue.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: December 22, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Alexander Schlemmer, Thomas Lilienkamp, Sebastian Berg, Ulrich Parlitz, Stefan Luther
  • Patent number: 10864261
    Abstract: The present invention relates to a synthetic saccharide of general formula (I) that is related to Streptococcus pneumoniae serotype 2 capsular polysaccharide, a conjugate thereof and the use of said saccharide and conjugate for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae type 2 bacteria.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: December 15, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Peter H. Seeberger, Claney Lebev Pereira, Chakkumkal Anish, Naeem Khan, Madhu Emmadi
  • Patent number: 10855049
    Abstract: A pulse laser apparatus (100) for creating laser pulses (1), in particular soliton laser pulses (1), based on Kerr lens mode locking of a circulating light field in an oscillator cavity (10), comprises at least two resonator mirrors (11, 12, . . .
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: December 1, 2020
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V., Ludwig-Maximilians-Universitaet Muenchen
    Inventors: Oleg Pronin, Ferenc Krausz, Jonathan Brons