Patents Assigned to Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
  • Patent number: 11408724
    Abstract: An interferometer apparatus includes a beam splitter arranged for splitting an input beam into a first beam propagating along a first interferometer arm including a deflection mirror and a second beam propagating along a second interferometer arm including a deflection mirror. The first and second interferometer arms have an identical optical path length. A beam combiner is arranged for recombining the first and second beams into a constructive output and a destructive output. In the first interferometer arm compared with the second interferometer arm, one additional Fresnel reflection at an optically dense medium is provided and a propagation of the electromagnetic fields of the first and second beams, when recombined by the beam combiner, results in a wavelength-independent phase difference of ? between the contributions of the two interferometer arms to the destructive output. Furthermore, an interferometric measurement apparatus and an interferometric measurement method are described.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: August 9, 2022
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Ioachim Pupeza, Ferenc Krausz, Theresa Buberl
  • Patent number: 11401301
    Abstract: The present invention relates in a first aspect to a method for the purification of biological macromolecular complexes. Typically, no chromatography steps are applied. That is, the present invention relates to a method for the purification of biological macromolecular complexes Furthermore, the present invention relates to a method for crystallization of biological macromolecular complexes comprising the step of purification as described followed by crystallization in a reservoir solution containing a water-soluble polymer. Furthermore, purified biological macromolecular complexes obtainable by the method according to the present invention are provided as well as crystallized biological macromolecular complexes. Finally, a method for determining the suitability of a candidate compound for inhibiting the 20S proteasome of an individual is provided.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: August 2, 2022
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Ashwin Chari, Holger Stark, Jil Schrader, Fabian Henneberg
  • Patent number: 11397163
    Abstract: A method of detecting particles (1), e.g. proteins, after separation of particles based on their specific features, e.g. charge, size, shape, density, as series of single light scattering events created by the individual particles is described. The particles (1) are separated from each other along the separation path (11) and particles have specific arrival times at the target side depending on the particle features. The detecting step comprises an interferometric sensing of the light scattered at individual particles bound or transient in the detection volume (30). Parameters of the scattering light signals e.g. the interferometric contrast are analysed for obtaining specific particle features, e.g. size, mass, shape, charge, or affinity of the particles (1). Furthermore, a detection apparatus (100) being configured for detecting particles (1) is described.
    Type: Grant
    Filed: September 7, 2015
    Date of Patent: July 26, 2022
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V.
    Inventors: Vahid Sandoghdar, Marek Piliarik, Katharina Koenig
  • Publication number: 20220220164
    Abstract: The present invention relates to an expression system for a genetically encoded protein synthesis inhibitor containing RNA N-glycosidase activity split into two components. The expression system can be combined with genetic targeting systems to achieve cell- and/or tissue-type-specific and/or temporally-specific control of protein synthesis in a host, particularly in a mammalian host.
    Type: Application
    Filed: May 28, 2020
    Publication date: July 14, 2022
    Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Erin M. SCHUMAN, Maximilian HEUMÜLLER, Caspar GLOCK
  • Patent number: 11378634
    Abstract: A method of magnetic resonance tomography includes arranging an object in a static magnetic field, subjecting it to radiofrequency (RF) pulses and magnetic field gradients for creating spatial encoding of magnetic resonance signals, acquiring the signals with at least two RF receive coils, each with a self-resonance frequency and a spatially restricted sensitivity profile, and reconstructing an object image. Spatial encoding of the signals by the gradients and the profiles is utilized, wherein the profile of at least one of the coils is subjected to a temporal sensitivity profile modulation while acquiring the signal. The self-resonance frequency of the at least one coil is set within a predetermined receive bandwidth of a constant resonance frequency value during the modulation. The reconstructing further utilizes the modulation for obtaining additional spatial information to the spatial encoding of the signals by the gradients. Furthermore, an MRI device is described.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: July 5, 2022
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.
    Inventors: Klaus Scheffler, Jonas Bause, Alexander Loktyushin, Kai Buckenmaier
  • Patent number: 11351497
    Abstract: The invention relates to a method for separating chlorine from a gaseous anode outlet stream mass flow of an electrochemical cell reactor. In a first aspect, the method makes use of an absorption step, wherein an anode outlet stream mass flow of the electrochemical cell reactor is exposed to an organic solvent being essentially immiscible with water for achieving an exergy-efficient separation of chlorine and hydrogen chloride. In a further aspect, the method makes use of absorption step, wherein the anode outlet stream mass flow is exposed to an ionic liquid, wherein the hydrogen chloride is dissolved in said ionic liquid, thereby forming a gas flow containing essentially chlorine and a solution mass flow comprising the ionic liquid and the hydrogen chloride. The hydrogen chloride is desorbed from the solution mass flow in a desorption step.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: June 7, 2022
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Simon Bechtel, Tanja Vidakovic-Koch, Kai Sundmacher
  • Patent number: 11345724
    Abstract: The present invention relates to a compound of formula (I), wherein X is C?O, C?S or B—OH; Y is an electrophile and Z is a leaving group, or Y?Z is an electrophile; R1 comprises or consists of (a) (i) a first group binding to a proteolytic site of a proteasome, the first group being bound to X; and (ii) optionally a second group enhancing delivery; or (b) a group binding between subunits ?1 and ?2 of a proteasome; R2 and R3 are independently selected from H, methyl, methoxy, ethyl, ethenyl, ethynyl and cyano, wherein methyl and ethyl may be substituted with OH or halogen.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: May 31, 2022
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Ashwin Chari, Holger Stark, Jil Schrader, Fabian Henneberg
  • Patent number: 11340162
    Abstract: For comparing first optical properties of a first fluid with second optical properties of a second fluid a first transparent grating having a grating constant is made of the first liquid, and a second transparent grating also having the grating constant is made of the second liquid. The second transparent grating is arranged at a lateral offset of less than 45% of the grating constant with regard to the first transparent grating such that grating bars of the first and second transparent gratings are arranged side by side. Coherent light is directed onto the first and second transparent gratings such that light which passed through the grating bars of the first and second transparent gratings forms a diffraction pattern comprising intensity maxima. Two light intensities of two intensity maxima of a same order higher than zero are measured and compared to each other.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: May 24, 2022
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Thomas P. Burg, Margherita Bassu, Foelke Purr, Andreas Dietzel
  • Patent number: 11342645
    Abstract: A non-reciprocal quantum device that comprises a first terminal and a second terminal, a transmission structure connected between the first and second terminals and configured to transmit microscopic particles in at least a partially phase-coherent manner from the first terminal to the second terminal and possibly from the second terminal to the first terminal, wherein a time-reversal symmetry of the transmission of the particles is broken with respect to at least a portion of the transmission structure; wherein the time-reversal symmetry is broken in such a way that the transmission structure comprises a higher transmission probability for particles moving in a first direction from the first terminal to the second terminal than in a second direction from the second terminal to the first terminal.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: May 24, 2022
    Assignee: Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V.
    Inventor: Jochen Mannhart
  • Publication number: 20220154220
    Abstract: The present invention relates to compounds suitable to increase precise genome editing efficiency in a eukaryotic target cell or target organism. Thus, the present invention can be applied in gene therapy.
    Type: Application
    Filed: December 19, 2019
    Publication date: May 19, 2022
    Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Stephan RIESENBERG, Tomislav MARICIC
  • Publication number: 20220146907
    Abstract: A hollow-core anti-resonant-reflecting fibre (HC-AF) includes a hollow-core region, an inner cladding region, and an outer cladding region. The hollow-core region axially extends along the HC-AF. The inner cladding region includes a plurality of anti-resonant elements (AREs) and surrounds the hollow-core region. The outer cladding region surrounds the inner cladding region. The hollow-core region and the plurality of AREs are configured to provide phase matching of higher order hollow-core modes and ARE modes in a broadband wavelength range.
    Type: Application
    Filed: January 25, 2022
    Publication date: May 12, 2022
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Philip RUSSELL, Patrick UEBEL, Michael Henoch FROSZ
  • Publication number: 20220127597
    Abstract: The present invention relates to methods for producing solid supports. The present invention further provides a mixture of said solid supports for tagmentation of target DNA for DNA sequencing approaches, a corresponding kit comprising the same and methods employing said mixture of solid supports and/or kit. Specifically, methods for producing sequencing libraries and corresponding DNA sequencing methods for analyzing the generated sequencing libraries and tools used therein are provided. In particular, DNA In sequencing approaches allowing preservation of contiguity information of long DNA fragments even when using short read sequencing approaches are disclosed. A key concept of the present invention is to employ segmented barcodes, with every barcode segmented allowing for barcode error detection and correction on a segment level.
    Type: Application
    Filed: February 14, 2020
    Publication date: April 28, 2022
    Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Yingguang Frank CHAN, Marek KUCKA, Andreea DREAU
  • Patent number: 11311010
    Abstract: The present invention provides lignin nanoparticles containing a hydrophobic active agent and a process for the production of the lignin nanoparticles. The process involves the following steps: (i) dissolving modified lignin and a hydrophobic active agent in an organic solvent having low solubility in water; (ii) combining the solution with water and a surfactant to form a pre-emulsion; (iii) forming an emulsion from the pre-emulsion; and (iv) crosslinking the modified lignin to form the lignin nanoparticles, in which the modified lignin is lignin which is chemically modified to contain at least two functional groups suitable for polymerization and/or crosslinking.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: April 26, 2022
    Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V., INSTITUT FÜR BIOTECHNOLOGIE UND WIRKSTOFF-FORSCHUNG GGMBH
    Inventors: Frederik Wurm, Katharina Landfester, Doungporn Yiamsawas, Eckhard Thines, Jochen Fischer
  • Patent number: 11306118
    Abstract: The present invention relates to compounds according to general formula (I) with enhanced absorption of UV-B irradiation. The present invention also relates to an UV-B tolerant plant and a method for enhanced production of compounds according to general formula (I) in a plant or plant cell. Furthermore, the invention relates to a nucleic acid sequence SEQ-ID No. 1 encoding FPT2 catalyzing the production of compounds according to general formula (I). The invention further relates to compositions comprising compounds according to general formula (I). Furthermore, the invention relates to a method of conferring UV-B tolerance to a plant as well as an UV-B tolerant plant comprising the nucleic acid sequence SEQ-ID No. 1 encoding FPT2 catalyzing the production of compounds according to general formula (I).
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: April 19, 2022
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.
    Inventors: Alisdair R. Fernie, Takayuki Tohge, Regina Wendenburg, Hirofumi Ishihara, Ronan Sulpice, Mark Stitt
  • Publication number: 20220089234
    Abstract: The invention relates to a robot leg comprising at least two joints, each joint connecting two segments one to another, with each joint comprising a cam, the robot leg further comprising at least one actuator and a common tendon interconnecting each cam.
    Type: Application
    Filed: January 20, 2020
    Publication date: March 24, 2022
    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Alexander Sprowitz, Alborz Aghamaleki Sarvestani
  • Patent number: 11274304
    Abstract: In a first aspect, the present invention relates to an isolated nucleic acid molecule, in particular, an RNA molecule containing particular substitutions. In a further aspect, the present invention relates to a composition comprising the same as well as virus-like particle, viral vector or virus particle containing the nucleic acid molecule according to the present invention. The virus-like particle, the viral vector or the virus particle is suitable for use as a medicament in particular for treating viral infection. Further, a pharmaceutical composition is provided in particular suitable for use as a pharmaceutical prophylactic vaccine containing the virus-like particle, viral vector or the virus particle or the nucleic acid molecule according to the present invention.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: March 15, 2022
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: Sascha Kupke, Timo Frensing, Pawel Zmora, Udo Reichl
  • Patent number: 11269135
    Abstract: A hollow-core anti-resonant-reflecting fibre (HC-AF) includes a hollow-core region, an inner cladding region, and an outer cladding region. The hollow-core region axially extends along the HC-AF. The inner cladding region includes a plurality of anti-resonant elements (AREs) and surrounds the hollow-core region. The outer cladding region surrounds the inner cladding region. The hollow-core region and the plurality of AREs are configured to provide phase matching of higher order hollow-core modes and ARE modes in a broadband wavelength range.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: March 8, 2022
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Philip Russell, Patrick Uebel, Michael Henoch Frosz
  • Publication number: 20220062849
    Abstract: The present invention relates to a method and a device for producing saccharides and saccharide arrays. Said method is particularly useful for the synthesis of saccharides in parallel and of high-density saccharide arrays, such as microarrays, which are required for high-throughput screenings.
    Type: Application
    Filed: December 17, 2019
    Publication date: March 3, 2022
    Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Felix Löffler, Marco Mende, Stephan Eickelmann, Peter H. Seeberger, Alexandra Tsouka, Jasmin Heidepriem, Grigori Paris
  • Patent number: 11262699
    Abstract: An ultrasonic apparatus (100) for creating a holographic ultrasound field (1) comprises an ultrasound source device (10) being adapted for creating an ultrasound wave, and a transmission hologram device (20) having a transmission hologram (21) and an exposed acoustic emitter surface (22), said transmission hologram device (20) being acoustically coupled with the ultrasound source device (10) and being arranged for transmitting the ultrasound wave through the acoustic emitter surface (22) and creating the holographic ultrasound field in a surrounding space, wherein the acoustic emitter surface (22) is a smooth surface which do not influence the field distribution of the ultrasound wave. Furthermore, a method of creating a holographic ultrasound field in an object (3), wherein the ultrasonic apparatus (100) is used, and applications of the ultrasonic apparatus (100) are described.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: March 1, 2022
    Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V., FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Kai Melde, Peer Fischer, Peter-Karl Weber
  • Patent number: 11263797
    Abstract: The invention relates to a method for transmitting 3D model data, the 3D model data comprising polygons, from a server to a client for rendering, the method comprising: obtaining the 3D model data by the server; and transmitting the 3D model data from the server to the client. According to the invention, the 3D model data is obtained by the server, based on a given multitude of possible views.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: March 1, 2022
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V.
    Inventors: Jozef Hladký, Markus Steinberger, Hans-Peter Seidel