Patents Assigned to MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN
  • Patent number: 10879477
    Abstract: The present invention relates to a cyclic amine surface modifier. In addition the present invention also relates to organic electronic devices comprising such cyclic amine surface modifier.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: December 29, 2020
    Assignees: MERCK PATENT GMBH, INNOVATIONLAB GMBH, TECHNISCHE UNIVERSITAET BRAUNSCHWEIG, MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Malte Jesper, Manuel Hamburger, Janusz Schinke, Milan Alt, Klaus Muellen
  • Patent number: 10877179
    Abstract: A method for forecasting an environmental event/a type of environmental event includes acquiring at least one test data set of at least one behavioural and/or physiological parameter of a population of animals; generating a test profile based on said at least one test data set, representing behaviour and/or physiological status of the population of animals; calculating a ratio between the test profile and a first reference profile; and setting an alert, if said ratio reaches a predefined threshold value.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: December 29, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Martin Wikelski, Uschi Müller, Wolfgang Arne Heidrich, Franz Xaver Kümmeth
  • Patent number: 10870006
    Abstract: An apparatus for applying at least one electric pulse to a living myocardial tissue comprises an input configured to receive an electric signal representing a present electric activity of the myocardial tissue; a signal processor configured to process the electric signal to calculate a present permutation value of the electric signal in the state space and to only output a control signal when the calculated present entropy value of the electric signal is lower than a predetermined entropy threshold value; a pulse generator configured to generate the at least one electric pulse in response to the control signal; and an output configured to output the at least one electric pulse to the myocardial tissue.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: December 22, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Alexander Schlemmer, Thomas Lilienkamp, Sebastian Berg, Ulrich Parlitz, Stefan Luther
  • Patent number: 10864261
    Abstract: The present invention relates to a synthetic saccharide of general formula (I) that is related to Streptococcus pneumoniae serotype 2 capsular polysaccharide, a conjugate thereof and the use of said saccharide and conjugate for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae type 2 bacteria.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: December 15, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Peter H. Seeberger, Claney Lebev Pereira, Chakkumkal Anish, Naeem Khan, Madhu Emmadi
  • Publication number: 20200376470
    Abstract: The present disclosure refers to increasing the catalytic efficiency of Weyl semimetals by subjecting Weyl semimetals to an external magnetic field of greater than 0 T, for example greater than 0.1 T. In a preferred embodiment of the present disclosure the Weyl semimetal is selected from the group consisting of NbP, TaP, NbAs and TaAs.
    Type: Application
    Filed: February 6, 2019
    Publication date: December 3, 2020
    Applicants: MAX PLANCK GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN EV, JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH (JNCASR)
    Inventors: Chintamani Nagesa Ramachandra RAO, Claudia FELSER, Catherine Ranjitha RAJAMATHI, Nitesh KUMAR, Uttam GUPTA
  • Patent number: 10855049
    Abstract: A pulse laser apparatus (100) for creating laser pulses (1), in particular soliton laser pulses (1), based on Kerr lens mode locking of a circulating light field in an oscillator cavity (10), comprises at least two resonator mirrors (11, 12, . . .
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: December 1, 2020
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V., Ludwig-Maximilians-Universitaet Muenchen
    Inventors: Oleg Pronin, Ferenc Krausz, Jonathan Brons
  • Publication number: 20200362312
    Abstract: The invention relates to a method of culturing an epithelial cell on a solid surface.
    Type: Application
    Filed: January 18, 2019
    Publication date: November 19, 2020
    Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Francesco BOCCELLATO, Thomas F. MEYER
  • Patent number: 10837062
    Abstract: A method of treating a human patient with depressive and/or anxiety symptoms which includes administering an effective amount of a V1B receptor antagonist and/or CRHR1 antagonist to the patient in need thereof, wherein the patient's genome has certain polymorphoric variants.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: November 17, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Florian Holsboer, Bertram Müller-Myhsok
  • Patent number: 10829515
    Abstract: The present invention relates in a first aspect to a method for the purification of biological macromolecular complexes. Typically, no chromatography steps are applied. That is, the present invention relates to a method for the purification of biological macromolecular complexes Furthermore, the present invention relates to a method for crystallization of biological macromolecular complexes comprising the step of purification as described followed by crystallization in a reservoir solution containing a water-soluble polymer. Furthermore, purified biological macromolecular complexes obtainable by the method according to the present invention are provided as well as crystallized biological macromolecular complexes. Finally, a method for determining the suitability of a candidate compound for inhibiting the 20S proteasome of an individual is provided.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: November 10, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Ashwin Chari, Holger Stark, Jil Schrader, Fabian Henneberg
  • Patent number: 10828358
    Abstract: The present invention relates to immunogenic compositions and their use in the prevention or treatment of diseases or disorders caused by or associated with Helicobacter pylori, in particular H. pylori infection and gastroduodenal disorders caused by H. pylori. The present invention further relates to methods of detecting H. pylori infection in a subject.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: November 10, 2020
    Assignees: TECHNISCHE UNIVERSITÄT MÜNCHEN, MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Tobias Kruse, Daniel Hornburg, Markus Gerhard, Matthias Mann, Felix Meissner
  • Patent number: 10822401
    Abstract: The marginal zone (MZ) and B1 subsets of B cells, which differ from conventional follicular (FO) B cells both developmentally and functionally, are involved in early responses to infectious pathogens and the production of self-reactive antibodies. A novel gene, mzb1, is expressed at high levels in MZ and B1 B cells but at low level, if at all, in FO B cells. MZB1 is involved in the regulation of proliferation, BCR-mediated signal transduction, and antibody production in B cells. Inhibitors, activators and enhancers of MZB1 expression or activity can be used as immune modulators for research and therapeutic purposes.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: November 3, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Rudolf Grosschedl, Henrik Flach, Sola Kim, Marlena Duchniewicz, Bernadette Schreiner, Marc Rosenbaum
  • Publication number: 20200339668
    Abstract: A cross-neutralizing monoclonal antibody that specifically recognizes a cross-reactive epitope of the lipopolysaccharide (LPS) antigen structure of Klebsiella pneumoniae, which is an O3b epitope, cross-reacting with an O3a epitope and an O3 epitope, wherein the antibody is characterized by specific CDR sequences or VH and VL sequences.
    Type: Application
    Filed: July 6, 2020
    Publication date: October 29, 2020
    Applicants: X4 Pharmaceuticals (Austria) GmbH, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V.
    Inventors: Valeria SZIJÁRTO, Gábor NAGY, Luis GUACHALLA, Katharina RAMONI, Adriana BADARAU, Eszter NAGY, Tim ROLLENSKE, Hedda WARDEMANN, Irina MIRKINA
  • Patent number: 10799393
    Abstract: The present invention relates to a laser surgery apparatus for contact laser surgery and to a method of using the laser surgery apparatus. The laser surgery apparatus (1) comprises a contact laser scalpel (3) for contact laser surgery, the contact laser scalpel (4) comprising an optical fiber (4) of IR laser radiation transmissive material and terminating at an optical fiber tip (5) having an exposed core region, and support means for holding said fiber and for positioning said scalpel (3). Said fiber tip (5) is tapered and disposed at a distal end of the scalpel (3) for contacting a tissue to be cut and comprises an uncoated contact surface (6) for transmit ting laser radiation and a guiding surface that is at least partially reflective to laser radiation and provided such that laser radiation guided by said optical fiber (4) to said fiber tip (5) will be at least partially reflected by said guiding surface and emitted through said uncoated contact surface.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: October 13, 2020
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventors: R. J. Dwayne Miller, Stephanie Maier, Sebastian Kruber, Nils-Owe Hansen
  • Patent number: 10794908
    Abstract: The present invention discloses functionalized nanomembranes, a method for preparation and their use. The functionalized nanomembrane comprises a) a first layer comprising a nanomaterial, b) a second layer comprising a biorepulsive material, the second layer being attached to at least one side of the first layer, and c) affinity groups, attached to the second layer.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: October 6, 2020
    Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., Quantifoil Micro Tools GmbH
    Inventors: Andreas Terfort, Daniel Rhinow, Andrey Turchanin
  • Publication number: 20200280159
    Abstract: A broadband light source device for creating broadband light pulses includes a hollow-core fiber and a pump laser source device. The hollow-core fiber is configured to create the broadband light pulses by an optical non-linear broadening of pump laser pulses. The hollow-core fiber includes a filling gas, an axial hollow light guiding fiber core configured to support core modes of a guided light field, and an inner fiber structure surrounding the fiber core and configured to support transverse wall modes of the guided light field. The pump laser source device is configured to create and provide the pump laser pulses at an input side of the hollow-core fiber. The transverse wall modes include a fundamental transverse wall mode and second and higher order transverse wall modes.
    Type: Application
    Filed: May 15, 2020
    Publication date: September 3, 2020
    Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Patrick Sebastian UEBEL, Philip St. J. RUSSELL, Sebastian Thomas BAUERSCHMIDT
  • Patent number: 10759848
    Abstract: A cross-neutralizing monoclonal antibody that specifically recognizes a cross-reactive epitope of the lipopolysaccharide (LPS) antigen structure of Klebsiella pneumoniae, which is an O3b epitope, cross-reacting with an O3a epitope and an O3 epitope, wherein the antibody is characterized by specific CDR sequences or VH and VL sequences.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: September 1, 2020
    Assignees: ARSANIS Biosciences GmbH, Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V.
    Inventors: Valeria Szijárto, Gábor Nagy, Luis Guachalla, Katharina Ramoni, Adriana Badarau, Eszter Nagy, Tim Rollenske, Hedda Wardemann, Irina Mirkina
  • Patent number: 10755464
    Abstract: Present application refers to a method, a model generation unit and a computer program (product) for generating trained models (M) of moving persons, based on physically measured person scan data (S). The approach is based on a common template (T) for the respective person and on the measured person scan data (S) in different shapes and different poses. Scan data are measured with a 3D laser scanner. A generic personal model is used for co-registering a set of person scan data (S) aligning the template (T) to the set of person scans (S) while simultaneously training the generic personal model to become a trained person model (M) by constraining the generic person model to be scan-specific, person-specific and pose-specific and providing the trained model (M), based on the co-registering of the measured object scan data (S).
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: August 25, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Michael Black, David L. Hirshberg, Matthew Loper, Eric Rachlin, Alex Weiss
  • Patent number: 10711244
    Abstract: The present invention relates to a method for producing mammalian neural plate border stem cells (NPBSCs), comprising: (a) differentiation of mammalian pluripotent stem cells by (a-i) culturing mammalian pluripotent stem cells in pluripotent stem cell medium for about 24 to about 96 hours, wherein the pluripotent stem cell medium comprises: (i) an inhibitor of the activin/TGF-? signalling pathway; (ii) an inhibitor of the BMP signalling pathway; (iii) an activator of the canonical WNT signalling pathway; and (iv) an activator of the Hedgehog signalling pathway; subsequently (a-ii) culturing the cells obtained in step (a-i) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises: (i) an inhibitor of the Activin/TGF-? signalling pathway; (ii) an inhibitor of the BMP signalling pathway; (iii) an activator of the canonical WNT signalling pathway; and (iv) an activator of the Hedgehog signalling pathway; subsequently (a-iii) culturing the cells obtained in step (a-ii) for about 24 to
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: July 14, 2020
    Assignee: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
    Inventors: Hans R. Schoeler, Jared L. Sterneckert, Michael Glatza, Peter Reinhardt
  • Patent number: 10703735
    Abstract: The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: July 7, 2020
    Assignees: Lead Discovery Center GmbH, Max Planck Gesellschaft zur Förderung der Wissenschaften e. V.
    Inventors: Raffaella Di Lucrezia, Tim Bergbrede, Peter Nussbaumer, Uwe Koch, Bert Klebl, Axel Choidas, Anke Unger, Nils-Göran Larsson, Maria Falkenberg-Gustafsson, Claes M. Gustafsson
  • Patent number: 10688169
    Abstract: The present invention relates to synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 that are related to carbapenem-resistant Klebsiella pneumoniae capsular polysaccharide and conjugates thereof. Said conjugates and pharmaceutical composition containing said conjugates are useful for prevention and/or treatment of diseases associated with carbapenem-resistant Klebsiella pneumoniae. Furthermore, the synthetic saccharides of general formula (I): V*—[Ux+2—Ux+1—Ux]n—V—O-L-NH2 are useful as marker in immunological assays for detection of antibodies against carbapenem-resistant Klebsiella pneumoniae bacteria.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: June 23, 2020
    Assignee: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
    Inventors: Peter H. Seeberger, Claney Lebev Pereira, Guozhi Xiao, Naeem Khan, Chakkumkal Anish