Abstract: The present invention relates to 2,6-methanobenzo[g][1]oxacin-4-one compounds and their analog compounds and pharmaceutically acceptable salts thereof as selective inhibitor of glucose transporters 1 and 3 (GLUTs 1 and 3), to methods of preparing said compounds, and to the use thereof as pharmaceutically active agents, especially for the prophylaxis and/or treatment of metabolic diseases, immunological diseases, autoimmune diseases, inflammation, graft versus host disease, cancer, and metastasis thereof. Furthermore, the present invention is directed to pharmaceutical composition comprising at least one of 2,6-methanobenzo[g][1]oxacin-4-one compounds and their analog compounds.

Abstract: A modified nanoparticle for use in a therapeutic method, wherein the therapeutic method comprises the administration of the modified nanoparticle to an organism, the targeting of the modified nanoparticles to a specific site in the organism followed by an uptake of the modified nanoparticle into a cell, and wherein the modified nanoparticle is obtainable by a process comprising the steps of i) providing a nanoparticle and ii) contacting the nanoparticle with one or more antibodies as at a pH value of less than 7.0 so as to non-covalently bind the one or more antibodies via its/their Fc region onto the surface of the nanoparticle, wherein the nanoparticle provided in step i) is made of a material having at least one protonable or deprotonable group on the surface thereof and/or the one or more targeting moieties contacted with the nanoparticle in step ii) has at least one protonable or deprotonable group.

Abstract: An optical module for imaging light emitting objects on an image sensor comprises a polarizing beam splitter having an entrance face, an exit face, first and a second return faces, a first reflector facing the first return face, a first achromatic quarter-wave retardation plate between the first return face and the first reflector, a second reflector facing the second return face, and a second achromatic quarter-wave retardation plate between the second return face and the second reflector. The first and second reflectors differ in at least one of their orientation with regard to the first and second return faces or their spectral properties. At least one of the first reflector and the second reflector comprises a dichroic mirror arranged between the respective achromatic quarter-wave retardation plate and a further mirror of the respective reflector. The dichroic mirror is tilted with regard to the further mirror of the respective reflector.

Abstract: The invention relates to a DEPFET comprising: a semiconductor substrate (100) of a first conduction type, which has a first main surface (101) and a second main surface (102), which are opposite one another; a source terminal region (1s) of a second conduction type on the first main surface (101); a drain terminal region (1d) of a second conduction type; a channel region (10), which is arranged between the source terminal region (1s) and the drain terminal region (1d); a gate electrode (11), which is separated from the channel region (10) by a gate insulator (6); a rear activation region (104) of a second conduction type, which is formed on the second main surface (102); and a substrate doping increase region (2) of a first conduction type, which is formed at least under the source terminal region (1s) and under the channel region (10), the substrate doping increase region (2) having a signal charge control region (20) of the first conduction type below the gate electrode (11), in which signal charge control

Abstract: The invention relates to a method for processing a measuring probe which is intended for detecting surface properties or for modifying surface structures in the sub-micrometer range. The method comprises at least the following steps. First, providing a precursor containing molecules polymerizable by light or electron beams and a measuring probe comprising at least one carrier with a tip having an upper end opposite the carrier and a light or electron source for emitting light or electron beams with a wavelength and intensity, which fulfil an energy input at least required for polymerization of the precursor and means for variable positioning of the light or electron source and a control file and an electronic data processing system, wherein the control file describes at least a part of the surface of the measuring probe and serves to control a change in position of the light or electron source.

Abstract: The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus.

Abstract: The present invention relates to System for analysing tissue, comprising: a dissociation means for at least partially dissociating a tissue sample so as to obtain individual cells, a microfluidic flow device through which a fluid comprising the dissociated cells can be made to flow, and an evaluation device arranged to evaluate the cells as they are being transported through the microfluidic flow device, the system preferably being arranged for a label free analysis of tissue.

Abstract: A method for photonic sampling of a test-waveform is provided. The method includes providing a sampling light pulse and generating a local oscillator by frequency multiplication of the sampling light pulse. The method further includes generating a signal wave by frequency mixing of the sampling light pulse and the test-waveform in a nonlinear optical element, wherein the frequency multiplication of the sampling light pulse and the frequency mixing of the sampling light pulse and the test-waveform are selected such that the local oscillator and the signal wave are at least partly spectrally overlapping. Moreover, the method includes detecting an interference signal of the local oscillator and the signal wave for various time delays of the sampling light pulse with respect to the test-waveform. A device for sampling a test-waveform is also disclosed.

Abstract: A first aspect of the invention relates to a non-covalently-HaloTag-binding compound characterized by the general formula D-L-T (I), wherein D is or comprises a functional moiety Z, particularly a fluorescent dye, or D is a linkable moiety (i.e. a moiety that can be coupled to other functional groups), L is a linear linker of 10-15 atoms in length, and T is a moiety selected from the group comprising methylamine, methylsulfonamide, acetamide, or their respective fluorinated analogues, azide, or hydroxyl. Another aspect of the invention relates to a HaloTag variant wherein position D106 of the HaloTag7 sequence is exchanged for a proteinogenic amino acid different from D. The variant has a different binding specificity for HaloTag substrates compared to the non-variant Halotag polypeptide. Yet another aspect of the invention relates to kits comprising polypeptides or nucleic acids and the non-covalently-HaloTag-binding compound according to the invention.

Abstract: The invention relates to a DEPFET comprising: a semiconductor substrate (100) of a first conduction type, which has a first main surface (101) and a second main surface (102), which are opposite one another; a source terminal region (1s) of a second conduction type on the first main surface (101); a drain terminal region (1d) of a second conduction type; a channel region (10), which is arranged between the source terminal region (1s) and the drain terminal region (1d); a gate electrode (11), which is separated from the channel region (10) by a gate insulator (6); a rear activation region (104) of a second conduction type, which is formed on the second main surface (102); and a substrate doping increase region (2) of a first conduction type, which is formed at least under the source terminal region (1s) and under the channel region (10), the substrate doping increase region (2) having a signal charge control region (20) of the first conduction type below the gate electrode (11), in which signal charge control

Abstract: The present invention relates to the recombinant production of a protein of interest in a prokaryotic host cell or eukaryotic host cell wherein the protein of interest is obtained in a correctly folded and stable form. The protein of interest may be a difficult-to-make polypeptide for use as a vaccine or a pharmaceutical. The protein of interest is co-expressed with or fused to a ‘fold promoter’, which may be a VHH antibody recognizing the said protein.

Abstract: The present invention relates to the provision of new means and methods for enzymatic peptide-peptide ligation. In particular, the present invention provides a novel family of transpeptidase enzymes, herein subsequently also referred to as Adriase (Archaeal Peptide Recombinase), transpeptidase or polypeptide recombinase. The members of the Adriase family, which are characterized by an N-terminal DUF2121 domain with an N-terminal serine or threonine residue were surprisingly found to recombine and ligate substrate peptides in a sequence specific manner via a short DUF2121 recognition motif. This way, compounds like proteins, synthetic compounds and/or whole cells may be linked specifically as long as they contain the motif or the parts thereof recognized by an Adriase enzyme. The ligation reaction described herein can be used to engineer novel molecules in a modular way, with broad applications in both research and pharmacology.

Abstract: The invention relates to a method of producing elongate metal strands or fibres with a crucible, the method comprising the steps of; directing molten metal through a nozzle having a nozzle direction in a deposition direction at a regulated pressure difference between the inside and the outside of the crucible; depositing said molten metal from said nozzle on a rotating planar surface having an axis of rotation; entraining said molten metal in one plane via said rotating planar surface to form elongate metal strands, wherein said rotating surface is aligned at an alignment angle, to the deposition direction during the entraining of the molten metal; cooling said elongate metal strands to form solidified metal strands; and guiding said metal strands to collecting means to collect the solidified metal strands formed on the rotating planar surface.

Abstract: The present invention relates to a storage device (1) for storing cryogenic samples (2), comprising at least one sample holder (3), the sample holder being configured to hold at least one cryogenic sample (2). According to the present invention, the storage device (1) further comprises an elongated sample transport unit (4) configured to releasably hold the at least one sample holder (3) and to be inserted into an internal space (50) of a cryogenic storage dewar (5) through an opening (51) of the cryogenic storage dewar to completely submerge the sample transport unit into a cryogenic liquid (6) residing in the internal space, wherein the sample transport unit is further configured to move said at least one sample holder along a predefined path from a storage position into a removal position, from which the at least one sample holder can be removed from the internal space of the cryogenic storage dewar.

Abstract: The present invention relates to a compound having the general formula (1) wherein in the general formula (1) the residues R1 to R8 and Ar are the same or different and are independently from each other selected from the group consisting of hydrogen, unsubstituted hydrocarbon groups, substituted hydrocarbon groups and inorganic groups, wherein at least one of the residues R1 to R8 and Ar is a hydrophilic group, such as for instance a group comprising one or more polyethylene groups.

Abstract: The invention relates to the detection of the cofactor reduced nicotinamide adenine dinucleotide phosphate (NADPH). Provided is a sensor molecule for the resonance energy transfer (RET)-based detection of NADPH, the sensor comprising a segment A connected via a linker to a segment B, wherein each of segment A and segment B comprises a member of a RET pair comprising a donor moiety and an acceptor moiety, further characterized in that (i) segment A comprises a binding protein (BP) for NADPH, the BP being dihydrofolate reductase (DHFR; EC 1.5.1.3) or a functional homolog, fragment, derivative or variant thereof, showing the desired NADPH binding properties, and wherein the BP comprises a heterologous protein domain inserted at or replacing at least part of the region corresponding to positions (20) to (27) of E.

Abstract: The present invention relates to autotrophic microorganisms with altered photorespiration and improved CO2 fixation as well as a method of producing said autotrophic microorganisms. Particularly, the autotrophic microorganisms show an improved growth rate, productivity and energy conversion efficiency.

Abstract: A method of treating a psychiatric disorder in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an N-methyl-D-aspartate (NMDA) receptor antagonist and a therapeutically effective amount of a KCNQ channel activator. Pharmaceutical compositions comprising an NMDA receptor antagonist and a KCNQ channel activator are also disclosed.

Abstract: An optical component (1) comprising a planar metasurface (2) arranged on a surface of a first substrate (3) and a top layer (4) arranged in a height direction Z above the metasurface (2), wherein the metasurface (2) comprises an array (9) of scattering structures (5, 5a, 5b), wherein the array (9) is a repeating pattern of unit cells (7), wherein a unit cell (7) comprises at least two different scattering structures wherein the optical properties of the metasurface (2) are controllable by a control signal, wherein first scattering structures (5, 5a) are at least partially contacting a layer of a first substance (6a) having a first refractive index and second scattering structures (5, 5b) are at least partially contacting a layer of a second substance (6b), which differs from the first substance (6a) and which provides a variable refractive index depending on the control signal.

Abstract: A tactile sensing system having a sensor component which comprises a plurality of layers stacked along a normal axis Z and a detection unit electrically connected to the sensor component, wherein the sensor component comprises a first layer, designed as a piezoresistive layer, a third layer, designed as a conductive layer which is electrically connected to the detection unit, and a second layer, designed as a spacing layer between the first layer and the third layer, wherein the first layer comprises a plurality of electrodes In electrically connected to the detection unit, wherein at least one contact force along the normal axis Z on the sensor component is detectable by the detection unit due to a change of a current distribution between the first layer and the third layer, wherein at least one lateral strain on the sensor component is detectable by the detection unit due to a change of the resistance distribution change in the piezoresistive first layer.