Abstract: The quantum device comprises a transmission structure, wherein based on its geometrical arrangement, interference and quantum collapse, the transmission structure is designed such that quantum waves emitted by at least two bodies, for example, by thermal excitation, are passed preferentially to a subset of these bodies, without the need for a magnetic field to be applied.

Abstract: The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.

Abstract: A method and system that utilizes an admissible heuristic to determine the fastest-path between two points on a road map is disclosed. The method and system are based in part on a set of separators disposed on the map and represented by line segments, either independent or organized into hierarchical tree structures and based on recursive spatial subdivision. A preprocessing step computes a vector of values per road junction based on the separators that is then stored with the map and used to efficiently compute a high-quality heuristic to be used at a query stage. The heuristic scales well to any map size, resulting in a very efficient determination of fastest-path queries between points at all distances. The implementation is economically feasible and the resulting query speeds are significantly faster than other known heuristics and other state-of-the-art systems used for computing fastest-paths on maps.

Abstract: The invention relates to a linear drive unit comprising a first and second actuator element, a guiding unit configured to enable a linear relative movement between both actuator elements, a first and second power unit, each attached to the first actuator element and configured to provide the second actuator element with a respective first and second driving force, and a control unit for controlling both power units and configured to control the first and second driving force such that the first driving force can be different from the second driving force. The invention further relates to a telescope comprising a linear drive unit as well as to a method of aligning such telescope.

Abstract: The present invention relates to a method for producing cytidine 5?-monophospho-N-acetyl-neuraminic acid (CMP-Neu5Ac, 1) from low-cost substrates N-acetyl-D-glucosamine (GlcNAc), pyruvate, cytidine and polyphosphate in a single reaction mixture with a set of optionally immobilized or optionally co-immobilized enzymes comprising N-acylglucosamine 2-epimerase (AGE), an N-acetylneuraminate lyase (NAL), an N-acylneuraminate cytidylyltransferase (CSS), a uridine kinase (UDK), a uridine monophosphate kinase and a polyphosphate kinase 3 (PPK3). Further, said process may be adapted to produce Neu5Acylated i.e. sialylated biomolecules and biomolecules including a saccharide, a peptide, a protein, a glycopeptide, a glycoprotein, a glycolipid, a glycan, an antibody, and a glycoconjugate, in particular, an antibody drug conjugate, and a carbohydrate conjugate vaccine, or a flavonoid.

Abstract: The present invention refers to a coating apparatus for coating a substrate of a substrate material with at least one material layer of a layer material, said coating apparatus comprising a process chamber having a process volume for receiving a substrate holder for arranging the substrate, wherein the substrate holder is arranged in a fixed position in the process volume such that the substrate holder can furthermore be provided rotatable and/or movable essentially in a plane normal to the deposition direction as a whole, wherein the process chamber has a chamber wall for at least substantially completely enclosing the process volume; a gas system connected in a fluid-communicating manner to the process volume for generating a coating atmosphere in the process volume; and a source holder arranged in the process volume and providing at least one source material.

Abstract: A magnetic field generator that comprises at least three groups of magnets, the magnetic moment of each magnet being rotatable about a rotation axis, wherein each group comprises at least two magnets, and each group has an orientation in the sense that the rotation axes of the magnetic moments of the magnets of the same group extend in the group's orientation. The orientations of the different groups are linearly independent.

Abstract: A hollow-core anti-resonant-reflecting fibre (HC-AF) includes a hollow-core region, an inner cladding region, and an outer cladding region. The hollow-core region axially extends along the HC-AF. The inner cladding region includes a plurality of anti-resonant elements (AREs) and surrounds the hollow-core region. The outer cladding region surrounds the inner cladding region. The hollow-core region and the plurality of AREs are configured to provide phase matching of higher order hollow-core modes and ARE modes in a broadband wavelength range.

Abstract: An apparatus for determining an arrhythmia of a living heart comprises a signal evaluation device receiving a signal representing a present electric activity of the heart, and determining a frequency spectrum of the signal. The apparatus further comprises a pulse generator generating a sequence of electric pulses to be applied to the heart at a pulse repetition frequency that depends on the frequency spectrum and decreases by at least 20% over the sequence.

Abstract: In order to map the surface of a macromolecule, at least one fluorescent probe is introduced into a medium in which the macromolecule is embedded or will be embedded. Then, a plurality of spatial positions of the at least one fluorescent probe with regard to the macromolecule are determined via localization of the at least one singularized fluorescent probe with a simple standard deviation of no more than 2 nm. For this purpose, fluorescence light photons emitted by the singularized fluorescent probe are recorded. In addition, a bounding surface bounding the determined spatial positions with regard to the macromolecule is determined; and a three-dimensional map of at least a part of the surface of the macromolecule is generated from the bounding surface.

Abstract: According to a method of manufacturing a magnetic memory device, various types of magnetic memory devices can be manufactured at low cost by manufacturing a plurality of magnetic modules by using a delamination phenomenon of pattern segments and stacking the plurality of magnetic modules to complete a stacked memory device.

Abstract: The present invention relates to a fusion protein, comprising the structure N-PCSY-degSigN-M-PCSX-degSigC-C; wherein N represents the N-terminus; PCSY and PCSX each represent a protease cleavage site (PCS), which differ from each other in at least one amino acid residue: degSigN represents a degradation signal which promotes degradation of the fusion protein in a host cell if PCSY is cleaved by a protease such that the first amino acid of degSigN becomes the new N-terminus of the remaining fusion; M represents a cytoplasmic selection marker; and degSigC represents a second degradation signal which promotes degradation of the fusion protein in a host cell if PCSX is not cleaved by a protease; and C represents the C-terminus.

Abstract: A magnetic memory device includes a lower magnetic track layer extending in a first direction and including a plurality of first magnetic domains, a spacer layer on the lower magnetic track layer and extending in the first direction, an upper magnetic track layer on the spacer layer and extending in the first direction, the upper magnetic track layer including a plurality of second magnetic domains, and a plurality of read units on the upper magnetic track layer and arranged apart from one another in the first direction, wherein the plurality of first magnetic domains and the plurality of second magnetic domains have magnetization directions parallel to each other at positions overlapping each other in a second direction perpendicular to the first direction.

Abstract: A method of operating a magnetic memory device includes: (i) applying a first current to a free layer of a magnetic tunnel junction structure, which includes a magnetic translation unit (MTU) extending between a first magnetic pad and a second magnetic pad, and a tunnel barrier layer and a pinned layer stacked on the MTU, so that a multi-domain is established within the MTU, (ii) applying a magnetic field to the free layer so that the magnetization direction of the MTU switches to become anti-parallel to the magnetization directions of the first magnetic pad and the second magnetic pad, (iii) applying a second current to the free layer so that a portion of the multi-domain penetrates into the first magnetic pad, and (iv) applying another magnetic field to the free layer so that the magnetization direction of the first magnetic pad switches.

Abstract: An avalanche photodiode array for detecting electromagnetic radiation comprises: a semiconductor substrate (100) having a first main surface (101) and a second main surface (102), which are opposite one another, a plurality of n-doped anode regions (1) formed at the first main surface (101) and separated from one another by pixel isolation regions (7), a p-doped cathode region (3) arranged at the second main surface (102) opposite the anode regions, a drift region (4) between the plurality of anode regions (1) and the cathode region (3), and a p-doped multiplication layer (2) arranged below the plurality of anode regions (1) and below the pixel isolation regions (7), and is characterized by an n-doped field reduction layer (9) arranged below the plurality of anode regions (1) and the pixel isolation regions (7) and above the multiplication layer (2).

Abstract: In one aspect the application relates to a computing system for providing data for modelling a human brain comprises a database including a plurality of datasets (or allow access to a plurality of datasets), each dataset including at least a dynamical model of the brain including at least one node and a neurodataset of a neuroimaging modality input. The at least one node include a representation of a local dynamic model and a parameter set of the local dynamic model.

Abstract: The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2 and that have been selected for potent cross-reaction and cross-neutralization between the original Wuhan strain and the Alpha, Beta, Gamma, Delta, and Mu variants of concern.

Abstract: A broadband light source device for creating broadband light pulses includes a hollow-core fiber and a pump laser source device. The hollow-core fiber is configured to create the broadband light pulses by an optical non-linear broadening of pump laser pulses. The hollow-core fiber includes a filling gas, an axial hollow light guiding fiber core configured to support core modes of a guided light field, and an inner fiber structure surrounding the fiber core and configured to support transverse wall modes of the guided light field. The pump laser source device is configured to create and provide the pump laser pulses at an input side of the hollow-core fiber. The transverse wall modes include a fundamental transverse wall mode and second and higher order transverse wall modes.

Abstract: The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.

Abstract: The present invention relates to compounds, compositions and kits suitable to precise genome editing efficiency in a eukaryotic target cell or target organism.