Abstract: Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca?? signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed.

Abstract: Antibodies, and particularly human antibodies, are disclosed that demonstrate activity in the treatment of demyelinating diseases as well as other diseases of the central nervous system that are of viral, bacterial or idiopathic origin, including neural dysfunction caused by spinal cord injury. Neuromodulatory agents are set forth that include and comprise a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, a hapten, active fragments thereof, agonists thereof, mimics thereof, monomers thereof and combinations thereof. The neuromodulatory agent has one or more of the following characteristics: it is capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed.

Abstract: A joint prosthesis for replacing a joint between two elongated bones of the hand. A first member is provided with an elongated stem for reception in one of the elongated bones and includes a head remote from the stem, the head having a convex articulating surface and lateral articulating surfaces adjacent the convex surface and on each side thereof. A second member has a stem for reception in the other bone and a base remote from the stem, the base having a concave articulating surface and lateral articulating surfaces on each side thereof, the concave and lateral surfaces being adapted to engage and articulate with the respective convex and lateral articulating surfaces of the first member.

Abstract: A joint prosthesis is provided for replacing a joint between two bones in which one bone is normally permitted a substantial degree of rotary circumduction with respect to a second bone. A first member of the prosthesis is provided with a coupling portion enabling it to be attached to the elongated bone and includes a head having a generally saddle-shaped articulating surface facing away from the stem. The second member similarly has a connector adapted to connect the second member to the second bone, and has a head provided with a saddle-shaped articulating surface configured and sized to articulate with the saddle-shaped surface of the first member to enable one of the long bones to move in rotary circumduction with respect to the other. The saddle-shaped surfaces preferably are substantially congruent in shape.

Abstract: A radiologic imaging system and method (20) using radiopaque microspheres for evaluating organ tissue perfusion. Radiopaque microspheres are administered to organ tissue (22) which is then scanned using a computerized tomography (CT) scanner (24) which provides a visual CT image (26) and/or statistical report (28) providing an indication and/or measurement of organ tissue perfusion.

Abstract: An improved femoral component for use in a total hip replacement prosthesis comprises a stem portion and a combined head and neck portion. The stem portion includes a proximal portion and a distal portion which are angularly related with respect to one another and with the proximal portion including a recess formed therein for receipt of the tapered portion of the head and neck component. The head and neck component includes a substantially part spherical head portion attached to a neck portion and a tapered portion angularly attached to the neck portion via a basalar neck portion with the tapered portion being adapted to be permanently inserted into the recess portion of the proximal end of the above described stem portion. The stem portion includes a plurality of recesses on the periphery and longitudinal extent thereof which recesses receive fiber metal pads which are provided to allow bony ingrowth therein to retain the femoral component permanently installed in the proximal end of the femur.

Abstract: A process for the treatment of collagenous tissue to adapt it for use in a prosthetic implant and to promote the growth of endothelial cells thereon after implantation comprising treatment with at least one surfactant prior to fixation, treatment with agents which inhibit calcification and agents which resist attack by phagocytic cells and optional treatment with stabilizing agents.

Abstract: A carrier apparatus (40) for mounting logic components on the surface of a circuit board (41). The carrier apparatus (40) includes a housing structure defining top and bottom surfaces and further defining a cavity (50) in the bottom surface for receipt of a logic component (51). A recessed cover portion (56) is attached to the housing so as to enclose the cavity (50) thereby effectively sealing the logic component (51) in the housing. The carrier apparatus (40) includes means for mounting the housing on a circuit board such that the cover (56) does not make contact with the surface of the circuit board (41). The housing further includes means for electrically interconnecting the logic component (51) to the circuit board (41).

Abstract: A carrier apparatus (40) for mounting logic components on the surface of a circuit board (41). The carrier apparatus (40) includes a housing structure defining top and bottom surfaces and further defining a cavity (50) in the bottom surface for receipt of a logic component (51). A recessed cover portion (56) is attached to the housing so as to enclose the cavity (50) thereby effectively sealing the logic component (51) in the housing. The carrier apparatus (40) includes means for mounting the housing on a circuit board such that the cover (56) does not make contact with the surface of the circuit board (41). The housing further includes means for electrically interconnecting the logic component (51) to the circuit board (41).