Abstract: Multiscale brain electrodes can be used for spatiotemporal mapping, probing, and therapeutic modulation of the human brain. The applications for such functional mapping and electrical stimulation modulation span, for example, neurological and psychiatric diseases, and brain rehabilitation.

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarcinoma.

Abstract: Intramedullary nails can be used for the treatment of a bone fracture. In some embodiments, such intramedullary nails can include an elongate shaft having a longitudinal axis, a distal nail component, and a proximal nail component. In some embodiments, the intramedullary nails include a first rotatable shaft and a second rotatable shaft. In some embodiments, the intramedullary nails include a handle coupled to the first and second rotatable shafts.

Abstract: Systems, methods, devices, and techniques for estimating a heart disease prediction of a mammal. An electrocardiogram (ECG) procedure is performed on a mammal, and a computer system obtains ECG data that describes results of the ECG over a period of time. The system provides a predictive input that is based on the ECG data to a predictive model, such as a neural network or other machine-learning model. In response, the predictive model processes the input to generate an estimated heart disease predictive characteristic of the mammal. The system outputs the estimated heart disease prediction of the mammal for presentation to a user.

Abstract: Devices and methods for the treatment of heart conditions, and other medical purposes, include cardiac pacing systems. For example, this document describes temporary transvenous endocardial pacemaker systems and devices for deploying such systems without the need for conventional imaging procedures.

Abstract: A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4+) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

Abstract: This document provides methods and materials for treating cancer (e.g., liver cancer such as hepatocellular carcinoma (HCC)) using one or more stearoyl CoA desaturase 1 (SCD1) polypeptide inhibitors (e.g., a selective SCD1 inhibitor (SSI)) and one or more tyrosine kinase inhibitors.

Abstract: Speech analysis devices and methods for identifying migraine attacks are provided. Migraine sufferers can experience changes in speech patterns both during a migraine attack and in a pre-attack phase (e.g., a time period before the migraine attack can be recognized by the migraine sufferer). Embodiments identify or predict migraine attacks during the pre-attack phase and/or the attack phase (such as early stages of a migraine attack) by comparing speech features from one or more speech samples provided by a user against baseline data. The speech features are indicative and/or predictive of migraine onset, and can be personalized to a user and/or based on normative data.

Abstract: The present disclosure addresses a quantitative analysis of tumor vascularity patterns, with the goal of identifying biomarkers correlated with malignancy. Herein, we identify new types of quantitative ultrasound biomarkers of microvessel morphology that correlate with the state of the disease in question. We propose a novel method to automatically extract quantitative features related to the morphology and distribution of the vascular networks reconstructed from contrast-free ultrasound data. For instance, spatial vascularity pattern, bifurcation angle, Murray's deviation, fractal dimension and closet vessel distance were clearly depicted.

Abstract: Methods for modulating the release and content of extracellular vesicles from target cells using electrical stimulation are provided. Compositions comprising extracellular vesicles or extracts of extracellular vesicles and methods of administering the compositions to a subject are also provided.

Abstract: This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.

Abstract: The present disclosure relates to a protective garment. The garment includes a body shaped for wear on a body part and a pocket assembly coupled to the body. The pocket assembly includes a first pocket comprising a wall and a pouch at least partially defined by the wall, a second pocket adjacent to the first pocket, the second pocket defining a second pouch separate from the first pouch, and an opening extending through the wall of the first pocket.

Abstract: Disclosed herein are improved compositions and methods involved in treating hematologic cancers, i.e., cancers that begin in blood-forming tissue, such as the bone marrow, or in the cells of the immune system. The compositions comprise complexes containing albumin-containing nanoparticles (e.g., ABRAXANE® nanoparticles) and antibodies. The compositions are used to effect hematologic cancer cell death.

Abstract: A system for bypassing a portion of a small intestine. The system includes an occlusion device and a bypass device. The occlusion device includes a tubular body, an occlusion member at a distal end portion of the tubular body, and an anchor member at a proximal end portion of the tubular body. The bypass device includes a liner, and an anchor member at a proximal end portion of the liner.

Abstract: A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.

Abstract: Provided herein are methods, systems, and computer program products for the detection and evaluation of cardiac condition in a lead-invariant manner.

Abstract: This document provides methods and materials involved in identifying mammals as having, or being likely to have, a traumatic brain injury (TBI). This document also provides methods for treating mammals identified as having, or being likely to have, a TBI, based on the identification methods described herein.

Abstract: This document describes systems and methods for managing glycemia in patients with diabetes mellitus by optimizing insulin delivery dosages and timing. For example, this document describes systems and methods that utilize a patient's gastric emptying rate and other parameters to determine the optimal insulin delivery dosages and timing for the patient.

Abstract: Disclosed herein are systems, devices, and methods for accessing a subdural space. In some embodiments, an apparatus may comprise a shaft configured to be slidably disposed within a lumen of a catheter. The shaft may be configured to be advanced distally from a distal end of the catheter and into a blood vessel of a subject. The shaft may include a perforating tip including an energy element configured to generate radiofrequency energy to form an opening through a wall of the blood vessel and dura of the subject and into an extravascular space of the subject. A curved section may be configured to be radially constrained within the lumen of the catheter and to curve toward the wall of the blood vessel and the dura upon exiting the lumen of the catheter such that the energy element is positioned to form the opening.

Abstract: This document relates to materials and methods for identifying and monitoring immunoglobulin J chains in a sample, such as a biological sample, using mass spectrometry techniques.