Patents Assigned to Mayo Foundation for Medical Education and Research
  • PAR2 MODULATION TO ALTER MYELINATION
    Publication number: 20230000928
    Abstract: Materials and methods for modulating protease activated receptor 2 (PAR2) activity in order to alter myelination or demyelination are provided herein.
    Type: Application
    Filed: September 14, 2022
    Publication date: January 5, 2023
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Hye-Sook Yoon, Isobel A. Scarisbrick
  • Detecting colorectal neoplasia
    Patent number: 11542557
    Abstract: Provided herein is technology for colorectal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of colorectal neoplasia in 1) individuals at, older or younger than 50 years of age, or 2) individuals having Lynch Syndrome.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: January 3, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney
  • Systems and methods for quality control in 3D printing applications using a 3D printed phantom
    Patent number: 11541605
    Abstract: The present disclosure provides systems and methods for performing quality control assessments of a three dimensional (3D) printing system. In particular, the present disclosure provides a phantom designs for use in 3D printing systems, as well as methods of quality control for a 3D printing system performed using a 3D printed phantom.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: January 3, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Shuai Leng, Kiaran P. McGee, Jane M. Matsumoto, Joel L. Kuhlmann, Jonathan M. Morris
  • Methods for estimating mechanical properties from magnetic resonance elastography data using artificial neural networks
    Patent number: 11543481
    Abstract: Magnetic resonance elastography (“MRE”), or other imaging-based elastography techniques, generate estimates of the mechanical properties, such as stiffness and damping ratio, of tissues in a subject. A machine learning approach, such as an artificial neural network, is implemented to perform an inversion of displacement data in order to generate the estimates of the mechanical properties.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: January 3, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Matthew C. Murphy, Richard L. Ehman, Kevin J. Glaser, Joshua D. Trzasko, Armando Manduca, John Huston, III, Jonathan M. Scott, Arvin Forghanian-Arani
  • Methods and systems for electroporation
    Patent number: 11541241
    Abstract: This document describes methods and materials for improving the delivery of electroporation. For example, this document describes methods and devices for delivering electroporation while mitigating risks of ventricular fibrillation.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: January 3, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Samuel J. Asirvatham
  • METHODS AND MATERIALS FOR TREATING FISTULAS
    Publication number: 20220409769
    Abstract: This document provides methods and materials for treating fistulas (e.g., refractory fistulas such as refractory anal fistulas). For example, methods and materials for implanting a synthetic scaffold (e.g., fistula plug) comprising randomly arranged fibers comprising polymers of PGA and TMC and seeded with mesenchymal stem cells (e.g., adipose derived mesenchymal stem cells) located in the spaces between the randomly arranged fibers into a fistula (e.g., refractory anal fistula) of a mammal (e.g., a human) are provided.
    Type: Application
    Filed: August 24, 2022
    Publication date: December 29, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Allan B. Dietz, William A. Faubion, Eric J. Dozois
  • COMPOUNDS AND METHODS FOR TREATING CANCER
    Publication number: 20220411389
    Abstract: This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
    Type: Application
    Filed: April 5, 2022
    Publication date: December 29, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: John A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
  • Methods for cell labeling and medical imaging
    Patent number: 11534506
    Abstract: Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89Zr-Desferrioxamine-NCS labeling agent.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: December 27, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Aditya Bansal, Timothy R. DeGrado, Mukesh K. Pandey
  • Integrated immunoassay
    Patent number: 11536723
    Abstract: Microfluidic devices and systems are provided. Methods for conducting immune assays with the devices and systems are also provided.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: December 27, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Nicholas Chia, William A. Faubion, Yuguang Liu, Marina R. Walther-Antonio
  • Authentication and informational displays with adaptive lighting array
    Patent number: 11538570
    Abstract: A display system for a medical suite comprises a scanning device configured to capture scanning data in the medical suite. At least one display configured to display information in an operating region of the medical suite. A controller is in communication with the scanning device and the display. The controller is configured to control the scanning device to capture identifying information of a patient. Based on the identifying information, the controller is configured to authenticate an identity of the patient. Based on the identity, the controller is configured to access a patient record for the patient. The controller is further configured to control the at least one display to display information based on the patient record.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: December 27, 2022
    Assignees: GENTEX CORPORATION, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Jason D. Hallack, Bradley R. Hamlin, David M. Falb, Jeremy A. Schut, Danny L. Minikey, Jr., Mark A. VanVuuren, David J. Wright
  • Methods for encoded multi-pulse contrast enhanced ultrasound imaging
    Patent number: 11534141
    Abstract: Methods for contrast-enhanced ultrasound imaging that implement coded multi-pulses in each of two or more different transmission events are described. Data acquired in response to the two different transmission events are decoded and combined. In some embodiments, the coded multi-pulses include two or more consecutive Hadamard encoded ultrasound pulses. In other embodiments, multiplane wave pulses can be used. Such multiplane wave pulses can be coded using Hadamard encoding, as one example. In addition, the multiplane wave pulses can be further coded using amplitude modulation, pulse inversion, or pulse inversion amplitude modulation techniques.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: December 27, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Ping Gong, Shigao Chen, Pengfei Song
  • Thorascopic heart valve repair method and apparatus
    Patent number: 11534156
    Abstract: An instrument for performing thorascopic repair of heart valves includes a shaft for extending through the chest cavity and into a heart chamber providing access to a valve needing repair. A movable tip on the shaft is operable to capture a valve leaflet and a needle is operable to penetrate a capture valve leaflet and draw the suture therethrough. The suture is thus fastened to the valve leaflet and the instrument is withdrawn from the heart chamber transporting the suture outside the heart chamber. The suture is anchored to the heart wall with proper tension as determined by observing valve operation with an ultrasonic imaging system.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: December 27, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Giovanni Speziali
  • Enhancing reading accuracy, efficiency and retention
    Patent number: 11531804
    Abstract: This document provides systems and methods for altering text presentation to increase reading accuracy, efficiency, and retention. This can include identification text specific attributes from machine readable text (through parsing of the text), varying the text presentation in accordance with the attributes, and creating an enhanced visual product for enhancing the reading experience. For example, a computer system can extract attributes such as parts of speech from an input sentence and display that sentence in cascading text segments down and across a display screen. The system can further use domain-specific dictionaries derived from domain-specific texts to identify domain-specific compound noun phrases and verb phrases that require specific linguistic tagging to be usable in other linguistic analysis steps.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: December 20, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Randall C. Walker
  • High specific activity preparation of F-18 tetrafluoroborate
    Patent number: 11532406
    Abstract: Embodiments of the invention provide methods of synthesizing 18F-tetrafluoroborate (18F-TFB) via direct radiofluorination on boron trifluoride (BF3) to enhance both labeling yield and specific activity. Uses of 18F-TFB are also contemplated.
    Type: Grant
    Filed: April 24, 2017
    Date of Patent: December 20, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Timothy R. DeGrado, Huailei Jiang
  • Detecting neoplasm
    Patent number: 11530449
    Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: December 20, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: William R. Taylor, Jonathan J. Harrington, Patrick S. Quint, Hongzhi Zou, Harold R. Bergen, III, David I. Smith, David A. Ahlquist
  • Methods and materials for treating hypocapnia
    Patent number: 11529492
    Abstract: This document provides methods and materials for treating hypocapnia. For example, methods and materials for delivering CO2 to a mammal to treat hypocapnia or compensate for a reduced level of CO2 are provided.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: December 20, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Jan Stepanek, Michael J. Cevette, Gaurav N. Pradhan, Karen K. Breznak
  • Polypeptide-antibody complexes and uses thereof
    Patent number: 11531030
    Abstract: Complexes containing a labeled polypeptide and an antibody, and the use of such complexes as research, diagnostic, and clinical tools, are described herein.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: December 20, 2022
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Wendy K. Nevala, Svetomir N. Markovic, John T. Butterfield, Daniel J. Knauer
  • TARGETING PD-L1 ON TUMOR CELLS
    Publication number: 20220396625
    Abstract: This document relates to materials and methods for treating cancer. For example, this document provides materials and methods for using PD-L1 targeting domains in bispecific chimeric polypeptides, chimeric transmembrane polypeptides, genetically modified viruses, nucleic acid vectors, and/or fusion-inducing cells to treat cancer.
    Type: Application
    Filed: July 7, 2022
    Publication date: December 15, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Stephen James Russell, Autumn J. Schulze, Arun Ammayappan, Kah-Whye Peng, Camilo Ayala Breton
  • EPHA3 DIRECTED CAR-T CELLS FOR TREATMENT OF TUMORS
    Publication number: 20220395532
    Abstract: This invention provides chimeric antigen receptors (CARs) targeting human EphA3 and dual targeting CARs that bind to human EphA3 and to human mutant epidermal growth factor receptor variant III (EGFRvIII). This invention also relates to CAR-T cells comprising the provided CARs or the dual targeting CARs. Methods for treating a solid tumor cancer by administering the CARs are provided.
    Type: Application
    Filed: November 9, 2020
    Publication date: December 15, 2022
    Applicants: HUMANIGEN, INC., MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Cameron DURRANT, Dale CHAPPELL, Saad J. KENDERIAN
  • ALBUMIN-PD-1 PACLITAXEL NANOPARTICLE COMPLEX COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20220387314
    Abstract: Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.
    Type: Application
    Filed: August 5, 2022
    Publication date: December 8, 2022
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Svetomir N. Markovic, Wendy K. Nevala