Patents Assigned to Mayo Foundation for Medical Education and Research
  • METHODS AND COMPOSITIONS FOR CROMAKALIM PRODRUG THERAPY
    Publication number: 20220387457
    Abstract: New medical uses for the compounds of Formula I, II, or III or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 5, 2022
    Publication date: December 8, 2022
    Applicants: Qlaris Bio, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Thurein M. Htoo, Barbara M. Wirostko, Michael P. Fautsch
  • System and method for basis material decomposition with general physical constraint for multi-energy computed tomography
    Patent number: 11517278
    Abstract: A system and method is provided for performing material decomposition using a computed tomography (CT) system. The method includes acquiring CT imaging data of an object including data subsets corresponding to at least two different energy spectral bins and using the CT imaging data at each of the at least two different energy spectral bins to form a series of equations for basis material decomposition. The method also includes using a general physical constraint, which quantifies how each basis material in the object is mixed together to form the object, within the series of equations. The method also includes determining at least one basis material density of the object using the physical constraint and the CT imaging data and generating an image of the object using the CT imaging data and the mass densities of at least one basis material.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: December 6, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Cynthia H. McCollough, Shuai Leng, Zhoubo Li, Lifeng Yu
  • Killing senescent cells and treating senescence-associated conditions using a SRC inhibitor and a flavonoid
    Patent number: 11517572
    Abstract: Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflanunatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: December 6, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: James L. Kirkland, Tamar Tchkonia, Yi Zhu, Allyson K. Palmer, Nathan K. LeBrasseur, Jordan D. Miller
  • In vivo targeting of extracellular vesicles
    Patent number: 11510876
    Abstract: A method for chemically induced homing of extracellular vesicles (EVs) to a specific tissue or organ in a subject for either treatment or diagnosis of a medical condition, the method comprising administering to the subject an amount of a homing agent. The homing agent is at least one of a derivative of poly(ethylene glycol), or a derivative of phenothiazine. The EVs are homed to the homing agent in the subject.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: November 29, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Aditya Bansal, Timothy R. DeGrado, Mukesh K. Pandey
  • SARS-CoV-2 POLYPEPTIDES
    Publication number: 20220370601
    Abstract: This document provides methods and materials related to selected severe acute respiratory distress coronavirus 2 (SARS-CoV-2) polypeptides. For example, this document provides vaccine compositions that contain one or more selected SARS-CoV-2 polypeptides provided herein and that have the ability to induce or increase immune responses against coronaviruses such as SARS-CoV-2 within a mammal (e.g., a human).
    Type: Application
    Filed: May 19, 2022
    Publication date: November 24, 2022
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Gregory A. POLAND, Inna G. OVSYANNIKOVA, Richard B. KENNEDY
  • Systems and methods for quality control in image-guided radiotherapy
    Patent number: 11504548
    Abstract: Systems and methods for quality control in image-guided radiotherapy are provided. In some aspects, a method includes acquiring treatment images from a patient using an imaging system, and performing a registration using the treatment images and simulation images acquired during a simulation process. The method also includes computing at least one similarity metric based on the registration performed, and determining a conformance of the at least one similarity metric to predetermined limits. The method further includes generating a report indicative of the conformance.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: November 22, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Luis E. Fong de los Santos, Michael P. Grams, Satomi Shiraishi
  • Targeting DNA-PKCS and B7-H1 to treat cancer
    Patent number: 11504376
    Abstract: Materials and methods for treating potentially chemoresistant tumors (e.g., using DNA-PKcs inhibitors and anti-B7-H1 antibodies) are provided herein.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: November 22, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Haidong Dong
  • Therapeutics for the treatment of glaucoma
    Patent number: 11505572
    Abstract: The present invention provides benzothiadiazine and chroman derivatives and particularly diazoxide and cromakalim derivatives for use in treating glaucoma, retinopathy, treating age related macular degeneration, treating, stabilizing and/or inhibiting blood and lymph vascularization, and reducing intraocular pressure by administering a pharmaceutically effective amount of a prodrug disposed in an ophthalmically acceptable carrier to the eye, wherein the prodrug specifically modulates a KATP channel to reduce an intraocular pressure.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: November 22, 2022
    Assignees: Mayo Foundation for Medical Education and Research, Regents of the University of Minnesota
    Inventors: Michael P. Fautsch, Peter Dosa, Michael A. Walters, Gunda I. Georg
  • Methods and materials for treating cancer
    Patent number: 11497729
    Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials for using an inhibitor of USP7 polypeptide to increase the sensitivity of cancer cells (e.g., CD340+ cancer cells such as HER2+ cancer cells) to treatment with an inhibitor of a CD340 polypeptide (e.g., an inhibitor of a HER2 polypeptide) are provided. Methods and materials for using USP7 polypeptide inhibitors in combination with CD340 polypeptide inhibitors to treat cancer (e.g., HER2+ breast cancer that was refractory to trastuzumab alone treatment) are provided.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: November 15, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Liewei Wang, Matthew P. Goetz, Judy C. Boughey, Jia Yu, Bo Qin
  • Weeping balloon devices
    Patent number: 11497898
    Abstract: Catheters with weeping balloons can be used for various medical purposes. For example, in some embodiments provided herein weeping balloons are used for catheter visualization devices. In some embodiments, weeping balloons are used to deliver therapeutic agents. Weeping balloons can include openings of a selected size and shape through which a fluid gradually flows or “weeps.” The design of the openings can affect performance characteristics such as, but not limited to, fluid flow rate, tear resistance, and mitigation of counter-flow.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: November 15, 2022
    Assignees: Boston Scientific Scimed, Inc., Mayo Foundation For Medical Education And Research
    Inventors: James M. Anderson, David Raab, Adam David Grovender, Roger W. McGowan
  • METHODS AND MATERIALS FOR IDENTIFYING AND TREATING AUTOIMMUNE GFAP ASTROCYTOPATHY
    Publication number: 20220357322
    Abstract: This document provides methods and materials involved in identifying and treating autoimmune GFAP (glial fibrillary acidic protein) astrocytopathy, a novel meningoencephalomyelitis, in humans as well as methods and materials for identifying and offering early treatment for patients having autoimmune GFAP astrocytopathy whose autoantibody profile predicts a high likelihood of having underlying cancer (e.g., adenocarcinoma or teratoma).
    Type: Application
    Filed: July 21, 2022
    Publication date: November 10, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Vanda A. Lennon, Andrew McKeon, Boyan Fang, Shannon Hinson, Thomas J. Kryzer
  • METHODS AND MATERIALS FOR TREATING HYPOCAPNIA
    Publication number: 20220355062
    Abstract: This document provides methods and materials for treating hypocapnia. For example, methods and materials for delivering CO2 to a mammal to treat hypocapnia or compensate for a reduced level of CO2 are provided.
    Type: Application
    Filed: July 25, 2022
    Publication date: November 10, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Jan Stepanek, Michael J. Cevette, Gaurav N. Pradhan, Samantha J. Kleindienst, Jamie M. Bogle, Rebecca S. Blue, Karen K. Breznak
  • Laparoscopic retractor devices
    Patent number: 11490882
    Abstract: Some devices for atraumatic retraction of tissue include a transcatheter deployable mesh hammock that is well-suited for laparoscopic, endoscopic, and robotic surgeries. Methods for atraumatic retraction of tissue include wrapping a mesh material around the tissue in a cradle-like fashion. In some embodiments, magnetic coupling of the proximal and distal ends of the mesh material can provide tissue containment and retractor securement to facilitate tissue retraction.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: November 8, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Johnathon M. Aho, Cornelius A. Thiels, Kimberly A. Holst
  • Assessing and treating autoimmune ataxia
    Patent number: 11493513
    Abstract: Methods and materials herein are useful for assessing and/or treating autoimmune ataxias associated with septin-specific autoantibodies (e.g., septin-5-specific autoantibodies). For example, septin-5 polypeptides are provided as well as methods for using septin-5 polypeptides to detect septin-5-specific autoantibodies and/or to treat a mammal having an autoimmune ataxia.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: November 8, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Josephe A. Honorat, Andrew McKeon, Sean J. Pittock, Vanda A. Lennon
  • DEVICES AND METHODS FOR ABLATION OF TISSUE
    Publication number: 20220346870
    Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.
    Type: Application
    Filed: July 18, 2022
    Publication date: November 3, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: David R. Holmes, JR., Samuel J. Asirvatham, Christopher V. DeSimone
  • MUMPS VIRUS AS A POTENTIAL ONCOLYTIC AGENT
    Publication number: 20220348887
    Abstract: This document relates to methods and materials for virotherapy. For example, this document provides methods and materials for treating cancer using a recombinant mumps virus as an oncolytic agent.
    Type: Application
    Filed: June 23, 2022
    Publication date: November 3, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Mark J. Federspiel, Arun Ammayappan, Gennett Pike, Stephen James Russell
  • Multivalent PD-L1 binding compounds for treating cancer
    Patent number: 11485767
    Abstract: This invention provides methods and materials for treating cancer. The invention encompasses methods and materials for delivering programmed death-ligand 1 (PD-L1) binding compounds and/or compositions containing one or more monovalent or multivalent programmed death-ligand 1 (PD-L1) binding compounds which are administered to a mammal having cancer to treat the mammal. In some cases, a multivalent PD-L1 binding compound can include two or more programmed cell death protein 1 (PD-1) polypeptides (and/or fragments thereof having the ability to bind PD-L1). This invention also provides methods and materials for making multivalent PD-L1 binding compounds and methods and materials for making nucleic acid molecules that encode PD-L1 binding compounds.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: November 1, 2022
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventor: Michael A. Barry
  • METHODS AND MATERIALS FOR TREATING CYTOKINE RELEASE SYNDROME
    Publication number: 20220339128
    Abstract: This document relates to methods and materials involved in treating a mammal having, or at risk of developing, cytokine release syndrome (CRS). For example, a mammal having, or at risk of developing, CRS can be treated by administering one or more biguanides (e.g., metformin) to the mammal.
    Type: Application
    Filed: May 13, 2022
    Publication date: October 27, 2022
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: David Dingli, Ameet K. Mishra
  • Computer-based dynamic data analysis
    Patent number: 11481701
    Abstract: A computer-implemented method comprises storing data that aggregates statuses, uploaded by healthcare providers, of a plurality of patients for a plurality of medical conditions; receiving via a remote upload from a healthcare provider data that characterizes the status of the particular patient with respect to at least some of the plurality of medical conditions; providing for review by the healthcare provider data that graphs a plotted location that is indicative of the particular patient's values in a common graph with locations that are indicative of the other patients' values, and that highlights the particular patient's values relative to the other patients' values; and adding data for conditions of the particular patient to a database that aggregates the statuses of the plurality of patients.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 25, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Piero Rinaldo, David M McHugh, Gregg Marquardt, Neil Maffitt, Robert J. Currier
  • Butyrylcholinesterases having an enhanced ability to hydrolyze acyl ghrelin
    Patent number: 11473069
    Abstract: This document provides butyrylcholinesterases having an enhanced ability to hydrolyze acyl ghrelin as well as nucleic acids encoding such butyrylcholinesterases. This document also provides methods and materials for treating obesity and/or aggression. For example, methods for administering a nucleic acid encoding a wild-type or mutant butyrylcholinesterase having the ability to hydrolyze acyl ghrelin to a mammal under conditions wherein the level of acyl ghrelin within the mammal is reduced, under conditions wherein the rate of body weight gain of the mammal is reduced, under conditions wherein the mammal's level of aggression is reduced, and/or under conditions wherein the mammal's rate of developing stress-induced tissue damage are provided.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: October 18, 2022
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Liyi Geng, Ping Chen, William S. Brimijoin, Yang Gao