Patents Assigned to Mayo Foundation
  • System and method for quantifying luminal stenosis using multi-energy computed tomography imaging
    Patent number: 11744538
    Abstract: A system and method for determining stenosis severity in a subject's vasculature using multi-energy computer tomography (MECT) imaging is provided. In some aspects, the method includes acquiring MECT data using a CT system, performing a material decomposition process on acquired MECT data to generate one or more material density maps, and selecting, using the one or more material density maps, one or more regions of interest (ROIs) encompassing at least one vessel cross-section. The method also includes measuring an iodine content in the one or more ROIs, and determining a stenosis severity based on the measured iodine content. The method further includes generating a report indicating the stenosis severity associated with the subject's vasculature.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 5, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhoubo Li, Cynthia H. McCollough, Lifeng Yu
  • Adenoviruses and methods for using adenoviruses
    Patent number: 11746334
    Abstract: This invention relates to methods and materials for nucleic acid delivery, vaccination, and/or treating cancer. More specifically, methods and materials for nucleic acid delivery, vaccination, and/or treating cancer using one or more recombinant adenoviruses (Ads) as an oncolytic agent are provided.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: September 5, 2023
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventor: Michael A. Barry
  • Systems and methods for Kalman filter-based microvessel inpainting for super-resolution imaging
    Patent number: 11748849
    Abstract: Described here are systems and methods for super-resolution imaging with ultrasound in which a Kalman filter-based microvessel inpainting technique is used to facilitate robust super-resolution imaging with limited or otherwise missing microbubble signals. The systems and methods described in the present disclosure can be combined with both local and global microbubble tracking methods.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: September 5, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Pengfei Song, Shigao Chen, Joshua D. Trzasko, Armando Manduca, Shanshan Tang
  • Systems and methods for performing electrophysiology (EP) signal processing
    Patent number: 11737699
    Abstract: Systems, methods, and computer program product embodiments are disclosed for performing electrophysiology (EP) signal processing. An embodiment includes an electrocardiogram (ECG) circuit board configured to process an ECG signal. The embodiment further includes a plurality of intracardiac (IC) circuit boards, each configured to process a corresponding IC signal. The ECG circuit board and the plurality of IC circuit boards share substantially a same circuit configuration and components. The ECG circuit board further processes the ECG signal using substantially a same path as each IC circuit board uses to process its corresponding IC signal.
    Type: Grant
    Filed: April 13, 2022
    Date of Patent: August 29, 2023
    Assignees: BioSig Technologies, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Budimir S. Drakulic, Sina Fakhar, Thomas G. Foxall, Branislav Vlajinic, Samuel J. Asirvatham
  • Methods and materials for assessing and treating obesity
    Patent number: 11740247
    Abstract: This document relates to methods and materials for assessing and/or treating obese mammals (e.g., obese humans). For example, methods and materials for using one or more interventions (e.g., one or more pharmacological interventions) to treat obesity and/or obesity-related comorbidities in a mammal (e.g., a human) identified as being likely to respond to a particular intervention (e.g., a pharmacological intervention) are provided.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: August 29, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Andres J. Acosta, Michael L. Camilleri
  • Intraocular lenses
    Patent number: 11737864
    Abstract: This document describes intraocular lenses and methods for their use. For example, this document describes intraocular lenses that are shaped with a concave posterior peripheral portion that mitigates occurrences of dysphotopsia. The intraocular lenses described herein are designed to reduce positive and negative dysphotopsias after cataract surgery.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: August 29, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Jay C. Erie, Mark H. Bandhauer
  • Endoluminal anastomosis and tissue closure devices
    Patent number: 11737757
    Abstract: Multiple endoscopic devices and methods for closing perforations and/or creating anastomoses in tissue are described. For example, this document provides devices and methods for performing esophagogastric anastomoses and for closing esophageal perforations in a minimally invasive fashion. The devices and methods provided herein can also be used for, without limitation, colorectal anastomoses, any bowel anastomosis, gastric bypass anastomoses, and broader vessel anastomoses.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: August 29, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Shanda Blackmon
  • Medical devices and methods for body conduit lengthening and anastomosis formation
    Patent number: 11737745
    Abstract: Devices and methods for body conduit lengthening and anastomosis creation can be used to treat patients with a variety of health conditions. For example, among other uses, this document describes esophageal lengthening and anastomosis devices that can be used to remedy esophageal atresia in neonatal patients.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: August 29, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: D. Dean Potter, Jr.
  • Methods and materials for expanding antigen-specific T cells in culture
    Patent number: 11739296
    Abstract: This document provides methods and materials for expanding antigen-specific T cells (e.g., antigen-specific CD4+ T cells and/or antigen-specific CD8+ T cells) in culture. For example, methods and materials for performing a polyclonal stimulation step for a particular duration (e.g., from about 1 hour to about 48 hours) to increase the expansion of T cells having a desired antigen specificity are provided.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: August 29, 2023
    Assignees: Mayo Foundation for Medical Education and Research, University of Washington
    Inventors: Peter A. Cohen, Sandra J. Gendler, Latha B. Pathangey, Dustin B. McCurry, Jessica E. Gorman, Mary L. Disis
  • Facet joint replacement devices
    Patent number: 11737793
    Abstract: Devices and systems can be used to treating spinal conditions. For example, this document describes artificial facet joint systems that can be implanted to treat spinal conditions while facilitating normal stability and motions of the spine. Such systems and methods can be used to treat spinal conditions such as, but not limited to, spondylosis, vertebral fractures, and the like.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: August 29, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Mohamad Bydon, Chunfeng Zhao, Hugo Giambini, Brandon A. McCutcheon, Panagiotis Kerezoudis, Timothy L. Rossman, Allen K. Rech, Joel L. Kuhlmann, Mohammed Ali Alvi, Daniel J. Mangiameli, Robert A. Highet
  • Using autologous mesenchymal stem cells to treat multiple system atrophy
    Patent number: 11723928
    Abstract: This document provides methods and materials for treating multiple system atrophy. For example, methods and materials for using autologous mesenchymal stem cells (e.g., adipose derived mesenchymal stem cells) to treat multiple system atrophy are provided.
    Type: Grant
    Filed: August 12, 2022
    Date of Patent: August 15, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Wolfgang Singer, Phillip Low
  • Replication-competent vesicular stomatitis viruses
    Patent number: 11723937
    Abstract: This document provides methods and materials related to vesicular stomatitis viruses. For example, replication-competent vesicular stomatitis viruses, nucleic acid molecules encoding replication-competent vesicular stomatitis viruses, methods for making replication-competent vesicular stomatitis viruses, and methods for using replication-competent vesicular stomatitis viruses to treat cancer or infectious diseases are provided.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: August 15, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Kah-Whye Peng, Stephen James Russell, Camilo Ayala Breton
  • Evaluation of mantle cell lymphoma and methods related thereto
    Patent number: 11725248
    Abstract: The present invention provides methods of determining a survival predictor score of a subject having mantle cell lymphoma (MCL). The present invention also provides methods of predicting the survival outcome of a subject having MCL and provides methods of selecting a treatment for a subject having MCL.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: August 15, 2023
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, British Columbia Cancer Agency Branch, Julius-Maximilians-University of Würzburg, Oregon Health & Science University, Hospital Clinic de Barcelona, Universitat de Barcelona, Oslo University Hospital HF, The Cleveland Clinic Foundation, Mayo Foundation for Medical Education and Research
    Inventors: Louis M. Staudt, David William Scott, George W. Wright, Andreas Rosenwald, Pau Abrisqueta, Rita Braziel, Elias Campo Guerri, Wing C. Chan, Joseph M. Connors, Jan Delabie, Diego Villa, Kai Fu, Randy D. Gascoyne, Timothy Greiner, Elaine S. Jaffe, Pedro Jares, Anja Mottok, German Ott, Lisa M. Rimsza, Graham Slack, Dennis Weisenburger, Erlend B. Smeland, James Robert Cook
  • COMPOUNDS FOR THE REDUCING LIPOTOXIC DAMAGE
    Publication number: 20230250057
    Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 3, 2023
    Publication date: August 10, 2023
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Vijay P. Singh, Sampath-Kumar Anandan, Kevin Greenman, Zeeshan Kamal
  • Abdominal measurement apparatuses and related methods
    Patent number: 11717182
    Abstract: An abdominal measurement apparatus includes multiple belts configured to be lengthened and shortened around respective portions of an abdomen, multiple tensioning mechanisms respectively coupled to the multiple belts and configured to maintain substantially constant tensions in the multiple belts around the respective portions of the abdomen, and multiple measurement devices respectively coupled to the multiple belts and configured to provide indications of lengths of the multiple belts while the multiple belts are maintained in tension around the respective portions of the abdomen.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: August 8, 2023
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Michael D. Jensen, Teresa B. Jensen
  • ISOTYPING IMMUNOGLOBULINS USING ACCURATE MOLECULAR MASS
    Publication number: 20230243845
    Abstract: This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.
    Type: Application
    Filed: February 7, 2023
    Publication date: August 3, 2023
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: David L. Murray, David R. Barnidge, Surendra Dasari, John R. Mills
  • Point-of-care apparatus and methods for analyte detections using electrochemical impedance or capacitance
    Patent number: 11714083
    Abstract: The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: August 1, 2023
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, AXIM BIOTECHNOLOGIES. INC.
    Inventors: Jeffrey LaBelle, Garrett Repp, Chi Lin, Mark Spano, Jennifer Blain Christen, Hongwu Jiang, Marcus Smith, Andrew Penman, Pierce Youngbar, Mackenzie Honikel, Curtiss Cook
  • Methods and materials for identifying and treating bet inhibitor-resistant cancers
    Patent number: 11712439
    Abstract: This document provides methods and materials involved in identifying and treating mammals having a cancer resistant to BET inhibitors. For example, methods and materials for administering one or more AKT inhibitors in combination with one or more BET inhibitors to mammals identified as having a cancer resistant to treatment with one or more BET inhibitors in the absence of AKT inhibitors are provided.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: August 1, 2023
    Assignees: Mayo Foundation for Medical Education and Research, Shanghai Changhai Hospital
    Inventors: Haojie Huang, Yinghao Sun, Shancheng Ren
  • TARGETING DNA-PKCS AND B7-H1 TO TREAT CANCER
    Publication number: 20230233571
    Abstract: Materials and methods for treating potentially chemoresistant tumors (e.g., using DNA-PKcs inhibitors and anti-B7-H1 antibodies) are provided herein.
    Type: Application
    Filed: November 21, 2022
    Publication date: July 27, 2023
    Applicant: Mayo Foundation for Medical Education and Research
    Inventor: Haidong Dong
  • TRANSORAL SURGICAL DEVICES AND METHODS
    Publication number: 20230225608
    Abstract: Devices and methods can be used for performing transoral surgery. For example, this document provides oral retractor devices and articulating surgical tools that are well-suited for transoral surgery uses. The devices and methods provided herein may be used to treat conditions such as, but not limited to, mouth cancer, throat cancer, tongue cancer, larynx cancer, tonsil cancer, obstructive sleep disorders, and pharyngeal diverticulum, to provide some examples.
    Type: Application
    Filed: January 4, 2023
    Publication date: July 20, 2023
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Kathryn M. Van Abel, Eric J. Moore