Abstract: The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure relates to multivalent antibody recruitment molecules and methods of treating cancer using same.

Abstract: A method for autonomous path planning triggered by freeway rubbernecking includes obtaining gaze directions of drivers of a plurality of connected vehicles in a region of a road. The method also includes determining whether an average speed of the plurality of connected vehicles in the region is less than a predetermined speed. The method further includes controlling mobility of one or more of the plurality of connected vehicles in response to determining that the gaze directions of one or more drivers of the plurality of connected vehicles deviate from the moving direction of the connected vehicles and determining that the average speed of the connected vehicles is less than the predetermined speed.

Abstract: System, methods, and other embodiments described herein relate to implementing cooperative management strategies. In one embodiment, a method includes determining a severity score and a risk area. The method may then determine whether vehicles should belong to a first vehicle set, which may perform a cooperative vehicle response action, or a second vehicle set, in which individual response actions may be performed. The method may then generate a cooperative response action or an individual response action corresponding to the cooperative or individual vehicle sets, provided such vehicle sets are not empty.

Abstract: A system and method is provided for implementing computer-controlled systems (e.g., vehicle safety and traffic management systems) based on compliance rates. A vehicle system and method are provided that estimate compliance rates in real-time, and have the capability to dynamically modify the computer-controlled instructions generated by a computer-controlled system (e.g., vehicle safety and traffic management systems) in a manner that improves compliance, and in-turn improves overall system performance. For example, a vehicle includes sensors receiving data from a plurality of communicative connected vehicles. The received data is associated with a real-time monitoring of traffic conditions for the vehicle. The vehicle also includes a controller device estimating a compliance rate in real-time based on the received data. The controller device of the vehicle also controls an automated operation of the vehicle using a modified computer-controlled instruction based on the estimated compliance rate.

Abstract: An optical grating comprising a refractive index with a periodic pattern that includes a base period ?0; a periodic sampling of the base period, with a first period ?1 and a first duty cycle p1, thereby defining a single-sampled grating (SSG); and a periodic sampling of the SSG, with a second period ?2 and a second duty cycle p2. The resulting dual-sampled grating (DSG) can have a reflection spectrum containing reflection peaks. If two DSGs having different reflection spectra share a common interface, a tunable optical filter can be produced, where electrical or heating means can cause a reflection peak of one spectrum to be shifted to coincide with a reflection peak of the other spectrum, thereby filtering the corresponding wavelength. By inserting between the two DSGs a gain medium and a phase-tuning medium, a laser source structure is realized. Either device can be produced by etching or stacking methods.

Abstract: This disclosure relates to methods of making omniphobic materials which are physically and chemically modified at their surface to create hierarchically structured materials with both nanoscale and microscale structures that provide the omniphobic properties. Uses thereof, including as flexible tubular structures that repel contaminants are also disclosed herein.

Abstract: This application relates to omniphobic materials which are physically and chemically modified at their surface to create hierarchically structured materials with both nanoscale and microscale structures that provide the omniphobic properties. Methods of making such omniphobic surfaces with hierarchical structures and uses thereof, including as flexible films that repel contaminants are also disclosed in the application.

Abstract: Systems, methods and devices for detecting a presence of an analyte in a fluid sample are described herein. The devices include a microfluidic module having a microfluidic channel configured to receive the fluid sample at an inlet thereof and direct the fluid sample towards an outlet thereof. The devices also include an image sensor positioned removably abutting the microfluidic module. The image sensor is positioned laterally between the inlet and the outlet of the microfluidic channel and below a lower surface of the microfluidic channel. The image sensor is communicatively coupled to a processor that is configured to receive signal data from the image sensor. The devices also include a light source configured to direct light through the fluid sample and towards the image sensor as the fluid sample passes through the microfluidic channel. The image sensor receives the light and outputs the signal data to the processor.

Abstract: This disclosure relates to superhydrophobic materials and/or surfaces comprising a shrinkable polymer substrate and at least one polysiloxane layer, wherein the materials and/or surfaces comprise microscale wrinkles and nanoscale features that form hierarchical structures. Methods of making and uses thereof are also disclosed herein.

Abstract: This application relates to omniphobic materials which are physically and chemically modified at their surface to create hierarchically structured materials with both nanoscale and microscale structures that provide the omniphobic properties. Methods of making such omniphobic surfaces with hierarchical structures and uses thereof, including as flexible films that repel contaminants are also disclosed in the application.

Abstract: An example operation includes one or more of receiving traffic data from a plurality of transports that are currently in operation within a predetermined geographic area, partitioning a map of the predetermined geographic area into a plurality of partitions based on link states within the traffic data, generating a plurality of macroscopic fundamental diagrams (MFDs) for the plurality of partitions based on flow rates and link densities in the traffic data, and mitigating congestion within the predetermined geographic area based on the plurality of MFDs for the plurality of partitions.

Abstract: An example operation includes one or more of receiving traffic data uploaded from vehicles that are currently operating within a geographic area via a computer network, generating a plurality of macroscopic fundamental diagrams (MFDs) for a plurality of sub-areas within the geographic area, respectively, based on the received traffic data, identifying a sub-area among the plurality of sub-areas which is congested based on the plurality of MFDs, and transmitting routing instructions to the vehicles within the geographic area to divert the vehicles away from the sub-area.

Abstract: The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted.

Abstract: A district energy system includes at least one energy provisioning unit, an energy management controller; a thermal distribution network coupled to the energy provisioning units and to a plurality of coupling interfaces connectable to the associated HVAC system of buildings within a district, and an electrical distribution network coupled to the energy provisioning units and to the coupling interfaces. The coupling interfaces may include both heat pumps and heat exchangers at each building, to provide heating, cooling and enable harvesting of normally wasted thermal energy from the buildings for re-distribution. The controller can manage the selection and number of energy provisioning units (and their operational set points) coupled to the district thermal distribution network and the electrical distribution network to meet the thermal and electrical demands of the district while satisfying other operational goals such as the minimization of greenhouse gas emissions.

Abstract: The present application is directed to methods of performing chemical reactions, including multi-step chemical reactions in which two or more of the reagents in the chemical reaction are incorporated or entrapped in a solid polymeric structure comprising pullulan. In certain embodiments, the chemical reaction or multi-step reaction serves as a sensor. Accordingly the present application is also directed to sensors for performing the methods of the application. In certain embodiments, at least one of the reagents is a biomolecule and the sensor is a biosensor. In certain other embodiments, the solid polymeric structure comprising pullulan and the reagents for performing a chemical reaction form a convenient device for performing a chemical reaction.

Abstract: An electrochemical sensor array for detecting analytes in water, including a frame; a plurality of sensor electrodes each mounted to the frame, including a free chlorine working electrode including a gold thin film and having a free chlorine sensing surface to be exposed to the water; and a reference electrode including a silver thin film and a silver and silver chloride layer and having a reference sensing surface to be exposed to the water. A method of manufacturing an electrochemical sensor array for detecting analytes in water, including forming a free chlorine electrode, including forming a gold thin film on a first base layer; forming a reference electrode, including forming a silver thin film on a second base layer and applying a silver and silver chloride paste to a portion of the silver thin film; and arranging the free chlorine electrode and the reference electrode on a common frame.

Abstract: This application relates to the use of 4-phenylbutyric acid, as well as pharmaceutically acceptable salts, co-crystals, polymorphs, solvates, analogs and/or pro-drugs thereof for the treatment of lysosomal storage disease, in particular gangliosidoses such as Tay Sachs disease (TSD) and Sandhoff disease (SD), alone, or in combination with other compounds and/or treatments.

Abstract: This application relates to a photoactive product comprising: a catechol-containing compound, an amine-containing polymer, and photoactive material. The photoactive product can act as a photocatalyst and can be used in photoelectrodes for use in, for example, photoelectrochemical analyte sensing, including biosensing. The photoelectrodes modified with hybrid organic/inorganic materials can provide increased light absorption and charge separation, binding sites for attaching biorecognition probes, and built-in film-forming properties for well-adhered and uniform photoactive frameworks on the collector electrodes.

Abstract: Provided herein are novel synthetic compounds having the structure of formula (1), wherein X is a substituted or unsubstituted aromatic or heteroaromatic mono- or polycyclic ring system; and Y is substituted or unsubstituted C5-C10 alkyl or alkenyl group, or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions. The compounds and pharmaceutical compositions are useful for inhibiting growth of a bacterium.

Abstract: The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure provides antibody recruitment molecules, pharmaceutical compositions comprising same and kits comprising same. The present disclosure also provides methods of treating cancer using the antibody recruitment molecules in combination with oncolytic virus therapy, and methods for enhancing the efficacy and/or reducing the toxicity of the oncolytic virus therapy.