Abstract: This application relates to compounds such as compounds of Formula (I) that block SREBP2-induced hepatic PCSK9 expression, compositions comprising these compounds and methods of use thereof; for example, for treating diseases, disorders or conditions treatable by blocking SREBP2 activation and/or PCSK9 gene expression.

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF, glycodelin and optionally ZAG, in a biological sample from the mammal, and determining that the mammal has endometriosis when the biomarker expression levels in the sample are elevated.

Abstract: Multivalent trident aptamers comprising the general formula [A-SA]2 or 3-L-[SB-B] in which a central branched linker molecule (L) possesses 2 or 3 variable arms ([A-SA]2 or 3), and a root ([SB-B]), connected by a central carbon atom, to provide enhanced affinity and/or avidity with a target are described, as well as methods of making and using the multivalent trident aptamers are provided.

Abstract: This disclosure is directed to novel CD133-binding agents. The disclosure is also directed to uses of novel CD133-binding agents for detecting CD133-expressing cells and/or quantitating levels of cellular CD133 expression, for targeting CD133-expressing cells, for decreasing levels of CD133 in CD133-expressing cells and for treating or preventing cancer.

Abstract: A cutting tool, comprising a substrate having a cutting surface and a coating adhered to the cutting surface in a solid state, wherein the coating includes a soft metal and is capable of melting and functioning as an in-situ liquid lubricant when the cutting tool is applied in a machining operation. Also, a method of applying a coating to a cutting tool, comprising receiving a premachining workpiece, the premachining workpiece formed of a coating material including a soft metal; and machining the premachining workpiece with the cutting tool such that a layer of the coating material adheres to a cutting surface of the cutting tool in a solid state.

Abstract: Systems and methods for assessing cognitive function are described that use tracked electrical activity of the brain of the individuals in response to a specific sequence of stimuli in generating data sets, which, for example, can be encapsulated as a data structure. The data sets can include tracked specific response types, at different times and amplitudes, including, but not limited to, event related potential signal components. Brainwave features including, event related potentials, are tracked in relation to both pre-attentive brain responses and consciously controlled attention responses.

Abstract: System, methods, and other embodiments described herein relate to implementing cooperative management strategies. In one embodiment, a method includes determining a severity score and a risk area. The method may then determine whether vehicles should belong to a first vehicle set, which may perform a cooperative vehicle response action, or a second vehicle set, in which individual response actions may be performed. The method may then generate a cooperative response action or an individual response action corresponding to the cooperative or individual vehicle sets, provided such vehicle sets are not empty.

Abstract: Methods of diagnosing Crohn's disease and ulcerative colitis in subjects is provided based on the determination of metabolites in urine samples, such as serine, hypoxanthine, kynurenine, threonine, dimethylglycine, tryptophan, indoxylsulfate, phenylacetylglutamine, sialic acid, 5-hydroxy-6-indolyl-o-sulfate, 5-(?-carboxybutyl) homocysteine, and/or an anion having m/z:RMT:polarity of 345.1553:0.770:n, or determination of metabolites in stool samples, such as ketodeoxycholic acid, cholic acid, choline, tryptophan, trimethyllysine, serine, butyric acid, lactic acid, hypoxanthine and/or guanine.

Abstract: In at least one embodiment, a DC-DC power converter comprises a primary circuit coupled to a DC input voltage, a secondary circuit coupled to a DC output voltage, and a transformer isolating the primary from the secondary circuit. The primary circuit comprises a first and second circuit branch. The first circuit branch comprises a plurality of switches, a diode, and a reconfiguration switch. The second circuit branch comprises a plurality of switches, and a plurality of diodes. The reconfiguration switch is operable to switch the primary circuit between a first mode and a second mode, wherein the primary circuit operates as a full-bridge circuit in the first mode and the primary circuit operates as a half-bridge circuit in the second mode.

Abstract: The present invention discloses novel pentamidine analogues such as pentamidine analogs having the general formula: wherein: X is C, N, or —CH—CH—, Y is Y1 when X is N, and Y is Y1 and Y2 when X is C, or —CH—CH—, Y1, or Y1 and Y2 independently, are selected from H, hydroxyl, lower alkyl, lower alkoxy, halogen, nitro, amino, cyano or thiol, wherein the lower alkyl or alkoxy is optionally substituted with one or more of hydroxyl, halogen, nitro, amino, cyano, thiol, or a 5- or 6-membered aromatic or non-aromatic ring, optionally substituted with one or more of hydroxyl, lower alkyl, lower alkoxy, halogen, nitro, amino, cyano or thiol, wherein Y1 is not H when X is N; or Y1 is a 5- or 6-membered aromatic or non-aromatic ring, optionally substituted with one or more groups selected from hydroxyl, lower alkyl, lower alkoxy, halogen, nitro, amino, cyano, carboxy, or thiol, and Y2 is H, if present; or Y1 and Y2 together with X form a 5- to 8-membered hydrocarbon ring, optionally substituted with one or more g

Abstract: Hybrid silicon devices are disclosed in which a silicon-based resonant structure is coated with a rare-earth-doped tellurium oxide layer that facilitates optical gain, thereby forming a silicon-based laser cavity. The silicon-based laser cavity supports at least one resonant mode that has a modal volume extending from the silicon resonant base structure into the rare-earth-doped tellurium oxide layer. The silicon-based laser cavity is optically coupled to a silicon waveguide to facilitate the delivery of pump laser energy to the silicon-based laser cavity, such that at least a portion of the pump laser energy propagating through the silicon waveguide is coupled to the silicon-based laser cavity for excitation of the rare earth dopant within the rare-earth-doped tellurium oxide layer. The silicon waveguide that is optically coupled to the silicon-based laser cavity also facilitates the external delivery of the laser energy generated within silicon-based laser cavity.

Abstract: Systems and methods are provided for determining a start time and severity value associated with the roadway incident to provide traffic management instructions. The system may, for example, receive sensor data from a vehicle at a location associated with a roadway incident. The system can determine a traffic flow profile for the location, where the traffic flow profile identifies characteristics of the roadway incident that match characteristics of the traffic flow profile. Based on the traffic flow profile, the system may determine a severity value for the roadway incident and calculate a start time of the roadway incident. The start time may correspond with the traffic flow profile for the location in view of the severity value.

Abstract: This disclosure relates to a biosensor, and methods of use thereof, for detecting a target in a sample comprising a photoelectrode comprising a conductive substrate and a photoactive material; a population of capture probes functionalized on the photoelectrode wherein the capture probes are capable of binding to the target and a reporter moiety; and the reporter moiety comprising a detectable label and a capture probe binding portion; wherein exposure of the target to the population of the capture probes results in binding of the target to a fraction of the population which results in a decrease in detection signal intensity compared to the intensity in the absence of the target, and subsequent binding of the reporter moiety to the remaining unbound capture probes results in an increase in detection signal intensity that is less than an increase from the reporter moiety binding to capture probes not exposed to the target.

Abstract: This application relates to a thermo-gel polymer system useful for ophthalmic drug delivery. The thermo-gel comprises a polymer and chitosan, and the polymer comprises monomers of N-isopropylacrylamide (NIPAAm), acrylic acid (AA) and at least one hydrophobic monomer.

Abstract: Provided is a system and method for determining an arrangement of network resources to provide network access security. The method including: assigning a weight to each network resource based on the associated security policy, where a greater weighting corresponds to a requirement for a greater level of security; segmenting the network resources into subsets if a operator acting on the network resource with other network resources in the subset has equal or more combined weight than the combined weight of the operator acting on the network resource with other network resources not in the subset; generating a network topology by adding subsets to nodes in the network graph in descending order by weight until one of the one or more access points is reached, where vertices between nodes are firewalled.

Abstract: An approach to control or monitoring of battery operation makes use of a recurrent neural network (RNN), which receives one or more battery attributes for a Lithium ion (Li-ion) battery, and determines, based on the received one or more battery attributes, a state-of-charge (SOC) estimate for the Li-ion battery.

Abstract: An approach to control or monitoring of battery operation makes use of an artificial neural network (ANN), which receives one or more battery attributes for a Lithium ion (Li-ion) battery, and determines, based on the received one or more battery attributes, a state-of-charge (SOC) and/or a state-of-health (SOH) estimate for the Li-ion battery. The ANN includes at least one of a recurrent neural network (RNN) and a convolutional neural network (CNN), and the series of values of the battery attributes includes at one of battery voltage values, battery current values, and battery temperature values.

Abstract: The disclosure relates to an in situ-gelling hydrogel composition based on functionalized zwitterionic polymers. The resulting hydrogels exhibit highly anti-fouling, anti-adhesive, and lubricating properties to enable the fabrication of bulk hydrogels or hydrogel-based coatings of relevance to biomedical applications.

Abstract: Methods of determining the risk of an adverse cardiovascular event or death in a mammal are provided which include determining in a biological sample obtained from the mammal the level of a combination of biomarkers selected from a glucose metabolism biomarker, a heart function biomarker, a renal function biomarker and at least one biomarker of cardiac injury. A score is allotted based on the level of each biomarker, and the cumulative score is indicative of the risk of an adverse cardiovascular event.

Abstract: The present application discloses biofunctional surfaces that have self-assembled monolayers of fluorine groups with “built-in” functional groups promote targeted cell and biomolecule binding to the surface while reducing non-specific binding. Further, this application also relates to methods for preparing functional biomolecules, viruses and cells that can be covalently immobilized to prepare biofunctional surfaces.