Abstract: A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film; providing sheet metal having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. The later applied force is greater than the initially applied force.

Abstract: Cpn0803, CopB (Cpn0809) and CopD (Cpn0808) proteins and homologues thereof are shown to induce an immune response that is protective against a live challenge with Chlamydia. Methods and uses of Cpn0803 or fragments or epitopes thereof alone or together with CopB and/or CopD or fragments or epitopes thereof for treating or preventing chlamydial infection in a subject in need thereof are provided.

Abstract: The present application provides a catalyst component for alkene polymerization. The catalyst component contains: (a) a group 4 transition metal or rare earth metal, (b) a rigid non-cyclopentadienyl ligand with a tricyclic backbone composed of three ortho-fused 6-membered rings in a linear arrangement (as is the case in xanthene), with or without additional fused rings; the tricyclic backbone contains at least one donor atom within the central ring (as is the case for xanthene, oxanthrene, or acridan); furthermore, donor atoms/groups or aryl rings are attached directly (i.e. via the donor atom in the case of donor groups) to both of the bondable carbon atoms adjacent to at least one of the donor atoms within the central ring (e.g.

Abstract: The present application relates to brush amphiphilic block copolymers comprising at least one block which is hydrophilic and at least another block which is hydrophobic.

Abstract: A method of diagnosing cystic fibrosis in a human subject is provided. The method includes the steps of: i) determining in a biological sample from the subject the level of one or more metabolic biomarkers; ii) comparing the level of the biomarker to a control level and determining the difference between the biomarker level and the control level; and iii) determining that the subject has cystic fibrosis or a related disorder when the difference in the level of the biomarker in the sample is statistically different from the control level.

Abstract: The present application includes stabilized adenovirus compositions comprising an adenovirus and an excipient, wherein the excipient comprises a mixture of dextran and mannitol in amounts effective to maintain at least 40% of the adenovirus activity after spray drying.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: A switched reluctance machine has a stator core salient with stator poles disposed concentrically with a rotor that is salient with rotor poles. A plurality of coil windings are wound about the stator core so that a pair of windings are adjacent each of the stator poles. The pair of coil windings induces magnetic flux in the adjacent stator poles and the rotor rotates to align the rotor poles with the stator poles having the induced magnetic flux. The rotor is rotatable at high speeds of up to 50,000 RPM and the coil windings can be directly cooled.

Abstract: A method of image projection including selecting a set of desired chromaticity coordinates of a projection system, the projection system including a plurality of laser sources; determining a set of parameters of an expected operational environment; and configuring each laser source to have a power ratio and a power spectrum density function generating a normalized power spectrum density function of the projection system having the set of desired chromaticity coordinates and a wavelength diversity factor of at least 2 in the expected operational environment. A projection system including an input device configured to receive a set of desired chromaticity coordinates and a set of operational parameters; a plurality of laser sources each having a power ratio and a power spectrum density function configured to generate a normalized power spectrum density function producing the set of desired chromaticity coordinates and a wavelength diversity factor of at least 2.

Abstract: This disclosure relates to the field of energy recovery systems, and more particularly to exhaust heat recovery devices and exhaust flow control devices.

Abstract: The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.

Abstract: The present application relates to methods of using compounds of Formulae (I) and (II): for treatment of various cancers. The application further relates to pharmaceutical compositions and uses comprising the compounds of the application.

Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.

Abstract: This application provides constructs for use as complex cell systems of a desired shape and methods of preparing thereof. The constructs comprise cells contained within a biocompatible gel matrix deposited on a scaffold material optionally cut into defined patterns and impregnated with a crosslinking agent, wherein the biocompatible gel matrix crosslinks upon contact with the crosslinking agent on the scaffold. By stacking multiple alternating layers of the scaffold material cut into defined patterns and the biocompatible gel matrix deposited on the scaffold in defined patterns, complex 3D structures with features like embedded channels are be formed. These complex cell system constructs can be used as in vitro models of biological processes.

Abstract: The present application relates to a method for improving analytical efficiency and cost effectiveness of oxygen isotope analysis of an aqueous sample. In particular, the present application relates to a method of determining an oxygen isotope composition of an aqueous sample by (a) equilibrating the aqueous sample with CO2 gas wherein the aqueous sample comprises an effective amount of carbonic anhydrase (CA) enzyme; and (b) measuring the oxygen isotope composition of the CO2 at equilibrium, wherein the oxygen isotope composition of the CO2 corresponds to the oxygen isotope composition of the aqueous sample.

Abstract: Biocompatible block copolymer micelles for use in mucoadhesive drug delivery are provided. The micelles comprise a degradable hydrophobic polymer, a degradable synthetic hydrophilic polymer and a mucoadhesive polymer. The micelles are particularly useful for ophthalmic uses.

Abstract: Provided herein are aptamers, aptamer probes and biosensor systems that detect C. difficile glutamate dehydrogenase (GDH). Also provided are methods of detecting C. difficile GDH using the aptamers, probes and biosensors and methods of determining whether a subject has a C. difficile infection.

Abstract: The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.

Abstract: Two isoforms of thyroid receptor alpha (THR?1 and THR?2) have been found to be associated with the growth of cancer. Use of inhibitors of THR?1 (Formula I) and/or agonists of THR?2 (Formula II) in the treatment of such cancers is disclosed. Treatment of other disorders associated with such receptors is also contemplated, as is the use of diagnostic methods for predicting therapeutic outcomes based on the levels of expression of THR?1 and THRa?2 in a tissue sample.

Abstract: A method of image projection including selecting a set of desired chromaticity coordinates of a projection system, the projection system including a plurality of laser sources; determining a set of parameters of an expected operational environment; and configuring each laser source to have a power ratio and a power spectrum density function generating a normalized power spectrum density function of the projection system having the set of desired chromaticity coordinates and a wavelength diversity factor of at least 2 in the expected operational environment. A projection system including an input device configured to receive a set of desired chromaticity coordinates and a set of operational parameters; a plurality of laser sources each having a power ratio and a power spectrum density function configured to generate a normalized power spectrum density function producing the set of desired chromaticity coordinates and a wavelength diversity factor of at least 2.