Abstract: Intra-enterprise wireless handset (WH) calls between WHs operating in a wireless local area network (WLAN) are established directly between the WHs via a call connection that is maintained within the LAN without being routed through the cellular network (CN). This eliminates the cost of placing and maintaining calls through the CN for intra-enterprise calls, and also enables use of capabilities that are available in the enterprise telecomm equipment. Upon detection of a trigger condition, if and when it is more likely that a complete vertical handover (VHO) may be needed, the call connection between the WHs in the LAN is replaced by one that is routed through the CN. Thereafter, a VHO may occur (if at all) upon detection of a radio handover condition.

Abstract: A method is presented for adapting the packet size for VoIP communications, determined on-the-fly by the total network delay inherent at the time of packet transmission. If network delays are small relative to the maximum permissible latency for VoIP communications, the payload size per packet may be increased to maximize efficiency for the transmitted call. Alternatively, if network delays are large, the payload size per packet may be decreased in order to assure that the perceived quality of the transmitted call is acceptable.

Abstract: The invention relates to the preparation of monolithic silica under mild conditions from alkoxysilanes derived from sugars, sugar acids, sugar alcohols and polysaccharides including glycerol, sorbitol, mannose and dextran. Unlike the commonly used silica starting material TEOS (Si(OEt)4), the sol-gel hydrolysis and cure of the sugar derivatives are not very sensitive to pH as similar rates of gelation were observed over a pH range of about 5.5-11. The morphology of the resulting silicas could be varied using specific additives, including multivalent ions and hydrophilic polymers.

Abstract: The invention provides asymmetric membranes composed of a microporous substrate whose pores contain a crosslinked gel, the density of the crosslinked gel being greater at or adjacent to one major surface of the membrane than the density at the other major surface. The membranes are useful for separating matter from liquids and display good flux and good rejection at low pressure.

Abstract: If a handoff by a mobile station currently associated with a particular access point is probable, then the particular access point sends an activation alert to one or more other access points. An access point receiving the activation alert that is in a low-power state enters a higher-power state. An access point receiving the activation alert that is in a higher-power state, remains in that higher-power state.

Abstract: Indications of one or more future unavailability time intervals are transmitted in a management frame by an access point to one or more wireless client devices associated therewith. During the unavailability time intervals, the access point is not available to receive unsolicited communication from the wireless client devices.

Abstract: Disclosed is a cyclic peptide antibiotic in which an enzyme-sensitive bond is replaced by an enzyme-resistant bond.

Abstract: The present invention relates to a two-step method of preparing methylsilsequixane (MSQ) materials suitable for chromatographic applications comprising treating a MSQ precursor with a suitable acid followed by treatment with a suitable base under conditions to form a MSQ monolith suitable for chromatographic applications.

Abstract: A system and method for processing an acoustic input signal and providing at least one output acoustic signal to a user of a hearing-aid system. The hearing-aid system includes first and second channels with one of the channels having an adaptive delay. The first channel includes a directional unit for receiving the acoustic input signal and providing a directional signal; a correlative unit for receiving the directional signal and providing a noise reduced signal by utilizing correlative measures for identifying a speech signal of interest in the directional signal; and, a compensator for receiving the noise reduced signal and providing a compensated signal for compensating for a hearing loss of the user.

Abstract: The present invention relates to a method of screening compounds for modulation and binding to proteins, in particular proteins that have been immobilized in a monolithic chromatographic stationary phase. The method involves observing the conversion of a substrate to product by the protein and determining a product to substrate ratio. Changes in this ratio in the presence of another compound indicates that the other compound is a modulator of the enzyme. Various applications of this method to compound screening, including high throughput screening formats, are described.

Abstract: Described is a carrier having a biomolecular interaction incorporated therein. The carrier is described as comprising a silica based glass and in an embodiment is a sol-gel derived glass. Also described are methods of incorporating biomolecular interaction within a carrier of the invention. Various types of biomolecular interaction are discussed as well as applications of carriers containing one or more biomolecular interactions.

Abstract: Novel compound called caloxins which are extracellular plasma membrane (PM) Ca2+-pump inhibitors are described. One caloxin is caloxin 2A1 and has the amino acid sequence VSNSNWPSFPSSGGG. Another caloxin is caloxin 3A1 and has the amino acid sequence DSHINNEPSRRRGGGK. The caloxins are useful in inhibiting PM Ca2+-pumps and can be used in the development of treatments of various diseases including hypertension, hypotension, degenerative brain disorders, mood disorders, diabetes, kidney failure and cancer.

Abstract: A method for assessing aspirin resistance and relative risk of a cardiovascular event in a patient taking aspirin is provided. The concentration of 11-dehydro-thromboxane B2 in a urine sample is measured and compared to a set of standardized quartile concentrations. A concentration of urinary 11-dehydro-thromboxane B2 that falls within the second, third, or fourth quartile is indicative of aspirin resistance and an elevated risk of a recurrent cardiovascular event.

Abstract: A method for extracting feature information from product images using multivariate image analysis based on Principal Component Analysis (PCA) which is used to develop predictive models for feature content and distribution on the imaged product. The imaging system is used to monitor product quality variables in an on-line manufacturing environment. It may also be integrated into a closed-loop feedback control system in automated systems.

Abstract: The present invention relates to methods of immobilizing nucleic acid aptamers within a sol-gel matrix. The aptamer system remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate.

Abstract: A novel screening assay for identifying therapeutic agents and their cellular targets is described. The assay is useful in developing new antibacterial, antifungal, antiparasitic and anti cancer therapeutics. New inhibitors of dihydrofolate reductase (DHFR) have been identified and their cellular target confirmed using the assay of the present invention. Methods of treating diseases that benefit from an inhibition of DHFR are also described.

Abstract: Disclosed are inhibitors of myosin light chain kinase, pharmaceutical compositions and kits comprising the inhibitors and methods of use.

Abstract: The present invention relates to a new method for the preparation of radiopharmaceuticals based on technetium and rhenium. The method involves the reaction of a salt of the formula [M(CO)3(Xm)3](1+3m), wherein M is selected from a radioisotope of rhenium, technetium and any other radioisotope that binds in a similar fashion, X is any suitable ligand and m is the formal charge for ligand X, with a nido-dicarbollide dianion of the formula [nido-(C2B9H11)]2? and functional derivatives thereof. The method has been shown to be applicable to the preparation of radiopharmaceuticals at the tracer level.

Abstract: The present invention relates to methods of immobilizing membrane-associated molecules within a sol-gel matrix. The membrane-associated molecule is embedded in the bilayer of a liposome. The molecule-liposome assembly remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate. The activity and stability of the entrapped membrane-associated molecule was significantly improved in macroporous silica.

Abstract: A method for inhibiting and for reversing the dysfunctional response of vascular endothelial cells to an inflammatory stimulus in a subject in need of such therapy has been developed in which an effective amount of a pharmaceutical composition comprising thrombin-activatable fibrinolysis inhibitor (TAFI) combined with a pharmaceutically acceptable carrier and optionally other treatments is administered to the subject.