Abstract: Absorbent products, especially catamenial tampons, for absorbing body fluids, such as menstrual fluid, blood and wound exudates, comprise an amount of a compound effective to inhibit the production of toxic shock syndrome toxin-1 by Staphylococcus aureus bacteria when the products are brought into contact with the bacteria. The compound is selected from the group consisting of monoesters of a polyhydric aliphatic alcohol and a C.sub.8 -C.sub.18 fatty acid; diesters of a polyhydric aliphatic alcohol and a C.sub.8 -C.sub.18 fatty acid; and mixtures thereof. The monoesters and diesters have at least one hydroxyl group associated with their aliphatic alcohol residue.
Abstract: A granulation process for preparing a solid dosage form containing acetaminophen and diphenhydramine hydrochloride, as active agents is disclosed. In addition, the solid dosage form produced by the process is described.
Type:
Grant
Filed:
July 20, 1993
Date of Patent:
June 3, 1997
Assignee:
McNeil-PPC, Inc.
Inventors:
Kishor B. Parekh, Peter F. Eisenhardt, Robert Hitchner
Abstract: The present invention relates to an aqueous pharmaceutical suspension for oral use, and a method of preparation, having antacid and antiulcer properties which contains a therapeutically effective amount of calcium carbonate in combination with magnesium carbonate and/or magnesium trisilicate and a carboxylic acid pH adjusting agent.
Abstract: Prebent, anatomically shaped, self-aligning absorbent products comprising a fluid permeable body facing cover, an absorbent element, a central, partially longitudinally disposed core, and a flexible, moisture barrier having partially longitudinally disposed permanent creases proximate to the longitudinal edges of the moisture barrier, are provided. Such products generally have a convex shape in the approximate center portion of the body facing surface which shape allows the product to conform to the body and more closely approximate the source of fluid discharge thereby reducing unwanted movement or misalignment which may result in leakage. Such products further generally have an hourglass shape which complements the general contour of the inside surfaces of the thighs.
Abstract: An improved system for applying labels to pharmaceutical vials or the like includes a heating tunnel assembly having an insulated heating chamber defined by a first stationary portion and a second removable portion, with a heater positioned within the insulated heating chamber. The assembly includes movable mounting structure for mounting the second removable portion of the insulated heating chamber for movement between a first position engaged with the first stationary portion, and a second retracted position remote from said first portion. An actuator is provided for moving the second portion of the insulated heating chamber into its engaged position, while a biasing spring resiliently biases the second removable portion of the chamber toward the retracted position. As a result, the heating tunnel assembly will automatically be opened to prevent products from overheating or burning in the event of an emergency that disables the actuator.
Abstract: This invention relates to polymer film or foam coatings for the covers of absorbent articles. More particularly, this invention relates to absorbent products and processes for making in situ foamed polymer coatings which give an opaque, soft, dry and clean-appearing water-permeable cover to absorbent products such as sanitary napkins, diapers and the like.
Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a suspension stabilizing effective amount of xanthan gum, pregelatinized starch and polyoxyethylene sorbitan monooleate; an effective amount of taste masking composition; and water, as well as a process for producing such aqueous pharmaceutical suspensions.
Abstract: A method for applying particulate powder material to a moving, pre-formed, fibrous substrate. In this method, particulate powder material is entrained in a continuous airstream. The air-entrained stream of particulate material exits a nozzle to be applied to the substrate or recirculated. The stream of air-entrained particulate matter has a velocity component in the direction of movement of the fibrous substrate.
Abstract: The present invention relates to a dry mouth lozenge comprising a lozenge base, a demulcent, a humectant, and a pharmaceutically acceptable acidulent to stimulate the flow of saliva.
Abstract: This invention relates to a pharmaceutical composition for treating gastrointestinal distress comprising an effective amount of an antidiarrheal composition, e.g. loperamide, and an antiflatulent effective amount of simethicone and methods of treating gastrointestinal distress comprising administering such pharmaceutical compositions.
Abstract: An apparatus for controlling the loading and feeding of tablets onto carrier plates for transfer to various processing stations of a coating system includes a novel plate indexing apparatus having a box cam follower device mounted to an engagement bar for incrementally advancing the plates in a precisely controlled manner. A second complementary shaped engagement bar provides a locking mechanism to ensure the plates are always under positive control. In one embodiment the plate indexing apparatus also controls the feeding of the tablets. An alternative embodiment includes a vacuum pick-up system for feeding tablets onto the carrier plates as the plates are incrementally advanced.
Abstract: A method of making solid oral dosage form for the treatment of gastrointestinal disorders comprising a therapeutically effective amount of a pharmaceutical suitable for the treatment of gastric disorders selected from the group consisting of cimetidine, ranitidine, famotidine, diphenoxylate, loperamide, loperamide-N-oxide, pharmaceutically acceptable salts thereof and combinations thereof; and a therapeutically effective amount of simethicone wherein the pharmaceutical and simethicone are separated by a barrier. The barrier is formed by coating with a polymer impermeable to simethicone.
Type:
Grant
Filed:
May 31, 1995
Date of Patent:
February 4, 1997
Assignee:
McNeil-PPC, Inc.
Inventors:
Charles A. Stevens, Michael R. Hoy, Edward J. Roche
Abstract: A feature of this invention is the raised longitudinal hydrophobic edges or edge members in combination with the raised central member. Since the raised central member captures the body fluids close to the source of fluid discharge it contains the body fluids in the central portion of the napkin. In addition, the raised hydrophobic longitudinal edges or edge members prevent fluid from wicking through to the undergarment of the user.
Abstract: An environmentally-friendly-tampon assembly of the type which includes an inner sleeve, an outer sleeve and an absorbent pledget has inner and outer sleeves which are fabricated from a biodegradable, flushable material such as paper. The outer sleeve has an inwardly extending tang for preventing movement of the pledget during retraction of the inner sleeve. The tang is also formed of biodegradable material, and may be formed of material which is from the same blank out of which the outer sleeve was formed. Six different methods of forming the outer sleeve and tang are disclosed.
Abstract: Oral dosage forms are disclosed which are effective for treating of gastric disorders. The dosage forms contain, as active ingredients, famotidine and sucralfate. In the dosage form, the famotidine is provided with a barrier layer which prevents interaction between the famotidine and the sucralfate, which improves the stability of the dosage form.
Abstract: Absorbent articles such as panty liners, thin full-sized sanitary napkins and the like having a garment facing side and a body facing side are provided which may be stored in a folded configuration prior to use. Means of attachment and means of release, most preferably silicone, are created on the garment facing side of the article. The patterns in which the attachment and release means are chosen such that when the article is folded, the adhesive means contact the release means, eliminating the need for release paper, but allowing the article to be unfolded and used. Other embodiments using barrier films affixed to the garment facing side of the article are also disclosed. Methods of making and packaging the articles disclosed are also provided.
Abstract: There is provided by this invention a least three integrated regions, each region having wherein the density and fluid affinity of the composite continuously increases from top to bottom thereby facilitating effective fluid transport and efficient utilization of storage capacity. An additional layer of SA and tissue may be provided to the absorbent product to provide an absorbent structure with dry feel and low stain. Methods of forming integrated, multi-layered absorbent composites and structures comprising at least three regions wherein each region has distinct density and fluid affinity gradients and wherein the density and fluid affinity of the composite continuously increases from top to bottom, are also provided herein.
Abstract: This invention relates to an improved multiple sliver absorbent product having a bottom sliver with low density edges. The low density edges engage a low density upper sliver and provide traction between the slivers which aids in stabilizing the product.
Type:
Grant
Filed:
March 9, 1995
Date of Patent:
December 10, 1996
Assignee:
McNeil-PPC, Inc.
Inventors:
Michelle L. Difilippantonio, Winifred C. Dabroski
Abstract: A child resistant container which describes: (1) a bottle having a neck, the bottle also having a containment area to store tablets accessible through an opening in the neck; (2) a cap having a skirt, the skirt engageable with the neck; and (3) an access device for allowing attachment of the neck with the skirt of the cap, including: (i) a push button associated with the cap; (ii) an irregularity contained on the inside of the cap; and (iii) an alignment device on the neck, engaged with the irregularity on the cap. When the push button is pushed by the user, the irregularity enters the alignment device such that the cap may be translated parallel to the longitudinal axis of the bottle. The skirt and neck respectively engage one another, so that thereafter the cap may be removed from the bottle.
Abstract: A multilayered absorbent structure is disclosed. The absorbent structure has a plurality of absorbent planar regions defined by decreasing pore size with increasing depth into the region. Generally, each planar region has an absorbent layer having relatively large average pore sizes at the top, body facing surface, and relatively small average pore sizes at the bottom, garment facing surface. A subsequent absorbent region has a top body facing surface with an average pore size which is larger than the bottom, garment facing surface of the previous absorbent region. The top surface of each subsequent planar region is in fluid communication with the lower surface of the planar region above.
Type:
Grant
Filed:
April 25, 1995
Date of Patent:
October 29, 1996
Assignee:
McNeil-PPC, Inc.
Inventors:
Richmond R. Cohen, James A. Minetola, John F. Poccia