Abstract: Bioadhesive pharmaceutical carrier consisting essentially of a polymer blend of sodium carboxymethyl cellulose and xanthan gum or sodium alginate. The invention also provides for a method of control releasing a pharmaceutical active comprising incorporating an active into the bioadhesive pharmaceutical carrier. The invention is particularly adaptable for oral use and teething gels.

Abstract: A process for producing a palatable dextromethorphan medicated hard candy lozenges on a continuous system comprising suspending dextromethorphan HBr adsorbate in a liquid suspension and adding this suspension to other candy materials in a novel continuous process.

Abstract: A process for producing substantially pure sucralose pentaester from a mixture of 6-O-acyl-4,1' ,6' -trichloro-4,1',6'-trideoxygalactosucrose in a reaction medium comprising a tertiary amide, wherein said process comprises the steps of:(a) recovering the 6-O-acyl-4,1' ,6' -trichloro-4,1' ,6' -trideoxygalactosucrose from said mixture;(b) peracylating the 6-O-acyl-4,1' ,6' -trichloro-4,1' ,6' -trideoxygalactosucrose product of step (a) to produce thereby 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester; and(c) crystallizing the 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester product of step (b) to produce substantially pure 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester.

Abstract: A simulated capsule-like medicament comprising a dual subcoating comprising an initial subcoating of a water soluble film forming polymer, e.g. povidone and a secondary subcoating of a mixture of two soluble film forming polymers, e.g. povidone and hydroxypropyl methylcellulose and a hydrophobic plasticizer, e.g. castor oil, which provides for a smooth uniform and substantially bubble free outer coating, e.g. gelatin, for the capsule-like medicament; and a process of making such medicaments.

Abstract: A method for producing low odor meso-2,3-dimercaptosuccinic acid is provided whereby a meso-2,3-dimercaptosuccinic acid substrate is washed with an aqueous wash medium and subsequently dried, preferably at a temperature of less than 40.degree. C. and a low odor meso-2,3-dimercaptosuccinic acid is also provided by this invention.

Abstract: A sanitary napkin having flaps extending laterally from each of the longitudinal sides of its central absorbent is provided with body fluid sealing means disposed between the absorbent element and at least one of the flaps for restricting the transmission of body fluid from the absorbent element into the flap. The napkin construction creates a plurality of absorption compartments that can minimize staining of undergarments by body fluid.

Abstract: A reduced calorie fruit spread comprising the gelled product of:a. water;b: fruit or fruit flavoring;c. sucralose high intensity sweetener;d. low methoxy pectin or carrageenan;e. carboxymethylcellulose;f. guar gum; andg. locust bean gum.

Abstract: A cover for a sanitary napkin or other absorbent product is provided which includes an outer layer of a hydrophobic material. The outer layer contains fluid passageways which are small enough so that the outer layer alone will not pass liquid therethrough. A second, liner layer is bonded to the interior surface of the outer layer and is comprised of a nonwoven web which is at least slightly wettable so as to draw liquids through the passageways of the outer layer. The liner layer contains large capillaries so that at least a majority of the liquid entering the liner layer from the fluid passageways will pass through the liner to the absorbent core of the product.

Abstract: Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of medicament, e.g. famotidine binder, e.g. polyvinylpyrrolidone, and carrier, e.g. lactose and the rotogranules are coated with cellulose acetate, cellulose acetate butyrate or a combination thereof and polyvinyl pyrrolidone and a process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules.

Abstract: Imidate derivatives of sulfamates having the following formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and X are as herein defined have been found to be useful prodrug and exhibit anticonvulsant activity when converted to the active agent upon administration to a mammal and are thus useful in the treatment of conditions such as epilepsy. Further, the present invention encompasses pharmaceutical compositions containing a compound of formula (I) as well as methods for their use.

Abstract: This invention relates to a pharmaceutical composition for treating gastrointestinal distress comprising an effective amount of an antidiarrheal composition, e.g. loperamide, and an antiflatulent effective amount of simethicone and methods of treating gastrointestinal distress comprising administering such pharmaceutical compositions.

Abstract: An absorbent mixture, as made from fibers formed into a fibrous web and a polymerizable, cross-linkable material, in a liquid carrier. The material, when polymerized and cross-linked, results in a superabsorbent polymer. The material, in the liquid carrier, is dispersed within the fibrous web, as dispersed inclusions, and is polymerized and cross-linked in situ, within the fibrous web, so as to form a composite web comprising the fibrous web and the superabsorbent polymer, as dispersed particles, at least some of which are bound to fibers from the fibrous web. The composite web is ground, so as to cause some of the superabsorbent polymers to become particulate while fragments of the superabsorbent polymer remain bound to fibers from the fibrous web. Before the composite web is ground, it may be provided with a fibrous layer or fibrous layers in intimate contact therewith, and also compressed.

Abstract: Non-woven fabrics comprising yarn-like fiber groups of parallel and tightly compacted fiber segments, which define apertures in the fabric. The apertures have substantially improved clarity and the yarn-like fiber groups have increased density.

Abstract: A carrier apparatus for a plurality of a product has a plurality of collets for maintaining the product in a fixed orientation wherein two specimens of the product are retained within one collet. The collets include a circumferential depression at one end and a resilient member which serve to retain the collets in the carrier apparatus.

Abstract: There is disclosed the process of incorporating a deodorant powder (of various mechanisms of action) into a hydrophilic, swellable, water-insoluble absorbent crosslinked polymer, which swellable polymer is coated on a thin, flexible, substrate e.g. a non-woven web, a paper tissue, or a water-insensitive film, and the resultant flexible structures which contain the deodorant powders, held in a dust-free stable manner, and their use as one or more components of body fluid absorbent structures such as sanitary napkins.

Abstract: Methods and apparatus for applying coating to products such as medicaments are disclosed. The present invention provides a apparatus comprising product holders and plates which interact with vacuum tubes to retain the product being coated in place while inverted and dipped into a tank of coating material. The vacuum tubes may be designed to hold product of nearly any shape or in any orientation. In a preferred embodiment, methods and apparatus for creating a two-color gelatin coating on a tablet are disclosed. In certain embodiments, additional apparatus are provided whereby the vacuum tubes rotate about their longitudinal axes and are placed in contact with a coating applicator, thereby applying a band or stripe of a coating material to a specified section of the product.

Abstract: Improved hydrophilic materials, such as foams and films, are provided. These material find use in a wide variety of fluid absorbent products, especially those relating to the absorption of bodily fluids. The soft, absorbent, and resilient foams of this invention exhibit greater wet and dry mechanical strength when compared with those known in the art, as well as improved fluid wicking capacity and lower density. These improved properties are believed attributable to the incorporation into the foams of at least one polyfunctional aliphatic amine.The provided hydrophilic materials comprise the polymeric reaction product of a mixture which comprises at least one epoxy resin, at least one amine-terminated poly(alkylene oxide), and at least one polyfunctional aliphatic amine. Methods for preparing foams and other hydrophilic materials are also provided.

Abstract: Chewable medicament tablets are made from coated rotogranules of a medicament wherein the rotogranules are formed from a granulation mixture of medicament, e.g. ibuprofen, polyvinylpyrrolidone, sodium starch glycolate and sodium lauryl sulfate and the rotogranules are coated with hydroxyethyl cellulose or a mixture of hydroxyethyl cellulose and hydroxypropyl methylcellulose and a process for making such tablets and a method of providing taste masking of medicaments utilizing such coated rotogranules in a tablet.

Abstract: An apparatus for applying particulate powder material to a moving fibrous substrate is disclosed. The apparatus includes a volumetric dry material feeder for forming a continuous stream of particulate powder material. The continuous stream is then transmitted through a nozzle and exits at an outlet thereof. The nozzle is movable between a first and second position by a motion control. The motion control includes an adjustable differential gear box and an encoder for synchronizing the dispensing of powder at a predetermined location of the substrate. A flow separator is disposed beyond the outlet of the nozzle and intermediate of the first and second positions. In operation, the motion input drives the nozzle to oscillate between the first and second positions at a variable speed over each product cycle. As the nozzle crosses a plane of the flow separator, the continuous stream of particulate powder material exiting the nozzle is split into two intermittent streams of particulate powder material.