Abstract: Apparatus and methods are described, including a water trap (28) that includes an inlet portion (40), via which a mixture of gas and water is configured to enter the water trap, and an outlet portion (42), via which the gas is configured to exit the water trap, the inlet portion and the outlet portion being formed separately from one another and being coupled to one another, such as to form a tube (44) that defines a longitudinal axis and that defines an internal hollow volume through which the gas is configured to flow. A membrane filter (46) is disposed in a flat configuration within the tube, between the inlet portion and the outlet portion, such that the membrane filter is substantially parallel to the longitudinal axis of the tube, the membrane filter being configured to prevent the water from passing therethrough. Other applications are also described.

Abstract: The present invention pertains to novel high avidity antigen recognizing constructs, such as antibodies or T cell receptors, which specifically bind to the melanoma associated antigen (MAGE) A1. The constructs of the invention are particularly useful for the diagnosis, prevention or therapy of tumorous diseases which are characterized by the specific expression of the MAGE-A1 antigen. Furthermore provided are nucleic acids, vectors and host cells—such as CD4 or CD8 positive T cells—which encode, comprise or present the antigen recognizing constructs of the invention. The invention thus provides new approaches for immune therapy, specifically adoptive T cell therapy, for treating cancer.

Abstract: Disclosed is a variable-geometry sealed coupling of the type of that connecting together two elements each arranged with a passage hole, the sealed coupling including two hollow bodies preformed to form a pivot connection, with the axis of this pivot connection making it possible to switch the axes of the passage holes from a straight position to a bent position, remarkable in that at least one of the bodies is preformed in such a way that the axis of the passage hole of the element with which it cooperates is offset with respect to the axis of the pivot connection, and is therefore not secant nor is it confounded with the axis of the pivot connection that it forms with the other body in such a way that the rotation of the bodies together is facilitated due to the out-of-roundness of the axes.

Abstract: The present invention relates to a method for the production of novel T-cell receptors (TCR) which provide a reduced risk of adverse events in immune therapy, specifically in adoptive T cell transfer. The TCRs produced according to the method of the invention are specific for tumor cells and do not react with healthy tissue. Furthermore provided are nucleic acids encoding the TCR of the invention, vectors and host cells comprising the TCRs of the invention as well as their use is the treatment of tumorous diseases.

Abstract: The present invention pertains to novel high avidity antigen recognizing constructs, such as antibodies or T cell receptors, which specifically bind to the melanoma associated antigen (MAGE) A1. The constructs of the invention are particularly useful for the diagnosis, prevention or therapy of tumorous diseases which are characterized by the specific expression of the MAGE-A1 antigen. Furthermore provided are nucleic acids, vectors and host cells—such as CD4 or CD8 positive T cells—which encode, comprise or present the antigen recognizing constructs of the invention. The invention thus provides new means for immune therapy, specifically adoptive T cell therapy, for treating cancer.

Abstract: A modular vault assembly including a plurality of vault modules variable in number and including a primary vault and one or more secondary vaults. The secondary vaults are interconnected in successively adjacent relation and a leading secondary vault is connected adjacent to the primary vault. The primary vault and each of the secondary vaults respectively include a master door and a slave door having a locking mechanism disposable in a locked and unlocked orientation. The locking mechanism of the leading secondary vault is manually positioned in the unlocked orientation from an interior of said primary vault and each of said locking mechanisms of a remainder of the secondary vaults is manually positioned, successively, in the unlocked orientation from an interior of a preceding, next adjacent one of the plurality of secondary vaults. Each master and slave door includes a sensor assembly indicating the locked orientation of a corresponding locking mechanism.

Abstract: The invention pertains to a means for downregulating or inhibiting or mislocalizing CAR in a cardiac cell for treating/curing a patient who has suffered or is predisposed to suffering a myocardial infarction (MI) or preventing myocardial infarction or complications thereof.

Abstract: The invention relates to a toothing processing machine comprising a machine frame and a spindle carrier having a first spindle. The spindle comprises a first spindle housing and a first spindle shaft, which is arranged in the first spindle housing such that it can rotate about a first spindle axis, and a free end for receiving a work piece or a tool. A second spindle is also provided having a second spindle housing and a second spindle shaft for receiving a tool or work piece, wherein the second spindle shaft is mounted in the second spindle housing such that it can rotate about a second spindle axis. In addition, at least one wall of the machine frame forms a part of the casing of a closable working chamber, in which the work piece can be processed and which can be closed in order to prevent the release of a material removal, a processing liquid and/or a processing mist from the working chamber into other machine regions or to the outside.

Abstract: A machine for honing gears comprises a workpiece spindle, the spindle axis of which is oriented vertically, wherein a workpiece to be machined is attachable in the region of a free end of the workpiece spindle, a honing ring carrier in which a honing ring for machining the workpiece attached to the workpiece spindle is clampable and is drivable in rotation about its central axis, and a machine frame on which the workpiece spindle and the honing ring carrier are mounted. The machine frame surrounds the honing ring carrier. The honing ring carrier is additionally mounted at two bearing points on the machine frame, said bearing points being substantially diametrically opposite one another with regard to the honing ring carrier, so as to be movable linearly along a horizontal axis which extends through the bearing points and so as to be movable in rotation about this axis. The machine has a simple and compact structure.

Abstract: The invention relates to method for cultivating stem cells in vitro, comprising the following steps: providing a sample comprising stem cells and cultivating the stem cells by subjecting the sample to a treatment for a first period of time. The treatment is carried out under hypothermic conditions having a defined temperature and a defined atmosphere, wherein the temperature does not exceed 15° C. and the atmosphere has an oxygen content not exceeding 21% (v/v). Thereby, the first period of time is 4 days to 4 weeks.

Abstract: A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular ?1 loop 2 or ?2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of ?-secretase activity, an increased release of ?-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.

Abstract: A machine for honing gears comprises a workpiece spindle, the spindle axis of which is oriented vertically, wherein a workpiece to be machined is attachable in the region of a free end of the workpiece spindle, a honing ring carrier in which a honing ring for machining the workpiece attached to the workpiece spindle is clampable and is drivable in rotation about its central axis, and a machine frame on which the workpiece spindle and the honing ring carrier are mounted. The machine frame surrounds the honing ring carrier. The honing ring carrier is additionally mounted at two bearing points on the machine frame, said bearing points being substantially diametrically opposite one another with regard to the honing ring carrier, so as to be movable linearly along a horizontal axis which extends through the bearing points and so as to be movable in rotation about this axis. The machine has a simple and compact structure.

Abstract: A machine for machining workpieces includes a machine frame (110, 120), a honing ring carrier (60) which is mounted on the machine frame and in which a honing ring or a honing ring blank is clampable and rotationally drivable about its central axis, and a workpiece spindle module (50) having a workpiece spindle (54), wherein a workpiece which is to be machined with the honing ring clamped in the honing ring carrier (60) is mountable in the region of a free end of the workpiece spindle (54). The machine further includes a grinding module (130) for profiling a honing ring as a result of grinding a honing ring blank, wherein the grinding module (130) is arranged in such a manner on the machine frame (110, 120) that a grinding wheel of the grinding module (130) can be positioned relative to the honing ring carrier (60) inside a truly three-dimensional space. The profiling of a honing ring and the honing of a workpiece can consequently be effected in the same clamping setup of the honing ring.

Abstract: The present invention relates to the use of a DNA expression construct comprising a dumbbell-shaped circular strand of deoxyribonucleic acids and provides such a construct with a double-stranded stem and single-stranded loops located at both ends of the stem, wherein the stem comprises complementary deoxyribonucleic acids of the circular strand with a promotor sequence, a coding sequence and a termination signal to be administered by jet injection for the treatment of cancer.

Abstract: The present invention provides compounds (n-3 PUFA derivatives) of formula (I) that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.

Abstract: The present invention relates to methods for isolating human forkhead box P3 (Foxp3+) CD4+ regulatory T cells (herein referred to a Foxp3+ Treg cells) from a sample containing (i) peripheral blood mononuclear cells (PBMCs), (ii) a lymphocyte containing fluid, or (iii) a lymphocyte containing tissue, a kit for isolating human Foxp3+ Treg cells, and the use of anti-CD49d antibody for the isolation of human Foxp3+ Treg cells.

Abstract: The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.