Abstract: The present disclosure relates to nutritional composition(s) comprising a carbohydrate source, a protein source, a fat source and magnesium threonate. Magnesium threonate may provide neurological health benefits when consumed. The disclosure further relates to methods of promoting neurological health by providing a nutritional composition comprising magnesium threonate. Additionally, the disclosure relates to methods of promoting GI tolerance in a pediatric subject by providing a nutritional composition comprising magnesium threonate.

Abstract: The present disclosure provides nutritional compositions in a compressed solid form comprising about 21 to about 35% by weight of protein, about 20 to about 30% by weight percent of fat, and about 40 to about 60% by weight percent of carbohydrate, wherein the porosity of the compressed solid is less than about 30% or greater than about 60%, and the compressed solid has a moisture level of greater than 40%. The nutritional compositions, in certain embodiments, are resistant to breakage during transport and packaging, while remaining readily dissolvable upon contact with a liquid. The disclosure further provides process for preparing a nutritional composition in a compressed solid form comprising contacting a powdered nutritional composition with steam, and compressing the powdered nutritional composition under a pressure of less than 400 psi.

Abstract: Provided herein are nutritional compositions comprising a protein source, a fat source, a carbohydrate source, and at least one nucleotide, wherein the protein source comprises at least one free amino acid, wherein the at least one free amino acid comprises a glutamate salt, glutamic acid, taurine, glutamine, alanine, or any combination thereof. Also provided herein are methods of promoting satiety, preventing or reducing the incidence of overweight or obesity, or preventing or reducing the incidence of diabetes in a subject comprising administering to a subject a nutritional composition comprising a protein source, a fat source, a carbohydrate source, and at least one nucleotide, wherein the protein source comprises at least one free amino acid, wherein the at least one free amino acid comprises a glutamate salt, glutamic acid, taurine, glutamine, alanine, or any combination thereof.

Abstract: The present invention relates to an amino acid-based nutritional formulation comprising, per 100 g total amino acids, between about 4.5 and about 5 g glutamate. The ratio of cysteine:methionine is in the range of about 0.9:1 to about 1:1.2. The nutritional formulation may also comprise a lipid source, a carbohydrate source, an emulsifier comprising CITREM or DATEM, and amino acids, wherein glutamate is present in an amount of between about 4.5 and about 5 g per 100 g total amino acids.

Abstract: An ingestible material delivery device for sequentially delivering first and second ingestible materials to a user through a feeding tube provides a tube body having first and second chambers separated by a seal. A puncture tool is disposed in the second chamber extending toward the seal. The puncture tool engages and disrupts the seal when the second chamber is compressed. In some embodiments, the second chamber includes a plurality of interconnected bellows operable for axial compression of the second chamber. Another embodiment of a delivery device provides a tube body having first and second chambers with exit nozzles extending in opposite flow directions. A method of sequentially delivering first and second ingestible materials to a user through a feeding tube is also provided.

Abstract: A method for inhibiting the adhesion of at least one pathogen in the gastrointestinal tract of a human is disclosed herein. In certain embodiments, the method involves administering to the human a nutritional composition including a fat or lipid source, a protein source, a prebiotic composition that includes galactooligosaccharide and/or polydextrose and lactoferrin produced by a non-human source.

Abstract: Provided herein are nutritional creamer compositions comprising a vegetable oil blend, wherein the vegetable oil blend provides a suitable fatty acid profile or saturated fats, polyunsaturated fats, monounsaturated fats, and trans fatty acids. The creamer compositions described herein are useful as a fat source for various nutritional compositions, such as infant formulas, children's nutritional products and adult nutritional compositions. Also provided herein are nutritional compositions comprises the aforementioned creamer compositions.

Abstract: A plunger-driven delivery device for use with a feeding tube for delivering an ingestible material to a user is provided. The delivery device includes a device body having a first chamber, a second chamber and an exit orifice through which the ingestible material is delivered to the feeding tube. A first plunger is disposed in the first chamber, and a second plunger is disposed in the second chamber. The delivery device can be provided with the ingestible material disposed in the first chamber and a flushing liquid disposed in the second chamber. The delivery device is operable to provide sequential delivery first of the ingestible material and then the flushing liquid into the feeding tube. In some embodiments, a mechanical interlock is disposed between the first and second plungers to prevent use of the second plunger until the first plunger has been depressed.

Abstract: The present disclosure relates to nutritional compositions comprising a prebiotic component for inhibiting adherence of pathogens in the gastrointestinal tract of a subject and to the prebiotic component, which comprises galactooligosaccharide, polydextrose or any mixture thereof. The nutritional compositions of the present disclosure comprise a fat or lipid source, a protein source, and a carbohydrate source comprising an effective amount of the prebiotic component.

Abstract: The present invention is directed to a novel method for increasing the production of acetate, decreasing the production of butyrate, increasing the population and species of beneficial bacteria and slowing the rate of fermentation of prebiotics within the gut of a formula-fed infant. The method comprises administration of a therapeutically effective amount of PDX to the infant.

Abstract: A container system for storing material includes a container and a mating closure having a tamper-evident ring frangibly attached to the closure. The container includes a neck having a container thread and an annular rim for engaging the tamper-evident ring when the closure is removed from the container. In some embodiments, the neck includes one or more retaining structures for engaging the tamper-evident ring during retort sterilization processing, packaging, shipping or handling. The retaining structure in some embodiments includes one or more ramps having multiple inclined surfaces. Each inclined surface is oriented at an acute angle between about five and about forty-five degrees such that the tamper-evident ring can slip past the retaining structure when a threshold removal torque is applied. A method of sealing a container using a tamper-evident container system is also provided.

Abstract: A composition comprising a culture supernatant from a late-exponential growth phase of a batch-cultivation process for a probiotic such as LGG, for use in the treatment or prevention of infection by a pathogen such as C. sakazakki.

Abstract: The invention comprises a novel apparatus for delivering a nutritive substance comprising a container body having a base at one end, an upper portion adapted for removable receipt of a closure, the upper portion defining an opening therein, and a chamber defined by the container body, the chamber being in fluid communication with the opening. A laminate seal having at least two layers is bonded across the opening and is adapted to provide an airtight seal across the opening and prevent contact between said nutritive substance and the contents of said container until said seal is altered. The laminate seal comprises a first layer permanently bonded to a rim defining the opening in the upper portion and a second layer that is releasably coupled to the first layer. A nutritive substance is bonded to the first layer. The container additionally comprises a closure removably coupled to the upper portion.

Abstract: Disclosed is the use of a composition comprising docosahexaenoic acid (DHA) and/or arachidonic acid (ARA) in human subjects that are on the typical ‘Western-type” high-fat high-sugar diet. It was found, in a humanized animal model, that said composition is capable of compensating for one or more of the adverse health effects of said diet. Particularly, an effect was found in body weight reduction, without a lowering of food intake. The composition can be administered as an oral (pharmaceutical) dosage unit, as a nutritional supplement, or as a component in a food or drink.

Abstract: The present disclosure relates to milk-based nutritional compositions comprising lactoferrin and/or a prebiotic component, wherein, when combined, the lactoferrin and prebiotic component may exhibit additive or synergistic beneficial effects on the health and development of a pediatric subject. The disclosure further relates to methods comprising the administration of said milk-based nutritional compositions to pediatric subjects.

Abstract: The present invention is directed to a container for delivering a nutritive substance. In an embodiment, the present invention comprises a container that protects a nutritive substance from contact with the contents of the container and from contact with the atmosphere until the consumer is ready to use or consume the product. When desired, a seal on the container is altered such that the nutritive substance can come into contact with the container contents, delivering the nutritive substance thereto.

Abstract: The present disclosure relates to nutritional compositions comprising a prebiotic component for inhibiting adherence of pathogens in the gastrointestinal tract of a subject and to the prebiotic component, which comprises galactooligosaccharide, polydextrose or any mixture thereof. The nutritional compositions of the present disclosure comprise a fat or lipid source, a protein source, and a carbohydrate source comprising an effective amount of the prebiotic component.

Abstract: Compositions comprising maltotriose are disclosed herein. In certain embodiments, the compositions comprise maltotriose and at least one component whose function is subject to impairment by a dehydration process, such as a live microorganism. Methods for inhibiting damage caused by dehydration are also disclosed herein. In particular embodiments, the method includes preparing a composition comprising maltotriose and at least one component whose function is subject to impairment by a dehydration process and removing water from the composition by one or more dehydration processes.

Abstract: The present disclosure relates to methods of reducing the onset of allergies. In certain embodiments, the method includes administering to an infant a nutritional composition that includes a fat or lipid source, a carbohydrate source, a protein source comprising whey and casein proteins and, optionally, a probiotic. In certain embodiments, the whey:casein ratio in the protein source is from about 50:50 to about 70:30 and the degree of hydrolysis of the proteins included in the protein source is from about 4% to about 10%.

Abstract: The present invention relates to a prenatal dietary supplement comprising at least one omega-3 fatty acid, at least one omega-6 fatty acid; folic acid; lutein; and at least one proanthocyanidin.