Patents Assigned to MED Institute
  • Publication number: 20090105797
    Abstract: A stent includes a radially expandable tubular structure having a first end, a second end, and a primary strut arrangement extending over substantially an entire length thereof. The primary strut arrangement includes a plurality of rows of struts. The struts are interconnected within each row in a sinusoidal arrangement about a circumference of the tubular structure. Crests and troughs in the sinusoidal arrangement include connection points of the struts. A plurality of longitudinal struts connect neighboring rows of struts at the connection points. In each row, four circumferentially adjacent struts are disposed between every two longitudinal struts joined to the row. One of the two longitudinal struts extends in a direction of the first end to a first neighboring row, and the other of the two longitudinal struts extends in a direction of the second end to a second neighboring row.
    Type: Application
    Filed: October 14, 2008
    Publication date: April 23, 2009
    Applicant: MED Institute, Inc.
    Inventors: Blayne A. ROEDER, Alan R. Leewood, David D. Grewe
  • Publication number: 20090099638
    Abstract: A motorized delivery system and method for deploying an endoluminal prosthesis is disclosed. The system comprises a delivery device and an electrical drive system. The prosthesis is disposed between an inner dilator and an elongate sheath. To deploy the prosthesis, the electrical drive system is actuated. One or more gear-pulley arrangements rotate to cause retraction of the sheath in relation to the inner dilator.
    Type: Application
    Filed: September 24, 2008
    Publication date: April 16, 2009
    Applicant: MED Institute, Inc.
    Inventor: David D. Grewe
  • Publication number: 20090061072
    Abstract: Methods of coating a medical device are provided to improve coating uniformity and reduce coating irregularities while reducing direct coating of the luminal surface of the medical device. Preferably, methods of coating a tubular medical device include the steps of: positioning the tubular medical device around a mandrel coating assembly, mounting the tubular medical device on the mandrel coating assembly and spraying a coating solution including a therapeutic agent and a solvent onto the abluminal surface of the tubular medical device mounted on the mandrel coating assembly. The mandrel coating assembly may include an axial member of a diameter that is less than the diameter of the lumen of the tubular medical device and at least one annular projection extending from the axial member to an outer surface having a diameter greater than or substantially equal to the diameter of the lumen of the medical device.
    Type: Application
    Filed: August 27, 2008
    Publication date: March 5, 2009
    Applicant: MED Institute, Inc.
    Inventors: Andrew P. Isch, Jeff P. Little, Patrick H. Ruane
  • Publication number: 20090024137
    Abstract: A device for delivering and deploying a prosthesis is described and comprises an elongate sheath having a sheath lumen and a delivery catheter slidably disposed within the sheath lumen. A deployment assist mechanism may be coupled to the delivery catheter and the sheath and configured to apply a retraction force to the delivery catheter and the sheath. Additional devices, systems, and methods of delivering and deploying a prosthesis are described.
    Type: Application
    Filed: July 15, 2008
    Publication date: January 22, 2009
    Applicants: Cook Incorporated, MED Institute, Inc.
    Inventors: Timothy A. Chuter, David D. Grewe, Blayne A. Roeder, Alan R. Leewood
  • Publication number: 20080286325
    Abstract: The present disclosure provides methods of measuring the release of a taxane therapeutic agent from a medical device as a function time in contact with a suitable elution medium. The method preferably comprises the step of contacting a coated medical device comprising a taxane therapeutic agent with an elution medium comprising a cyclodextrin to provide an elution profile indicative of the composition or configuration of a medical device coating comprising a taxane therapeutic agent. The elution profile can provide information about the medical device coating that is useful in lot release testing.
    Type: Application
    Filed: July 6, 2007
    Publication date: November 20, 2008
    Applicant: MED Institute, Inc.
    Inventors: Priscilla Reyes, Patrick H. Ruane, Melinda S. Morrell
  • Patent number: 7445628
    Abstract: Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: November 4, 2008
    Assignees: Cook Incorporated, MED Institute, Inc.
    Inventors: Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, III, Thomas G. Kozma, Brian L. Bates, Thomas A. Osborne
  • Patent number: 7441652
    Abstract: A mixing system and method for forming bone cement by mixing liquid monomer methyl methacrylate (MMA) with a powder component comprising polymethyl methacrylate (PMMA). A container of MMA is received in a bag. The MMA is emptied from the container into the bag, and a syringe is connected to the bag in substantially leak-free manner to receive the MMA from the bag. The syringe is disconnected from the bag and thereafter connected to a receptacle housing the powder component. The MMA is then transferred into the receptacle in substantially leak-free manner.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: October 28, 2008
    Assignee: Med Institute, Inc.
    Inventors: William D. Armstrong, Richard B. Sisken
  • Publication number: 20080243103
    Abstract: A device and method for delivering a bioactive to the uterine wall. In one embodiment, the device comprises a balloon having the bioactive present within the material of the balloon or on an outside surface of the balloon. Another embodiment provides a method comprising inserting the balloon into the uterus, inflating the balloon so that the outside surface of the balloon exerts pressure on uterine wall and delivering the bioactive to the uterine wall.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 2, 2008
    Applicants: Cook Urological Inc., MED Institute, Inc.
    Inventors: Daniel K. Whetham, Jessica Watts Miller, Andrew P. Isch, Brandt M. Davis, Steven Pendleton
  • Patent number: 7410665
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: August 12, 2008
    Assignees: Cook Incorporated, MED Institute, Inc.
    Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III, Anthony H. Gershlick
  • Publication number: 20080183268
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Application
    Filed: December 27, 2007
    Publication date: July 31, 2008
    Applicants: Cook Incorporated, MED Institute, Inc.
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, Thomas G. Kozma, David D. Grewe, Darin G. Schaeffer, JiChao Sun
  • Publication number: 20080167724
    Abstract: Medical devices for implantation within a body vessel comprising a graft material and a releasable therapeutic agent are provided. The graft material preferably comprises a biocompatible polyurethane and a therapeutic agent. Preferably, the medical device is a stent graft formed by attaching a polyurethane graft material comprising an elutable taxane therapeutic agent to a radially expandable frame.
    Type: Application
    Filed: December 17, 2007
    Publication date: July 10, 2008
    Applicant: MED Institute, Inc.
    Inventors: Patrick H. Ruane, Priscilla Reyes, Blayne A. Roeder, Amy M. Vibbert
  • Publication number: 20080132992
    Abstract: A coated implantable medical device includes a structure adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer posited on one surface of the structure; and at least one layer of a bioactive material posited on at least a portion of the coating layer. Preferably, the structure is a stent graft.
    Type: Application
    Filed: June 5, 2007
    Publication date: June 5, 2008
    Applicants: Cook Incorporated, MED Institute, Inc.
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees
  • Publication number: 20080114435
    Abstract: A delivery system for an intraluminal medical device is disclosed. The delivery system comprises an elongate tubular sheath and an elongate tubular pusher. The pusher is slidably disposed within a lumen of the sheath and comprises at least one generally helical score in an exterior surface thereof for providing enhanced flexibility to the pusher.
    Type: Application
    Filed: March 7, 2007
    Publication date: May 15, 2008
    Applicant: MED Institute, Inc.
    Inventor: Jason Samuel-Horner Bowe
  • Publication number: 20080108824
    Abstract: One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.
    Type: Application
    Filed: September 27, 2007
    Publication date: May 8, 2008
    Applicant: MED Institute, Inc
    Inventors: Andrew Isch, Patrick Ruane, Waleska Perez-Segarra
  • Publication number: 20080109065
    Abstract: An endovascular delivery device (2) for a stent graft which has a pusher catheter (4), a flexible sheath (10) over the pusher catheter and at least one auxiliary catheter (32) extending between the pusher catheter and the flexible sheath. The pusher catheter has one or more longitudinal grooves (30) on its outside surface and the auxiliary catheter or catheters extend along the longitudinal grooves. A guide wire in the auxiliary catheter can be used to pre-catheterise a fenestration in the stent graft and a branch stent or stent graft delivered through the auxiliary catheter.
    Type: Application
    Filed: September 28, 2007
    Publication date: May 8, 2008
    Applicant: Med Institute, Inc.
    Inventor: Jason Bowe
  • Publication number: 20080081829
    Abstract: Non-metallic implantable medical devices including an anesthetic having a proton binding site with a non-ionic form and an ionic form. At least 5% w/w of the anesthetic is present with the proton binding site in the non-ionic form and the remainder of the anesthetic is present with the proton binding site in the ionic form. Methods of preparing such devices are also provided.
    Type: Application
    Filed: September 27, 2007
    Publication date: April 3, 2008
    Applicant: MED Institute, Inc
    Inventors: Andrew Isch, Patrick Ruane, Waleska Perez-Segarra
  • Publication number: 20080033522
    Abstract: Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device can include a frame with a vessel-engaging region on at least a portion of the medical device. The vessel-engaging region may be a particulate coating configured and adapted to engage the interior wall of a body vessel or to attach a material, such as a valve leaflet or graft material, to the frame. Methods of making an implantable medical device and methods of treating a subject are also disclosed.
    Type: Application
    Filed: July 24, 2007
    Publication date: February 7, 2008
    Applicant: MED Institute, Inc.
    Inventors: David D. Grewe, William D. Voorhees, Anthony O. Ragheb
  • Publication number: 20080020013
    Abstract: This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.
    Type: Application
    Filed: June 27, 2007
    Publication date: January 24, 2008
    Applicants: Cook Incorporated, MED Institute, Inc.
    Inventors: Priscilla Reyes, William Moore, Randy Myers, Patrick Ruane
  • Publication number: 20070299518
    Abstract: An implantable medical device including a nanocomposite coating deposited on at least a portion of a surface of at least one structural element of the device to provide a controlled release of a bioactive agent in one or more dosages is described. The nanocomposite coating includes a matrix, a bioactive agent and inorganic particles. The inorganic particles respond to a stimulus, preferably by generating heat. The response of the particles to the stimulus causes the matrix of the nanocomposite coating to undergo a volume change by, for example, contracting or swelling, thereby releasing at least a portion of the bioactive agent. A method of providing a controlled release of a bioactive agent from a nanocomposite coating on an implantable medical device is described. A method for providing a nanocomposite coating for the controlled release of a bioactive agent on the implantable medical device is also described.
    Type: Application
    Filed: January 26, 2007
    Publication date: December 27, 2007
    Applicant: Med Institute, Inc.
    Inventor: Patrick Ruane
  • Publication number: 20070293934
    Abstract: A system for delivering and deploying an expandable endoluminal prosthesis comprises a delivery catheter and a sheath. The delivery catheter has a proximal end and a distal end and is slidably disposed within a lumen of the sheath. An operating mechanism comprises a contractible air vessel that couples the sheath and the delivery catheter so that contraction of the air vessel causes the sheath to retract proximally over the delivery catheter. Additional aspects of the invention include a method of deploying an expandable endoluminal prosthesis.
    Type: Application
    Filed: June 19, 2007
    Publication date: December 20, 2007
    Applicant: MED Institute, Inc.
    Inventor: David Grewe