Abstract: A signal processing arrangement generates electrical stimulation signals to electrode contacts in an implanted cochlear implant array. An input sound signal is processed to generate band pass signals that each represent an associated band of audio frequencies. A characteristic envelope signal is extracted for each band pass signal based on its amplitude. Stimulation timing signals are generated for each band pass signal, including for one or more selected band pass signals using a timing function defined to: i. represent instantaneous frequency as determined by the band pass signal temporal fine structure features, and ii. exclude temporal fine structure features occurring within a time period shorter than a band-specific upper frequency limit. The electrode stimulation signals are produced for each electrode contact based on the envelope signals and the stimulation timing signals.

Abstract: This invention relates to a novel method of reducing dermal scars resulting from various types of dermal injuries. Particularly, this invention relates to wound dressings and to scar management products each of which incorporate an active pharmaceutical ingredient to reduce and/or prevent dermal scarring.

Abstract: A composite implant device for use in a medical application, comprising a synthetically-derived mesh that mimics particular critical aspects of a biologically-derived mesh. The composite implant device can be used for the reinforcement and reconstruction of tissues within the body and can be comprised of a majority of synthetic components and minority of naturally-derived components which mimic the structure and function of a naturally-derived mesh.

Abstract: A middle ear prosthesis is made of a stiff deformable material and includes a planar head end with a central portion having a central diameter. The head end is adapted for engagement with a tympanic membrane from the middle ear of an implanted patient. An opposing pair of U-shaped stapes engagement legs bend down from the central portion so that an end distance between ends of the engagement legs is less than the central diameter. The engagement legs are adapted for adjustable length engagement with the stapes in the middle ear of the implanted patient. The head end and the engagement legs are adapted to transmit vibrations from the tympanic membrane to the stapes for perception as sound by the implanted patient.

Abstract: Approaches are described for fitting an implanted cochlear implant having electrode array contacts to an implanted patient. For multiple different fitting methods, each fitting method is assigned one or more electrode contacts wherein no electrode contact is assigned more than one fitting method. For each fitting method, the assigned electrode contacts are fitted according to the fitting method and fitting values for non-assigned electrode contacts are interpolated. Then a fitting is performed for each electrode contact in the electrode array based on a weighted averaging of the fittings for the various different fitting methods.

Abstract: A method for cleaning an implant (10) within an interdental space (4) in which an interdental space brush (6) with a non-circular cross-section (15) of the brush head (7) is inserted into an interdental space (4) and moved back and forth.

Abstract: A chimeric antigen receptors (CARs) specific to B-cell maturation antigen (BCMA), a recombinant expression vector and a method for the development of the genetically modified immune effector cells especially natural killer-92 cells (NK-92 cells) that target Multiple Myeloma (MM) and other hematological malignancies. The invention encompasses a single chain variable region (scFv) from BCMA specific antibody fused via transmembrane domain to intracellular signaling domain and two co-stimulatory molecules. Expression of CARs across the plasma membrane of immune effector cells such as natural killer cells (NK cells), NK-92 cells, T lymphocytes (T cells) and natural killer T cells (NKT cells) with exposed scFv interacting with the BCMA tumor target. The interaction initiates cascade of events through the intracellular stimulatory and signaling domains leading to the activation of immune effector cells followed by lysis of the tumor.

Abstract: A method for cleaning the gum in a widened interdental space (14) in which an interdental space brush (6) with a non-circular cross-section (15) of the brush head (7) is inserted into the widened interdental space (14) and moved back and forth.

Abstract: Disclosed is a station, for testing an analyte in a sample, enabling accurate and quick reaction and analysis of the sample and a reagent in one apparatus. To this end, the present disclosure provides a station, which is for testing a sample by means of inserting a cuvette, having a standby chamber on which a collecting member is placed, a sample chamber, a reagent chamber and a detection unit. The station comprises: a housing which has an input/output part into which a cuvette is inserted; a driving unit which is provided inside the housing, horizontally moves the cuvette, vertically moves a collecting member, reacts a sample in a sample chamber and a reagent in a reagent chamber, and injects a reaction result thereof into a detection unit; and an optical reader which is provided on the horizontal movement path of the cuvette and is for analyzing the reaction result.

Abstract: A cochlear implant electrode includes an implantable electrode array made of resilient material with a center longitudinal axis and an outer surface. Electrode contacts are distributed on the outer surface of the electrode array along the longitudinal axis for applying electrical stimulation signals to adjacent neural tissue. At least one biocompatible hydrogel layer is fixed to the electrode array solely by mechanical connection and adapted to swell from contact with perilymph fluid within a cochlea without separating away from the outer surface of the electrode array.

Abstract: A hearing implant fitting system includes a physiological database containing physiological data characterizing auditory neural tissue response to electrical stimulation. A neural action potential (NAP) measurement system measures NAP signals from cochlear tissue responding to electrical stimulation signals delivered by one or more of the electrode contacts, including: deriving a compound discharge latency distribution (CDLD) of the cochlear tissue by deconvolving: (1) a tissue response measurement signal taken responsive to the delivered electrical stimulation signals, with (2) an elementary unit response signal representing voltage change at a measurement electrode contact due to the electrical stimulation, and then comparing the CDLD to physiological data from the physiological database to detect an NAP signal from the tissue response measurement signal.

Abstract: The present invention relates to a device capable of disinfecting and sterilizing a medical sensor by ultraviolet radiation, the device comprising: a box-shaped case having a space portion formed therein and having an opening formed through a surface thereof; a door hingedly coupled to a side of the case so as to open and close the opening of the case; a holding member installed in the space portion of the case and allowing a medical sensor to be held on a side thereof; and an ultraviolet sterilizer installed on a side of the holding member.

Abstract: A hearing prosthesis arrangement is described for a hearing assisted patient. A microphone senses an acoustic environment around the hearing assisted patient and generates a corresponding microphone output signal. An audio signal processor processes the microphone output signal and produces a corresponding prosthesis stimulation signal to the patient for audio perception. The audio signal processor includes a dereverberation process that measures a dedicated reverberation reference signal produced in the acoustic environment to determine reverberation characteristics of the acoustic environment, and reduces reverberation effects in the hearing prosthesis stimulation signal based on the reverberation characteristics.

Abstract: Absorbable composite medical devices such as surgical meshes and braided sutures, which display two or more absorption/biodegradation and breaking strength retention profiles and exhibit unique properties in different clinical settings, are made using combinations of at least two types of yarns having distinctly different physicochemical and biological properties and incorporate in the subject construct special designs to provide a range of unique properties as clinically useful implants.

Abstract: A process for producing a daughter radionuclide from a parent radionuclide includes a) loading the parent radionuclide on a first solid medium contained in a generator and onto which the parent radionuclide is retained and whereby the daughter radionuclide is formed by radioactive decay of the parent radionuclide; b) eluting this medium with a A0 solution so as to recover a A1 solution comprising the daughter radionuclide; c) optionally adjusting the pH of the A1 solution so as to obtain a A1? solution, d) loading this A1 or A1? solution onto the head of a second solid medium contained in a chromatography column; e) first washing said second solid medium with a A2 solution; f) second washing said second solid medium with a A2? solution; g) eluting the daughter radionuclide with a A3 solution. The first washing step is conducted from head to tail of the column and the second washing step and the second eluting step are conducted from tail to head of the column.

Abstract: A heartbeat analyzing method and a heartbeat analyzing system are provided. The heartbeat analyzing method includes: sensing a user using a wearable device and acquiring a physiological signal record; performing a dispersion calculation to the physiological signal record using the wearable device and generating a Poincaré plot of the physiological signal record; and inputting the Poincaré plot into a heart rhythm classifier model and determining a heartbeat classification of the user based on personal health data of the user.

Abstract: A method and system for making an orthodontic aligner, as well as an orthodontic aligner. The method comprising: determining at least one super contact region between upper teeth and lower teeth of a subject, the super contact region comprising identifying an area around an at least one contact region between the upper teeth and the lower teeth which exceeds a predetermined magnitude of contact between the upper and lower teeth during a predefined upper/lower teeth position; and generating a digital model of the aligner comprising applying the determined super contact region to a digital model of a pre-form aligner such that a thickness of the aligner body at the determined super contact region is less than a thickness of the aligner body at regions which are not determined super contact regions.

Abstract: The present disclosure is directed to an instrument kit tracking system that includes a housing that has tracking electronics that is contained in either a compartment or wall of the medical instrument kit or in a standalone unit that is affixed to a medical instrument kit to contain and protect an electronic device from external temperatures between 120-135° C.; where the medical instrument kit contains at least one medical instrument. The internal temperature of the instrument kit tracking system is maintained such that the electronic device contained therein is operable when the external temperature is between 120-135° C. A further layer, such as of a thickness of 1 mm, resides between the electronic device and the outer walls of the compartment or module. Access to the tracking electronics may also be selectively lockable.

Abstract: A biopsy marker having a spring-loaded anchor. The biopsy marker includes an insertion orientation and an anchored orientation. In the insertion orientation, the biopsy marker is manipulated under force to reduce the lateral span/cross-sectional area of the marker. In the anchored orientation, the biopsy marker is released and free to actively spring into a configuration in which the lateral span/cross-sectional area is greater than the lateral span/cross-sectional area of the biopsy marker when in the insertion orientation. In an embodiment, the spring-loaded anchor is configured to spring about a predefined rotational axis. An embodiment of the biopsy marker may be comprised of a single wire construction.