Abstract: An interference edge filter is mounted on the end of an optical fiber to provide a sensor for pressure or temperature. The filter is formed such that the transition slope of the filter curve will move to the left or right depending upon the changes in the parameter being monitored. The shift in the position of the slope of the edge filter curve is detected by passing the reflected light through an interference bandpass filter having an edge slope intersecting the transition slope and measuring the intensity of the light passing the bandpass filter.

Abstract: Leucine aminopeptidase (LAP) activity or .gamma.-glutamyltranspeptidase (.gamma.-GTP) activity in a sample is determined by converting a substrate represented by the formula (I): ##STR1## wherein Z represents (CH.sub.3).sub.2 CHCH.sub.2 CH(NH.sub.2)--or (NH.sub.2)(COOH) CHCH.sub.2 CH.sub.2 --, R.sub.1 represents hydrogen, alkyl or substituted alkyl, R.sub.2 represents alkylene or hydroxyalkylene, R.sub.3 and R.sub.4 are the same or different and represents hydrogen, halogen, nitro, hydroxyl, sulfo, carboxyl, alkyl, and alkoxy, and salts thereof into a compound represented by the formula (II): ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the same meanings as defined above. The compound (II) is reacted with a chromogen to form a pigment or converted into a diazonium salt which is reacted with a coupling agent to form an azo dye. Absorption of a resultant colored reaction solution is measured.

Abstract: Blood gases and the like are monitored by a single probe having multiple dye wells and dyes immobilized in the wells, the dyes being exposed to the blood gases. Optical fibers and waveguides connected to the dye wells permit light to be directed from a light source to be dyes and the light due to absorption or the spontaneous emission of the dye returned to a light detector. The intensity, phase shift or other mechanism of the returned radiation is a measure of the partial pressure of a respective blood gas.

Abstract: A pressure transducer has a thin central portion formed of a molded thermoplastic resin. A conductive polymer forms the resistive elements of a Wheatstone bridge printed and baked onto the molded substrate.

Abstract: The present invention provides a method for the determination of NAD(P)H which comprises reacting a chromogen represented by the following general formula (I): ##STR1## wherein Y is hydrogen or hydroxyl; R.sub.1, R.sub.2 and R.sub.3 may be the same or different, and are groups represented by the following general formula (II), (III) or (IV): ##STR2## wherein Z is hydrogen, hydroxyl, amino, substituted amino, alkyl, substituted alkyl, alkenyl, aryl, substituted aryl, acyl, halogen, nitro, sulfo, carboxyl or alkoxy; n is 1, 2, or 3; provided that at least one Z in R.sub.1, R.sub.2 and R.sub.3 is hydroxyl, amino, or substituted amino; and Z.sub.s in Z.sub.n may be the same or different, with NAD(P)H in the presence of (1) peroxidase or thiol oxide reductase and (2) diaphorase or an electron carrier, and determining the pigment thus formed.

Abstract: A method and test composition for colorimetrically determining hydrogen peroxide in a sample includes a chromogen of the formula: ##STR1## which is reacted with hydrogen peroxide in the sample in the presence of peroxidase. The absorbancy of the reaction solution is then measured.

Abstract: Disclosed is a method for diagnosing and differentiating cancer by qualitative and quantitative determination according to an immuno-serological assay of cancer-related antigens in a body fluid, particularly glycoprotein, glycolipid and glycoantigen produced by cancerization or dedifferentiation of normal cells.

Abstract: In a blood pressure monitoring system, a transducer which is a conductive rubber tube having conductive terminals at each end. The terminals are connected to a circuit for detecting changes in resistance of the tube. The internal surface of the tubing is coated with a dielectric material.

Abstract: A system for calibrating a blood pressure transducer and monitor combination. The transducer assembly has a calibration resistor. The monitor cable has a housing which contains a switch and a shunt resistor. Electrical connections are provided to place the calibration resistor and shunt resistor in series with each other and in shunt across one leg of a transducer bridge to produce a reading of 100 mmHg on the monitor.

Abstract: A device for controlling the flow of liquid to a catheter. Two end caps support a capillary tube that provides continuous flow of liquid from one end cap to the other. A flexible, resilient sleeve is connected at its ends to said end caps and surrounds said capillary tube. Said sleeve, when pulled away from said capillary tube, provides an alternate high flow volume flow from one end cap to the other outside of the tube.

Abstract: The present invention provides a method for assaying a biocomponent on the basis of an amount of bound peroxidase by the steps of supporting a biocomponent or a target substance containing a biocomponent on a gel-like carrier, developing the biocomponent or the target substance by electrophoresis, binding a receptor to the biocomponent or the target substance, binding peroxidase to the receptor, and determining the amount of the bound peroxidase, wherein hydrogen peroxide and 4-methoxy-1-naphthol are used as substrates.

Abstract: Blood gases and the like are monitored by a single probe having multiple dye wells and dyes immobilized in the wells, the dyes being exposed to the blood gases. Optical fibers and waveguides connected to the dye wells permit light to be directed from a light source to the dyes and the light due to absorption or the spontaneous emission of the dye returned to a light detector. The intensity, phase shift or other mechanism of the returned radiation is a measure of the partial pressure of a respective blood gas.

Abstract: The present invention provides a method for the determination of ceruloplasmin activity, wherein a member selected from the group consisting of (a) ferrocene or derivatives thereof (b) metallocene and (c) chelate metal containing iron or copper is reacted with a chromogen in the presence of ceruloplasmin to form colored material which is determined photometrically, as well as a reagent suitable therefor.

Abstract: The present invention provides a method for the determination of bilirubin which comprises reacting the bilirubin with a compound represented by the formula ##STR1## and determing the pigment thus formed.

Abstract: Apparatus for monitoring and regulating intracranial pressure. Primary components are a manometer tube connected to a fluid collector, a transducer for dynamic electronic monitoring, and an automatic regulator. These components are interconnected by tubing and three main stopcocks which permit multiple procedures to be performed. A fourth stopcock, syringe and appropriate connections permit the system to be connected to a dedicated source of sterile liquid.

Abstract: An apparatus for measuring pressure within a conduit is disclosed preferably comprising a tube whose resonant frequency varies with the pressure of fluid within the tube; means for passing the fluid to be measured through the tube; two active piezoelectric films disposed in intimate contact with the tube on opposite sides thereof; first electronic means for energizing the first of the films to cause the tube to resonate at its natural frequency, and second electronic means connected to the other of the films to monitor the frequency of the tube.

Abstract: A pressure infusor for introduction of fluids into the human body. Two sheets of polyurethane overlie each other and are continuously sealed to form an air-inflatable bladder. A strip of polyurethane projects from one vertical margin of the bladder to wrap completely around the liquid-filled bag. A narrow elongated strap is centrally attached to one margin of the infusor and is long enough to wrap completely about the infusor with a bag enclosed. Velcro strips are secured to the strap so that it can be fastened upon itself.

Abstract: A blood pressure monitoring system in which an intravascular catheter is connected through flexible tubing to a transducer. The tubing between the catheter and the transducer is filled with physiological solution supplied from a bag under pressure of approximately 300 mm. of mercury. The supply line from the bag to the tube is in series with a capillary so that after the system is filled with the physiological solution, the capillary passes fluid from the supply to the catheter at the rate of around two to seven cc. per hour. Provision is made for bypassing the capillary for the purpose of fast flushing the system as would occur when the system is initially filled with fluid. The fast flush line consists of a plug in series with the line from the supply, the plug having upstream and downstream longitudinal grooves separated by a central collar. A flexible tube surrounds the plug and blocks passage from the upstream and downstream groove past the collar.

Abstract: A two-piece swivel coupling for a catheter system having Luer connections on either end of the coupling. One piece has a recess which receives an O-ring and the other piece has a spigot which projects through the O-ring into a recess. The O-ring provides radial, fluid-tight interference between the spigot and the recess. Means are provided for preventing the pieces from axially compressing the O-ring so that one piece is freely rotatable with respect to the other as the catheter is inserted in a blood vessel through a tortuous path into a patient's heart.

Abstract: A transducer dome for isolating a transducer from the liquid which actuates it. The transducer dome has a hemispherical or conical portion containing a single inlet and a threaded portion for connection to a transducer. The inlet is isolated from the transducer by a diaphragm formed from a hydrophobic bacterial filter, which allows venting of air during priming.