Abstract: The present invention relates to a method for quantitative determination of NAD(P)H derived from a specific component, which comprises converting NAD(P)H present in a sample or formed from components other than the objective component by reactions into NAD(P) by the action of glutathione of oxidation type and glutathione reductase; decomposing the remaining glutathione of oxidation type by the action of .gamma.-glutamyl transpeptidase in the presence or in the absence of a mercapto compound; forming NAD(P)H from the component to be determined in the sample utilizing an NAD(P)H-forming reaction system; and quantitatively determining NAD(P)H.According to the method of the present invention, amylase activity, etc. in vital components containing maltose and glucose can be determined accurately.

Abstract: A method for determination of an analyte in a sample containing reducing substances is disclosed. After the decomposition of the reducing substances by reaction with hydrogen peroxide formed by enzymatic Redox reaction using a component in the sample which does not participate in another enzymatic Redox reaction using the analyte, the remaining hydrogen peroxide is decomposed, and then the analyte is subjected to enzymatic Redox reaction to form hydrogen peroxide which is then determined by a known method.

Abstract: A composition for testing periodontal diseases which diagnoses or prognosticates contraction or progress of the diseases or diagnoses the therapeutic value by promptly determining peptidase-like enzymatic activity in a specimen. The composition is a combination of a compound of the formula [1] or [2] or a mixture thereof, a chromogen and an oxidase:X-T-Pro-Y [1]orX'-Z'-Arg-Y' [2]wherein Pro is proline residue; Arg is arginine residue; X and X' are hydrogen or an amino protecting group, respectively; Y and Y' are a residue of a compound which can increase oxidation reaction rate of a chromogen with a oxidase in the presence of oxygen and is attached to the C-terminal of Pro or Arg, respectively; and T and Z' are an amino acid or peptide residue composed of 0 to 4 amino acids or their protected derivatives the C-terminal of which is attached to the N-terminal of Pro or Arg, respectively.

Abstract: A sample site for obtaining a whole blood sample includes flow directors in the ports. The flow directors may include ramp surfaces. Blood flowing into the sample site is diverted by the flow directors to mix with and flush out all of the saline otherwise present in the sample site to allow for a whole blood sample to be taken.

Abstract: A sample site having a needleless connector access port including a flush mounted valve assembly which is readily accessible for wiping clean with a disinfectant. A male Luer connector may be operatively connected into the access port by a split Luer arrangement of female Luer connector portions adjacent the access port aperture. The split Luer arrangement does not generally obstruct wiping access to the access port and may include moveable connector portions to provide completely unobstructed wiping access thereto.

Abstract: Disclosed is a method for determination of an activity of .gamma.-glutamyl transpeptidase, leucine aminopeptidase, alanine aminopeptidase, cystine aminopeptidase, X factor as a coagulation factor, thrombin, plasmin of plasminogen series, kallikrein, chymotrypsin, alkali phosphatase, N-acetyl glucosaminase and amylase, by allowing a particular substrate to act on the enzyme to thereby form an enhancer; oxidizing a chromogen by an oxidase in the presence of the enhancer and oxygen to form a pigment; and determining the pigment. Also disclosed is a test composition for carrying out the determination.

Abstract: A fast flush catheter valve is disclosed having a valve body with a longitudinal bore therethrough for the flow of fluids through the valve. A tube is mounted substantially transverse to the longitudinal bore to substantially block the longitudinal bore. An actuating member is mounted through the exterior of the valve body so that one end of the actuating member is proximate the tube and the second end extends beyond the exterior of the valve body. A resilient biasing flange connects the second end of the actuating member to the exterior of the valve body. A capillary is mounted through the tube to provide a drip rate flow. Depressing the second end of the actuating member deforms the tube to produce a flush rate around the tube and releasing the second end causes the resilient flange to return the actuating member to a position where the tube can elastically return to the longitudinal bore blocking position. The valve is constructed from a few components and is simply and inexpensively constructed.

Abstract: A source of saline solution under pressure is connected through tubing to a catheter inserted in a patient's blood vessel. A waste collection bag is connected to the tubing through a stopcock which permits the selective connecting of the catheter to the waste collection bag or the bag of saline solution. The sampling site is in the tubing between the catheter and the stopcock. Normally, saline solution flows into the patient's blood vessel. When a sample is to be taken, the stopcock is shifted so that the pressure of the patient's blood forces blood into the tubing, driving saline into the waste collection bag. When blood has reached the sampling site, blood is extracted with a hypodermic syringe.

Abstract: In a blood gas sensing probe, a cylindrical sleeve contains an optical fiber. The end of the optical fiber is withdrawn into the sleeve thereby creating a receptacle at the end of the sleeve. A sensitive dye, HOPSA for example, is encapsulated in a gel and deposited in the receptacle to form the probe. In making the probe, the end of the optical fiber is in the same plane as the end of the sleeve in which it is placed. The dye and gel contact the combined ends of optical fiber and sleeve. The fiber is withdrawn into the sleeve thereby creating a vacuum which is filled by the dye and gel.

Abstract: A blood chemical sensor has a blood gas sensitive dye contained in a hydrogel matrix, the combination of dye and gel being mounted on the end of an optical fiber. The hydrogel is freeze-dried to facilitate packaging and handling.

Abstract: In a blood gas sensing probe, a cylindrical sleeve contains an optical fiber. The end of the optical fiber is withdrawn into the sleeve thereby creating a receptacle at the end of the sleeve. A sensitive dye, HOPSA for example, is encapsulated in a gel and deposited in the receptacle to form the probe. In making the probe, the end of the optical fiber is in the same plane as the end of the sleeve in which it is placed. The dye and gel contact the combined ends of optical fiber and sleeve. The fiber is withdrawn into the sleeve thereby creating a vacuum which is filled by the dye and gel.

Abstract: A source of saline solution under pressure is connected through tubing to a catheter inserted in a patient's blood vessel. A waste collection bag is connected to the tubing through a stopcock which permits the selective connecting of the catheter to the waste collection bag or the bag of saline solution. The sampling site is in the tubing between the catheter and the stopcock. Normally, saline solution flows into the patient's blood vessel. When a sample is to be taken, the stopcock is shifted so that the pressure of the patient's blood forces blood into the tubing, driving saline into the waste collection bag. When blood has reached the sampling site, blood is extracted with a hypodermic syringe.

Abstract: In blood pressure monitoring apparatus, apparatus for withdrawing blood from a tube connected to a patient's blood vessel. A stopcock is connected to the tube. A T-connector is connected to one port of the stopcock. A storage syringe is connected to one branch of the T-connector and a latex self-sealing cap covers the other port to provide an IV site suitable for penetration with a syringe needle to withdraw a blood sample through the IV site. The storage syringe brings blood to the T-connector so that it can be withdrawn through the IV site.

Abstract: The present invention provides a method for the determination of a compound having mercapto group which comprises reacting the compound with a chromogen represented by the following general formula (I): ##STR1## wherein Y is hydrogen or hydroxyl; R.sub.1, R.sub.2 and R.sub.3 may be the same or different, and are groups represented by the following general formula (II), (III) or (IV): ##STR2## wherein Z (which may be the same or different) is hydroxyl, amino, substituted amino, alkyl, substituted alkyl, alkenyl, aryl, substituted aryl, acyl, halogen, nitro, sulfo, carboxyl or alkoxy; n is 0, 1, 2, or 3; provided that at least one Z in R.sub.1, R.sub.2 and R.sub.3 is hydroxyl, amino, or substituted amino, in the presence of peroxidase or thiol oxide reductase, and determining the pigment thus formed.

Abstract: An infusion pump has a housing for receipt of a syringe, a motor to drive the plunger of the syringe to expel a medicant within the syringe, a computer for controlling the motor and a place to mount the syringe. A bar code reader is mounted adjacent the syringe and the syringe has a pharmacist-applied bar code that programs the computer with the data for the dispensing of the medicant.

Abstract: A transducer has a thick perimeter and an integral diaphragm extending across said perimeter, all formed of a thermoplastic resin. A thick mass is molded at the center of the diaphragm. Resistive elements formed of a conductive polymer are printed and baked on the diaphragm to form a Wheatstone bridge. The transducer is used as an accelerometer or load cell.

Abstract: In a blood pressure monitoring system, a transducer which is a conductive rubber tube having conductive terminals at each end,and circumferentially spaced conductors connected to said semi-conductive band,whereby fluid under varying pressure will cause said insulative tube to expand and contract, thereby causing said semi-conductive band to expand and contract, thereby varying the resistance of the semi-conductive band.

Abstract: A reusable pressure transducer for use with a detachable dome. The pressure transducer includes a body having a recess with an opening covered by a flexible diaphragm. The body has a hole opposite the flexible diaphragm and a sensor placed over the hole. A dielectric gel fills the recess to transmit to the sensor variations in pressure imparted to the diaphragm.

Abstract: Disclosed is a method for the colorimetric determination of hydrogen peroxide in a sample by reacting a particular chromogen with the hydrogen perioxide in the presence of peroxidase and measuring the absorbancy of the reaction solution in the visible or near inflared ray region. Also disclosed is a test composition for carrying out the determination.

Abstract: A connector has a main passage through which a dilatation catheter passes. Combined Tuohy-Borst valve and membrane seals are provided in the main passage to seal the catheter and main passage against flow-by.