Abstract: A lancet device includes a housing, a removable front cap mounted to the housing, a lancet holding member, a trigger and an arming system comprising a grippable cocking member structured and arranged to place the lancet device in a trigger-set or armed position. A depth adjustment system includes a member that is at least slidable and partially rotatably mounted and that has an axis of rotation arranged substantially parallel to a center axis of the lancet holding member. An ejection system includes an ejector having a portion extending outside a sidewall opening of the housing and being located closer to a front end of the housing than to a rear end of the housing. The sidewall opening of the housing is arranged on an area of the housing located between the trigger and a wall of the housing located opposite the trigger. The ejection system is structured and arranged to at least one of prevent axial movement of the lancet holding member or remove or eject a lancet from the lancet holding member.

Abstract: The present invention provides a method of conducting a sleep analysis by collecting physiologic and kinetic data from a subject, preferably via a wireless in-home data acquisition system, while the subject attempts to sleep at home. The sleep analysis, including clinical and research sleep studies and cardiorespiratory studies, can be used in the diagnosis of sleeping disorders and other diseases or conditions with sleep signatures, such as Parkinson's, epilepsy, chronic heart failure, chronic obstructive pulmonary disorder, or other neurological, cardiac, pulmonary, or muscular disorders. The method of the present invention can also be used to determine if environmental factors at the subject's home are preventing restorative sleep.

Abstract: In one embodiment, the present application discloses, in part, a balloon catheter assembly comprising: a) a balloon catheter comprising a proximal end, a distal end; and b) a connecting line comprising a proximal end and a distal end, wherein the proximal end comprises a first terminal magnetic connector for forming a water tight connection with the magnetic click connector on the port panel.

Abstract: The present disclosure describes a bone screw for use in orthopedic procedures. The bone screw includes a shank portion having a helical thread and a head portion also having a helical thread. The head portion has a reverse frustoconical shape, with the conical taper decreasing in the proximal direction.

Abstract: Modular mammalian body implantable fluid flow influencing device, comprising: docking unit having receiving surface, distal and proximal ends, proximal guide hole. Functional unit having docking surface shaped to mate with receiving surface, distal and proximal ends. Control wire extends from proximal end of functional unit then goes through guide hold then extends proximally away from docking unit. Functional and docking units are dimensioned and shaped to be deliverable to an implantation site via catheter. Functional unit has docked configuration in which docking surface mates with receiving surface of docking unit and undocked configuration in which docking surface is unmated with and spaced apart from receiving surface of docking unit. Functional unit moveable at implantation site between undocked and docked configurations via movement of control wire. Functional unit moveable into docked configuration by pulling control wire, and moveable from into undocked configuration by pushing control wire.

Abstract: A system and method for performing a portable, fast, field assay of a small sample biological analyte includes a microfluidic cartridge and a reader with which the microfluidic cartridge is selectively communicated. A closed microfluidic circuit mixes and recirculates the analyte with a buffer. A shear horizontal surface acoustic wave (SAW) detector communicates with the microfluidic circuit and has a plurality of channels including at least one functionalized sensing channel in which the mixed analyte and buffer is recirculated and sensed. Capture of the analyte is amplified by recirculation of the analyte and buffer, and detection is amplified by use of an all-purpose endospore display mass amplification.

Abstract: A needle tip assembly for a pre-loaded syringe or a pen needle injection device, including a needle with a first puncturing end projecting from a front side of a needle support and a second puncturing end projecting from a rear side of the needle support. A body sized to receive therein the needle support and the needle. The body including a front portion, a rear portion, and an overall axial length that is greater than an axial length of the needle. Prior to the needle tip assembly being in an installed condition on the pre-loaded syringe or pen needle injection device, the front portion covers the first puncturing end and the rear portion covers the second puncturing end. Prior to removal from the pre-loaded syringe or pen needle injection device, the body is at least axially movable to a position where the front portion covers the first puncturing end.

Abstract: A bead mill and an associated bead-mill-based machine for testing mechanical fragility of red blood cells, employing a cartridge configured to contain a sample while cells get stressed via bead oscillation and, in the case of the fragility testing machine, also while lysis levels get detected, for presentation of fragility information.

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor.

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample.

Abstract: A core-severing cannula for use with tissue biopsy devices, comprising a plurality of flexible fingers for severing a tissue core. The core-severing cannula is positioned coaxially outside of a core-cutting cannula, and is slidable relative to the core-cutting cannula. As the device is activated, the core cutting cannula and core-severing cannula advance together to cut a core of tissue. Subsequently, the core-severing cannula is advanced relative to the core cutting cannula, and the fingers of the core-severing cannula assume a closed position to sever the core from the target site.

Abstract: The present invention provides a method of conducting a sleep analysis by collecting physiologic and kinetic data from a subject, preferably via a wireless in-home data acquisition system, while the subject attempts to sleep at home. The sleep analysis, including clinical and research sleep studies and cardiorespiratory studies, can be used in the diagnosis of sleeping disorders and other diseases or conditions with sleep signatures, such as Parkinson's, epilepsy, chronic heart failure, chronic obstructive pulmonary disorder, or other neurological, cardiac, pulmonary, or muscular disorders. The method of the present invention can also be used to determine if environmental factors at the subject's home are preventing restorative sleep.

Abstract: Disclosed are devices and methods for creating a bore in bone. The devices and methods described involve controlling the drive and measuring the drilling energy of a working tool such that a user can avoid injuries to surrounding structures.

Abstract: A method using variable bead-oscillation-based stress parameters, including relative bead dimensionality or other structural features as well as stress duration or intensity or overall magnitude, in inducing different shear stresses in biological samples, for testing the effects of different combinations of various defined stress conditions.

Abstract: An anastomosis device may include an anchor including a base with an opening and a riser portion securably associated with the base. The base is configured to be disposed within a body lumen. The riser portion includes at least one attachment point with a tubular and hollow graft secured directly to the at least one of attachment point of the riser portion. The at least one attachment point of the riser portion is free of sutures or pins traversing portions of the graft proximal the riser portion. The at least one of attachment point of the riser portion may be in the form a tip of a hook. The anastomosis device may further include at least two additional attachment points for securing the graft to the riser portion.

Abstract: A body model system for temporary hemorrhage control training and simulation includes a frame simulating at least a torso of the body having a hollow portion, a simulated artery positioned in the hollow portion, a thigh patch mounted to the frame proximate the hollow portion, a pump connected in fluid communication with the simulated artery and a reservoir connected in fluid communication with the simulated artery and the pump. The frame is substantially rigid. The thigh patch is constructed of a resilient material that is pierceable by a needle. The simulated artery extends through the thigh patch. The pump is configured to produce a pulsatile flow in the simulated artery.

Abstract: Methods and devices for minimally-invasive delivery of radiation to the eye (such as the posterior portion of the eye) including cannula systems with multiple treatment positions and/or multiple channels in the distal tip of the cannula systems. The channels can accommodate emanating sources and exposing a target at various treatment positions. The emanating sources may be annulus-shaped.

Abstract: Compositions and methods involving administration of agents useful for the treatment, prevention, inhibition, etc., of inflammatory disease or fibrous adhesions using low sulphate fucans and, if desired, one or more other anti-inflammatory disease or anti-fibrous adhesion agent.

Abstract: A handheld vascular access device for gaining access to a patient's vessel includes a hub, a plurality of access needles and a manifold. The hub has an inner wall and side walls that define a plurality of ports. Each of the plurality of ports has a proximal port end and a distal port end. The proximal port ends define a proximal cross-sectional area and the distal port ends define a distal cross-sectional area. The proximal cross-sectional areas are greater than the distal cross-sectional areas. Each of the plurality of ports taper from the proximal port end to the distal port end. The plurality of hollow access needles is arranged along a plane and fixedly coupled to the distal end of the hub. Each of the plurality of needles has a tip. The manifold removably engages the hub at the proximal end of the hub.

Abstract: A system including an instrument having a working tool configured to penetrate a tissue; a sensor configured to generate in real-time one or more torque signals related to torque of the working tool; a controller in operative communication with the sensor and configured to receive the one or more torque signals. The controller processes the torque signals into one or more processed signals representative of torque, energy, power or a combination thereof. The system also includes a display providing to the user in real-time the one or more processed signals. Related devices, systems, methods, and articles are provided.