Abstract: The present disclosure relates generally to polypeptides derived from marsupial adeno-associated vims (AAV). The disclosure is also related to nucleic acid molecules encoding the polypeptides, and vectors comprising the nucleic acid molecules, and AAV vectors comprising the polypeptides. The disclosure also relates to uses of the nucleic acid molecules, polypeptides and AAV vectors, such as for capsid diversification.
Type:
Application
Filed:
May 31, 2019
Publication date:
April 29, 2021
Applicants:
Children's Medical Research Institute, The Sydney Children's Hospitals Network (Randwick and Westmead) (Incorporating the Royal Alexandra
Abstract: Provided is a polynucleotide, including a cis-regulatory element and a nucleotide sequence encoding a vestigial like 4 protein, wherein the cis-regulatory element includes an uncoupling protein 1 enhancer and an uncoupling protein 1 promoter. Also provided is a viral vector including said polynucleotide. Also provided is a method of transfecting a cell or a subject with said polynucleotide or said viral vector.
Abstract: Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.
Type:
Grant
Filed:
May 3, 2017
Date of Patent:
January 5, 2021
Assignees:
CHILDREN'S MEDICAL RESEARCH INSTITUTE, THE SYDNEY CHILDREN'S HOSPITALS NETWORK (RANDWICK AND WESTMEAD) (INCORPORATING THE ROYAL ALEXANDRA HOSPITAL FOR CHILDREN), THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (WASHINGTON DC)
Inventors:
Claus Hallwirth, Ian Alexander, Richard Smith, Robert Kotin
Abstract: This invention relates generally to methods for assessing telomeres, including methods of measuring the length of a telomere and methods for detecting extension of a telomere and methods for measuring telomere extension, and associated systems.
Abstract: N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
Type:
Grant
Filed:
August 9, 2017
Date of Patent:
September 29, 2020
Assignees:
UNIVERSITY OF KANSAS, THE REGENTS OF THE UNIVERSITY OF MICHIGAN, SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, WAYNE STATE UNIVERSITY
Inventors:
Jennifer E. Golden, Jeffrey Aube, Daniel P. Flaherty, Andrew M. Fribley, Randal J. Kaufman, Thomas D. Y. Chung, Anthony B. Pinkerton, Michael Pablo Hedrick
Abstract: Provided is a method for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus, as well as novel compounds that are useful in the method.
Type:
Grant
Filed:
February 6, 2017
Date of Patent:
April 7, 2020
Assignees:
Sanford-Burnham Medical Research Institute, Southern Research Institute
Inventors:
Marintha L. Heil, Nicholas D. P. Cosford, Robert Ardecky, Jiwen Zou
Abstract: Polynucleotides and vectors can be used for the expression of a transgene in cells, such as liver cells. The expression of the transgene from the polynucleotides and vectors can be useful in gene therapy. Various methods can be used for expressing the transgene from the polynucleotides and vectors in liver cells.
Type:
Application
Filed:
January 10, 2018
Publication date:
December 5, 2019
Applicants:
Children's Medical Research Institute, The Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexandra
Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
Type:
Grant
Filed:
June 22, 2010
Date of Patent:
August 6, 2019
Assignee:
Sanford-Burnham Medical Research Institute
Inventors:
Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
Abstract: A stretcher has a rectangle-shaped subject placement portion on which a subject is placed and a carrying device carrying the subject placement portion, comprising: a switching part switched to any one of at least two states; and a switching device switching a state of the switching part in accordance with a supplied gas pressure. The at least two states include a state in which the switching part prevents movement of the subject placement portion and a state in which the switching part allows the movement.
Type:
Grant
Filed:
June 15, 2015
Date of Patent:
July 23, 2019
Assignees:
FUJIDENOLO CO., LTD., MEDIPOLIS MEDICAL RESEARCH INSTITUTE
Abstract: An operating table includes a patient placement table for placing and securing a patient in a required posture; a main body for supporting the patient placement table; engaging pieces for removably coupling the patient placement table to the main body; and a motor for rotating the patient placement table with a head-feet direction of the patient as a rotation axis to hold the patient placement table at any given rotation angle.
Type:
Grant
Filed:
March 10, 2015
Date of Patent:
June 18, 2019
Assignees:
FUJIDENOLO CO., LTD, MEDIPOLIS MEDICAL RESEARCH INSTITUTE
Abstract: Polypeptides are encoded by an adeno-associated virus (AAV)-derived endogenous viral element (mAAV-EVE1) found within the germline of numerous closely-related marsupial species. Nucleic acid molecules encode the polypeptides. Vectors can include the nucleic acid molecules, and recombinant AAV virions can include the polypeptides. A chimeric capsid protein can also include an MAAV-EVE1 polypeptide.
Type:
Application
Filed:
May 3, 2017
Publication date:
May 9, 2019
Applicants:
Children's Medical Research Institute, The Sydney Children's Hospitals Network (Randwick and Westmead) (incorporating The Royal Alexanndra, The United States of America, as represented by the Secretary, Department of Health and Human
Inventors:
Claus Hallwirth, Ian Alexander, Richard Smith, Robert Kotin
Abstract: The invention provides methods, compositions and kits for the identification and enrichment of progenitor cell lines obtained from pluripotent stem cells.
Type:
Grant
Filed:
November 2, 2015
Date of Patent:
March 12, 2019
Assignees:
Mandala Biosciences, LLC, BioTime, Inc., Sanford-Burnham Medical Research Institute
Inventors:
Dana Larocca, Paola Bignone, Michael D. West, Evan Snyder
Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated LyP-1 peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
Type:
Grant
Filed:
August 24, 2012
Date of Patent:
January 15, 2019
Assignee:
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Inventors:
Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara, Lise Roth
Abstract: The present disclosure describes methods of treating a central nervous system condition associated with oxidative stress using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. The present disclosure also describes methods of treating a central nervous system condition with N-acetylcysteine and a second therapeutic agent such as prostaglandin E2.
Type:
Application
Filed:
May 1, 2018
Publication date:
December 6, 2018
Applicant:
Burke Medical Research Institute
Inventors:
Rajiv R. RATAN, Saravanan KARUPPAGOUNDER, Thomas I. BRADSHAW
Abstract: This invention relates to methods of administering compounds containing selenium, selenocysteine, or a selenocysteine peptide to treat, for example, conditions associated with selenium deficiency, or ferroptoptic, parthanototic, and endoplasmic reticulum stress, and/or cancer. The methods of treatment may activate or inhibit (via TFAP2C and Sp1 proteins) the adaptive homeostatic response of the selenome. The compounds may contain a targeting sequence that causes them to be delivered to specific organs and/or tissues. The compounds may be administered, for example, orally, intranasally, intravenously, or by a minimally invasive catheter or BrainPath.
Type:
Application
Filed:
May 2, 2018
Publication date:
November 15, 2018
Applicant:
Burke Medical Research Institute
Inventors:
Rajiv R. Ratan, Ishraq Alim, I, Saravanan Karuppagounder
Abstract: Compositions and methods useful in connection with magnetic resonance imaging are provided. Metabolites hyperpolarized by dynanic nuclear polarization are used as reporter molecules in nuclear magnetic resonance (“NMR”) spectroscopy to study metabolic pathways and diagnose disease states. The reporter molecules include hyperpolarized glutamine and hyperpolarized acetate. The invention includes the reporter molecules, compositions including the reporter molecules in pharmaceutically acceptable carriers, methods for studying metabolic pathways that include introducing one or more of the reporter molecules to a mammalian subject and imaging a target substance using NMR spectroscopy, and kits useful in studying metabolic pathways that incorporate one or more of the reporter molecules and instructions for their use.
Abstract: Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.
Type:
Application
Filed:
June 18, 2018
Publication date:
October 25, 2018
Applicants:
Sanford-Burnham Medical Research Institute, Vala Sciences, Inc.
Inventors:
Jeffrey H. Price, Derek N. Fuller, Albert L. Kellner, Behrad Azimi
Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
Type:
Grant
Filed:
April 6, 2015
Date of Patent:
October 16, 2018
Assignee:
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Inventors:
Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford, Russell Dahl
Abstract: Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPB), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
Type:
Grant
Filed:
November 29, 2016
Date of Patent:
August 14, 2018
Assignee:
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Inventors:
Nicholas David Peter Cosford, Mitchell Dennis Vamos