Abstract: Disclosed are compositions and methods for selectively targeting an endometriosis cell. Also disclosed are compositions and methods for treating endometriosis.

Abstract: Provided herein are small molecule Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) modulator compounds, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. EBI2 is a therapeutic target for the treatment of a variety of diseases or conditions. In some embodiments, EBI2 is a therapeutic target for the treatment of diseases or conditions such as, but not limited to, autoimmune diseases or conditions, cancer, and cardiovascular disease.

Abstract: The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and signals via interaction with a gp130/LIF receptor heterodimer. In a related aspect, the present invention provides a method of increasing insulin sensitivity in a mammal. The method of present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterized by unwanted lipid accumulation (such as obesity, obesity induced-metabolic disorders, type II diabetes, dyslipidemia, glucose intolerance, insulin resistance, obstructive sleep apnea, cardiovascular disease or non-alcoholic fatty liver disease) or inadequate insulin sensitivity.

Abstract: N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.

Abstract: Provided herein are methods for the diagnosis of cancer by comparison of a quantification of long non-coding RNA with the same measurement taken in a reference sample from a healthy patient. Further provided herein are methods of anticipating the likelihood that such a disease will develop, and methods of treatment in the event of such development.

Abstract: A minimally invasive spinous process fixation system includes dual rigid spinous clamps, each configured to articulate axially along a cylindrical shaft, and together configured to enclose and clamp around the adjacent or superior spinous process by means of opposing and swiveling spherical contact heads with spiked spinous contact faces. The spinous clamps are lockable when desired compression is achieved. A pedicle clamp has right and left clamp bodies for enveloping pre-existing pedicle rods. Each of the right and left clamp bodies includes upper and lower rigid metal plates supporting medial and lateral swivel cups. The upper and lower medial swivel cups engage and clamp about a connecting rod extending from the spinous clamp, and the upper and lower lateral swivel cups engage and clamp about one of the pedicle rods. A channel through the upper and lower metal plates accepts a locking screw to simultaneously tighten and fix the swivel cups in place about the connecting rod and the pedicle rod.

Abstract: A stretcher has a rectangle-shaped subject placement portion on which a subject is placed and a carrying device carrying the subject placement portion, comprising: a switching part switched to any one of at least two states; and a switching device switching a state of the switching part in accordance with a supplied gas pressure. The at least two states include a state in which the switching part prevents movement of the subject placement portion and a state in which the switching part allows the movement.

Abstract: Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenvironment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.

Abstract: Provided is a process for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus.

Abstract: A positioning device is described for supporting an infant with myelomeningocele during surgery, transport and pre- and post-operative procedures. The device allows the patient to be expeditiously re-positioned from prone to supine and lateral positions and vice versa before, during and after surgery. The device allows access to the myelomeningocele while the patient is secured in the device.

Abstract: Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

Abstract: Provided is a device for multi-portal irradiation of particle beams which makes it possible to carry out multi-portal irradiation by remote operation without an operator having to enter an irradiation room. This device for remotely multi-portal irradiation of particle beams includes an irradiation room and a control room. The irradiation room comprises an irradiation device for emitting a particle beam at an irradiation target, an irradiation control device for controlling the position and direction of the irradiation device, and a support stand for supporting the irradiation target. The control room, in turn, includes a control device and a remote operation controller. The control device controls the position and direction of the irradiation device by controlling the irradiation control device.

Abstract: The invention entails synthetic short peptides based on Rift Valley Fever Virus (RVFV) fusion protein. The peptides are broad-spectrum antivirals, and are useful for prophylactic treatment against or therapeutic treatment of infection by hemorrhagic fever viruses, such as RVFV, Ebola Virus, and Andes Virus, as well as vesicular stomatitis virus.

Abstract: Disclosed herein are nucleotide sequences which encode a plurality of structural proteins, except the capsid, of an equine encephalitis virus, wherein the nucleotide sequence is codon-optimized for mammalian expression. The nucleotide sequences are codon-optimized for expression in humans. As disclosed herein, the nucleotide sequences confer protection against Venezuelan equine encephalitis virus (VEEV), western equine encephalitis virus (WEEV), and/or eastern equine encephalitis virus (EEEV).

Abstract: An operating table includes a patient placement table for placing and securing a patient in a required posture; a main body for supporting the patient placement table; engaging pieces for removably coupling the patient placement table to the main body; and a motor for rotating the patient placement table with a head-feet direction of the patient as a rotation axis to hold the patient placement table at any given rotation angle.

Abstract: Provided herein are compounds that modulate the activity of inhibitor of apoptosis proteins (IAPs), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Abstract: Disclosed are compositions and methods useful for targeting tumors, sites of injury and blood clots. The compositions and methods are based on peptide sequences that selectively bind to and home to tumors, sties of injury and blood clots in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tumors, sites of injury and blood clots.

Abstract: Provided herein are methods for the diagnosis of cancer by comparison of a quantification of long non-coding RNA SPRY4-IT1 with the same measurement taken in a reference sample from a healthy patient. Further provided herein are methods of anticipating the likelihood that such a disease will develop, and methods of treatment in the event of such development.

Abstract: Provided herein are methods for the diagnosis of human melanoma by assessing MITF, miR-211, TRPM1, and/or KCNMA1 and methods for the diagnosis of resistance to chemotherapeutic agents by assessing the regulatory pathways of PGC1?. Methods for treating melanoma, including drug-resistant melanoma, are also provided.