Patents Assigned to Medical Research Institute
  • DETERMINATION OF CANCER PREDISPOSITION
    Publication number: 20130210124
    Abstract: Disclosed herein are systems and methods for using demethylation of genomic DNA for diagnosing, predicting, and/or monitoring the status or outcome of a neoplasm or a cancer in a subject.
    Type: Application
    Filed: February 8, 2013
    Publication date: August 15, 2013
    Applicants: Institut de Medicina Predictiva I Personalitzada Del Cancer (IMPPC), SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: SANFORD- BURNHAM MEDICAL RESEARCH INSTITUTE, Institut de Medicina Predictiva I Personalitzada Del Cancer (IMPPC)
  • R-RAS activity in vascular regulation
    Patent number: 8506965
    Abstract: The invention provides means and methods for vascular regulation through enhancement or inhibition of R-Ras activity. The invention specifically provides means and methods for promoting a quiescent state of a vascular cell by providing additional R-Ras activity to the cell. The invention further provides means and methods for diagnosing a condition of vasculature of an individual.
    Type: Grant
    Filed: November 11, 2005
    Date of Patent: August 13, 2013
    Assignees: Vascular BioSciences, Sanford Burnham Medical Research Institute
    Inventors: Masanobu Komatsu, David Marshall Mann, Erkki Ruoslahti
  • CAR PEPTIDE FOR HOMING, DIAGNOSIS & TARGETED THERAPY FOR PULMONARY AND FIBROTIC DISORDERS
    Publication number: 20130196896
    Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.
    Type: Application
    Filed: February 28, 2011
    Publication date: August 1, 2013
    Applicants: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, VASCULAR BIOSCIENCES, INC.
    Inventors: Masanobu Komatsu, David Marshall Mann, Erkki Ruoslahti
  • COMBINED QUANTITATIVE MRI AND QUANTITATIVE MRS FOR DIAGNOSIS OF ALZHEIMERS DISEASE AND HIPPOCAMPAL SCLEROSIS
    Publication number: 20130190606
    Abstract: Using both quantitative MRI and quantitative MRS, the inventor demonstrates herein that as age and dementia progress, hippocampal volume (HV), amygdala volume (AV), and NAA/mI ratio all decrease compared to normal controls. The inventor's data also demonstrate herein that NAA/mI vs. total amygdala volume showed a very strong linear correlation, while NAA/mI vs. mean total hippocampal volume had a lesser but still significant correlation. Further, after analyzing the data derived from both quantitative MRI and quantitative MRS methods, the inventor made the surprising discovery that the two tests, when combined, provide significantly improved biomarkers over either alone, and are more effective at early MCI and/or AD diagnosis, as well as HS diagnosis.
    Type: Application
    Filed: January 25, 2013
    Publication date: July 25, 2013
    Applicant: Huntington Medical Research Institutes
    Inventor: Huntington Medical Research Institutes
  • APPARATUS AND METHOD FOR TREATING OBSTRUCTIVE SLEEP APNEA
    Publication number: 20130190836
    Abstract: The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.
    Type: Application
    Filed: December 18, 2012
    Publication date: July 25, 2013
    Applicant: Huntington Medical Research Institutes
    Inventor: Douglas B. McCreery
  • PEPTIDES THAT HOME TO TUMOR LYMPHATIC VASCULATURE AND METHODS OF USING SAME
    Publication number: 20130183241
    Abstract: The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering to the subject a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature.
    Type: Application
    Filed: December 10, 2012
    Publication date: July 18, 2013
    Applicant: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventor: Sanford-Burnham Medical Research Institute
  • Optically pure apogossypol derivative as pan-active inhibitor of anti-apoptotic B-cell lymphoma/leukemia-2 (BCL-2)
    Patent number: 8487131
    Abstract: A compound of Formula I: or a pharmaceutically acceptable salt thereof is disclosed. In addition, pharmaceutical compositions thereof, methods for preparing and methods for using this compound or composition for treating a variety of diseases, including cancer and inflammation are also provided.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: July 16, 2013
    Assignee: Sanford-Burnham Medical Research Institute
    Inventor: Maurizio Pellecchia
  • COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE AND INFLAMMATORY DISORDERS
    Publication number: 20130164306
    Abstract: Ligand-specific HVEM variants, compositions comprising such variants, and methods of treating inflammatory diseases comprising administering such variants, are provided.
    Type: Application
    Filed: November 15, 2012
    Publication date: June 27, 2013
    Applicant: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventor: SANFORD-BURNHAM MEDICAL RESEARCH IN
  • Methods and compositions related to targeting wounds, regenerating tissue, and tumors
    Patent number: 8470780
    Abstract: Disclosed are compositions and methods useful for targeting regenerating tissue, wounds, and tumors. The compositions and methods are based on peptide sequences that selectively bind to and home to regenerating tissue, wound sites, and tumors in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to regenerating tissue, wound sites, and tumors in animals.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: June 25, 2013
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Tero Järvinen
  • IDENTIFICATION OF COMPOUNDS THAT REGULATE APOPTOSIS
    Publication number: 20130157260
    Abstract: An assay for identifying compounds that affect conversion of Bcl-2 family protein from an antiapoptotic to a proapoptotic form or inhibit activity of Bcl-2 family protein is described.
    Type: Application
    Filed: December 2, 2010
    Publication date: June 20, 2013
    Applicant: Sanford-Burnham Medical Research Institute
    Inventors: Arnold Satterthwait, Xiao-kun Zhang, Xiuwen Zhu, Siva Kolluri, John C. Reed
  • SUBSTITUTED ANDROST-4-ENE DIONES
    Publication number: 20130157988
    Abstract: The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds containing them, and the use of said compounds for the treatment of hormone-related disorders in mammals. This includes hormone-dependent cancers, particularly those caused by elevated levels of estrogen and its intermediates. These compounds can also be used in the treatment of other hormone-related disorders, including benign prostatic hyperplasia, cardiovascular disease, and neurodegenerative disorders.
    Type: Application
    Filed: April 7, 2011
    Publication date: June 20, 2013
    Applicants: EMORY UNIVERSITY, HAUPTMAN-WOODWARD MEDICAL RESEARCH INSTITUTE, THE RESEARCH FOUNDATION OF STATE OF NEW YORK
    Inventors: Huw Davies, Debashis Ghosh, Daniel Morton
  • Neuroprotective compositions and methods
    Patent number: 8466311
    Abstract: Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keap1, a negative regulator of the transcription factor Nrf2, and prevent Keap1-mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keap1/Nrf2 complex.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: June 18, 2013
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Stuart A. Lipton, Takumi Satoh
  • HYBRID MULTIELECTRODE ARRAYS
    Publication number: 20130150696
    Abstract: A method of forming a multielectrode array includes forming an alignment plate having at least two openings, forming an array bottom plate having at least two openings corresponding to the at least two openings of the alignment plate, temporarily fixing the array bottom plate to the alignment plate, inserting one or more probes or array sub-assemblies into the at least two openings, fixing the probes or array sub-assemblies to the array bottom plate, and removing the array bottom plate from the alignment plate to form a multielectrode array.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 13, 2013
    Applicant: HUNTINGTON MEDICAL RESEARCH INSTITUTES
    Inventor: Huntington Medical Research Institutes
  • Needle safety guard adapted to attach to a liquid container
    Patent number: 8460268
    Abstract: A needle safety guard device adapted to attach to a liquid container is provided. The device includes a disk-shaped shield having a medial opening connected with a radial opening between two radial edges. The device also includes a substantially U-shaped holder having two sidewalls coupled substantially perpendicular to the disk-shaped shield along the two radial edges, and a top cover connecting to the two sidewalls and extending from the shield above the radial opening. The U-shaped holder includes a wedged protrusion and a curved protrusion extending from each of the two sidewalls, the curved protrusion being between the top cover and the wedged protrusion for blocking a cap of the liquid container from moving toward the medial opening.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: June 11, 2013
    Assignee: Mercy Medical Research Institute
    Inventors: Bruce Hedgepeth, Roger Huckfeldt, Cindy Lowe, Martin Reuter, Matt Price, Keela Davis, Rahul Eapen
  • PEPTIDES THAT HOME TO ATHEROSCLEROTIC PLAQUES AND METHODS OF USE
    Publication number: 20130115167
    Abstract: The invention provides methods of targeting atherosclerotic plaques using LyP-1 related peptides. The invention additionally provides methods of treating an inflammatory condition using LyP-1 related peptides.
    Type: Application
    Filed: June 22, 2012
    Publication date: May 9, 2013
    Applicant: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Juliana Hamzah
  • Bi-dentate compounds as kinase inhibitors
    Patent number: 8431529
    Abstract: The present disclosure provides compound having the general structure A or pharmaceutically acceptable salts thereof: Het-L-P??(A) wherein Het is an aromatic moiety comprising a heterocyclic structure mimicking ATP, P is a docking site derived peptide or a docking site peptide mimetic, and L is a linking moiety, wherein L links the ATP mimetic to the docking site peptide moiety. The compounds having the general structure A can serve as inhibitors of kinases, such as the kinases JNK, Erk and p38.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: April 30, 2013
    Assignee: Sanford-Burnham Medical Research Institute
    Inventor: Maurizio Pellecchia
  • Intermaxillary fixation device and method of use
    Patent number: 8414581
    Abstract: An apparatus and method for fixing a patient's jaw by using arcuate arch bars which are fastened to both the upper and lower teeth using a plurality of zip ties. The arch bars are provided with bores and zip ties are passed through these bores and fastened to the patient's teeth. Each arch bar is provided with interarch receptacles which receive and engage a zip tie. The receptacles are rotatable and are generally aligned between the upper and lower arch bars. Additional zip ties with opposed teeth are passed through the upper and lower pairs of arch bar receptacles and tightened to fix the lower jar to the upper jaw.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: April 9, 2013
    Assignee: Mercy Medical Research Institute
    Inventors: Bharat Shah, Kara Childers, Keela Davis
  • Methods and compositions related to internalizing RGD peptides
    Patent number: 8367621
    Abstract: Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing ?v integrins. The compositions and methods are based on peptide sequences that selectively bind to and home to tissue undergoing angiogenesis or to cells or tissue expressing ?v integrins in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tissue experiencing angiogenesis or to cells or tissue expressing ?v integrins.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: February 5, 2013
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
  • Apparatus and method for treating obstructive sleep apnea
    Patent number: 8359108
    Abstract: The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: January 22, 2013
    Assignee: Huntington Medical Research Institutes
    Inventor: Douglas B. McCreery
  • Sanitary Disposable Unisex Urine Device
    Publication number: 20130018346
    Abstract: A sanitary disposable urine device is provided that includes an inner ring and outer ring each having a top surface and opposing bottom surface. The outer ring is substantially concentric with the inner ring and may be offset. At least one of the top surfaces of the inner and outer rings conforms to a body contour of a user's perineum. The device includes a hand holder coupled to the bottom surface of the inner ring, the hand holder having an opening configured to match to the inner ring. The device includes a fluid containing bag having an open end attached to the hand holder such that fluid flows through the inner ring and the opening of the hand holder into the fluid containing bag during usage. The device includes an inner bag inside the fluid containing bag having an absorbent material and an outer sealable bag to secure the device after use.
    Type: Application
    Filed: June 13, 2012
    Publication date: January 17, 2013
    Applicant: MERCY MEDICAL RESEARCH INSTITUTE
    Inventors: Roger Huckfeldt, Cindy Lowe, Keela Davis, Martin Reuter, John Price, Debbie Sue Mikkelson