Abstract: Provided is a process for treating or preventing a viral infection in a subject, wherein the viral infection is from a flavivirus selected from the group consisting of Hepatitis C Virus (genotypes 1-7) and Japanese Encephalitis Virus.
Type:
Application
Filed:
August 10, 2012
Publication date:
September 11, 2014
Applicants:
Sanford-Burnham Medical Research Institute, Southern Research Institute
Inventors:
Marintha L. Heil, Nicholas D.P. Cosford, Robert Ardecky, Jiwen Zou
Abstract: The invention relates to a multielectrode probe having a silicon substrate which supports multiple conductive electrodes for deep-brain electrical stimulation or recording of neural responses. The substrate has an upper end with multiple conductive portions for bonding to lead wires, and an elongated shank extends from the upper end. The shank supports multiple spaced-apart electrodes, typically ten in number, and conductive traces electrically connect the electrodes and conductive traces. Multiple probes are combined, and supported as an array by a cylindrical alignment cylinder.
Abstract: The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.
Type:
Application
Filed:
May 5, 2014
Publication date:
August 28, 2014
Applicant:
Pfantastic Medical Research Institute, LLC
Abstract: The present invention relates to regulation of cardiac contractile function. The present invention is based on the discovery that microRNAs contribute to the loss of cardiac contractility. Specifically, miR-25 binds to SERCA2a which results in a loss of function and interferes with Ca2+ handling. Accordingly, the present invention relates to methods of increasing cardiac contractile function by inhibiting miR-25. The invention further provides methods to identify agents that can modulate miR-25 activity, including high throughput screening methods, and provides a means to identify agents that are useful for treating patients having cardiac contractile function associated disorders.
Type:
Application
Filed:
December 17, 2013
Publication date:
August 28, 2014
Applicants:
Icahn School of Medicine at Mount Sinai, Sanford-Burnham Medical Research Institute
Inventors:
Mark Mercola, Agustin Rojas-Munoz, Christine Wahlquist, Alexandre Colas, Roger J. Hajjar, Dongtak Jeong
Abstract: Disclosed are compositions and methods useful for targeting tumors, sites of injury and blood clots. The compositions and methods are based on peptide sequences that selectively bind to and home to tumors, sites of injury and blood clots in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tumors, sites of injury and blood clots.
Type:
Grant
Filed:
February 5, 2007
Date of Patent:
August 26, 2014
Assignee:
Sanford-Burnham Medical Research Institute
Abstract: Compounds of Formula (I) wherein B is selected from the group consisting of substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl; Y is a linker moiety selected from the group consisting of a direct bond. R, R1, R2, and R3 are each individually selected from the group consisting substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or heterocycle.
Type:
Application
Filed:
August 27, 2012
Publication date:
August 21, 2014
Applicants:
Sanford-Burnham Medical Research Institute, Southern Research Institute
Inventors:
Marintha L. Heil, Nicholas D.P. Cosford, Nicholas Pagano, Peter Teriete
Abstract: There is provided a method for promoting dynamin ring formation and/or maintenance of dynamin rings in a cell, comprising treating the cell with an effective amount of a dynamin ring stabilizer, or a prodrug or pharmaceutically acceptable salt of the dynamin ring stabilizer. The maintenance or accumulation of dynamin ring formation has particular application in the prophylaxis or treatment of a kidney disease or condition characterized by proteinuria. A dynamin ring stabilizer can be any agent that interacts with dynamin to promote dynamin ring assembly and/or inhibit dynamin ring disassembly. There are also provided methods for prophylaxis or treatment of podocyte dysfunction and/or maintaining or inducing actin cytoskeleton formation in a cell utilizing dynamin ring stabilizers, and for screening a test agent for use as a dynamin ring stabilizer.
Type:
Grant
Filed:
May 21, 2010
Date of Patent:
August 19, 2014
Assignees:
Children's Medical Research Institute, The General Hospital Corporation
Abstract: The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a variety of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimetic thereof.
Type:
Application
Filed:
November 27, 2013
Publication date:
August 7, 2014
Applicant:
Sanford-Burnham Medical Research Institute
Inventors:
Lianglin Zhang, Jason A. Hoffman, Erkki Ruoslahti
Abstract: This invention relates to a new application of compound Clonidine Hydrochloride in a use of preparation of information intervention agent, a new preparation method of information intervention agent, and a product. The Clonidine Hydrochloride interacts with the human information receptor, therefore realizing the intervention through the Clonidine Hydrochloride information physical method, and treatment was not a chemical treatment. This invention comprises: putting the compound Clonidine Hydrochloride information package filler (3) into a container (4), closing the lid (7), sealing by a glue, attaching a hanging piece to the container (4) to form the Clonidine Hydrochloride information intervention agent (9) for clinical use. The usage of this invention is simple, convenient, safe, reliable and easy to accept. It is especially appropriate for use by senior people, unhealthy people, children, or people with disturbance of consciousness, mental retardation, and behavioral disorders.
Type:
Application
Filed:
January 21, 2013
Publication date:
July 24, 2014
Applicant:
Beijing Zhongwei Shennong Chronic Disease Medical Research Institute Co., Ltd.
Inventor:
Beijing Zhongwei Shennong Chronic Disease Medical Reasearch Institute Co., Ltd.
Abstract: The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based inhibitor development. To this end, the inventors have identified small molecule compounds that inhibit bacterial target enzymes by interacting with a novel inhibitory binding site on the enzyme while having no effect on functionally equivalent human enzymes.
Type:
Grant
Filed:
July 12, 2010
Date of Patent:
July 22, 2014
Assignees:
University of Maryland, Baltimore, The Board of Regents of the University of Texas System, Sanford-Burnham Medical Research Institute
Inventors:
Alexander Mackerell, Jr., Hong Zhang, Andrei Osterman, Rohit Kolhatkar
Abstract: The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.
Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.
Abstract: A positioning device is described for supporting an infant with myelomeningocele during surgery, transport and pre- and post-operative procedures. The device allows the patient to be expeditiously re-positioned from prone to supine and lateral positions and vice versa before, during and after surgery. The device allows access to the myelomeningocele while the patient is secured in the device.
Type:
Grant
Filed:
August 22, 2012
Date of Patent:
July 1, 2014
Assignee:
Mercy Medical Research Institute
Inventors:
Bharat Shah, Dawn Zablocki, Sami Khoshyomn
Abstract: Disclosed are compositions and methods useful for targeting therapeutics to cancerous cells and tumors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells and tumors.
Type:
Grant
Filed:
December 23, 2009
Date of Patent:
June 17, 2014
Assignee:
Sanford-Burnham Medical Research Institute
Inventors:
Erkki Ruoslahti, Venkata Ramana Kotamraju, Priya Karmali
Abstract: The present invention relates to methods for treating obstructive sleep apnea (OSA), alleviating a negative OSA symptom, reducing snoring, or improving quality of life in a subject, comprising administering to the subject an effective amount of a pharmaceutical composition comprising pyridostigmine before sleep. Also provided are related medicaments as well as methods for preparing the medicaments.
Type:
Grant
Filed:
January 27, 2012
Date of Patent:
June 17, 2014
Assignee:
Pfantastic Medical Research Institute, LLC
Abstract: The disclosure provides compounds and compositions, and methods of using these compounds and compositions, as positive allosteric modulators of the metabotropic glutamate subtype 2 (mGlu2) receptor, and for treating CNS disorders associated with the mGlu2 receptor including schizophrenia, anxiety, addiction, e.g. cocaine addiction, nicotine addiction, and the like.
Type:
Grant
Filed:
March 18, 2011
Date of Patent:
June 10, 2014
Assignees:
Sanford-Burnham Medical Research Institute, The Regents of the University of California
Inventors:
Nicholas D. P. Cosford, Dhanya Raveendra Panickar, Shyama Sidique, Svetlana Semenova, Athinia Markou
Abstract: The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and signals via interaction with a gp130/LIF receptor heterodimer. In a related aspect, the present invention provides a method of increasing insulin sensitivity in a mammal. The method of present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by unwanted lipid accumulation (such as obesity, obesity induced-metabolic disorders, type II diabetes, dyslipidemia, glucose intolerance, insulin resistance, obstructive sleep apnea, cardiovascular disease or non-alcoholic fatty liver disease) or inadequate insulin sensitivity.
Type:
Application
Filed:
August 16, 2013
Publication date:
May 22, 2014
Applicants:
Christian-Albrechts-Universität Zu Kiel, Baker Medical Research Institute
Inventors:
Mark Anthony Febbraio, Stefan Rose-John
Abstract: Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases.
Type:
Grant
Filed:
December 7, 2011
Date of Patent:
April 1, 2014
Assignee:
Sanford-Burnham Medical Research Institute
Abstract: The invention contemplates a new synthetic, codon-optimized Sin Nombre virus (SNV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The SNV ORF was cloned into a plasmid to form the first stable recombinant SNV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a vaccine system, and is useful to protect mammals against infection with Sin Nombre virus.
Type:
Application
Filed:
January 31, 2011
Publication date:
March 20, 2014
Applicant:
The United States of America as rep. by the Sec'y the army for U.S. Army Medical Research Institute