Abstract: Systems and methods for training deep neural networks (DNNs) for blood vessel and lesion segmentation using synthetically generated training data, are provided. Systems may comprise parametric simulation modules for generating 3D branching blood vessels and 3D lesion structures and an augmentation module configured to add noise, background and organ boundaries to the 3D models, to yield the synthetic training data for training the DNNs. The 3D vessel model may be generated as a hierarchical tree comprising segments that are generated as anti-aliased lines with specified length and start and end thicknesses, which are elongated by segment addition(s) and/or by branching to follow semi-linear or curved lines, while avoiding overlapping of segments. The 3D lesion model and/or combined vessel/lesion models may be generated using multiple input images such as contrast enhancement phases.

Abstract: Ultrasound (US) modules and methods in US image-guided systems for thermal ablation are provided, which utilize regular two-dimensional (2D) B mode US images to evaluate in real-time the damage achieved by the thermal ablation, including the prediction of tissue damage immediately after completion of the thermal ablation procedure, as well as the expected damage after 24 hours. Three-dimensional (3D) biotrace map (BTM) representation(s) may be constructed from the received US images by applying deep neural networks (DNN) to segment tissue damage in US frames, and present the damage to the user in 3D and/or in virtual sections through the BTM representation(s). Using regular 2D US probes allows much flexibility in operating the US probe and imaging the target successfully, while the construction of the 3D BTM representation(s) enables accumulating, updating and analyzing the volume data to provide a full and updating representation of the ablation procedure.

Abstract: Disclosed is an apparatus for enriching and screening a target object such as a cell, bacteria or biomolecule from a sample. The apparatus includes a plurality of multi-channel mesh bodies arranged in parallel, and each multi-channel mesh body includes a mesh body formed by intersecting a plurality of threads, a plurality of screen pores formed by intersecting the plurality of threads, and a capturing layer formed on the mesh body. The capturing layer includes a capturing material specifically binding with the target object.

Abstract: A multi-lumen insertion tube for use with an endoscope, the multi-lumen insertion tube having a circumferential outer wall defining a main inner lumen, and a plurality of inner septa dividing the main inner lumen into a plurality of lumens. The circumferential outer wall is configured to expand radially outwardly when positive pressure is applied through the insertion tube, and to at least partially collapse against at least one of the inner septa when negative pressure is applied through the insertion tube, such that further collapse of the circumferential wall is prevented by at least one of the inner septa.

Abstract: Provided are an eye tracking method and apparatus for anterior segment OCTA, a device, and a storage medium. The eye tracking method for anterior segment OCTA includes: acquiring two consecutive frames of pupil images; separately performing contour extraction on the two frames of pupil images to obtain two corresponding pupil contours; determining whether the two pupil contours are similar to a reference contour, and in response to the two pupil contours being similar to the reference contour, calculating a central position offset of one of the two pupil contours with respect to the other pupil contour.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: The present disclosure provides a kit for identifying tumor tissue-of-origin, including an adapter and PCR amplification primers, where the adapter includes nucleotide sequences of A01-T, A01-B, A02-T, A02-B, A03-T, A03-B, A04-T, A04-B, A05-T, A05-B, A06-T, and A06-B; and the PCR amplification primers include nucleotide sequences of R01-F, R01-R, R02-F, and R02-R. In the present disclosure, new adapter nucleotide sequences and PCR amplification primers are designed, with higher accuracy and effectiveness. The present disclosure further provides a data analysis method for a kit for identifying tumor tissue-of-origin, including data preprocessing, alignment, methylation information statistics, quality control, and analysis. In the present disclosure, the analysis of a Beta value-based methylation index further improves a recognition ratio.

Abstract: A system and method use impedance, optionally in combination with one or more imaging techniques (e.g., US, CT, MRI, PET scan, SPECT, fluoroscopy, endoscopy) to discern between diseased and healthy tissue, and/or to determine location, size, boundaries and/or multifocal foci of diseased tissue. Impedance is measured between groups of electrodes. The electrodes may be inserted with a plurality of interstitial probes positionable within tissue (e.g., prostate). One or more electrodes may be mounted on each probe. An algorithm (e.g., machine learning capable) may discern diseased tissue and/or compile a histological map of the tissue. The same system optionally delivers ablative energy, or electroporation and/or electrochemotherapy to identified diseased (or high risk) tissue as a treatment modality. Mapping, treatment on the mapping and/or post-treatment scanning may be performed via the same device. The multi-use system may reduce navigating of the tissue to deliver focal treatment to tumor foci.

Abstract: System and method for presentation of tissue sensing data being collected from a tissue being measured are presented and configured for on-line as well as for off-line presentation of the tissue sensing data, the system comprising a device configured and operable to display a graphical user interface, the graphical user interface comprises at least one observation field and is configured to be responsive to the tissue sensing data comprising one or more sensing datum of measured tissue property value, to transform each measured tissue property value into virtual representation in the at least one observation field in the form of a parametric space of two different characteristic parameters of tissue corresponding to the measured tissue property value.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: A handle for at least partially covering an endoscope with a protective thin sleeve, the handle comprising: a handle body shaped and sized to receive a distal portion of an endoscope therein; a detachable portion at a proximal end of the handle body, the detachable portion configured to detach from the handle body and to be moved proximally along at least a portion of a length of an endoscope received within the handle body; and a thin elongate protective sleeve axially compacted within the handle body, a proximal end of the sleeve coupled to the detachable portion, wherein movement of the detachable portion proximally along the endoscope pulls on the proximal end of the sleeve and extends the sleeve in length from its axially compacted state to a lengthened state, thereby covering the at least a portion of the length of the endoscope.

Abstract: According to some embodiments of the invention there is provided a colon cleaning system comprising: a working channel, a vacuum source, a separate vacuum pipe provided alongside the working channel, and a sensor positioned at a conduit connected externally to the working channel, the sensor configured for providing an indication related to pressure within at least a segment of the working channel. In some embodiments, the system comprises a controller configured for controlling one or more parameters of a vacuum induced in the separate vacuum pipe, the parameter determined according to the pressure related indication provided by the sensor.

Abstract: The present invention provides a plasma device for skin repair, which includes a plasma head, a power supply, a gas supply source, and a control box. The plasma head includes an inner sleeve and an outer sleeve which are sleeved together. The inner sleeve has a first bottom portion having several first through holes. The outer sleeve has a second bottom portion having several second through holes. A gap is formed between the first bottom portion and the second bottom portion. The power supply is configured to provide 13.56 MHz to 54 MHz radio frequency power to generate a discharge in the gap. The gas supply source is configured to provide reaction gas into the gap, and plasma is formed by the reaction gas under the discharge. The control box is configured to control operating parameters of the plasma head, the power supply, and the gas supply source.

Abstract: Systems and methods for cleaning a colon or other portion of an intestine include optional use of sensors to detect conditions of blockage of flow of materials within an evacuation channel used to remove fecal material from the body; and devices and methods for purging such blockages from the evacuation channel.

Abstract: Double-lumen infusion catheter including: a shaft having proximal section, distal section, and intermediate section therebetween; first and second lumens extending along a length of the shaft and having arc shaped wall therebetween; and an inflatable member provided distally to intermediate section, and over the distal section. First lumen has cross section larger than cross section of second lumen and is configured to receive a guidewire therethrough and allow fluid flow via an unobstructed portion of first lumen. Unobstructed portion is formed along guidewire outer surface, between guidewire outer surface and inner wall of first lumen, and extends from an inlet at proximal end of intermediate section to an outlet at distal end of intermediate section. First lumen is narrowed to approximate a first diameter in shaft proximal and distal sections, and is widened to approximate a second diameter greater than first diameter in the shaft intermediate section.

Abstract: The present invention relates to a method and system that allows input mammography images to be converted between domains. More particularly, the present invention relates to converting mammography images from the image style common to one manufacturer of imaging equipment to the image style common to another manufacturer of imaging equipment. Aspects and/or embodiments seek to provide a method of converting input images from the format output by one imaging device into the format normally output by another imaging device. The imaging devices may differ in their manufacturer, model or configuration such that they produce different styles of image, even if presented with the same raw input data, due to the image processing used in the imaging device(s).

Abstract: According to some embodiments of the invention there is provided a colon cleaning system comprising: a working channel, a vacuum source, a separate vacuum pipe provided alongside the working channel, and a sensor positioned at a conduit connected externally to the working channel, the sensor configured for providing an indication related to pressure within at least a segment of the working channel. In some embodiments, the system comprises a controller configured for controlling one or more parameters of a vacuum induced in the separate vacuum pipe, the parameter determined according to the pressure related indication provided by the sensor.

Abstract: This application presents methods and devices for continuously cleaning a colon by at least partially filling a segment of the colon with liquid and agitating the fluid to dislodge matter adhering to the colon walls. Methods for automatic maintenance of liquid levels in the colon during continuous cleaning are taught.

Abstract: A method for fabricating a multi-cell electroacoustic transducer comprises placing a rail layer onto a base, the rail layer comprising a plurality of apertures arranged in an array, filling cavities in the rail layer with a polymer, and applying a flexural plate to the rail layer. The transducer achieves high transmission sensitivity across a broad bandwidth. The transducer may be designed to have a broad or a focused directivity pattern, or may be multi-frequency, depending on the particular application and has a range of applications.